Four polymers that contain alkyl chains branched at different positions on the polymer backbone are prepared. A polymer with 4‐decyltetradecyl chains gives an impressive mobility of 3.62 cm2 V−1 s−1. ...This may arise from tighter polymer packing as well as stacking conformation change of the polymer backbone induced by the branching of the alkyl chains.
Interfacial charge collection efficiency has demonstrated significant effects on the power conversion efficiency (PCE) of perovskite solar cells (PSCs). Herein, crystalline phase‐dependent charge ...collection is investigated by using rutile and anatase TiO2 electron transport layer (ETL) to fabricate PSCs. The results show that rutile TiO2 ETL enhances the extraction and transportation of electrons to FTO and reduces the recombination, thanks to its better conductivity and improved interface with the CH3NH3PbI3 (MAPbI3) layer. Moreover, this may be also attributed to the fact that rutile TiO2 has better match with perovskite grains, and less trap density. As a result, comparing with anatase TiO2 ETL, MAPbI3 PSCs with rutile TiO2 ETL delivers significantly enhanced performance with a champion PCE of 20.9 % and a large open circuit voltage (VOC) of 1.17 V.
A rutile TiO2 electron transport layer (ETL) was prepared. The thickness and crystallinity can be controlled by deposition time and sintering temperature. Rutile TiO2 has higher conductivity than anatase for faster electron transfer, better interface contact with the perovskite layer, and a lower trap density. These facilitate the charge extraction and collection and reducing carrier recombination.
Electroless deposition via a spontaneous redox reaction between the metal precursor and support is believed to be a promising approach for the syntheses of supported metal nanoparticles (SMNPs). ...However, its widespread applications are significantly prohibited by the low reductivity and high cost of support. To overcome these shortcomings, a porous carbon (PC) is herein developed as a promising matrix for the electroless deposition of metal NPs. Benefiting from abundant oxygen‐based surface functional groups, the PC shows stronger reducibility (low redox potential) than conventional carbon substrate such as carbon nanotubes or graphene oxide, enabling a facile electroless deposition of Ir, Rh, and Ru NPs on its surface. These SMNPs exhibit an impressive electrocatalytic activity for the hydrogen evolution reaction (HER) or hydrogen oxidation reaction (HOR). For example, the Rh NP/PC can deliver an HER current density of 10 mA cm−2 with a small overpotential of 21 mV in 0.5 m H2SO4, while the Ru NP/PC exhibits excellent HOR activity in 0.1 m KOH in terms of high mass and surface specific exchange current density of 263 A g−1Ru and 0.227 mA cm−2Ru. The present strategy may open up opportunities for mass production of efficient supported NPs for diverse applications.
Ultrafine well‐dispersed Ir, Rh, and Ru nanoparticles (NPs) are synthesized by cost‐effective room‐temperature electroless deposition using the support itself as the reducing agent. Rh NP/PC (porous carbon) shows superior hydrogen evolution reaction activity with a small overpotential (21 mV) at 10 mA cm−2 whereas Ru NP/PC exhibits excellent hydrogen oxidation reaction activity in terms of high exchange current density.
ConspectusHydrogen is an ideal energy carrier and plays a critical role in the future energy transition. Distinct from steam reforming, electrochemical water splitting, especially powered by ...renewables, has been considered as a promising technique for scalable production of high-purity hydrogen with no carbon emission. Its commercialization relies on the reduction of electricity consumption and thus hydrogen cost, calling for highly efficient and cost-effective electrocatalysts with the capability of steadily working at high hydrogen output. This requires the electrocatalysts to feature (1) highly active intrinsic sites, (2) abundant accessible active sites, (3) effective electron and mass transfer, (4) high chemical and structural durability, and (5) low-cost and scalable synthesis. It should be noted that all these requirements should be fulfilled together for a practicable electrocatalyst. Much effort has been devoted to addressing one or a few aspects, especially improving the electrocatalytic activity by electronic modulation of active sites, while few reviews have focused on the synergistic modulation of these aspects together although it is essential for advanced electrochemical water splitting.In this Account, we will present recent innovative strategies with an emphasis on our solutions for synergistically modulating intrinsic active sites, electron transportation, mass transfer, and gas evolution, as well as mechanical and chemical durability, of non-precious-metal electrocatalysts, aiming for cost-effective and highly efficient water splitting. The following approaches for coupling these aspects are summarized for both cathodic hydrogen evolution reaction (HER) and anodic oxygen evolution reaction (OER). (1)
. The electronic structure of a catalytic site determines the adsorption/desorption of reactive intermediates and thus intrinsic activity. It can be tuned by heterogeneous doping, strain effect, spin polarization, etc. Coupling these effects to optimize the reaction pathways or target simultaneously the activity and stability would advance electrocatalytic performance. (2)
. The crystallinity, crystalline phase, crystalline facets, crystalline defects, etc. affect both activity and stability. Coupling these effects with electronic modulation would enhance the activity together with stability. (3)
. It will focus on concurrently modulating electronic structure for improving the intrinsic activity and morphology for increasing accessible active sites, especially through single action or processing. The mass transfer and gas evolution properties can also be enhanced by morphological modulation to enable water splitting at large output. (4)
. Electrocatalytic reaction generally consists of a couple of elementary reactions. Each one may need a specific active site. Designing and combining various components targeting every elementary step on a space-limited catalyst surface will balance the intermediates and these steps for accelerating the overall reaction. (5)
Taking all these strategies together into account is necessary to integrate all above essential features into one electrocatalyst for enabling high-output water electrolysis. Beyond the progress made to date, the remaining challenges and opportunities is also discussed. With these insights, hopefully, this Account will shed light on the rational design of practical water-splitting electrocatalysts for the cost-effective and scalable production of hydrogen.
Esophageal cancer is one of the most fatal diseases worldwide mainly because of its rapid progression and poor prognosis. Although the incidence of esophageal adenocarcinoma has markedly risen in ...North America and Europe in the past several decades, esophageal squamous cell carcinoma is still the predominant subtype of esophageal cancer, especially in China. It accounts for more than 90% of all esophageal squamous cell carcinoma cases in China. Geographical differentiation is one of the most distinctive characteristics of esophageal cancer. The progression, risk factors, and prognosis of these two subtypes of esophageal cancer differ. This study reviews the epidemiology, etiology, and prevention of esophageal squamous cell carcinoma in China, thereby providing systematic references for policy-makers who will decide on issues of esophageal cancer prevention and control.
Statins: a repurposed drug to fight cancer Jiang, Wen; Hu, Jin-Wei; He, Xu-Ran ...
Journal of experimental & clinical cancer research,
07/2021, Letnik:
40, Številka:
1
Journal Article
Recenzirano
Odprti dostop
As competitive HMG-CoA reductase (HMGCR) inhibitors, statins not only reduce cholesterol and improve cardiovascular risk, but also exhibit pleiotropic effects that are independent of their ...lipid-lowering effects. Among them, the anti-cancer properties of statins have attracted much attention and indicated the potential of statins as repurposed drugs for the treatment of cancer. A large number of clinical and epidemiological studies have described the anticancer properties of statins, but the evidence for anticancer effectiveness of statins is inconsistent. It may be that certain molecular subtypes of cancer are more vulnerable to statin therapy than others. Whether statins have clinical anticancer effects is still an active area of research. Statins appear to enhance the efficacy and address the shortcomings associated with conventional cancer treatments, suggesting that statins should be considered in the context of combined therapies for cancer. Here, we present a comprehensive review of the potential of statins in anti-cancer treatments. We discuss the current understanding of the mechanisms underlying the anti-cancer properties of statins and their effects on different malignancies. We also provide recommendations for the design of future well-designed clinical trials of the anti-cancer efficacy of statins.
Green and scalable syntheses of highly dispersed supported metal nanocatalysts (SMNCs) are of significant importance for heterogeneous catalysis in industry. In order to achieve nanosized SMNCs and ...prevent metal nanoparticles (NPs) from aggregation, the traditional liquid syntheses commonly require organic capping agents and low metal loading, which are unfavorable for practical production of SMNCs. Herein, a green and facile solid‐state approach is reported for a general synthesis of Rh, Ru, and Ir NPs highly dispersed on different carbon supports via a room‐temperature mortar grinding. The synthesis is easy to scale up and no organic solvent is needed. Metal NPs are free of capping agents and in a couple of nanometers with a uniform size distribution. Benefiting from the above features and high intrinsic activity, Rh NP/C shows the superior activity for hydrogen evolution reaction (HER) in terms of an ultralow overpotential of 7 mV at 10 mA cm−2, outperforming the state‐of‐the‐art HER electrocatalysts. The cell voltage to output a stable current density of 10 mA cm−2 is only 1.53 V for the electrolyzer with Rh NP/C cathode. These results indicate that the present scalable solid‐state synthetic strategy paves a new avenue for mass production of highly efficient SMNCs for diverse applications.
A facile scalable grinding strategy is developed to produce a series of highly dispersed metal nanoparticles (NPs) on various carbon supports. Among them, Rh NPs in ≈2.05 nm shows superior HER activity with an ultralow overpotential of 7 mV at 10 mA cm−2, enabling an efficient electrolyzer with a low cell voltage of 1.53 V at 10 mA cm−2.
Practical electrochemical water splitting requires cost‐effective electrodes capable of steadily working at high output, leading to the challenges for efficient and stable electrodes for the oxygen ...evolution reaction (OER). Herein, by simply using conductive FeS microsheet arrays vertically pre‐grown on iron foam (FeS/IF) as both substrate and source to in situ form vertically aligned NiFe(OH)x nanosheets arrays, a hierarchical electrode with a nano/micro sheet‐on‐sheet structure (NiFe(OH)x/FeS/IF) can be readily achieved to meet the requirements. Such hierarchical electrode architecture with a superhydrophilic surface also allows for prompt gas release even at high output. As a result, NiFe(OH)x/FeS/IF exhibits superior OER activity with an overpotential of 245 mV at 50 mA cm−2 and can steadily output 1000 mA cm−2 at a low overpotential of 332 mV. The water‐alkali electrolyzer using NiFe(OH)x/FeS/IF as the anode can deliver 10 mA cm−2 at 1.50 V and steadily operate at 300 mA cm−2 with a small cell voltage for 70 h. Furthermore, a solar‐driven electrolyzer using the developed electrode demonstrates an exceptionally high solar‐to‐hydrogen efficiency of 18.6%. Such performance together with low‐cost Fe‐based materials and facile mass production suggest the present strategy may open up opportunities for rationally designing hierarchical electrocatalysts for practical water splitting or diverse applications.
A 3D hierarchical NiFe(OH)x/FeS/IF electrode with a nano/micro sheet‐on‐sheet structure exhibits superior oxygen evolution reaction activity and durability with a low overpotential of 261 mV at 100 mA cm−2 and 332 mV at 1000 mA cm−2. The water‐alkali electrolyzer, using it as an anode, achieves stable overall water splitting at 300 mA cm−2 with a small cell voltage.
Low‐threshold two‐photon‐pumped (TPP) perovskite microcavity lasers are achieved in crystal perovskite 1D or 2D microstructures fabricated through a liquid‐phase self‐assembly method assisted by two ...distinct surfactant soft templates. The lasing actions from the perovskite materials exhibit a shape‐dependent microcavity effect, which is subsequently utilized for the modulation of the lasing modes and for the achievement of two‐photon‐pumped single‐mode perovskite microlasers.
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