The effect of ethaverine hydrochloride on exercise tolerance of patients with intermittent claudication was evaluated in a double-blind, placebo-controlled study conducted at three sites. Forty-five ...patients with symptoms of occlusive arterial insufficiency of the lower extremities were randomly assigned to receive ethaverine 200 mg or placebo four times daily. The patients were evaluated biweekly for 12 weeks with treadmill claudication tests, patient and investigator assessments of symptom severity, and reports of adverse reactions. Doppler ankle/brachial pressure ratios were recorded for 26 patients. Walking tolerance improved for patients in both groups during the course of the study. Increases in distance-to-claudication were significantly greater for patients receiving ethaverine after 6, 8, 10, and 12 weeks of therapy. Ankle/brachial pressure index after exercise was unchanged in both groups. Incidence of adverse reactions was similar for the two groups. Although patients were generally unaware of any improvement in symptoms, the investigators judged significant relief of claudication among those receiving ethaverine compared to those receiving placebo. It was concluded that ethaverine safely increased distance-to-claudication in patients with intermittent claudication.
An update of the Graves-Marchand-Thompson (GMT) 1982 rankings of university economics department in the US is presented, based on publications from 1978 through spring 1983. Rankings are also ...provided for the top 40 economics departments outside the US. Finally, a comparison of concentration ratios is presented measuring the dispersion in published pages among US departments between 1974-1978 and 1978-1983. Using the GMT methodology, rankings are based on American Economic Review-standardized page counts in 24 leading journals. A number of departments have moved significantly up and down, but the aggregate concentration ratios of published pages have remained unchanged between the 2 periods. An alternate method of quantifying the publication performance of departments is presented, and the results demonstrate that this procedure produces significantly different results when compared to the usual method. Discussion also centers on how the data can be interpreted as measures of interinstitution flows of publishing faculty. A number of valid criticisms of the GMT method are addressed, as well as errors of attribution and omission.
The MEGA Data Acquisition System Oothoudt, Michael A.; Amann, James F.; Bolton, Richard D. ...
IEEE transactions on nuclear science,
1987, Letnik:
34, Številka:
4
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
An engineering run with a partial detector is scheduled for Fall of 1987. The run will test the response of Phillips TDCs and nonsparse latches, the performance of SEs and SIs, and the data path from ...Fastbus through the ACP system to the MicroVAX II. Debugging of the GPM and FBBC is currently in progress. Software development for the GPM, ACP nodes, and MicroVAX II host is in progress and will be ready for use by the Fall run. Production data taking will start in late 1988.
Bluegills (Lepomis macrochirus Rafinesque) and largemouth bass (Micropterus salmoides Lacepede) were exposed to two applications of Dursban(R), an organophosphorus insecticide, at the recommended ...rates for mosquito control of 0.05 or 0.01 lb of active ingredient/A in experimental 0.1 acre ponds. Residues of Dursban in water 1 day after the applications ranged from 2.39 parts per billion (ppb) in the highest treatment to 0.97 ppb in the low treatment. Cumulative mortality in the untreated ponds during 63 days of observation was approximately 1% of the total population of each species of fish. Cumulative mortality of fishes during the same period in ponds treated at 0.01 lb/A was 3% for bluegills and 10% for bass, whereas the corresponding mortalities for the high application rate (0.05 lb/A) were 55% for bluegills and 46% for bass. Uptake of Dursban by fishes produced maximum residue values of 3.82 parts per million (ppm) in bluegills and 2.55 ppm in bass within 1 to 3 days after application of the insecticide at 0.05 lb/A. These residues decreased greatly within 2 weeks to less than 0.4 ppm and were undetectable after 4 weeks. Both species of fish taken from the ponds treated at 0.05 lb/A exhibited more than 80% inhibition of brain acetylcholinesterase activity as compared to fish from untreated ponds; fishes from these ponds had not recovered normal acetylcholin‐esterase activity 28 days after application of the insecticide. Histological examination of tissues from bluegills and largemouth bass exposed to Dursban did not show conclusive evidence for pesticide‐induced pathology. The high treatment reduced the total number of insects colonizing plate samplers by three‐fourths, eliminated caddisflies, and severely reduced mayfly populations. We believe that the results of this investigation confirm the inadvisability, as suggested on product labels, of using Dursban at the current recommended rates of application for mosquito control in habitats where valuable fishery resources are to be protected.
Quantitative measurements of the time course of calcium levels in experimental spinal cord trauma have been made. The injury was produced in rats by dropping a 10 g weight from 30 cm upon exposed ...dura-invested spinal cord. Lumbar sections of traumatized spinal cord and internal controls from remote cervical cord were excised and analyzed for calcium using atomic absorption spectroscopy. Total calcium levels in the lesioned cord were significantly elevated over control values within 45 min post-trauma (P less than 0.005), with maximal increase at 8 h. The increased levels of calcium in the lesion tissue confirm the previous morphologic finding of calcium deposits within axons in the lesion.
Low-cost fabrication of optical subassemblies Cohen, M.S.; Johnson, G.W.; Trewhella, J.M. ...
IEEE transactions on components, packaging, and manufacturing technology. Part B, Advanced packaging,
08/1997, Letnik:
20, Številka:
3
Journal Article, Conference Proceeding
The optical subassembly is a major contributor to the cost of a fiberoptic computer data link. A technology for low-cost fabrication of optical subassemblies is described, with emphasis on a ...transmitter subassembly designed for fiber-channel standard operation (266 Mb/s for 2 km; 1063 Mb/s for 500 m). A factor of three cost reduction is achieved by limiting the parts count to only three: a laser or receiver chip packaged in a TO-can, a plastic housing, and a plastic aspheric lens; and by employment of a fast, automated active-alignment and subsequent fixing technique. Key enabling features include the use of precision injection molding of specially chosen plastics, an aspheric lens design which permits wide positional variations in the axial direction, and curing of a fast setting epoxy through the use of RF power. A tool was constructed which produced subassemblies at high yield having satisfactory performance.
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