Accumulating evidence has suggested that ω3-polyunsaturated fatty acids (ω3-PUFAs) may have beneficial effects in the prevention/treatment of cardiovascular diseases, while controversies still remain ...regarding their anti-arrhythmic potential. It is not clear yet whether ω-3-PUFAs can suppress early afterdepolarizations (EADs) induced by oxidative stress. In the present study, we recorded action potentials using the patch-clamp technique in ventricular myocytes isolated from rabbit hearts. The treatment of myocytes with H(2)O(2) (200 μM) prolonged AP durations and induced EADs, which were significantly suppressed by docosahexaenoic acid (DHA, 10 or 25 μM; n = 8). To reveal the ionic mechanisms, we examined the effects of DHA on L-type calcium currents (I(Ca.L)), late sodium (I(Na)), and transient outward potassium currents (I(to)) in ventricular myocytes pretreated with H(2)O(2). H(2)O(2) (200 μM) increased I(Ca.L) by 46.4% from control (-8.4 ± 1.4 pA/pF) to a peak level (-12.3 ± 1.8 pA/pF, n = 6, p < 0.01) after 6 min of H(2)O(2) perfusion. H(2)O(2)-enhanced I(Ca.L) was significantly reduced by DHA (25 μM; -7.1 ± 0.9 pA/pF, n = 6, p < 0.01). Similarly, H(2)O(2)-increased the late I(Na) (-3.2 ± 0.3 pC) from control level (-0.7 ± 0.1 pC). DHA (25 μM) completely reversed the H(2)O(2)-induced increase in late I(Na) (to -0.8 ± 0.2 pC, n = 5). H(2)O(2) also increased the peak amplitude of and the steady state I(to) from 8.9 ± 1.0 and 2.16 ± 0.25 pA/pF to 12.8 ± 1.21 and 3.13 ± 0.47 pA/pF respectively (n = 6, p < 0.01, however, treatment with DHA (25 μM) did not produce significant effects on current amplitudes and dynamics of I(to) altered by H(2)O(2). In addition, DHA (25 μM) did not affect the increase of intracellular reactive oxygen species (ROS) levels induced by H(2)O(2) in rabbit ventricular myocytes. These findings demonstrate that DHA suppresses exogenous H(2)O(2)-induced EADs mainly by modulating membrane ion channel functions, while its direct effect on ROS may play a less prominent role.
Through the experiment of the vibration modal of gearbox shell,the gearbox shell vibration state is analyzed and the stability of its operation is evaluated.By using DASP（Data Acquisition& Signal ...Processing）software,the vibration modal of the HW25505 TCL type aluminum alloy gearbox shell is tested.By the contrast between ERA method and PloyLSCF method,the reliable 14order of frequency and damping are obtained,and thus the vibration mode analysis is carried out.By using modal correlation matrix of modal to test and verify,through the comparison with calculating modal,the validity and reliability are proved.Applied DASP to vibration modal test of gearbox shell,not only the gearbox shell high order frequency,damping,vibration mode,and vibration condition can be acquired,but also the vibration problem of similar shell gearbox in operation can be solved,The theoritical basis for the improvement of the gearbox shell structure characteristics and the fault diagnosis of gearbox shell are provided,and had better promo
The manifold learning algorithm is a method of nonlinear data dimensionality reduction and can get available low dimensional geometry,it is also better reflects the nature of things. In order to ...improve the classification ability of gearbox vibration signals,a new feature extraction method from fault signals of gearbox vibration based on the manifold learning method（ MLM） is proposed. The results show that the fault feature information of gearbox vibration can be MLM effectively extracted and the different types of fault feature information can be separated. The diagnostic accuracy of features extracted by MLM is higher than that of the time domain statistical method.
Based on the method of ERA,a system of modal analysis is built,the model of HW25505 TCL gearbox is set up under the Coinv DASP MAS modal analysis module.The relating modal datum are obtained by ...hammering test of single-input multi- output analysis method,then the state-space equation is established after the analysis of modal datum.The various modal parameters of the gearbox are obtained by order selection and fitting of the datum which extracted through the method of ERA modal parameter identification,and by using modal correlation matrix,the modal test and verification are carried out.Through the comparison with calculating modal,the validity and reliability are proved.The theoretical basis for the improvement of the gear box structure characteristics and the fault diagnosis of gearbox is provided.
In the process of power system reform, the construction of power market and trading platform is undoubtedly the most challenging, and also the key link to the success of power reform. In order to ...better design and structure the cloud platform for power trading, this paper summarizes the resource management related to cloud platform. Resource management of cloud platforms is very important for building efficient cloud computing architecture. In this paper, we investigate various cloud computing resource allocation and management technologies, which includes workload prediction, resource scheduling, resource mapping etc. And analyzed advantages and disadvantages of each method. We hope that through our research and analysis, we can lay a foundation for the future development of a new cloud platform resource management model, and hope that on this basis, we can put forward the key resource architecture of cloud platform for power trading.
This article reported the experience of endovascular treatment in giant middle cerebral artery (MCA) aneurysms with parent artery occlusion or stent-assisted coiling.
Eleven consecutive patients with ...giant MCA aneurysms were included. The aneurysms predominantly involved the M1 segment in two cases, bifurcation in four cases, and M2 in five cases. Four M2 fusiform aneurysms were treated with parent artery sacrifice after balloon occlusion test. The seven unruptured aneurysms and one ruptured one were treated with stent-assisted coiling. The post-operation and long-term follow-up angiographic and clinical outcomes were analyzed.
Endovascular coiling was performed successfully in all 11 cases. All four M2 fusiform cases using parent artery occlusion strategy achieved complete occlusion of aneurysms. In the seven cases with stent-assisted coiling, four were completely occluded, two were partially occluded and one remained small residue. Mild perioperative complications occurred in six patients. The follow-up angiography taken at a mean of 13.5 months of eight patients showed that seven aneurysms remained stable or improved and one M1 aneurysms relapsed and needed further treatment.
Stent-assisted coiling or parent artery occlusion of selected giant MCA aneurysms is an option to consider.
Two new complex copper(II) sulfates Cu(1,10-phen)(H
O)
SO
(1, 1,10-phen = 1,10-phenanthroline) and Cu(2,2′-bipy)(H
O)
SO
(2, 2,2′-bipy = 2,2′-bipyridine) have been hydrothermally synthesized and ...characterized by IR spectroscopy, elemental analysis, thermogravimetric analysis, and X-ray crystallography. 1 and 2 consist of complex cations Cu(1,10-phen/2,2′-bipy)(H
O)
+ and SO
anions, which are interconnected via weak Cu・ ・ ・O interactions to form rare examples of 1-D metal sulfates
A method based on surface enhanced laser desorption and ionization time of flight mass spectrometry (SELDI-TOF MS) was developed for the rapid identification of
Klebsiella pneumoniae
by directly ...applying bacterial colonies without further protein extraction. A total of 40
K. pneumoniae
and 114 other related microorganisms isolated clinically were analyzed by SELDI-TOF MS. An identification model for
K. pneumoniae
was established by artificial neural networks (ANNs) with classification accuracy of 100%. The model was blindly tested with 43
K. pneumoniae
and 53 control bacteria again. The results showed that the model was successful with accuracy of 96.9%, sensitivity of 100% and specificity of 943%. This strategy is potential for rapid identification of
K. pneumoniae
.
In order to promote the digital transformation of the power grid and improve the statistical analysis ability of the power market business, this paper proposes the data modeling method under the ...power market statistical analysis business based on the analysis of the statistical analysis demand of the power market business, studies the statistical analysis technology for the power market business, The results show that the modeling method and analysis technology can effectively support the development of power market statistical analysis business.
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