Androgen-independent prostate cancer accounts for mortality in the world. In this study, various extracts of a medical fungus dubbed Ganoderma formosanum were screened for inhibition of DU145 cells, ...an androgen-independent prostate cancer cell line. Results demonstrated that both hexane (GF-EH) and butanol (GF-EB) fraction of G. formosanum ethanol extract inhibited DU145 cell viability in a dose-dependent manner. GF-EH induced cell-cycle arrest in G1 phase of DU145 cells via downregulation of cyclin E2 protein expression. In addition, GF-EB triggered extrinsic apoptosis of DU145 cells by activating caspase 3 gene expression resulting in programed cell death. Above all, both GF-EH and GF-EB show lower toxicity to normal human fibroblast cell line compared to DU145 cell, implying that they possess specific drug action on cancer cells. This study provides a molecular basis of G. formosanum extract as a potential ingredient for treatment of androgen-independent prostate cancer.
碩士
國立海洋大學
電子工程學系
83
As the availability of computer networks and high-speed
workstations grows rapidly,parallel computing across a network
of computers has gradually become a practical alternative to
...the use of a single high-performance parallel computer.To
overcome the limitation imposed by message-passing scheme
normally associated with the distributed memory multicomputers,
including computers connected by a LAN, researchers have
proposed and implemented many different types of distributed
shared memory (DSM). Under the page-based or shared-variable
DSM, it is often a burden for the programmer to manage memory
consistency problems explicitly with the synchronization
facilities. Furthermore, parallel computation across a network
is far more susceptible to communication or system failures.
This can have a serious impact on the reliability of a DSM
system. To solve these problems,We have developed a library-
based DSM system which not only provides backup mechanism for
increased reliability, but he programmer
