Although acute exacerbation of idiopathic pulmonary fibrosis (IPF) has become well recognised, the reported incidence and outcomes are highly variable, and risk factors are unknown. The aim of this ...study was to estimate the incidence, risk factors and impact of acute exacerbations, and other known causes of rapid deterioration. This was a retrospective review of 461 patients with IPF (269 cases were biopsy-proven). The median follow-up period was 22.9 months. Rapid deterioration requiring hospitalisation occurred in 163 (35.4%) patients, with multiple episodes in 42 patients. Acute exacerbation was the most frequent cause (55.2%), followed by infection. The 1- and 3-yr incidences of acute exacerbation were 14.2 and 20.7%, respectively. Never having smoked and low forced vital capacity (FVC) were significant risk factors. The in-hospital mortality rate was 50.0%, and the 1- and 5-yr survival rates from the initial diagnosis were 56.2 and 18.4%, respectively. Acute exacerbation was a significant predictor of poor survival after the initial diagnosis, along with increased age, low FVC and diffusing capacity of the lung for carbon monoxide, and steroid use with or without cytotoxic therapy. 1- and 3-yr incidences of acute exacerbation were 14.2 and 20.7%, respectively. Never having smoked and low FVC were risk factors. Acute exacerbation had a serious impact on the overall survival of the patients with IPF.
•Informativeness and advertising creativity were the key drivers of favorable behavioral responses to an SNS ad.•Perceived herd behavior had an indirect impact on intention to express ...empathy.•Privacy concerns negatively influenced user intention to express empathy for an SNS ad.•Attitude and subjective norm were positively related to user intention to express empathy for the given SNS ad.•Intention to express empathy positively influenced purchase intention.
As social network services become more pervasive, social media advertising emerges as an attractive vehicle for augmenting advertising effectiveness. To leverage this new means of marketing, one must understand what engages SNS users in a favorable online behavior (i.e., overtly indicating personal interest in, or support for, the exposed message by clicking the Like or Share button in Facebook), thereby resulting in an effective advertising campaign. This research conceptualizes SNS ad effectiveness as a concept encompassing emotional appeal, informativeness and creativity that all have a potential to contribute to a positive online behavior. It empirically investigates the antecedents of positive user behavior for a SNS ad based on the theory of reasoned action, the social influence theory, and a persuasion theory. It proposes and tests a conceptual model of the formation of online user’s behavioral responses with regards to SNS advertising. The results of our empirical tests of the model reveal that informativeness and advertising creativity were key drivers of favorable behavioral responses to an SNS ad and that intention to engage in favorable user responses was positively associated with purchase intention. Based on these findings, the paper suggests further research directions and offers implications for harnessing the full potential of the new SNS advertising platform.
Penicillium is a diverse genus occurring worldwide and its species play important roles as decomposers of organic materials and cause destructive rots in the food industry where they produce a wide ...range of mycotoxins. Other species are considered enzyme factories or are common indoor air allergens. Although DNA sequences are essential for robust identification of Penicillium species, there is currently no comprehensive, verified reference database for the genus. To coincide with the move to one fungus one name in the International Code of Nomenclature for algae, fungi and plants, the generic concept of Penicillium was re-defined to accommodate species from other genera, such as Chromocleista, Eladia, Eupenicillium, Torulomyces and Thysanophora, which together comprise a large monophyletic clade. As a result of this, and the many new species described in recent years, it was necessary to update the list of accepted species in Penicillium. The genus currently contains 354 accepted species, including new combinations for Aspergillus crystallinus, A. malodoratus and A. paradoxus, which belong to Penicillium section Paradoxa. To add to the taxonomic value of the list, we also provide information on each accepted species MycoBank number, living ex-type strains and provide GenBank accession numbers to ITS, β-tubulin, calmodulin and RPB2 sequences, thereby supplying a verified set of sequences for each species of the genus. In addition to the nomenclatural list, we recommend a standard working method for species descriptions and identifications to be adopted by laboratories working on this genus.
Aspergillus comprises a diverse group of species based on morphological, physiological and phylogenetic characters, which significantly impact biotechnology, food production, indoor environments and ...human health. Aspergillus was traditionally associated with nine teleomorph genera, but phylogenetic data suggest that together with genera such as Polypaecilum, Phialosimplex, Dichotomomyces and Cristaspora, Aspergillus forms a monophyletic clade closely related to Penicillium. Changes in the International Code of Nomenclature for algae, fungi and plants resulted in the move to one name per species, meaning that a decision had to be made whether to keep Aspergillus as one big genus or to split it into several smaller genera. The International Commission of Penicillium and Aspergillus decided to keep Aspergillus instead of using smaller genera. In this paper, we present the arguments for this decision. We introduce new combinations for accepted species presently lacking an Aspergillus name and provide an updated accepted species list for the genus, now containing 339 species. To add to the scientific value of the list, we include information about living ex-type culture collection numbers and GenBank accession numbers for available representative ITS, calmodulin, β-tubulin and RPB2 sequences. In addition, we recommend a standard working technique for Aspergillus and propose calmodulin as a secondary identification marker.
Aflatoxins and ochratoxins are among the most important mycotoxins of all and producers of both types of mycotoxins are present in Aspergillus section Flavi, albeit never in the same species. Some of ...the most efficient producers of aflatoxins and ochratoxins have not been described yet. Using a polyphasic approach combining phenotype, physiology, sequence and extrolite data, we describe here eight new species in section Flavi. Phylogenetically, section Flavi is split in eight clades and the section currently contains 33 species. Two species only produce aflatoxin B1 and B2 (A. pseudotamarii and A. togoensis), and 14 species are able to produce aflatoxin B1, B2, G1 and G2: three newly described species A. aflatoxiformans, A. austwickii and A. cerealis in addition to A. arachidicola, A. minisclerotigenes, A. mottae, A. luteovirescens (formerly A. bombycis), A. nomius, A. novoparasiticus, A. parasiticus, A. pseudocaelatus, A. pseudonomius, A. sergii and A. transmontanensis. It is generally accepted that A. flavus is unable to produce type G aflatoxins, but here we report on Korean strains that also produce aflatoxin G1 and G2. One strain of A. bertholletius can produce the immediate aflatoxin precursor 3-O-methylsterigmatocystin, and one strain of Aspergillus sojae and two strains of Aspergillus alliaceus produced versicolorins. Strains of the domesticated forms of A. flavus and A. parasiticus, A. oryzae and A. sojae, respectively, lost their ability to produce aflatoxins, and from the remaining phylogenetically closely related species (belonging to the A. flavus-, A. tamarii-, A. bertholletius- and A. nomius-clades), only A. caelatus, A. subflavus and A. tamarii are unable to produce aflatoxins. With exception of A. togoensis in the A. coremiiformis-clade, all species in the phylogenetically more distant clades (A. alliaceus-, A. coremiiformis-, A. leporis- and A. avenaceus-clade) are unable to produce aflatoxins. Three out of the four species in the A. alliaceus-clade can produce the mycotoxin ochratoxin A: A. alliaceus s. str. and two new species described here as A. neoalliaceus and A. vandermerwei. Eight species produced the mycotoxin tenuazonic acid: A. bertholletius, A. caelatus, A. luteovirescens, A. nomius, A. pseudocaelatus, A. pseudonomius, A. pseudotamarii and A. tamarii while the related mycotoxin cyclopiazonic acid was produced by 13 species: A. aflatoxiformans, A. austwickii, A. bertholletius, A. cerealis, A. flavus, A. minisclerotigenes, A. mottae, A. oryzae, A. pipericola, A. pseudocaelatus, A. pseudotamarii, A. sergii and A. tamarii. Furthermore, A. hancockii produced speradine A, a compound related to cyclopiazonic acid. Selected A. aflatoxiformans, A. austwickii, A. cerealis, A. flavus, A. minisclerotigenes, A. pipericola and A. sergii strains produced small sclerotia containing the mycotoxin aflatrem. Kojic acid has been found in all species in section Flavi, except A. avenaceus and A. coremiiformis. Only six species in the section did not produce any known mycotoxins: A. aspearensis, A. coremiiformis, A. lanosus, A. leporis, A. sojae and A. subflavus. An overview of other small molecule extrolites produced in Aspergillus section Flavi is given.
► Of the three factors of trustworthiness, benevolence and integrity have a statistically significant influence on consumer trust in an intermediary in B2C e-marketplaces. ► Trust is transferred from ...an intermediary to the community of sellers in B2C e-marketplaces. ► Trust in an intermediary influences both attitudinal loyalty and purchase intentions in B2C e-marketplaces. ► Trust in the community of sellers affects neither attitudinal loyalty nor purchase intentions in B2C e-marketplaces. ► Attitudinal loyalty is an important determinant of purchase intentions in B2C e-marketplaces.
The online merchant of an e-marketplace consists of an intermediary, providing the market infrastructure, and the community of sellers conducting business within that infrastructure. Typically, consumers willingly buy from unknown sellers within an e-marketplace, despite the apparent risk, since they trust the institutional mechanisms furnished by the relatively well-known intermediary. Consumers’ trust in one component of the e-marketplace merchant may not only affect their trust in the other, but also influence the way consumers make online purchases. This paper explores the impact of trust on consumer behavior in e-marketplaces. An empirical study has been conducted to accomplish our research objectives, using a questionnaire survey of 222 active e-marketplace shoppers in Korea. The results reveal that consumer trust in an intermediary has a strong influence upon both attitudinal loyalty and purchase intentions, although consumer trust in the community of sellers has no significant effect on the two constructs representing consumer behavior. In addition, it was found that trust is transferred from an intermediary to the community of sellers, implying that the trustworthiness of the intermediary plays a critical role in determining the extent to which consumers trust and accept the sellers in the e-marketplace. This paper offers some implications from the findings of the research.
We report a new attentional cueing effect, which shows how attention models the physical force of friction. Most objects we see are in frictive contact with a 'floor', such that clockwise rotation ...causes rightward movement and counterclockwise rotation leftward movement. Is this regularity encoded in spatial orienting responses? In Experiment 1, seeing a clockwise-rotating 'wheel' produced faster responses to subsequent targets appearing on the right vs. left (and vice versa for counterclockwise rotation). Thus, when viewing a lone rotating wheel, we orient attention toward where we predict it will move next, assuming frictive floor contact. But what happens if the rotating wheel is seen touching another visible surface? In Experiment 2, rotational cueing was stronger for wheels touching a visible floor, was abolished for wheels near but not touching another surface, and reversed for wheels touching a ceiling. We conclude that the visual system makes an assumption of frictive floor contact, and rapidly analyzes visual cues to frictive contact with other surfaces, in order to orient attention toward where objects are likely to move next.
Beyond seemingly lower-level features such as color and motion, visual perception also recovers properties more commonly associated with higher-level thought, as when an upwardly accelerating object ...is seen not just as moving, but moreover as self-propelled, and resisting the force of gravity. Given past research demonstrating the prioritization of living things in attention and memory, here we hypothesized that observers would be more sensitive to an object's speed changes if those speed changes were opposite to natural gravitational acceleration. Across six experiments, we found that observers were more sensitive to objects' accelerations when they moved upward (when those accelerations were opposite to gravity) and less sensitive to their accelerations when they moved downward (when those accelerations were consistent with gravity). Moreover, observers were more sensitive to objects' decelerations when they moved downward (when those decelerations appeared as "braking" against gravity), and less sensitive to their decelerations when they moved upward (when those decelerations were consistent with gravity). This greater visual sensitivity to speed changes opposite to gravity is consistent with previous results suggesting that we readily monitor the world for cues to animacy.
Public Significance StatementWhen an object changes speed, what causes you to notice this? In several experiments, observers were better at noticing a change in an object's speed when it accelerated opposite to natural gravitational acceleration. Greater sensitivity to speed changes opposite gravity may help us to detect the movements of living things.
Titanium dioxide (TiO
2) is extensively used as a photocatalyst due to the strong oxidizing power of its holes, high photostability and redox selectivity. In the present work, the microstructural and ...chemical properties of TiO
2, obtained by a sol–gel procedure, were investigated. TiO
2 sols were prepared by the hydrolysis and condensation of titanium (IV)
n-butoxide in
iso-propyl alcohol. The particle dimensions and morphology of the product were examined by transmission electron microscopy (TEM), the crystal structure by X-ray diffraction (XRD) and chemical state was identified by electron spectroscopy for chemical analysis. The titania particles in the initial sol was elliptical in shape. Upon annealing at 400
°C, the TiO
2 particles turned polygonal in shape. The XRD pattern was sensitive to heat treatment. At a calcination temperature of 400
°C, only anatase phase was observed. As calcination temperature was increased to 700
°C, the rutile phase became the major constituent of TiO
2. The XRD data also showed that the crystal size of TiO
2 increased from 4 to 35
nm as the temperature was increased to 700
°C. Simultaneously, the BET surface area recorded a decreased from 122 to 11.5
m
2
g
−1. To examine the photocatalytic activity of the as-prepared TiO
2, the photodecomposition of salicylic acid was carried out. It was found that the anatase phase dominated the salicylic acid decomposition under the experimental conditions. A plausible explanation correlating the photocatalytic activity and the TiO
2 preparation conditions is discussed.
Aspergillus section Nidulantes includes species with striking morphological characters, such as biseriate conidiophores with brown-pigmented stipes, and if present, the production of ascomata ...embedded in masses of Hülle cells with often reddish brown ascospores. The majority of species in this section have a sexual state, which were named Emericella in the dual name nomenclature system. In the present study, strains belonging to subgenus Nidulantes were subjected to multilocus molecular phylogenetic analyses using internal transcribed spacer region (ITS), partial β-tubulin (BenA), calmodulin (CaM) and RNA polymerase II second largest subunit (RPB2) sequences. Nine sections are accepted in subgenus Nidulantes including the new section Cavernicolus. A polyphasic approach using morphological characters, extrolites, physiological characters and phylogeny was applied to investigate the taxonomy of section Nidulantes. Based on this approach, section Nidulantes is subdivided in seven clades and 65 species, and 10 species are described here as new. Morphological characters including colour, shape, size, and ornamentation of ascospores, shape and size of conidia and vesicles, growth temperatures are important for identifying species. Many species of section Nidulantes produce the carcinogenic mycotoxin sterigmatocystin. The most important mycotoxins in Aspergillus section Nidulantes are aflatoxins, sterigmatocystin, emestrin, fumitremorgins, asteltoxins, and paxillin while other extrolites are useful drugs or drug lead candidates such as echinocandins, mulundocandins, calbistrins, varitriols, variecolins and terrain. Aflatoxin B1 is produced by four species: A. astellatus, A. miraensis, A. olivicola, and A. venezuelensis.
PDF
