The high storage capacity versus high selectivity trade‐off barrier presents a daunting challenge to practical application as an acetylene (C2H2) adsorbent. A structure–performance relationship ...screening for sixty‐two high‐performance metal–organic framework adsorbents reveals that a moderate pore size distribution around 5.0–7.5 Å is critical to fulfill this task. A precise pore space partition approach was involved to partition 1D hexagonal channels of typical MIL‐88 architecture into finite segments with pore sizes varying from 4.5 Å (SNNU‐26) to 6.4 Å (SNNU‐27), 7.1 Å (SNNU‐28), and 8.1 Å (SNNU‐29). Coupled with bare tetrazole N sites (6 or 12 bare N sites within one cage) as high‐density H‐bonding acceptors for C2H2, the target MOFs offer a good combination of high C2H2/CO2 adsorption selectivity and high C2H2 uptake capacity in addition to good stability. The optimized SNNU‐27‐Fe material demonstrates a C2H2 uptake of 182.4 cm3 g−1 and an extraordinary C2H2/CO2 dynamic breakthrough time up to 91 min g−1 under ambient conditions.
Benchmark metal–organic framework (MOF) adsorbents for C2H2/CO2 separation are reported. The MOFs offer moderate pore size distributions, which are regulated by precise pore space partitions and coupled with a high‐density of hydrogen‐bonding acceptors.
A strategy called ultramicroporous building unit (UBU) is introduced. It allows the creation of hierarchical bi‐porous features that work in tandem to enhance gas uptake capacity and separation. ...Smaller pores from UBUs promote selectivity, while larger inter‐UBU packing pores increase uptake capacity. The effectiveness of this UBU strategy is shown with a cobalt MOF (denoted SNNU‐45) in which octahedral cages with 4.5 Å pore size serve as UBUs. The C2H2 uptake capacity at 1 atm reaches 193.0 cm3 g−1 (8.6 mmol g−1) at 273 K and 134.0 cm3 g−1 (6.0 mmol g−1) at 298 K. Such high uptake capacity is accompanied by a high C2H2/CO2 selectivity of up to 8.5 at 298 K. Dynamic breakthrough studies at room temperature and 1 atm show a C2H2/CO2 breakthrough time up to 79 min g−1, among top‐performing MOFs. Grand canonical Monte Carlo simulations agree that ultrahigh C2H2/CO2 selectivity is mainly from UBU ultramicropores, while packing pores promote C2H2 uptake capacity.
Hole to differentiate, and hole to accommodate. Two types of pores can mingle together using a strategy called UBU (ultramicroporous building unit). This strategy results in a promising gas absorbent for excellent C2H2 storage capacity and top‐level C2H2/CO2 separation ability.
Precise design of low‐cost, efficient and definite electrocatalysts is the key to sustainable renewable energy. Herein, this work develops a targeted‐anchored and subsequent spontaneous‐redox ...strategy to synthesize nickel‐iron layered double hydroxide (LDH) nanosheets anchored with monodispersed platinum (Pt) sites (Pt@LDH). Intermediate metal‐organic frameworks (MOF)/LDH heterostructure not only provides numerous confine points to guarantee the stability of Pt sites, but also excites the spontaneous reduction for PtII. Electronic structure, charge transfer ability and reaction kinetics of Pt@LDH can be effectively facilitated by the monodispersed Pt moieties. As a result, the optimized Pt@LDH that with the 5% ultra‐low content Pt exhibits the significant increment in electrochemical water splitting performance in alkaline media, which only afford low overpotentials of 58 mV at 10 mA cm−2 for hydrogen evolution reaction (HER) and 239 mV at 10 mA cm−2 for oxygen evolution reaction (OER), respectively. In a real device, Pt@LDH can drive an overall water‐splitting at low cell voltage of 1.49 V at 10 mA cm−2, which can be superior to most reported similar LDH‐based catalysts. Moreover, the versatility of the method is extended to other MOF precursors and noble metals for the design of ultrathin LDH supported monodispersed noble metal electrocatalysts promoting research interest in material design.
A targeted‐anchored and subsequent spontaneous‐redox strategy is developed to synthesize nickel‐iron layered double hydroxide (LDH) nanosheets anchored with monodispersed platinum (Pt) sites (Pt@LDH). As‐prepared Pt@LDH‐4h can drive an overall water‐splitting at low cell voltage of 1.49 V at 10 mA cm−2, which can be superior to most reported similar LDH‐based catalysts.
It was demonstrated that the lattice simulation of
B
-meson light-cone distribution amplitude (LCDA) is feasible via the quasi-distribution amplitude (quasi-DA) in large momentum effective theory ...(LaMET). The structures of logarithmic moments (LMs) of
B
-meson quasi-DA are explored in this work. The one-loop results indicate mixing in the matching: the
n
-th LM would be not only factorized into the
n
-th LM of LCDA, but also other moments with different power, accompanied by short distance coefficients. These results supply the understanding of the matching in LaMET and may provide guidance to the lattice study of LMs or other parameters of
B
-meson LCDA.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
High-quality CoP nanorings (CoP NRs) are easily achieved using a phosphorating treatment of CoOOH nanorings, and reveal high activity towards the hydrogen evolution reaction and the nitrate ...electrocatalytic reduction reaction due to substantial coordinately unsaturated active sites, a high surface area, and available mass transfer pathways. Consequently, the CoP NRs can achieve a faradaic efficiency of 97.1% towards NO
3
−
-to-NH
3
conversion and provide an NH
3
yield of 30.1 mg h
−1
mg
−1
cat
at a −0.5 V potential.
High-quality CoP nanorings (CoP NRs) show high activity towards the nitrate electrocatalytic reduction reaction due to substantial coordinately unsaturated active sites, a high surface area, and available mass transfer pathways.
The precise design of low‐cost, efficient, and definite electrocatalysts is the key to sustainable renewable energy. The urea oxidation reaction (UOR) offers a promising alternative to the oxygen ...evolution reaction for energy‐saving hydrogen generation. In this study, by tuning the lattice expansion, a series of M‐FeNi layered double hydroxides (M‐FeNi LDHs, M: Mo, Mn, V) with excellent UOR performance are synthesized. The hydrolytic transformation of Fe‐MIL‐88A is assisted by urea, Ni2+ and high‐valence metals, to form a hollow M‐FeNi LDH. Owing to the large atomic radius of the high‐valence metal, lattice expansion is induced, and the electronic structure of the FeNi‐LDH is regulated. Doping with high‐valence metal is more favorable for the formation of the high‐valence active species, NiOOH, for the UOR. Moreover, the hollow spindle structure promoted mass transport. Thus, the optimal Mo‐FeNi LDH showed outstanding UOR electrocatalytic activity, with 1.32 V at 10 mA cm−2. Remarkably, the Pt/C||Mo‐FeNi LDH catalyst required a cell voltage of 1.38 V at 10 mA·cm−2 in urea‐assisted water electrolysis. This study suggests a new direction for constructing nanostructures and modulating electronic structures, which is expected to ultimately lead to the development of a class of auxiliary electrocatalysts.
The spindle‐like hollow M‐FeNi layered double hydroxides (M = Mo, V, and Mn) doping with high‐valence metal are prepared. Owing to the large atomic radius of the high‐valence metal, lattice expansion is induced, and the electronic structure of the FeNi‐LDH is regulated. Moreover, the hollow structure promotes mass transport. Thus, the optimal Mo‐FeNi LDH shows excellent electrocatalytic performance in urea‐assisted alkaline media.
Background
Renal tubular injury is the main feature of diabetic nephropathy (DN). We intend to investigate the function and related mechanisms of lncRNA SOX2 overlapping transcript (SOX2OT) in high ...glucose (HG)‐induced oxidative stress and apoptosis of renal tubular epithelial cells (RTECs).
Methods
To construct diabetes models, the human kidney‐2 (HK‐2) cells were treated with HG (30 mM), and mice were injected with streptozotocin. The levels of intracellular and mitochondrial reactive oxygen species (ROS) were assessed by dihydroethidium staining and MitoSox staining. The cell apoptosis was assessed by flow cytometry and TUNEL staining. Levels of serum creatinine, blood urea nitrogen (BUN), Urinary ACR, and oxidative stress marker 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) were detected by relevant kits. In addition, fluorescence in situ hybridization staining, RNA‐pull down, RNA immunoprecipitation (RIP), co‐immunoprecipitation (co‐IP), dual‐luciferase reporter gene assay and chromatin immunoprecipitation (ChIP) were also executed.
Results
Levels of SOX2OT and silent information regulator 1 (SIRT1) were down‐regulated in HG‐cultured HK‐2 cells. Overexpressing SOX2OT reduced intracellular and mitochondrial ROS levels and cell apoptosis in vitro. Moreover, SOX2OT overexpression also reduced serum creatinine, BUN, urinary ACR, 8‐OHdG, renal tubular injury markers KIM1 and NGAL, ROS levels, and cell apoptosis in vivo. In addition, SOX2OT promoted SIRT1 expression by suppressing its ubiquitination. Besides, interference with SIRT1 reversed the inhibitory effect of SOX2OT overexpression on HG‐induced oxidative stress and apoptosis. Forkhead box A2 (Foxa2) levels were up‐regulated in HG‐cultured HK‐2 cells. Foxa2 could bind to the SOX2OT promoter and suppress its expression. Furthermore, interfering with SOX2OT reversed the inhibitory effect of Foxa2 interference on HG‐induced oxidative stress and apoptosis.
Conclusion
Foxa2‐mediated SOX2OT up‐regulation reduced oxidative stress and apoptosis of RTECs by promoting SIRT1 expression, thus alleviating the progression of DN.
Summary at a Glance
Renal tubule injury plays a major role in the progression of diabetic nephropathy (DN). This study explored the pathogenesis of DN from the perspective of renal tubular epithelial cell injury mediated by oxidative stress under the effect of high glucose (HG). Authors revealed that lncRNA SOX2OT was lowly expressed in renal tubular epithelial cells; Foxa2 was highly expressed in the DN mouse model and HG‐induced renal tubular epithelial cells; lncRNA SOX2OT promoted SIRT1 expression by suppressing its ubiquitination; Foxa2 could bind to the lncRNA SOX2OT promoter and suppress its expression; overexpression of lncRNA SOX2OT inhibits oxidative stress and apoptosis by up‐regulating the SIRT1 levels and improves renal function.
A porous MOF platform (SNNU-65s) formed by creatively combining paddle-wheel-like Cu2(COO)4 and trigonal prismatic M3(μ3-O)(COO)6 building blocks was designed herein. The mixed and high-density open ...metal sites and the OH-functionalized pore surface promote SNNU-65s to exhibit ultra-high C2H2 uptake and separation performance. Impressively, SNNU-65-Cu-Ga stands out for the highest C2H2/CO2 (18.7) and C2H2/CH4 (120.6) selectivity among all the reported MOFs at room temperature.
Pattern-recognition receptors (PRRs), which consist of receptor kinases (RKs) and receptor-like proteins, sense microbe- and host-derived molecular patterns associated with pathogen infection to ...trigger immune responses in plants. Several kinases of the 46-member Arabidopsis (Arabidopsis thaliana) receptor-like cytoplasmic kinase (RLCK) subfamily VII play important roles in pattern-triggered immunity, but it is unclear whether different RLCK VII members act specifically or redundantly in immune signaling. Here, we constructed nine higher order mutants of this subfamily (named rlck vii-1 to rlck vii-9) and systematically characterized their immune phenotypes. The mutants rlck vii-5, -7, and -8 had compromised reactive oxygen species production in response to all patterns tested, indicating that the corresponding members are broadly required for the signaling of multiple PRRs. However, rlck vii-4 was defective specifically in chitin-induced reactive oxygen species production, suggesting that RCLK VII-4 members mediate the signaling of specific PRRs. Furthermore, RLCK VII-4 members were required for the chitin-triggered activation of MAPK, demonstrating that these kinases link a PRR to MAPK activation. Moreover, we found that RLCK VII-6 and -8 also were required for RK-mediated root growth. Together, these results show that numerous RLCK VII members are involved in pattern-triggered immune signaling and uncover both common and specific roles of these kinases in plant development and immunity mediated by various RKs.
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