Abstract We present the updated galaxy cluster catalog of the second Planck catalog of Sunyaev–Zel’dovich sources (PSZ2) through the compilation of the data for clusters and galaxies with ...spectroscopically measured redshifts in the literature. The original version of PSZ2 comprises 1653 Sunyaev–Zel’dovich (SZ) sources, of which 1203 have been validated as genuine galaxy clusters, while the remaining 450 sources are yet to be validated. To increase the number of genuine clusters in PSZ2, we first update the validations of the cluster candidates and their redshift information using the data compiled for the confirmed clusters and the member galaxies in the literature. We then use the galaxy redshift data in the fields of the remaining cluster candidates by searching for possible member galaxies with measured spectroscopic redshifts around the SZ centroids. In this search process, we classify clusters as strong candidates if they contain more than nine galaxies within a 4500 km s −1 velocity range and within 15′ around the SZ centroids. This process results in the validation of 139 new genuine clusters, the update of redshift information on 399 clusters, and the identification of 10 strong candidates, which increases the number of validated clusters up to 1334 among the 1653 SZ sources. Our updated galaxy cluster catalog will be very useful for studies of galaxy formation and cosmology through a combination with other all-sky surveys including the Wide-field Infrared Survey Explorer and SPHEREx.
Background
With improved short-term surgical outcomes, laparoscopic distal gastrectomy has rapidly gained popularity. However, the safety and feasibility of laparoscopic total gastrectomy (LTG) has ...not yet been proven due to the difficulty of the technique. This single-arm prospective multi-center study was conducted to evaluate the use of LTG for clinical stage I gastric cancer.
Methods
Between October 2012 and January 2014, 170 patients with pathologically proven, clinical stage I gastric adenocarcinoma located at the proximal stomach were enrolled. Twenty-two experienced surgeons from 19 institutions participated in this clinical trial. The primary end point was the incidence of postoperative morbidity and mortality at postoperative 30 days. The severity of postoperative complications was categorized according to Clavien–Dindo classification, and the incidence of postoperative morbidity and mortality was compared with that in a historical control.
Results
Of the enrolled patients, 160 met criteria for inclusion in the full analysis set. Postoperative morbidity and mortality rates reached 20.6% (33/160) and 0.6% (1/160), respectively. Fifteen patients (9.4%) had grade III or higher complications, and three reoperations (1.9%) were performed. The incidence of morbidity after LTG in this trial did not significantly differ from that reported in a previous study for open total gastrectomy (18%).
Conclusions
LTG performed by experienced surgeons showed acceptable postoperative morbidity and mortality for patients with clinical stage I gastric cancer.
IMPORTANCE The number of geriatric patients who undergo surgery has been increasing, but there are insufficient tools to predict postoperative outcomes in the elderly. OBJECTIVE To design a ...predictive model for adverse outcomes in older surgical patients. DESIGN, SETTING, AND PARTICIPANTS From October 19, 2011, to July 31, 2012, a single tertiary care center enrolled 275 consecutive elderly patients (aged ≥65 years) undergoing intermediate-risk or high-risk elective operations in the Department of Surgery. MAIN OUTCOMES AND MEASURES The primary outcome was the 1-year all-cause mortality rate. The secondary outcomes were postoperative complications (eg, pneumonia, urinary tract infection, delirium, acute pulmonary thromboembolism, and unplanned intensive care unit admission), length of hospital stay, and discharge to nursing facility. RESULTS Twenty-five patients (9.1%) died during the follow-up period (median interquartile range, 13.3 11.5-16.1 months), including 4 in-hospital deaths after surgery. Twenty-nine patients (10.5%) experienced at least 1 complication after surgery and 24 (8.7%) were discharged to nursing facilities. Malignant disease and low serum albumin levels were more common in the patients who died. Among the geriatric assessment domains, Charlson Comorbidity Index, dependence in activities of daily living, dependence in instrumental activities of daily living, dementia, risk of delirium, short midarm circumference, and malnutrition were associated with increased mortality rates. A multidimensional frailty score model composed of the above items predicted all-cause mortality rates more accurately than the American Society of Anesthesiologists classification (area under the receiver operating characteristic curve, 0.821 vs 0.647; P = .01). The sensitivity and specificity for predicting all-cause mortality rates were 84.0% and 69.2%, respectively, according to the model’s cutoff point (>5 vs ≤5). High-risk patients (multidimensional frailty score >5) showed increased postoperative mortality risk (hazard ratio, 9.01; 95% CI, 2.15-37.78; P = .003) and longer hospital stays after surgery (median interquartile range, 9 5-15 vs 6 3-9 days; P < .001). CONCLUSIONS AND RELEVANCE The multidimensional frailty score based on comprehensive geriatric assessment is more useful than conventional methods for predicting outcomes in geriatric patients undergoing surgery.
Background
We performed a prospective, multicenter, randomized controlled study to investigate the clinical outcomes, including postoperative pancreatic fistulas (POPF), after using the TachoSil® ...patch in distal pancreatectomy (NCT01550406).
Methods
Between June 2012 and September 2014, 101 patients at five centers were randomized into Control (n = 53) and TachoSil (n = 48) groups. In all patients, the pancreas was resected using a stapler with Endo‐GIA™ staples. The TachoSil patch was wrapped around the pancreatic stump only in the TachoSil group, not in Control group.
Results
The patient characteristics, including age and diagnosis, were comparable in both groups. The mean operation time (159.4 vs. 172.3 min, P = 0.081) and postoperative hospital stay (10.0 vs. 9.7 days, P = 0.279) were similar in the Control and TachoSil groups, respectively. The overall incidence of POPF was 62.4% (n = 63). The distribution of grades A, B, and C POPF was similar in the Control (n = 14/14/1) and TachoSil (n = 23/11/0) groups, as were the overall incidence (54.7% vs. 70.8%, P = 0.095) and the incidence of grade B and C POPF (28.3% vs. 22.9%, P = 0.536).
Conclusion
This study showed that the TachoSil® patch did not reduce the incidence of POPF after distal pancreatectomy.
Highlight
The authors performed a prospective, multicenter, ramdomized controlled study to investigate the efficacy of TachoSil® patches in preventing pancreatic fistula, the most frequent and serious complication after distal pancreatectomy, for which effective prevention and management methods remain lacking. The patch did not reduce the incidence of postoperative pancreatic fistula.
ABSTRACT
We use the IllustrisTNG cosmological hydrodynamical simulation to study the evolution of star formation rate (SFR)–density relation over cosmic time. We construct several samples of galaxies ...at different redshifts from z = 2.0 to z = 0.0, which have the same comoving number density. The SFR of galaxies decreases with local density at z = 0.0, but its dependence on local density becomes weaker with redshift. At z ≳ 1.0, the SFR of galaxies increases with local density (reversal of the SFR–density relation), and its dependence becomes stronger with redshift. This change of SFR–density relation with redshift still remains even when fixing the stellar masses of galaxies. The dependence of SFR on the distance to a galaxy cluster also shows a change with redshift in a way similar to the case based on local density, but the reversal happens at a higher redshift, z ∼ 1.5, in clusters. On the other hand, the molecular gas fraction always decreases with local density regardless of redshift at z = 0.0–2.0 even though the dependence becomes weaker when we fix the stellar mass. Our study demonstrates that the observed reversal of the SFR–density relation at z ≳ 1.0 can be successfully reproduced in cosmological simulations. Our results are consistent with the idea that massive, star-forming galaxies are strongly clustered at high redshifts, forming larger structures. These galaxies then consume their gas faster than those in low-density regions through frequent interactions with other galaxies, ending up being quiescent in the local universe.
Background
To evaluate a risk‐adjusted comparison of clinically relevant postoperative pancreatic fistula POPF (CR‐POPF) following laparoscopic pancreatoduodenectomy (LPD) vs open ...pancreatoduodenectomy (OPD) using the fistula risk score (FRS).
Methods
We retrospectively analyzed 579 patients who underwent LPD (n = 274) or OPD (n = 305) between 2012 and 2019 at two tertiary hospitals. Using the FRS, the risk was stratified into four categories; negligible, low, intermediate and high risk.
Results
The median FRS was significantly higher in the LPD than in the OPD group (5.4 ± 1.2 vs 3.9 ± 1.8, P < .001). The overall incidence of CR‐POPF in the LPD vs OPD groups were 16.4% vs 17.7% (P = .187). When POPF risks were stratified by FRS, CR‐POPF following LPD vs OPD in patients with low risk (0% vs 6.3%, P = .294), intermediate risk (16.1% vs 22.9%, P = .053) and high risk (33.3% vs 27.3%, P = .577) were not significantly different.
Conclusion
Despite a higher risk score in the LPD group, the CR‐POPF was similar following both procedures in the unadjusted and FRS‐risk‐adjusted comparisons. The CR‐POPF was more significantly affected by patient risk factors such as the soft pancreas and small pancreatic duct.
Highlight
Lee and colleagues conducted a risk‐adjusted comparison of clinically‐relevant postoperative pancreatic fistula following laparoscopic pancreatoduodenectomy versus open pancreatoduodenectomy using the fistula risk score system. The incidence of clinically‐relevant postoperative pancreatic fistula was similar following the two procedures, in both the unadjusted as well as the fistula risk score‐adjusted comparisons.
Background
Laparoscopic distal gastrectomy for early gastric cancer has been widely accepted, but laparoscopic total gastrectomy has still not gained popularity because of technical difficulty and ...unsolved safety issue. We conducted a single-arm multicenter phase II clinical trial to evaluate the safety and the feasibility of laparoscopic total gastrectomy for clinical stage I proximal gastric cancer in terms of postoperative morbidity and mortality in Korea. The secondary endpoint of this trial was comparison of surgical outcomes among the groups that received different methods of esophagojejunostomy (EJ).
Methods
The 160 patients of the full analysis set group were divided into three groups according to the method of EJ, the extracorporeal circular stapling group (EC;
n
= 45), the intracorporeal circular stapling group (IC;
n
= 64), and the intracorporeal linear stapling group (IL;
n
= 51). The clinicopathologic characteristics and the surgical outcomes were compared among these three groups.
Results
There were no significant differences in the early complication rates among the three groups (26.7% vs. 18.8% vs. 17.6%, EC vs. IC vs. IL;
p
= 0.516). The length of mini-laparotomy incision was significantly longer in the EC group than in the IC or IL group. The anastomosis time was significantly shorter in the EC group than in the IL group. The time to first flatus was significantly shorter in the IL group than in the EC group. The long-term complication rate was not significantly different among the three groups (4.4% vs. 12.7% vs. 7.8%; EC vs. IC vs. IL;
p
= 0.359), however, the long-term incidence of EJ stenosis in IC group (10.9%) was significantly higher than in EC (0%) and IL (2.0%) groups (
p
= 0.020).
Conclusions
The extracorporeal circular stapling and the intracorporeal linear stapling were safe and feasible in laparoscopic total gastrectomy, however, intracorporeal circular stapling increased EJ stenosis.
Major concerns about donor safety cause controversy and limit the use of living donor liver transplantation to overcome organ shortages. The Korean Organ Transplantation Registry established a ...nationwide organ transplantation registration system in 2014. We reviewed the prospectively collected data of all 832 living liver donors who underwent procedures between April 2014 and December 2015. We allocated the donors to a left lobe group (n = 59) and a right lobe group (n = 773) and analyzed the relations between graft types and remaining liver volumes and complications (graded using the Clavien 5‐tier grading system). The median follow‐up was 19 months (range, 10‐31 months). During the study period, 553 men and 279 women donated livers, and there were no deaths after living liver donation. The overall, biliary, and major complication (grade ≥ III) rates were 9.3%, 1.7%, and 1.9%, respectively. The graft types and remaining liver volume were associated with significantly different overall, biliary, and major complication rates. Of the 16 patients with major complications, 9 (56.3%) involved biliary complications (2 biliary strictures 12.5% and 7 bile leakages 43.8%). Among the 832 donors, the mean aspartate transaminase, alanine aminotransferase, and total bilirubin levels were 23.9 ± 8.1 IU/L, 20.9 ± 11.3 IU/L, and 0.8 ± 0.4 mg/dL, respectively, 6 months after liver donation. In conclusion, biliary complications were the most common types of major morbidity in living liver donors. Donor hepatectomy can be performed successfully with minimal and easily controlled complications. Our study shows that prospective, nationwide cohort data provide an important means of investigating the safety in living liver donation. Liver Transplantation 23 999–1006 2017 AASLD.
Background/Purpose
Although routine preoperative biliary drainage (PBD) in patients with distal malignant biliary obstruction is generally not recommended, there are still various situations where it ...may be necessary. The current study aims to compare the uncovered self‐expandable metal stent (uSEMS) and plastic stent (PS), where PBD may be necessary.
Patients and Methods
In this multicenter prospective randomized study, patients with resectable periampullary cancer with cholangitis, deep jaundice, or expected long waiting time for surgery were included. PBD was performed endoscopically, but percutaneous drainage was allowed if the initial endoscopic drainage was not feasible. The primary outcome was the reintervention rate; the secondary outcomes were the complication rates, rate of decrease of total bilirubin, waiting time for surgery, and postoperative hospital stay.
Results
Of the 60 enrolled patients, 53 were included for analysis (26 PS and 27 uSEMS). Common bile duct cancer was the most common (27, 50.9%), followed by pancreatic head cancer (20, 37.7%). Regarding PBD indication, 36 (67.9%) had cholangitis and 21 (39.6%) had a total bilirubin level of more than 10 mg/dL at randomization; 10 (18.9%) were included due to delayed surgery by more than 7 days. Fifty (94.3%) patients received pancreaticoduodenectomy, and one (1.9%) patient received palliative hepaticojejunostomy. The median waiting time for surgery was 11.0 days. There was no difference in the reintervention rate (3.8% and 3.8% in PS and uSEMS, P > .999), PBD‐related complication rate (23.1% and 22.2%, P > .999), PBD‐ or surgery‐related complication rate (57.7% and 48.1%, P = .674), and the rate of decrease of total bilirubin (P = .541). The median hospital stay after surgery was 13.0 days without significant difference.
Conclusion
For patients who received surgery within the first 2 weeks from receiving PBD, there was no superiority of uSEMS to PS. According to the expected waiting time for surgery, selective approach for stent choice should be considered.
Highlight
In this prospective randomized trial, Cho and colleagues demonstrated no superiority of self‐ expandable metal stents over plastic stents for patients with resectable periampullary cancer who received surgery within 2 weeks after preoperative biliary drainage. Considering the cost, stent selection should be made according to the expected waiting time for surgery.
Abstract A recent study from the Horizon Run 5 (HR5) cosmological simulation has predicted that galaxies with log M * / M ⊙ ≲ 10 in the cosmic morning (10 ≳ z ≳ 4) dominantly have disk-like ...morphology in the ΛCDM universe, which is driven by the tidal torque in the initial fluctuations of matter. For a direct comparison with observation we identify a total of about 19,000 James Webb Space Telescope (JWST) galaxies with log M * / M ⊙ > 9 at z = 0.6–8.0 utilizing deep JWST/NIRCam images of publicly released fields, including North Ecliptic Pole Time-Domain Fields, Next Generation Deep Extragalactic Exploratory Public survey, Cosmic Evolution Early Release Science Survey, Cosmic Evolution Survey, UltraDeep Survey, and SMACS J0723-7327. We estimate their stellar masses and photometric redshifts with the redshift dispersion of σ NMAD = 0.009 and an outlier fraction of only about 6%. We classify galaxies into three morphological types, disks, spheroids , and irregulars , applying the same criteria used in the HR5 study. The morphological distribution of the JWST galaxies shows that disk galaxies account for 60%–70% at all redshift ranges. However, in the high-mass regime ( log M * / M ⊙ ≳ 11 ), spheroidal morphology becomes the dominant type. This implies that the mass growth of galaxies is accompanied by a morphological transition from disks to spheroids. The fraction of irregulars is about 20% or less at all masses and redshifts. All the trends in the morphology distribution are consistently found in the six JWST fields. These results are in close agreement with the results from the HR5 simulation, particularly confirming the prevalence of disk galaxies at small masses in the cosmic morning and noon.
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