Paul Simon Hochman, Dave
Entertainment weekly,
01/1999
510
Magazine Article
Paul Simon is ranked 70th on the list of the 100 greatest entertainers of the last half of the 20th century. Simon's influence on the music industry is discussed.
Diane Keaton Hochman, Dave
Entertainment weekly,
01/1999
510
Magazine Article
Diane Keaton is ranked 96th on the list of the 100 greatest entertainers of the last half of the 20th century. Keaton has starred in such movies as "The First Wives Club," "Looking for Mr. Goodbar," ...and "Baby Boom."
The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase ...III of the Encyclopedia of DNA Elements (ENCODE) Project has expanded analysis of the cell and tissue repertoires of RNA transcription, chromatin structure and modification, DNA methylation, chromatin looping, and occupancy by transcription factors and RNA-binding proteins. Here we summarize these efforts, which have produced 5,992 new experimental datasets, including systematic determinations across mouse fetal development. All data are available through the ENCODE data portal (https://www.encodeproject.org), including phase II ENCODE
and Roadmap Epigenomics
data. We have developed a registry of 926,535 human and 339,815 mouse candidate cis-regulatory elements, covering 7.9 and 3.4% of their respective genomes, by integrating selected datatypes associated with gene regulation, and constructed a web-based server (SCREEN; http://screen.encodeproject.org) to provide flexible, user-defined access to this resource. Collectively, the ENCODE data and registry provide an expansive resource for the scientific community to build a better understanding of the organization and function of the human and mouse genomes.
Perspectives on ENCODE Snyder, Michael P; Gingeras, Thomas R; Moore, Jill E ...
Nature (London),
07/2020, Letnik:
583, Številka:
7818
Journal Article
Recenzirano
Odprti dostop
The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, ...biochemical regions associated with gene regulation (for example, transcription factor binding sites, open chromatin, and histone marks) and transcript isoforms. The marks serve as sites for candidate cis-regulatory elements (cCREs) that may serve functional roles in regulating gene expression
. The project has been extended to model organisms, particularly the mouse. In the third phase of ENCODE, nearly a million and more than 300,000 cCRE annotations have been generated for human and mouse, respectively, and these have provided a valuable resource for the scientific community.
In the original article, the authors Rizi Ai (Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, USA) and Shantao Li (Program in Computational Biology and ...Bioinformatics, Yale University, New Haven, CT, USA) were mistakenly omitted from the ENCODE Project Consortium author list. The original Article has been corrected online.
In the version of this article initially published, two members of the ENCODE Project Consortium were missing from the author list. Rizi Ai (Department of Chemistry and Biochemistry, University of ...California, San Diego, La Jolla, CA, USA) and Shantao Li (Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA) are now included in the author list. These errors have been corrected in the online version of the article.
The Oscar house rules Harris, Mark; Hochman, David; Karger, Dave ...
Entertainment weekly,
03/2000
532
Magazine Article
This year's Oscar race is the tightest in years, with hardly a shoo-in in the bunch. Harris et al offer their picks for who will win on the big night. Findings from an Oscar online poll are also ...presented.
PDF
