We find that scattering amplitudes in massive scalar QCD can manifest the duality between color and kinematics at loop-level. Specifically we construct the one-loop integrands for four-point ...scattering between two distinct massive scalars, and the five-point process encoding the first correction to massive scalar scattering with gluonic radiation. We find that factorization and the color-kinematics duality are sufficient principles to entirely bootstrap these calculations, allowing us to construct all contributions ultimately from the three-point tree-level amplitudes which are themselves entirely constrained by symmetry. Double-copy construction immediately provides the associated predictions for massive scalars scattering in the so called N = 0 supergravity theory.
In 1995, the American Society of Human Genetics (ASHG) and American College of Medical Genetics and Genomics (ACMG) jointly published a statement on genetic testing in children and adolescents. In ...the past 20 years, much has changed in the field of genetics, including the development of powerful new technologies, new data from genetic research on children and adolescents, and substantial clinical experience. This statement represents current opinion by the ASHG on the ethical, legal, and social issues concerning genetic testing in children. These recommendations are relevant to families, clinicians, and investigators. After a brief review of the 1995 statement and major changes in genetic technologies in recent years, this statement offers points to consider on a broad range of test technologies and their applications in clinical medicine and research. Recommendations are also made for record and communication issues in this domain and for professional education.
A
bstract
The naive double-copy of (multi) loop amplitudes involving massive matter coupled to gauge theories will generically produce amplitudes in a gravitational theory that contains additional ...contributions from propagating antisymmetric tensor and dilaton states even at tree-level. We present a graph-based approach that combines the method of maximal cuts with double-copy construction to offer a systematic framework to isolate the pure Einstein-Hilbert gravitational contributions through loop level. Indeed this allows for a bootstrap of pure-gravitational results from the double-copy of massive scalar-QCD. We apply this to construct the novel result of the
D
-dimensional one-loop five-point QFT integrand relevant in the classical limit to generating observables associated with the radiative effects of massive black-hole scattering via pure Einstein-Hilbert gravity.
Genomic sequencing provides many opportunities in newborn clinical care, but the challenges of interpreting and reporting newborn genomic sequencing (nGS) results need to be addressed for its broader ...and effective application. The BabySeq Project is a pilot randomized clinical trial that explores the medical, behavioral, and economic impacts of nGS in well newborns and those admitted to a neonatal intensive care unit (NICU). Here we present childhood-onset and actionable adult-onset disease risk, carrier status, and pharmacogenomics findings from nGS of 159 newborns in the BabySeq Project. nGS revealed a risk of childhood-onset disease in 15/159 (9.4%) newborns; none of the disease risks were anticipated based on the infants’ known clinical or family histories. nGS also revealed actionable adult-onset disease risk in 3/85 (3.5%) newborns whose parents consented to receive this information. Carrier status for recessive diseases and pharmacogenomics variants were reported in 88% and 5% of newborns, respectively. Additional indication-based analyses were performed in 29/32 (91%) NICU newborns and 6/127 (5%) healthy newborns who later had presentations that prompted a diagnostic analysis. No variants that sufficiently explained the reason for the indications were identified; however, suspicious but uncertain results were reported in five newborns. Testing parental samples contributed to the interpretation and reporting of results in 13/159 (8%) newborns. Our results suggest that nGS can effectively detect risk and carrier status for a wide range of disorders that are not detectable by current newborn screening assays or predicted based on the infant’s known clinical or family history, and the interpretation of results can substantially benefit from parental testing.
A
bstract
We calculate the inelastic 2 → 3 one-loop amplitude for the scattering of two point-like, spinless objects with generic masses involving the additional emission of a single graviton. We ...focus on the near-forward, or classical, limit. Our results include the leading and subleading orders in the soft-region expansion, which captures all non-analytic contributions in the transferred momentum and in the graviton’s frequency. This allows us to check the first constraint arising from the inelastic exponentiation put forward in refs.
1
–
3
, and to calculate the 2 → 3 one-loop matrix element of the
N
-operator, linked to the
S
-matrix by
S
=
e
iN
, showing that it is real, classical and free of infrared divergences. We discuss how our results feature in the calculation of the
O
(
G
3
) corrections to the asymptotic waveform.
In 2011, an Advanced Notice of Proposed Rulemaking proposed that de-identified human data and specimens be included in biobanks only if patients provide consent. The National Institutes of Health ...Genomic Data Sharing policy went into effect in 2015, requiring broad consent from almost all research participants.
We conducted a systematic literature review of attitudes toward biobanking, broad consent, and data sharing. Bibliographic databases included MEDLINE, Web of Science, EthxWeb, and GenETHX. Study screening was conducted using DistillerSR.
The final 48 studies included surveys (n = 23), focus groups (n = 8), mixed methods (n = 14), interviews (n = 1), and consent form analyses (n = 2). Study quality was characterized as good (n = 19), fair (n = 27), and poor (n = 2). Although many participants objected, broad consent was often preferred over tiered or study-specific consent, particularly when broad consent was the only option, samples were de-identified, logistics of biobanks were communicated, and privacy was addressed. Willingness for data to be shared was high, but it was lower among individuals from under-represented minorities, individuals with privacy and confidentiality concerns, and when pharmaceutical companies had access to data.
Additional research is needed to understand factors affecting willingness to give broad consent for biobank research and data sharing in order to address concerns to enhance acceptability.
Individuals participating in biobanks and other large research projects are increasingly asked to provide broad consent for open-ended research use and widespread sharing of their biosamples and ...data. We assessed willingness to participate in a biobank using different consent and data sharing models, hypothesizing that willingness would be higher under more restrictive scenarios. Perceived benefits, concerns, and information needs were also assessed. In this experimental survey, individuals from 11 US healthcare systems in the Electronic Medical Records and Genomics (eMERGE) Network were randomly allocated to one of three hypothetical scenarios: tiered consent and controlled data sharing; broad consent and controlled data sharing; or broad consent and open data sharing. Of 82,328 eligible individuals, exactly 13,000 (15.8%) completed the survey. Overall, 66% (95% CI: 63%–69%) of population-weighted respondents stated they would be willing to participate in a biobank; willingness and attitudes did not differ between respondents in the three scenarios. Willingness to participate was associated with self-identified white race, higher educational attainment, lower religiosity, perceiving more research benefits, fewer concerns, and fewer information needs. Most (86%, CI: 84%–87%) participants would want to know what would happen if a researcher misused their health information; fewer (51%, CI: 47%–55%) would worry about their privacy. The concern that the use of broad consent and open data sharing could adversely affect participant recruitment is not supported by these findings. Addressing potential participants’ concerns and information needs and building trust and relationships with communities may increase acceptance of broad consent and wide data sharing in biobank research.
Xsec: the cross-section evaluation code Buckley, Andy; Kvellestad, Anders; Raklev, Are ...
European physical journal. C, Particles and fields,
12/2020, Letnik:
80, Številka:
12
Journal Article
Recenzirano
Odprti dostop
The evaluation of higher-order cross-sections is an important component in the search for new physics, both at hadron colliders and elsewhere. For most new physics processes of interest, total ...cross-sections are known at next-to-leading order (NLO) in the strong coupling
α
s
, and often beyond, via either higher-order terms at fixed powers of
α
s
, or multi-emission resummation. However, the computation time for such higher-order cross-sections is prohibitively expensive, and precludes efficient evaluation in parameter-space scans beyond two dimensions. Here we describe the software tool xsec, which allows for fast evaluation of cross-sections based on the use of machine-learning regression, using distributed Gaussian processes trained on a pre-generated sample of parameter points. This first version of the code provides all NLO Minimal Supersymmetric Standard Model strong-production cross-sections at the LHC, for individual flavour final states, evaluated in a fraction of a second. Moreover, it calculates regression errors, as well as estimates of errors from higher-order contributions, from uncertainties in the parton distribution functions, and from the value of
α
s
. While we focus on a specific phenomenological model of supersymmetry, the method readily generalises to any process where it is possible to generate a sufficient training sample.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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