The evolutionarily conserved splicing regulator neuro-oncological ventral antigen 1 (
) plays a key role in neural development and function.
also includes a protein-coding difference between the ...modern human genome and Neanderthal and Denisovan genomes. To investigate the functional importance of an amino acid change in humans, we reintroduced the archaic allele into human induced pluripotent cells using genome editing and then followed their neural development through cortical organoids. This modification promoted slower development and higher surface complexity in cortical organoids with the archaic version of
Moreover, levels of synaptic markers and synaptic protein coassociations correlated with altered electrophysiological properties in organoids expressing the archaic variant. Our results suggest that the human-specific substitution in
, which is exclusive to modern humans since divergence from Neanderthals, may have had functional consequences for our species' evolution.
Predicting the development of epidemic infection caused by the COVID-19 coronavirus is a matter of the utmost urgency for health care and effective anti-epidemic measures. Given the rapidly changing ...initial information and the ambiguous quality of data coming from various sources, it is important to quickly optimize the existing prognostic models by using more sophisticated algorithms.
is to test the originally developed mathematical algorithms for predicting the development of the COVID-19 epidemic process.
To assess the situation in China, Italy, and the USA, we used the information from Russian- and English-language sources available in official websites. The generally accepted descriptive statistics were used; mathematical modeling was based on linear regression. Statistical data processing was performed using the IBM SPSS Statistics 24.0 and R (RStudio) 3.6.0.
We found significant differences not only in the incidence rate of COVID-19 in the countries in question, but also in the death rate. The risk of death associated with COVID-19 is high due to the high number of severe clinical cases of the disease reported from these countries.Two preliminary regression models were created. The first, initial model was based on the increase in new cases of infection
this factor was significantly associated with the outcome; the regression coefficient was 0.02 (95% CI 0.01-0.03). In the second, expanded model, in addition to the increase in new cases, the increase in the number of severe forms of infection was also considered; the regression coefficients were 0.017 (95% CI 0.012-0.022) and 0.01 (95% CI 0.008-0.011), respectively. Adding the second variable contributed to a more accurate description of the available data by the model.
The developed regression models for infection control and predicting the number of lethal outcomes can be successfully used under conditions of spreading diseases from the group of "new infections" when primary data received from various sourced are changing rapidly and updates of the information are continually required. In addition, our initial model can produce a preliminary assessment of the situation, and the expanded model can increase the accuracy and improve the analytic algorithm.
The article analyzes the effectiveness of methods for monitoring motor vehicles during operation. The relevance of the study lies in the fact that the braking system is an important element ...responsible for the safe operation of the car.
Purpose. To increase the efficiency of the technical operation of motor vehicles on the basis of the road method for diagnosing brake systems.
Methodology or methodology for conducting work. The article considers the road method using accelerometers.
Results. The main disadvantages of the road method and stands of various designs are considered, which give low reliability of the determined parameters of efficiency and stability during vehicle braking. The effectiveness of the implementation of on-line road diagnostics of automotive braking systems of multi-channel accelerometers is shown, which, when assessing course stability during braking, provide visually convincing information with a fairly high level of reliability.
Practical implications: the results of the study can be used by car service organizations.
The phase equilibria in the ternary Tl-S-I system were investigated experimentally by means of powder X-ray diffraction (PXRD) and differential thermal analysis (DTA). Five isopleth sections, ...liquidus surface projection and room temperature isothermal section were constructed based on experimental data. dc-and ac-electric properties of the TlS and Tl6SI4 crystals were studied within the temperature and frequency ranges from 120 K to 300 K and from 50 kHz to 35 MHz, respectively. The hopping mechanism for charge transfer over the localized states near the Fermi level was established at low temperatures and high frequencies for these compounds. The density and energy scatter of the states which are located in the vicinity of the Fermi level as well as the average time and distances of jumps were estimated for the title compounds.
•The self-consistent phase diagram of the Tl–S–I system is constructed.•The existence of the wide immiscibility fields was revealed.•dc-and ac-electric properties for the TlS and Tl6SI4 crystals were studied.
TlInSe
2
crystals are investigated in dc and ac electric fields in the temperature range of 100–400 K. A decrease in the electrical conductivity σ with time in a dc field is revealed. The ...complex-impedance spectra
Z
*(
f
) are measured in the frequency range of 10–10
6
Hz. Diagrams in the (
Z
″-
Z
′) complex plane are analyzed using the method of equivalent circuits. It is shown that the electrical properties of TlInSe
2
crystals in the investigated ranges of temperatures and frequencies are determined by hopping conductivity and the accumulation of charge carriers near blocking platinum electrodes.
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