The CHaracterizing ExOPlanet Satellite (CHEOPS) is set to be launched in December 2019 and will detect and characterize small size exoplanets via ultra high precision photometry during transits. ...CHEOPS is designed as a follow-up telescope and therefore it will monitor a single target at a time. The scientific users will retrieve science-ready light curves of the target that will be automatically generated by the CHEOPS data reduction pipeline of the Science Operations Centre. This paper describes how the pipeline processes the series of raw images and, in particular, how it handles the specificities of CHEOPS data, such as the rotating field of view, the extended irregular point spread function, and the data temporal gaps in the context of the strict photometric requirements of the mission. The current status and performance of the main processing stages of the pipeline, that is the calibration, correction, and photometry, are presented to allow the users to understand how the science-ready data have been derived. Finally, the general performance of the pipeline is illustrated via the processing of representative scientific cases generated by the mission simulator.
Nosologically, Alzheimer disease is not a single disorder in spite of a common clinical phenotype. Etiologically, two different types or even more exist. (1) In a minority of about 5% or less of all ...cases, Alzheimer disease is due to mutations of three genes, resulting in the permanent generation of βA4. (2) The great majority (95% or more) of cases of Alzheimer disease are sporadic in origin, with old age as main risk factor, supporting the view that susceptibility genes and aging contribute to age-related sporadic Alzheimer disease. However, disturbances in the neuronal insulin signal transduction pathway may be of central pathophysiological significance. In early-onset familial Alzheimer disease, the inhibition of neuronal insulin receptor function may be due to competitive binding of amyloid beta (Aβ) to the insulin receptor. In late-onset sporadic Alzheimer disease, the neuronal insulin receptor may be desensitized by inhibition of receptor function at different sites by noradrenaline and/or cortisol, the levels of which both increase with increasing age. The consequences of the inhibition of neuronal insulin signal transduction may be largely identical to those of disturbances of oxidative energy metabolism and related metabolism, and of hyperphosphorylation of tau-protein. As far as the metabolism of amyloid precursor protein (APP) in late-onset sporadic Alzheimer disease is concerned, neuronal insulin receptor dysfunction may result in the intracellular accumulation of Aβ and in subsequent cellular damage. In this context, the desensitization of the neuronal insulin receptor in late-onset sporadic Alzheimer disease is different from that occurring in normal aging and early-onset familial Alzheimer disease. In late-onset sporadic Alzheimer disease changes in the brain are similar to those caused by non-insulin-dependent diabetes mellitus.
Although OGLE-TR-56b was the second transiting exoplanet discovered, only one light curve, observed in 2006, has been published besides the discovery data. We present 21 light curves of 19 different ...transits observed between 2003 July and 2009 July with the Magellan Telescopes and Gemini South. The combined analysis of the new light curves confirms a slightly inflated planetary radius relative to model predictions, with Rp = 1.378 ? 0.090 RJ . However, the values found for the transit duration, semimajor axis, and inclination values differ significantly from the previous result, likely due to systematic errors. The new semimajor axis and inclination, a = 0.01942 ? 0.00015 AU and i = 7372 ? 018, are smaller than previously reported, while the total duration, T 14 = 7931 ? 38 s, is 18 minutes longer. The transit midtimes have errors from 23 s to several minutes, and no evidence is seen for transit midtime or duration variations. Similarly, no change is seen in the orbital period, implying a nominal stellar tidal decay factor of Q * = 107, with a 3 Delta *s lower limit of 105.7.
We present results of the photometric campaign for planetary and low- luminosity object transits conducted by the OGLE survey in the 2005 season (Campaign #5). About twenty of the most promising ...candidates discovered in these data were subsequently verified spectroscopically with the VLT/FLAMES spectrograph. One of the candidates, OGLE-TR-211, reveals clear changes of radial velocity with a small amplitude of 82 m/s, varying in phase with photometric transit ephemeris. Further analysis confirms the planetary nature of this system. Follow-up precise photometry of OGLE-TR-211 with VLT/FORS, together with radial velocity spectroscopy, supplemented with high- resolution, high S/N VLT/UVES spectra allowed us to derive parameters of the planet and host star. OGLE-TR-211b is a hot Jupiter orbiting an F7-8 spectral type dwarf star with a period of 3.68 days. The mass of the planet is equal to 1.03\pm0.20 M_{\rm Jup}, while its radius {\rm 1.36} R_{\rm Jup}. The radius is about 20% larger than the typical radius of hot Jupiters of similar mass. OGLE-TR-211b is, then, another example of inflated hot Jupiters-a small group of seven exoplanets with large radii and unusually low densities- objects that are a challenge to the current models of exoplanets.
Assuring the Legacy of the CoRoT Planets Deeg, H.J.; Klagyivik, P.; Alonso, R. ...
EPJ Web of Conferences,
01/2015, Letnik:
101
Journal Article, Conference Proceeding
Recenzirano
Odprti dostop
For the long-lasting impact of CoRoT’s planet findings, precise knowledge of the times of their transits is of vital importance for any future observing campaigns. Here we give the motivation and ...first results of a systematic revisit of the transits of most CoRoT planets to refine their ephemeris. As secondary objectives, more precise planet characterisations, from period or transit shape variations on/and from use of a well-defined passband may be obtained.
The triplicate intracerebroventricular (icv) application of the diabetogenic compound streptozotocin (STZ) in low dosage was used in 1-year-old male Wistar rats to induce a damage of the neuronal ...insulin signal transduction (IST) system and to investigate the activities of hexokinase (HK), phosphofructokinase (PFK), glyceraldehyde-3-phosphate dehydrogenase (GDH), pyruvate kinase (PK), lactate dehydrogenase (LDH) and α-ketoglutarate dehydrogenase (α-KGDH) in frontoparietotemporal brain cortex (ct) and hippocampus (h) 9 weeks after damage. In parallel, the concentrations of adenosine triphosphate (ATP), adenosine diphosphate (ADP), guanosine triphosphate (GTP) and creatine phosphate (CrP) were determined. We found reductions of HK to 53% (ct) and 60% (h) of control, PFK to 63/64% (ct/h); GDH to 56/61% (ct/h), PFK to 57/59% (ct/h), α-KGDH to 37/35% (ct/h) and an increase of LDH to 300/240% (ct/h). ATP decreased to 82/87% (ct/h) of control, GTP to 69/81% (ct/h), CrP to 82/81% (ct/h), ∼P to 82/82% (ct/h), whereas ADP increased to 189/154% (ct/h). The fall of the activities of the glycolytic enzymes HK, PFK, GDH and PK was found to be more marked after 9 weeks of damage when compared with 3- and 6-week damage whereas the diminution in the concentration of energy rich compound was stably reduced by between 20 and 10% relative to control. The abnormalities in glucose/energy metabolism were discussed in relation to tau-protein mismetabolism of experimental animals, and of sporadic AD.
Sporadic Alzheimer's disease (SAD), a progressive neurodegenerative disease, is the most common cause of dementia. The etiology of the disease is still unknown, but it is suspected to be a concert of ...genetic and environmental factors. Intracerebroventricular injection of streptozotocin (STZ), which inhibits insulin receptor function, develops long-term and progressive deficits in learning, memory and cognitive behavior as well as biochemical changes and neuronal degeneration in rats similar to SAD. Micro-array analysis provides a genome-wide, non-biased study of gene expression patterns. The aim of this study was to investigate the gene expression pattern in the STZ animal model for SAD. RNA from rat cortex, striatum and cerebellum were analyzed for gene expression pattern via Affymetrix neurobiology chip-array and confirmed by real-time RT-PCR. Genes such as potassium channels, GABA receptors and glutamate transporter were up regulated, while insulin-like growth factor receptor was down regulated in STZ rats. These pathways may reveal molecular events causing the neuronal death in SAD.
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