Computational models of cardiac electromechanics (EM) are increasingly being applied to clinical problems, with patient-specific models being generated from high fidelity imaging and used to simulate ...patient physiology, pathophysiology and response to treatment. Current structured meshes are limited in their ability to fully represent the detailed anatomical data available from clinical images and capture complex and varied anatomy with limited geometric accuracy. In this paper, we review the state of the art in image-based personalization of cardiac anatomy for biophysically detailed, strongly coupled EM modeling, and present our own tools for the automatic building of anatomically and structurally accurate patient-specific models. Our method relies on using high resolution unstructured meshes for discretizing both physics, electrophysiology and mechanics, in combination with efficient, strongly scalable solvers necessary to deal with the computational load imposed by the large number of degrees of freedom of these meshes. These tools permit automated anatomical model generation and strongly coupled EM simulations at an unprecedented level of anatomical and biophysical detail.
This work reports on the microstructure and mechanical properties of porous silver films produced with different sintering parameters. The microstructure is investigated by high-resolution ...ptychographic X-ray computed tomography and scanning electron microscopy. The mechanical properties are obtained from constant strain rate tensile tests. It is found that for this class of samples both grain size and ligament diameter have little effect on the magnitude of the yield stress. Instead, a clear correlation is found between strength and porosity.
Display omitted
Calcium aluminate cements are used for special applications but are nowadays banned for general structural purposes due to the calcium aluminate hydrate conversion, that has led, for concretes ...fabricated with high water contents, to building collapses. The stoichiometries of these conversion chemical reactions are relatively well established but the consequences in porosity, key to predict durability, were unknown. Here, we have used hard X-ray ptychographic nanotomography to study the hydration of CaAl2O4 at different temperatures and chiefly, at 4 °C and then at 50 °C to provoke conversion similar to field conditions. The mass densities of the resulting Al (OH)3 gels were 1.94, 1.98 and 2.23 g·cm−3, for samples hydrated at 4, 20 and 50 °C, respectively. These values are lower than that of gibbsite, 2.42 g·cm−3. Above all, this 3D imaging technique has allowed measuring the secondary water porosity developed in the conversion, which has an average pore dimension close to 140 nm.
Introduction
INTRODUCTION-OBJECTIVES. Similar to philosophy (regina-scientiarum) is psychiatry fundamental-discipline for all-medical&social sciences. Immanuel KANT: Primus inter pares of ...ARISTOTELES&PLATON considered over 200years ago physiological and pragmatic anthropology-1. Social physiology is given-3-4. Consideration of social-psychopathology in German-justice-2.
Objectives
REFERENCES. 1-Kant,I: BdXI,371-393,
BdXII,399,625-638:Suhrkamp-TB-Wiss. 2-Neu,E/Michailov, M.Ch/Welscher,U/et-al.: 2a.-FISP-2018-Beijing/Philos (1348-50,1373-4,1420); 2013-Athens Abstr.Book(AB):464-5/503-4/766; 2008-Seoul-ProcVol.4: 101-108/195-214/229-237; 2003-Istanbul:273-281; IVR-2019-Luzern (Law), Progr-Book p.116. 2b.-EPA-2020-Madrid, Eur.Psychiatry 63S, EPP0834/5+EPV0581/1470; EPA-2019-Warsaw, 56S,S689; EPA-2018-Nice, 48/S1, S623&567&662. 2c.-WPA-2021-Bangkok (in-press). 2019-Lisbon, E-Poster WCP19-2137/-1822/-1839. 2018-Mexico-City, Abs.-Book WCP18-0584/-0625/-0643/-0654. 2011-Buenos-Aires, AB:PO1.200. 3-Glasachev,O: Sechenov Physiol.J 80/no5, 1994,p.139-143 (Russian), ref. in English. 4-Seeley,T.D: Social-Physiology Honey-Bee, Book-1996.
Methods
5-Daily-journal-“tz”-München, esp. every Tuesday 2016-2019: reports on Res.-Houses,e.g. 14.02.2019, 15.02.17, 06.12.16/p.10, 18.10.16/p.10, 17.11.2020/p.6. Süddt.Zeitung-München no172/p.30,2017. Mü.-Merkur:16.11.2020/p.32; 19.11.2020/p.29. FAZ:20.10.2019/p.53; 16.11.2020/p.21. BUROW,P: Justiz am Abgrund&Ein Richter klagt an. GNISA,J, Präs.-Dt.Richterverein: „Ende der Gerechtigkeit“, Herder-2017. SCHLEIF,T/Amtsrichter: Buch „Urteil: ungerecht“, zeit-online 24.10.2019. Hans-Jochen&Liselotte VOGEL:„Mehr Gerechtigkeit“, 2019 „Wohn-Irrsinn“(Enteignungen). ZANTKE,S (Richter-Amtsgericht-Zwickau): TV-Programm„Auf einen Blick“ Nr.47,2018,S.24. 6-Luetge,Ch et-al.(ed): Experimental-Ethics, Palgrave-Macmillan 2014. 7-Pegoraro,R/Vatican: «Arzt&Christ» 38:3-55,1992.
Results
RESULTS Prominent German experts for justice: Patrick BUROW, Jens GNISA/President Law-Association/Germany, Torsten SCHLEIF/Amtsrichter, Hans-Jochen VOGEL/Ex-Minister, Stephan ZANTKE/Richter reflect in their books fundamental-criticism of German justice 5. Inst.-Ecol.-Med./IUM investigated psychopathology of juridical-offices&law-court in Munich (Amtsgericht). Analysis suggests presence of symptoms for pseudologia-phantastica, psychopathy, cyclophrenia (esp.mania),etc. conc. observations on many persons (n>30).
Conclusions
CONCLUSION. Juridical situation in Germany demonstrates contradiction to human-rights (EU-CHARTA, art.1-8/25-26/33-35), ignoring moral-philosophy, related to human obligations/I.Kant-1, experimental ethics/Ch.Luetge et-al.-6, medical personnel/R.Pegoraro-7. Only paradigm change in law-policy incl. enlarged implication of moral philosophy-theology, psychiatry-psychology, social philosophy in juridical eduction & practices could counteract disastrous juridical situation in Germany and on global level, supporting UNO-AGENDA21 for better education-health-ecology-economy (see 2.).
Disclosure
No significant relationships.
Disclaimer: The opinions or assertions contained herein are the private views of the authors and are not to be construed as official or as reflecting the views of the Department of the Army.
Drugs ...derived from amphetamine, methamphetamine and their methylenedioxy- analogues, although being sold as plant food or bath salts, are being used as legal alternatives to scheduled amphetamine stimulants. These products often contain methylone, mephedrone and methylenedioxypyrovalerone (MDPV)-three amphetamine derivatives shown to have strong pharmacological effects. Four postmortem cases were analyzed for methylone, mephedrone and MDPV, with drug levels quantitated in multiple biological matrices. All four cases had detectable levels of methylone, with heart blood concentrations of 0.740, 0.118, 0.060 and 1.12 mg/L. Analysis of several tissue samples shows that methylone does not sequester in a particular tissue type after death. The average liver-to-blood ratio was 2.68. Two cases also had MDPV present, but insufficient data were collected to formulate a hypothesis on postmortem sequestration or redistribution. Two different extraction methods, as well as analysis of derivatized and underivatized methylone, show that the drug is suitable for analysis in either method. The cases are believed to show one instance of chronic methylone use, with a urine concentration of 38 mg/L.
The C-Band All-Sky Survey is a project to map the full sky in total intensity and linear polarization at 5 GHz. The northern component of the survey uses a broad-band single-frequency analogue ...receiver fitted to a 6.1-m telescope at the Owens Valley Radio Observatory in California, USA. The receiver architecture combines a continuous-comparison radiometer and a correlation polarimeter in a single receiver for stable simultaneous measurement of both total intensity and linear polarization, using custom-designed analogue receiver components. The continuous-comparison radiometer measures the temperature difference between the sky and temperature-stabilized cold electrical reference loads. A cryogenic front-end is used to minimize receiver noise, with a system temperature of 30 K in both linear polarization and total intensity. Custom cryogenic notch filters are used to counteract man-made radio frequency interference. The radiometer 1/f noise is dominated by atmospheric fluctuations, while the polarimeter achieves a 1/f noise knee frequency of 10 mHz, similar to the telescope azimuthal scan frequency.
We have investigated the intensity dependence of high-order harmonic generation in argon when the two shortest quantum paths contribute to the harmonic emission. For the first time to our knowledge, ...experimental conditions were found to clearly observe interference between these two quantum paths that are in excellent agreement with theoretical predictions. This result is a first step towards the direct experimental characterization of the full single-atom dipole moment and demonstrates an unprecedented accuracy of quantum path control on an attosecond time scale.
Composite materials based on carbon fiber (CF) are prone to failure at the fiber-matrix interface upon compression or stress transverse to the fiber axis. The direct growth of carbon nanotubes on CF ...constitutes a novel approach to enhance the mechanical properties of the interface. However, the challenge is that, during the growth, tensile properties of the fiber are altered due to the diffusion effect of iron nanoparticles used in the process, leading to CF surface defect formation. In this work, we deliver and discuss an analysis methodology on ptychographic X-ray computed tomography (PXCT) images in order to assess the iron nanoparticle abundance within CFs. PXCT provides 50 nm - resolved 3D electron density maps of the CFs. We evidence the protective effect of an ultrathin alumina film against iron infiltration into CF during the CNT growth. This method potentially allows to evaluate the efficiency of other diffusion-minimizing approaches. The conclusions of the PXCT examination are validated by energy-dispersive X-ray spectroscopy and scanning transmission electron microscopy carried out on thin sample slices cut with a focused ion beam. The results provide a new insight into the mechanical performance of CFs and therefore constitute valuable knowledge for the development of hierarchical composites.
Display omitted
PDF
