A case of non-invasive secretory carcinoma of the breast is reported. The patient was a 33-year-old Japanese woman who complained of abnormal nipple discharge from the right breast. Although physical ...and radiological examinations failed to find any abnormal nodular lesions in the breast, a cytological examination revealed signet-ring-like atypical cells in the smears of nipple discharge. Radical mastectomy with axillary lymph nodes dissection was performed. No nodular lesions were macroscopically observed. However, intraductal proliferation of atypical cells was microscopically found in the excised breast. Diastase-resistant PAS-positive mucus was observed in the tumor-cell-forming-lumina and in the cytoplasm of tumor cells. No metastases were observed in the axillary lymph nodes.
Double Base Lesions in DNA X-Irradiated in the Presence or Absence of Oxygen. Previously, double lesions in which two adjacent bases are modified were identified in DNA oligomers exposed in solution ...to ionizing radiation. However, the formation of such lesions in polymer DNA had not been demonstrated. Using reference oligomer containing a specific double lesion and employing liquid chromatography-mass spectrometry (LC-MS), it was possible to show directly that double lesions are formed in irradiated calf thymus DNA. The double lesion in which a pyrimidine base is degraded to a formamido remnant and an adjacent guanine base is oxidized to 8-oxoguanine was detected in DNA X-irradiated in oxygenated aqueous solution. The double lesion in which the methyl carbon atom of a thymine base is covalently linked to carbon at the 8-position of an adjacent guanine base was detected in DNA irradiated in a deoxygenated environment.
O-(5-Acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-2- nonulopyranoxylonic acid)-(2---6)-O-(2-acetamido-2-deoxy-alpha-D-galactopyranosyl)-(1---3) -L-serine, a structural unit occurring in various ...submaxillary mucins, was synthesized for the first time by using O-methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-alpha-D- galacto-2-nonulopyranosyl)onate-(2---6)-3,4-di-O-acetyl-2- azido-2-deoxy-D- galactopyranosyl trichloroacetimidate (13) and N-(benzyloxycarbonyl)-L-serine benzyl ester as the key intermediates. The trichloroacetimidate 13 was prepared by starting from two monosaccharide synthons, namely, allyl 2-azido-2-deoxy-beta-D-galactopyranoside and methyl (5-acetamido-4,7,8,9-tetra-O-acetyl-3,5-dideoxy-D-glycero-beta-D- galacto-2-nonulopyranosyl chloride)onate, which were coupled in the presence of silver triflate in tetrahydrofuran to give the desired alpha-(2---6)-linked disaccharide in moderate selectivity.
We studied retrospectively the visual outcome of 20 eyes of 19 patients with symptomatic retinal arterial macroaneurysm. The macular pathology responsible for the acute visual loss was categorized as ...macular edema (5 eyes), preretinal hemorrhages alone (3 eyes), subretinal hemorrhages with or without preretinal hemorrhages (10 eyes) and vitreous hemorrhage (2 eyes). Thirteen eyes were treated with argon or dye laser photocoagulation. Five eyes with preretinal hemorrhage underwent YAG laser photodisruption of the posterior hyaloid membrane to release the preretinal hemorrhage into the vitreous space. Five eyes with macular edema, 3 eyes with preretinal hemorrhage without subretinal hemorrhage and 2 eyes with vitreous hemorrhage showed final vision of 0.5 or better, but of the other 10 eyes with subretinal hemorrhage with or without preretinal hemorrhage, 9 showed final visual acuity of 0.2 or worse. Visual prognosis of submacular hemorrhage due to ruptured retinal macroaneurysm is poor, but that of macular edema, preretinal hemorrhage or vitreous hemorrhage is relatively good.
Quadrupole Moment of the 7/21 Isomer State of 43mS Tsuchiya, M; Hass, M; Kameda, D ...
Exotic Nuclei: EXON-2012 : Proceedings of the International Symposium, Vladivostok, Russia, 1 – 6 October 2012,
2013
Reference
K18 is an anticancer drug for oral administration comprising about five molecules of melphalan, an alkylating drug, covalently bonded to human immunoglobulin G. This study measured the in vitro ...antitumour activity of K18, melphalan and immunoglobulin G on human myeloma cells (RPMI-8226) and the in vivo antitumour effects of K18 and melphalan in BALB/c nude mice bearing human lung cancer cells (LC-10). The relative tumour-inhibitory effect, in vitro, was found to be: immunoglobulin G less than K18 less than melphalan. This activity of K18 was about half the theoretical value indicating that melphalan molecules are not released easily from the conjugate. K18 showed strong antitumour activity in vivo which continued after stopping administration. On the other hand, the effects of melphalan did not continue after administration was stopped. The distribution of 125I K18 and 14Cmelphalan was examined in BALB/c nude mice 14 days after implantation of LC-10 cells. Radioactivity levels in the major organs showed a transient rapid increase followed by a gradual decline. In tumours, 14Cmelphalan levels increased transiently and then decreased, whereas 125IK18 levels persisted following intravenous administration.
K18 is a newly synthesized antitumor agent which is the conjugate form of human immunoglobulin with p-di (2-chloroethyl)-amino-L-phenylalamine (melphalan). The antitumor effect of K18 on two animal ...metastatic models was investigated: (a) Lewis lung carcinoma was transplanted into thigh muscle of mice, followed by the reaction of the primary lesion, or the tumor was transplanted through the tail vein: (b) a renal model was also created, where colon-26 was inoculated into the renal capsule of BALB/c mice. Oral administration of K18 resulted in the decrease in the number of nodules in the lung in the case of tumor transplantation through tail vein.
