From the apocalyptic era of antibiotic resistance, the scientific community around the world is engaged in designing and developing metal-based compounds to inhibit and control continuously rising ...microbial infections. Metal based triazole-derived compounds are being explored for antimicrobial actions and potentially applicable to provide effective and nontoxic drug candidates having preferred and improved pharmacological activity. Updating the existing literature supporting such details, this review combines the chemistry, synthetic aspects of formation of triazole Schiff bases, mechanism of bioactivity of metal complexes accompanied by the assessment of the biological efficacy including antibacterial, antifungal, enzyme inhibition and antioxidant activity. This review covers bioactive symmetrical and assymmetrical mono and bis-Schiff bases synthesized from condensation involving the amine group of 3-amino-1,2,4-triazole and 3,5-diamino-1,2,4-triazole with the carbonyl group of several aromatic aldehydes and ketones along with their transition metal complexes which were characterized by physical, spectral and chemical properties. In most of the studies highlighting the biomedical assessment of imine functionalized compounds, metal complexes showed outstanding results in comparison to free ligands.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, GIS, IJS, IZUM, KILJ, KISLJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Developing high-performance batteries relies on material breakthroughs. During the past few years, various in situ characterization tools have been developed and have become indispensible in studying ...and the eventual optimization of battery materials. However, soft X-ray spectroscopy, one of the most sensitive probes of electronic states, has been mainly limited to ex situ experiments for battery research. Here we achieve in situ and operando soft X-ray absorption spectroscopy of lithium-ion battery cathodes. Taking advantage of the elemental, chemical and surface sensitivities of soft X-rays, we discover distinct lithium-ion and electron dynamics in Li(Co(¹/₃)Ni(¹/₃)Mn(¹/₃))O₂ and LiFePO₄ cathodes in polymer electrolytes. The contrast between the two systems and the relaxation effect in LiFePO₄ is attributed to a phase transformation mechanism, and the mesoscale morphology and charge conductivity of the electrodes. These discoveries demonstrate feasibility and power of in situ soft X-ray spectroscopy for studying integrated and dynamic effects in batteries.
The versatile roles of D-amino acids (D-AAs) in foods, diseases, and organisms, etc., have been widely reported. They have been regarded, not only as biomarkers of diseases but also as regulators of ...the physiological function of organisms. Over the past few decades, increasing data has revealed that D-AAs have great potential in treating disease. D-AAs also showed overwhelming success in disengaging biofilm, which might provide promise to inhibit microbial infection. Moreover, it can effectively restrain the growth of cancer cells. Herein, we reviewed recent reports on the potential of D-AAs as therapeutic agents for treating neurological disease or tissue/organ injury, ameliorating reproduction function, preventing biofilm infection, and inhibiting cancer cell growth. Additionally, we also reviewed the potential application of D-AAs in drug modification, such as improving biostability and efficiency, which has a better effect on therapy or diagnosis.
Productivity modeling and validation is the assessment of data to establish scientific indications that a process is stable. The aim of this paper is to present a novel approach using statistical ...analyses for process improvement. This study highlights the process behavior of three different lathe machines unit with the intention to replace one of them. The research methodology has illustrated by producing a steel rod of 3.175 millimeter diameter based on 180 samples collected from each machine. For statistical data value analysis, MS Excel 2016 and Minitab 18 were utilized. The results showed that lathe machine 1 and 2 had an equivalent inconsistency, but significantly different data spreads. Similarly, the throughput for machine 2 was higher with greater variability as compared to machine 1 while machine 3 encountered a low rate of throughput. On the basis of the fallouts of the analysis, the research team has officially suggested to substitute lathe machine 3.
Android has a large number of users that are accumulating with each passing day. Security of the Android ecosystem is a major concern for these users with the provision of quality services. In this ...paper, multimodal analysis of malware apps has been presented. We exploit static, dynamic, and visual features of apps to predict the malicious apps using information fusion. The proposed study applies case-based reasoning; for catalyzing the process of training and validation over renowned datasets with enriched feature-set. Our proposed semi-supervised technique uses benign and malicious apps to predict and classify malware. The prediction process uses a hybrid analysis of malware. The proposed approach, due to the efficient and adaptive nature of CBR, outperforms prevalent approaches. Our approach has an accuracy of 95% and reduced rate of false negative rate and a better precision metric, which beat the state-of-the-art techniques.
Medicinal plants of Moraceae family have been well-recognized traditionally due to their versatile applications in various fields including agriculture,cosmetic and food as well as in pharmaceutical ...industries. Their biomedical and medicinal importance is reflected from their broad range of pharmacological activities for treatment of various inflammatory conditions,cancer,infectious diseases,and gastrointestinal disorders.The present review was aimed to summarize and critically discuss the biomedical implications of Morus species,their bioactive compounds,and phytochemicals.Bioactivity guided fractionation of these medicinal plants revealed that different types of bioactive phytochemicals and secondary metabolites such as steroids, saponins, alkaloids, glycosides and phenolic compounds including terpenoids,flavonoids,anthocyanins and tannins were present.The critical analysis of the literature revealed that the aqueous,methanolic,and ethanolic ex-tracts of Morus species and their bioactive compounds exhibit remarkable anti-oxidative, anti-diabetic, anti-stress, nephroprotective, antimicrobial, anti-mutagenic, anticancer, anxiolytic, hepatoprotective, anthelmintic, antimicrobial, immune-modulatory and cholesterol lowering effects.Based on the literature review and bioactivity guided inves-tigation of Morus species and their phytomedicinal effects,we anticipate that these herbal products hold excellent potential for future research.
Digitalization in healthcare through advanced methods, tools, and the Internet are prominent social development factors. However, hackers and malpractices through cybercrimes made this digitalization ...worrisome for policymakers. In this study, the role of E-Government Development as a proxy for digitalization and corruption prevalence has been analyzed in Healthcare sustainability in developing and underdeveloped countries of Asia from 2015 to 2021. Moreover, a moderator role of Cybersecurity measures has also been estimated on EGDI, CRP, and HS through the two-step system GMM estimation. The results show that EGDI and CRP control measures significantly improved HS in Asia. Furthermore, by deploying strong and effective Cybersecurity measures, Asia’s digitalization and institutional practices are considerably enhanced, which also has an incremental impact on HS and ethical values. This present study added a novel contribution to existing digitalization and public health services literature and empirical analysis by comprehensively applying advanced econometric estimation. The study concludes that cybersecurity measures significantly improved healthcare digitalization and controlled the institutional malfunctioning in Asia. This study gives insight into how cybersecurity measures enhance the service quality and promote institutional quality of the health sector in Asia, which will help draft sustainable policy decisions and ethical values in the coming years.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•An innovative in-house organisation-wide digital engineering platform was developed and used in simplifying the operational complexity in a multinational engineering company.•Help to regulate and ...control the running of engineering projects and to create a new work-related mind-set and organisational discourse. It helped the organisation to achieve compliance with major health and safety regulation and to deliver projects more efficiently.•Research data were collected using a longitudinal case study approach that spanned over six months.•The digital engineering platform has had real influence on working processes and employees at all levels while encouraging transparency, responsiveness, agility and accountability.•The digital engineering platform continues to help the organisation to govern, manage and maintain good standard service but many barriers still remain. The digital engineering platform did manage to simplify the workings of different employees and change the work-related mind-set and organisational discourse, by: standardising the stages in involved in running a project; serving as a single platform for undertaking engineering projects; facilitating project-related communication between project workers; introducing a new shared and company-wide discourse; suitable conformity to health and safety standards (ISO9001:2000); and defining the sourcing of materials used in installations.
This paper reports on a case study involving a strategic and innovative approach to creation of an in-house multifaceted digital engineering platform (the DEP) in overcoming a number of organisational problems at a multinational engineering company. The DEP was to be used strategically for simplifying the operational complexity and to create and appropriate new work-related mind-set and new organisational discourse to achieve homogenous working across the organisation, which is a huge challenge. The need for this system emerged from the need to resolve many organisational services related problems that carried phenomenal amount of processes, health and safety risks and to regulate, and, control the running of engineering project. Research data were collected using a longitudinal case study approach over a period of six months. In order to make sense of how the DEP helped the organisation, the study used certain elements of Extended Structuration Theory as a lens to assess the case study. This research discovered that the DEP succeeded in creating and appropriating work-related mind-set and organisational discourse. It also had real influence on working processes and employees at all levels while encouraging transparency, responsiveness, agility and accountability. It continues to help the organisation to govern, manage and maintain good standard of service but many barriers still remain.
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