Mammalian chromosome structure Tyler-Smith, C; Willard, H F
Current opinion in genetics & development,
06/1993, Letnik:
3, Številka:
3
Journal Article
Recenzirano
The DNA sequences that are necessary for the formation of a functional mammalian chromosome are thought to be the origins of replication, the telomeres and the centromere. Telomere structure is now ...well understood, with the functional element characterized as the motif (TTAGGG)n. The structures of the DNA regions that contain origins of replication and a centromere are known, but the functionally important elements within these regions are still only poorly defined.
In an effort to reduce application costs and to integrate plant health management strategies in soybean, growers may combine POST herbicides with foliar fertilizers or cytokinin mixtures. Field ...experiments were conducted at the Delta Research and Extension Center in Stoneville, MS in 2015 and 2016 to evaluate soybean Glycine max (L.) Merr. injury, weed control, and agronomic performance when combining blended or single-nutrient foliar fertilizers with POST herbicide applications. Field experiments were also conducted at the Delta Research and Extension Center in Stoneville, MS in 2015 and 2016 to evaluate the influence of cytokinin mixtures on soybean injury and weed control when combined with common POST soybean herbicides.
Objective—To evaluate the United Kingdom Huntington's disease presymptomatic testing programme. Design—Postal questionnaire survey to collect data on all tests performed by clinical genetics centres ...between 1987 and 1990. Setting—Genetic centres providing presymptomatic testing in the United Kingdom. Subjects—248 subjects at risk of Huntington's disease who had presymptomatic testing at their request. Main outcome measures—Sex, age, prior risk, and risk after testing. Results—The risk of carrying the Huntington disease gene was reduced for 151 (61%) of the applicants and raised for 97 (39%). 158 (64%) of the subjects were female and 90 (36%) male. The median age at which the results were given was 32.5 years. Conclusions—The demand for testing was lower than expected and may have reached its peak in 1990. The excess of low risk results was not fully explained by the age effect. All the genetics centres concerned have agreed a common service protocol which requires extensive pre-test counselling and post-test follow up. The worth of the procedure remains to be decided. The availability of a large body of pooled data from all the United Kingdom testing centres, which individually are likely to have only a few results, will form a valuable resource for monitoring the long term psychosocial impact of testing.
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