In this study, we explore a relation between reflection colors and a chiral concentration. Basing on our observation, the reflection colors in BPI are dominated by lattice surface of the platelets ...and the lattice constant of a unit cell, but they do not depend linearly on the chiral concentration. The reflection peak moves to a short wavelength as increasing the chiral concentration because of contracting the lattice constant. However, when the lattice plane is changed, the reflection is dominated by the lattice plane, and it may move to a longer wavelength.
Generation of tissue harmonic signals during acoustic propagation is based on the combined effect of two different spectral interactions of the transmit signal. One produces harmonic whose frequency ...is the sum of transmit frequencies. The other results in harmonic at difference frequency of the transmit signals. Both the frequency-sum component and the frequency-difference component are sensitive to the phase of their constitutive spectral signals. In this study, a novel approach for modifying the amplitude of tissue harmonic signal is proposed based on phasing these two components to achieve either harmonic enhancement or suppression. Both experiments and simulations were performed to investigate the effects of 3f o transmit phasing on tissue harmonic generation. Results indicate that the relative phasing between the frequency-sum component and the frequency-difference component markedly changes the amplitude of the second harmonic signal. For harmonic enhancement, approximate 6 dB increase of second harmonic amplitude can be achieved while the lateral harmonic beam pattern also is improved as compared to conventional situations in which only the frequency-sum component is considered. For harmonic suppression, the second harmonic signal also could be significantly reduced by about 11 dB when the frequency-difference component is out of phase with the frequency-sum component. Hence, the method of 3f o transmit phasing has potentials for both improving signal-to-noise ratio in tissue harmonic imaging and enhancing image contrast in contrast-agent imaging by suppression of tissue harmonic background.
In this paper, a multi-sensor based suspension robot has been designed for the application of autonomous detection and surveillance. For fire fighters and rescuers, the disaster relief works are ...difficulty performed in the tunnels because of its constricted space. To reduce the losses of accident, the safety of tunnel should be ordinarily kept under surveillance. In the design of suspension robot, BASIC Stamp has been utilized as its control kernel and multiple sensors have been applied for detecting the emergencies. Once the surveillance center is announced of the emergencies, the fire fighters and rescuers could timely execute the saving mission.
As one of the major steps toward a fully intelligent autonomous robotic weapon, we have made progress in three major areas, (1) design of the surveillance system by an AVR microcontroller, (2) ...implementation of the design mechanism, and (3) performance of the human- machine interface surveillance system via the LabVIEW graphical programming environment, so that the supervisor can control the vehicle with a keyboard or a specially adapted mouse. In order to accomplish all these achievements, there have been major additions and overhauls in both system software codes and system circuit board developments. All these developments, including a new algorithm and hardware implementation, are described in this article. The experimental results have shown the practicality of the AVR microcontroller, the LabVIEW graphical programming environment, and ZigBee wireless technology applied to a robotic weapon.
The dysfunction of voltage-gated ion channels contributes to the pathology of ischemic stroke. In this study, we developed rat models of transient ischemic attack (TIA) and reversible ischemic ...neurological deficit (RIND) that was induced via the injection of artificial embolic particles during full consciousness, that allow us to monitor the neurologic deficit and positron emission tomography (PET) scans in real-time. We then evaluated the infarction volume of brain tissue was confirmed by 2,3,5-triphenyl tetrazolium chloride (TTC) staining, and gene expressions were evaluated by quantitative real-time PCR (qPCR). We found that rats with TIA or RIND exhibited neurological deficits as determined by negative TTC and PET findings. However, the expression of voltage-gated sodium channels in the hippocampus was significantly up-regulated in the qPCR array study. Furthermore, an altered expression of sodium channel β-subunits and potassium channels, were observed in RIND compared to TIA groups. In conclusion, to our knowledge, this is the first report of the successful evaluation of voltage-gated ion channel gene expression in TIA and RIND animal models. This model will aid future studies in investigating pathophysiological mechanisms, and in developing new therapeutic compounds for the treatment of TIA and RIND.
Transient receptor potential canonical 7 (TRPC7) has been reported to mediate aging-associated tumorigenesis, but the role of TRPC7 in cancer malignancy is still unclear. TRPC7 is associated with ...tumor size in patients with lung adenocarcinoma and the present study further evaluated the underlying mechanism of TRPC7 in the regulation of cancer progression. The clinicopathological role of TRPC7 was assessed using immunohistochemistry staining and the pathological mechanism of TRPC7 in lung adenocarcinoma cells was determined using cell cycle examination, invasion and calcium response assays, and immunoblot analysis. The results indicated that high TRPC7 expression was associated with a lower 5-year survival rate compared with low TRPC7 expression, which suggested that TRPC7 expression was inversely associated with overall survival in patients with lung adenocarcinoma. TRPC7 serves a pathological role by facilitating the enhancement of cell growth and migration with increased phosphorylation of Ca2+/calmodulin-dependent protein kinase II, AKT and ERK. TRPC7 knockdown in lung adenocarcinoma cells restrained cell cycle progression and cell migration by interrupting the TRPC7-mediated Ca2+ signaling-dependent AKT and MAPK signaling pathways. These findings demonstrated for the first time a role of oncogenic TRPC7 in the regulation of cancer malignancy and could provide a novel therapeutic molecular target for patients with lung adenocarcinoma.
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