碩士
國立新竹教育大學
教育與學習科技學系
103
Teacher positive leadership and student academic optimism are the important factors of the student well-being.This study aimed to investigate the current situations and ...circumstances of elementary school teacher positive leadership, student academic optimism and student well-being.The research methods included literature review and questionnaire survey. The survey objects were elementary school 6 grades students among Taoyuan County, Hsinchu County, Hsinchu City and Miaoli County. The study issued a total of 1001 questionnaires, with the return rate of 89.7%, among which there were 822 questionnaires valid.The data was analyzed by factor analysis, reliability analysis, descriptive statistics and structural equation modeling. The findings based on the results of the research are as follows:
1.The current situations of the teacher positive leadership perceived by students is good.
2.The current situations of the student well-being perceived by students is good.
3.The current situations
博士
大葉大學
管理研究所博士班
95
In a knowledge-based economy, knowledge is the motivation of remaining sustainable competitive advantage. Due to the highly competitive environment and the fluid property of ...knowledge, the organizational learning is demonstrated not only by intraorganizational learning but also by interorganizational learning. An effective interorganizational learning consists of interorganizational learning competence and interorganizational willingness. The relationship among networking organizations is the key factor in facilitating the willing to share knowledge, and promoting the dissemination and accumulation of knowledge.
On the basis of the relationship among leaning, memory, and capability, this study attempted to examine the impact of relationship learning and relationship memory on organizational learning capability by expanding organizational learning from internal learning system into external learning activities. This research focused the investigation on the firms which have signed the contr
As one of the major steps toward a fully intelligent autonomous robotic weapon, we have made progress in three major areas, (1) design of the surveillance system by an AVR microcontroller, (2) ...implementation of the design mechanism, and (3) performance of the human- machine interface surveillance system via the LabVIEW graphical programming environment, so that the supervisor can control the vehicle with a keyboard or a specially adapted mouse. In order to accomplish all these achievements, there have been major additions and overhauls in both system software codes and system circuit board developments. All these developments, including a new algorithm and hardware implementation, are described in this article. The experimental results have shown the practicality of the AVR microcontroller, the LabVIEW graphical programming environment, and ZigBee wireless technology applied to a robotic weapon.
The dysfunction of voltage-gated ion channels contributes to the pathology of ischemic stroke. In this study, we developed rat models of transient ischemic attack (TIA) and reversible ischemic ...neurological deficit (RIND) that was induced via the injection of artificial embolic particles during full consciousness, that allow us to monitor the neurologic deficit and positron emission tomography (PET) scans in real-time. We then evaluated the infarction volume of brain tissue was confirmed by 2,3,5-triphenyl tetrazolium chloride (TTC) staining, and gene expressions were evaluated by quantitative real-time PCR (qPCR). We found that rats with TIA or RIND exhibited neurological deficits as determined by negative TTC and PET findings. However, the expression of voltage-gated sodium channels in the hippocampus was significantly up-regulated in the qPCR array study. Furthermore, an altered expression of sodium channel β-subunits and potassium channels, were observed in RIND compared to TIA groups. In conclusion, to our knowledge, this is the first report of the successful evaluation of voltage-gated ion channel gene expression in TIA and RIND animal models. This model will aid future studies in investigating pathophysiological mechanisms, and in developing new therapeutic compounds for the treatment of TIA and RIND.
A low driving voltage and fast response blue phase III (BPIII) liquid-crystal device with very low dielectric anisotropy is demonstrated. To stabilize BPIII in a wide temperature range (> 15°C), a ...chiral molecule with good solubility was chosen. By studying field-dependent polarization state of the transmitting light, it was found that the field-induced birefringence becomes saturated in the high field. However, the transmitting intensity exhibits a tendency to increase as the electric field increases. This indicates that the electro-optical behavior in BPIII device may be from the flexoelectric effect, which induces tilted optical axis and then induces birefringence. Because the phase transition from BPIII to chiral nematic phase does not happen, the device shows no hysteresis effect and no residual birefringence, exhibits fast response, and can be a candidate for fast photonic application.
Transient receptor potential canonical 7 (TRPC7) has been reported to mediate aging-associated tumorigenesis, but the role of TRPC7 in cancer malignancy is still unclear. TRPC7 is associated with ...tumor size in patients with lung adenocarcinoma and the present study further evaluated the underlying mechanism of TRPC7 in the regulation of cancer progression. The clinicopathological role of TRPC7 was assessed using immunohistochemistry staining and the pathological mechanism of TRPC7 in lung adenocarcinoma cells was determined using cell cycle examination, invasion and calcium response assays, and immunoblot analysis. The results indicated that high TRPC7 expression was associated with a lower 5-year survival rate compared with low TRPC7 expression, which suggested that TRPC7 expression was inversely associated with overall survival in patients with lung adenocarcinoma. TRPC7 serves a pathological role by facilitating the enhancement of cell growth and migration with increased phosphorylation of Ca2+/calmodulin-dependent protein kinase II, AKT and ERK. TRPC7 knockdown in lung adenocarcinoma cells restrained cell cycle progression and cell migration by interrupting the TRPC7-mediated Ca2+ signaling-dependent AKT and MAPK signaling pathways. These findings demonstrated for the first time a role of oncogenic TRPC7 in the regulation of cancer malignancy and could provide a novel therapeutic molecular target for patients with lung adenocarcinoma.
Systemic sclerosis (SSc) causes progressive fibrosis of multiple organs with the low efficacy of immunosuppressive therapies. Our previous study indicated the SSc pathological pathways are closely ...correlated with Ca
signals, and blockage of the intracellular Ca
elevation facilitates inhibition of SSc pathogenesis.
Transforming growth factor β (TGF-β)-modulated SMAD signaling is crucial in regulating SSc pathogenesis. Whether Ca
signals are involved in TGF-β1/SMAD signaling-induced fibrotic process has been further investigated.
We utilized TGF-β1-induced myofibroblasts as a model to detect how Ca
signals affected SSc pathogenesis, and investigated the combination of treatment with store-operated Ca
entry (SOCE) associated inhibitors, 2-aminoethyl diphenylborinate (2-APB) and SKF96365 to restrain the increased Ca
signaling in myofibroblasts. In addition, the SSc bleomycin mouse model was used to detect the effect of 2-APB on SSc pathogenesis in vivo.
Our findings revealed increased levels of TGF-β1 production in SSc was associated with intracellular Ca
activity, and inhibition of intracellular Ca
regulation by 2-APB resulted in the dedifferentiation of TGF-β1-induced myofibroblasts. This was due to the fact that 2-APB restrained the expression fibrotic markers, α-SMA, fibronectin and vimentin through inhibiting TGF-β1/SMAD3 signaling. Thus, subcutaneous injection of 2-APB improved bleomycin-induced skin and pulmonary fibrosis.
2-APB is a potential candidate for treating fibrosis, by disrupting intracellular Ca
regulation in SSc to induce the dedifferentiation of myofibroblasts and meliorates fibrosis pathogenesis via inhibiting TGF-β1/SMAD3 signaling.
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