The Baksan Experiment on Sterile Transitions (BEST) was designed to investigate the deficit of electron neutrinos νe observed in previous gallium-based radiochemical measurements with high-intensity ...neutrino sources, commonly referred to as the "gallium anomaly," which could be interpreted as evidence for oscillations between νe and sterile neutrino (νs) states. A 3.414-MCi 51Cr νe source was placed at the center of two nested Ga volumes and measurements were made of the production of 71Ge through the charged current reaction, 71Ga(νe,e-)71Ge, at two average distances. The measured production rates for the inner and the outer targets, respectively, are 54.9$_{-2.4}^{+2.5}$(stat)±1.4(syst) and 55.6$_{-2.6}^{+2.7}$(stat)±1.4(syst) atoms of 71Ge/d. The ratio (R) of the measured rate of 71Ge production at each distance to the expected rate from the known cross section and experimental efficiencies are Rin=0.79±0.05 and Rout=0.77±0.05. The ratio of the outer to the inner result is 0.97±0.07, which is consistent with unity within uncertainty. The rates at each distance were found to be similar, but 20%-24% lower than expected, thus reaffirming the anomaly. Therefore these results are consistent with νe→νs oscillations with a relatively large Δm2 (> 0.5 eV2) and mixing sin22θ (≈0.4).
Introduction.
In recent years, more and more attention has been paid to the issues of genital prolapse. This is largely due to the increase in women life expectancy and the need to provide them with ...a decent quality of life, as prolapse is quite often accompanied by dysfunction of the pelvic organs. In recent years, there has been an increasing amount of literature on undifferentiated connective tissue dysplasia (UCTD). However, most of these studies consider therapeutic or vertebro-neurological problems, while the high prevalence rates of this pathology call for additional research on the pathogenetic mechanisms of the effect of UCTD on pelvic organ prolapse, which will allow us to decide on the choice of subsequent treatment.
The purpose and objectives
. Asess the effect of undifferentiated connective tissue dysplasia (UCTD) on the formation of disorders of the somatic, gynecological and reproductive health status in women with genital prolapse.
Materials and methods
. To achieve this goal, we examined 204 women with genital prolapse in the POP-Q classification of stage 2–3, of which 97 were diagnosed with UCTD (the main group), and the remaining 107 patients made up the comparison group.
Results
. To evaluate the influence of UCTD on the formation of somatic, gynecological and reproductive health disorders in women with genital prolapse. We analyzed anamnestic indications for somatic, gynecological and reproductive pathology of women, as well as assessed the current state of health of patients with genital prolapse. It was found that it is UCTD that determines the development of a particular form of gynecological pathology and affects the formation of genital prolapse.
Conclusion
. UCTD manifests as various forms of somatic and gynecological health disorders throughout the life of women with genital prolapse.
The myocardium of the right and left atrial appendages (auricles) in patients with paroxysmal, persistent, and permanent forms of atrial fibrillation was examined by histological methods and electron ...microscopy. Isolated atrial amyloidosis was detected in the left (50.0-56.3% patients) and in the right (45.0-55.6% patients) atrial appendages. In all cases, immunohistochemistry revealed atrial natriuretic peptide in fibrillary amyloid deposits. Ultrastructurally, amyloid masses formed clusters of myofibrils 8-10 nm in diameter. They were chaotically located in the extracellular space along the sarcolemma as well as in membrane invaginations, dilated tubules of cardiomyocyte T
-
tubular system, and vascular walls. Amyloidosis was predominantly observed in women; its degree positively correlated with age of patients and duration of atrial fibrillation but negatively correlated with atrial fibrosis. The study revealed positive (in permanent atrial fibrillation) and negative (in paroxysmal atrial fibrillation) correlation of amyloidosis with myofibril content in atrial cardiomyocytes.
The structures of phenol-formaldehyde oligomers functionalized by benzylamine were studied. The mechanisms of the synthesis and transformations of initial oligomers with various molar ratios of the ...nitrogen-containing modifier were discussed. The optical densities of the main bonds were obtained by the IR spectroscopy method, the regularities of their changes were reported and substantiated.
Certain subtypes of acute myeloid leukemia occur as a result of the cooperation of several events these are, the formation of fusion genes as a result of chromosomal rearrangements, which leads to ...the disruption of cell differentiation, and the emergence of mutations that enhance cellular proliferation by activating intracellular signaling pathways. High-throughput sequencing methods reveal characteristic mutation spectra in leukemia associated with different chromosomal disorders. However, the role of mutation events in malignant cell transformation processes remains obscure. We searched for driver mutation events in leukemic cells containing the chimeric
CBFB-MYH11
gene, which results from inversion of chromosome 16. Using target enrichment, the coding regions of 84 genes in genomes of 12 children with acute myeloid leukemia with inv(16) were investigated. Somatic mutations have been found in the genes of the proteins of intracellular signaling cascades mediated by receptor tyrosine kinases, such as
KIT
(41%),
NRAS
(25%),
KRAS
(17%), and
FLT3
(8.3%). Comparative analysis of samples at the time of diagnosis and during remission was used to assess the role of mutations in the pathogenesis of the disease. Previously undescribed mutations in the
KDM6A
,
NOTCH1
, and
IDH1
genes, which may be involved in leukemogenesis processes have been identified.
Aim. To conduct a comparative analysis of the self-assessment of health by urban and rural residents of the Republic of Dagestan, using as examples the city of Makhachkala and the Untsukulskiy ...district.Material and Methods. Sociological research methods were employed on the basis of questionnaires.Results. According to the results of the study the majority of the residents of Makhachkala and the Untsukulskiy district surveyed - 71% and 68.2% respectively -gave positive assessments of their health. In both samples, the proportion of respondents who rated their health as "mediocre" and "bad" increased with age. In rural areas the number of young and middle-aged respondents who assessed their health as worse exceeded the number of city dwellers of the same age. Among male respondents, 77.8% in Makhachkala and 74.9% in the Untsukulskiy district gave a positive self-assessment of health and among the female population, 66.7% and 62.93% respectively.Conclusion. Self-assessment of health is a tool recommended by the World Health Organization for monitoring health within selected population groups. The slight difference between the assessment of their health by urban and rural residents is due to differences in lifestyle and standard of living, access to medical as well as cultural, leisure and other types of services.
We analyzed treatment outcomes in patients with pelvic organ prolapse (POP), some of whom had signs of undifferentiated connective tissue dysplasia (uCTD). Women from subgroup 1 used a pessary, ...while women from subgroup 2 underwent electromyostimulation in an outpatient department and performed Kegel exercises. After two treatment courses and pharmacotherapy, all patients demonstrated positive dynamics. Electrostimulation in combination with Kegel exercises was more effective than pessary; the effect was more pronounced in women without uCTD than in patients with uCTD. The results of our study were used for the development of a scale to assess POP severity, which enables a tailored approach to the diagnosis and management of such patients depending on the presence of uCTD.
The paper considers the results of therapy of clinical manifestations of genital prolapse using electromyosymmulation and Kegel exercises. The obtained data allow us to consider this type of ...conservative treatment quite effective. This therapy can be recommended for women with contraindications to surgical correction of prolapse.
Using chromatography on nanostructured carbon sorbent we had isolated an unusual nanocomplex from filling grains of wheat and maize, which consists of only phosphatidylinositol (PI) and one ...protein—glutamate dehydrogenase (GDh). It was very surprising that this nanocomplex shows activity of Nicotinamide adenine dinucleotide phosphate-GDh (NADP-GDh) without any treatment. Thus, the whole body of nanocomplex shows its activity without disturbing its integrity. This makes the nanocomplex very convenient for using it as a biosensor. The main feature of nanocomplex is its high sensitivity to ammonia ions. Linear response concentration for nanocomplex is from 0.5
μM to 10
μM ammonia ions. Due to these properties the nanocomplex may be very useful as nanobiosensor for ecological monitoring of pollution by sewer waters of natural reservoirs—lakes and rivers. Also this nanosensor can be applied for determination of ammonia ions, NADPH and 2-oxoglutarate in biological liquids for clinical diagnostic.
The alkylation reactions of phosphonoacetic aldehyde and ethyl phosphonoacetate with ethyl α-bromopropanoate in DMSO in the presence of K
2
CO
3
have been studied.
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