Efficient operation of control systems in robotics or autonomous driving targeting real-world navigation scenarios requires perception methods that allow them to understand and adapt to unstructured ...environments with good accuracy, adaptation, and generality, similar to humans. To address this need, we present a memristor-based differential neuromorphic computing, perceptual signal processing, and online adaptation method providing neuromorphic style adaptation to external sensory stimuli. The adaptation ability and generality of this method are confirmed in two application scenarios: object grasping and autonomous driving. In the former, a robot hand realizes safe and stable grasping through fast ( ~ 1 ms) adaptation based on the tactile object features with a single memristor. In the latter, decision-making information of 10 unstructured environments in autonomous driving is extracted with an accuracy of 94% with a 40×25 memristor array. By mimicking human low-level perception mechanisms, the electronic neuromorphic circuit-based method achieves real-time adaptation and high-level reactions to unstructured environments.
In the past decades, China has undergone dramatic land use/land cover (LULC) changes. Such changes are expected to continue and profoundly affect our environment. To navigate future uncertainties ...toward sustainability, increasing efforts have been invested in projecting China's future LULC following the Shared Socioeconomic Pathways (SSPs) and/or Representative Concentration Pathways (RCPs). To supplements existing datasets with a high spatial resolution, comprehensive pathway coverage, and delicate account for urban land change, here we present a 1-km gridded LULC dataset for China under 24 comprehensive SSP-RCP scenarios covering 2020-2100 at 10-year intervals. Our approach is to integrate the Global Change Analysis Model (GCAM) and Future Land Use Simulation (FLUS) model. This dataset shows good performance compared to remotely sensed CCI-LC data and is generally spatio-temporally consistent with the Land Use Harmonization version-2 dataset. This new dataset (available at https://doi.org/10.6084/m9.figshare.14776128.v1 ) provides a valuable alternative for multi-scenario-based research with high spatial resolution, such as earth system modeling, ecosystem services, and carbon neutrality.
A continuously tunable optical delay line with low delay ripple based on four cascaded tunable silicon nitride microring resonators for Ka-band beamforming network is proposed. The delay responses of ...the tunable optical delay line were investigated theoretically and experimentally. And a maximum delay tuning range of 300.3 ps, 169.4 ps and 88.6 ps were achieved when the delay bandwidth is set as 2 GHz, 5 GHz and 10 GHz respectively. In addition, low delay ripple about 8.5 ps and low additional loss less than 3.6 dB were obtained. Moreover, the maximum delay tuning range was increased to about 395 ps by combining the off-resonance region of the cascaded MRRs.
Rapid and sensitive detection of Mycobacterium tuberculosis (M. Tb) in cerebrospinal fluid is crucial in the diagnosis of tuberculous meningitis (TBM), but conventional diagnostic technologies have ...limited sensitivity and specificity or are time-consuming. In this work, a novel, highly sensitive molecular diagnostic method, one-tube nested PCR-lateral flow strip test (OTNPCR-LFST), was developed for detecting M. tuberculosis. This one-tube nested PCR maintains the sensitivity of conventional two-step nested PCR and reduces both the chance of cross-contamination and the time required for analysis. The PCR product was detected by a lateral flow strip assay, which provided a basis for migration of the test to a point-of-care (POC) microfluidic format. The developed assay had an improved sensitivity compared with traditional PCR, and the limit of detection was up to 1 fg DNA isolated from M. tuberculosis. The assay was also specific for M. tuberculosis, and no cross-reactions were found in other non-target bacteria. The application of this technique to clinical samples was successfully evaluated, and OTNPCR-LFST showed 89% overall sensitivity and 100% specificity for TBM patients. This one-tube nested PCR-lateral flow strip assay is useful for detecting M. tuberculosis in TBM due to its rapidity, high sensitivity and simple manipulation.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A seven-bit optical true time delay unit with a delay tuning increment of 1.42 ps was designed and fabricated on silicon photonics platform, which can be utilized in Ka-band phased array antenna ...systems. The delay unit consists of eight thermo-optical switches and seven waveguide delay lines with different lengths. By manipulating the states of the thermo-optical switches, 128 stages of discrete time delays varying from 0 to 191.37 ps has been obtained with low average power consumption of 178.77 mW. Besides, the integrated delay unit was fabricated on the silicon-on-insulator chip that has a very compact footprint of 7.4 mm × 1.8 mm. In addition, as the waveguide delay dependence on the modulation frequency is very limited and can be neglected, the proposed delay unit should process a large bandwidth that allows it to be utilized in microwave applications with abundant bandwidth.
A binary solvent ink exploiting solutal Marangoni flows to suppress the coffee-ring effect for uniform printing of 2D crystals.
Recent advances in inkjet printing of two-dimensional (2D) crystals ...show great promise for next-generation printed electronics development. Printing nonuniformity, however, results in poor reproducibility in device performance and remains a major impediment to their large-scale manufacturing. At the heart of this challenge lies the coffee-ring effect (CRE), ring-shaped nonuniform deposits formed during postdeposition drying. We present an experimental study of the drying mechanism of a binary solvent ink formulation. We show that Marangoni-enhanced spreading in this formulation inhibits contact line pinning and deforms the droplet shape to naturally suppress the capillary flows that give rise to the CRE. This general formulation supports uniform deposition of 2D crystals and their derivatives, enabling scalable and even wafer-scale device fabrication, moving them closer to industrial-level additive manufacturing.
Various global land use/land cover (LULC) products have been developed to drive land-relevant climate and hydrological models for environmental assessments. However, systematic studies remain scarce ...that assess the uncertainties of using these products. By using a total of 16 commonly used global LULC products, we find a logarithm law of upscaling with the spatial resolution. The law reveals spatial details of urban features will be majorly distorted when using LULC products with coarser resolutions. A tipping point of the law around the 30-m resolution was identified by additional analysis of the 1-m and 10-m local land use dataset. Through the example of assessing crop production loss, we further find that most of these products will yield a significant underestimation of crop production losses, globally and locally. We conclude that the underestimated urban land rooted in most of these products would cause vital impacts on global change analyses and modeling.
Display omitted
•A logarithm law can portray the underestimation of urban land by LULC products•A potential tipping point of the law is found at around the 30-m resolution•Urban features will be majorly distorted when using coarsening products•Coarse resolutions yield a significant underestimation of crop production losses
Earth sciences; Earth-surface processes; Agricultural science; Land use.
We propose a compact, broadband 2×2 3-dB adiabatic coupler using trapezoidal subwavelength gratings on silicon-on-insulator platform. The proposed device is constructed by two tapered waveguides, ...which are composed of trapezoidal subwavelength gratings. Broadband 3-dB optical power splitting with a coupling length of 24 μm is achieved by the adiabatic mode evolution of the two lowest order transverse electric modes. By using the finite time difference method, the power splitting ratio better than 3±0.21 dB and the insertion loss less than 0.19 dB are obtained in the wavelength range of 1450 nm to 1650 nm.
The shell of inclined conveyor of combine often has the defect of serious vibration. In order to solve this problem, this study uses the dynamic signal test and analysis system and control the ...electromagnetic directional valve to realize the horizontal stability control of agricultural machinery. In order to improve the bearing accuracy, this paper designs a bearing tilt detection device. When the tilt reaches its set point, an alarm can be issued to initiate an emergency response. Taking tractor as the object, the application of real-time tilt angle measurement algorithm on three-axis multifunctional turntable is tested. At the same time, the automatic leveling system of agricultural machinery was tested in the field, and the minimum inclination angle of the chute conveying all kinds of grain and oil materials was obtained. The image collected by AGV has the characteristics of high speed, high efficiency and small resolution error. It can also correct the tilt image in real time. This study is helpful to adapt to the new requirements of modern agricultural large-scale agricultural machinery or production facilities. The monitoring system has practical guiding significance in the construction process, and has a certain promotion value.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Patients with hypopharyngeal carcinoma (HPC) have a poor prognosis mainly because of lymphatic metastasis. This research aimed to determine the PKM2 role in lymphatic metastasis in HPC and the ...underlying molecular mechanism contributing to this phenomenon.
PKM2 in HPC was studied for its expression and its likelihood of overall survival using TCGA dataset. Western blotting, qRT-PCR, and IHC were employed to confirm PKM2 expression. Methods including gain- and loss-of-function were used to examine the PKM2 role in HPC metastasis in vitro and in vivo. In vitro and in vivo studies also confirmed lymphatic metastasis's mechanism.
Prominent PKM2 overexpression was seen in patients with lymphatic metastasis of HPC, and there was an inherent relationship between a high PKM2 level and poor prognosis. In vitro research showed that knocking down PKM2 decreased tumor cell invasion, migration, and proliferation while promoting apoptosis and inhibiting epithelial-mesenchymal transition, but overexpressing PKM2 had the reverse effect. Animal studies suggested that PKM2 may facilitate tumor development and lymphatic metastasis.
Our findings suggest that PKM2 may be a tumor's promoter gene of lymphatic metastasis, which may promote lymphatic metastasis of HPC by regulating epithelial-mesenchymal transition. PKM2 may be a biomarker of metastatic potential, ultimately providing a basis for exploring new therapeutic targets.
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