The resurfacing process on Ryugu accompanying the artificial impact crater formation by Hayabusa2's Small Carry-on Impactor (SCI) was studied by comparing pre- and post-impact images of this region ...captured by an optical navigation camera. Three different aspects of the resurfacing process were examined: the crater rim profiles, the motion of boulders and the appearance of new boulders, and the motion vectors of Ryugu's surface around the SCI crater. The averaged crater rim height, h, was derived as follows: h = hr exp −(r/Rrim − 1)/λrim, where Rrim is the SCI crater rim radius of 8.8 m, the fitted parameter, hr, is 0.475 m, and the λrim is 0.245. The ejecta blanket thickness of the SCI crater was thinner than that estimated from both the observation of natural craters and the crater formation theory. However, this discrepancy of the ejecta blanket thickness was resolved by taking into account the new boulders appearing in the post-impact images in the volume. The motion of the discovered boulders could be classified by its mechanisms as follows: a dragging motion created by excavation flow during the crater formation, a pushing motion created by falling-back ejecta, a dragging motion created by the slight motion of the Okamoto boulder, and a motion caused by seismic shaking induced by the SCI impact itself. The seismic shaking caused boulders to move farther than 3 cm from the original site in most of the region within 15 m distance from the SCI crater center, where the maximum acceleration of the impact induced seismic waves 7 times larger than the surface gravity of Ryugu based on the laboratory experiments (Matsue et al. 2020 Icarus, 338, 113520), and the evidence of the seismic shaking for boulders with a movement of >3 cm was detected in about 10% of the boulders in the region between 15 m and 30 m from the crater center, which region was inferred to experience acceleration larger than the Ryugu's surface gravity based on previous laboratory experiments (Matsue et al. 2020 Icarus, 338, 113520).
•We studied resurfacing processes caused by the artificial impact on asteroid Ryugu.•Pre- and post-impact images enabled us to determine the disturbed area.•The impactor disturbed the surface within a 40 m radius from the crater center.•The ejecta blanket thickness was approximated by the exponential equation.•More than 50% of boulders within a 15 m radius was moved by seismic shaking.
Abnormal gut motility is a feature of several mitochondrial encephalomyopathies, and mutations in genes such as TYMP and POLG, have been linked to these rare diseases. The human genome encodes three ...DNA ligases, of which only one, ligase III (LIG3), has a mitochondrial splice variant and is crucial for mitochondrial health. We investigated the effect of reduced LIG3 activity and resulting mitochondrial dysfunction in seven patients from three independent families, who showed the common occurrence of gut dysmotility and neurological manifestations reminiscent of mitochondrial neurogastrointestinal encephalomyopathy. DNA from these patients was subjected to whole exome sequencing. In all patients, compound heterozygous variants in a new disease gene, LIG3, were identified. All variants were predicted to have a damaging effect on the protein. The LIG3 gene encodes the only mitochondrial DNA (mtDNA) ligase and therefore plays a pivotal role in mtDNA repair and replication. In vitro assays in patient-derived cells showed a decrease in LIG3 protein levels and ligase activity. We demonstrated that the LIG3 gene defects affect mtDNA maintenance, leading to mtDNA depletion without the accumulation of multiple deletions as observed in other mitochondrial disorders. This mitochondrial dysfunction is likely to cause the phenotypes observed in these patients. The most prominent and consistent clinical signs were severe gut dysmotility and neurological abnormalities, including leukoencephalopathy, epilepsy, migraine, stroke-like episodes, and neurogenic bladder. A decrease in the number of myenteric neurons, and increased fibrosis and elastin levels were the most prominent changes in the gut. Cytochrome c oxidase (COX) deficient fibres in skeletal muscle were also observed. Disruption of lig3 in zebrafish reproduced the brain alterations and impaired gut transit in vivo. In conclusion, we identified variants in the LIG3 gene that result in a mitochondrial disease characterized by predominant gut dysmotility, encephalopathy, and neuromuscular abnormalities. Bonora et al. identify a new mitochondrial recessive disorder caused by biallelic variants in the LIG3 gene encoding DNA ligase III, which is responsible for mitochondrial DNA repair. Clinical signs include gut dysmotility and neurological features such as leucoencephalopathy, epilepsy and stroke-like episodes.
An artificial impact experiment is scheduled for 2018–2019 in which an impactor will collide with asteroid 162137 Ryugu (1999
JU
3
) during the asteroid rendezvous phase of the Hayabusa2 spacecraft. ...The small carry-on impactor (SCI) will shoot a 2-kg projectile at 2 km/s to create a crater 1–10 m in diameter with an expected subsequent ejecta curtain of a 100-m scale on an ideal sandy surface. A miniaturized deployable camera (DCAM3) unit will separate from the spacecraft at about 1 km from impact, and simultaneously conduct optical observations of the experiment. We designed and developed a camera system (DCAM3-D) in the DCAM3, specialized for scientific observations of impact phenomenon, in order to clarify the subsurface structure, construct theories of impact applicable in a microgravity environment, and identify the impact point on the asteroid. The DCAM3-D system consists of a miniaturized camera with a wide-angle and high-focusing performance, high-speed radio communication devices, and control units with large data storage on both the DCAM3 unit and the spacecraft. These components were successfully developed under severe constraints of size, mass and power, and the whole DCAM3-D system has passed all tests verifying functions, performance, and environmental tolerance. Results indicated sufficient potential to conduct the scientific observations during the SCI impact experiment. An operation plan was carefully considered along with the configuration and a time schedule of the impact experiment, and pre-programed into the control unit before the launch. In this paper, we describe details of the system design concept, specifications, and the operating plan of the DCAM3-D system, focusing on the feasibility of scientific observations.
TIR, the thermal infrared imager on Hayabusa2, acquired high-resolution thermal images of the asteroid 162173 Ryugu for one asteroid rotation period on August 1, 2018 to investigate the ...thermophysical properties of the asteroid. The surface temperatures of Ryugu suggest that the surface has a low thermal inertia, indicating the presence of porous materials. Thermophysical models that neglect or oversimplify surface roughness cannot reproduce the flat diurnal temperature profiles observed during daytime. We performed numerical simulations of a thermophysical model, including the effects of roughness on the diurnal brightness temperature, the predictions of which successfully reproduced the observed diurnal variation of temperature. The global thermal inertia was obtained with a standard deviation of 225 ± 45 J m−2 s−0.5 K−1, which is relatively low but still within the range of the value estimated in our previous study (Okada et al., Nature 579, 518–522, 2020), confirming that the boulders on Ryugu are more porous in nature than typical carbonaceous chondrites. The global surface roughness (the ratio of the variance of the height relative to a local horizontal surface length) was determined as 0.41 ± 0.08, corresponding to a RMS surface slope of 47 ± 5°. We identified a slightly lower roughness distributed along the equatorial ridge, implying a mass movement of boulders from the equatorial ridge to the mid-latitudes.
•Thermophysical model using a shape model of rough surface reproduces observations.•We obtain a global thermal inertia of 225 ± 45 J m−2 s−0.5 K−1.•We obtain a global RMS surface slope of 47 ± 5°.•We confirm Ryugu's low global thermal inertia owing to porous constituent boulders.
Asteroid 162173 Ryugu has numerous craters. The initial measurement of impact craters on Ryugu, by Sugita et al. (2019), is based on Hayabusa2 ONC images obtained during the first month after the ...arrival of Hayabusa2 in June 2018. Utilizing new images taken until February 2019, we constructed a global impact crater catalogue of Ryugu, which includes all craters larger than 20 m in diameter on the surface of Ryugu. As a result, we identified 77 craters on the surface of Ryugu. Ryugu shows variation in crater density which cannot be explained by the randomness of cratering; there are more craters at lower latitudes and fewer at higher latitudes, and fewer craters in the western bulge (160°E – 290°E) than in the region around the meridian (300°E – 30°E). This variation implies a complicated geologic history for Ryugu. It seems that the variation in crater density indicates that the equatorial ridge located in the western hemisphere is relatively young, while that located in the eastern hemisphere is a fossil structure formed during the short rotational period in the distant past.
•We examined the spatial distribution of impact craters on Ryugu.•We completed a global impact crater catalogue of Ryugu (D > 20 m).•Crater density variations cannot be explained by the randomness of cratering.•More craters are seen at lower latitudes and less at higher latitudes.•There are fewer craters in the western bulge and more around the meridian.
Precise information of spacecraft position with respect to target body is of importance in terms of scientific interpretation of remote sensing data. In case of Hayabusa2, a sample return mission ...from asteroid Ryugu, such information is also necessary for landing site selection activity. We propose a quick method to improve the spacecraft trajectory when laser altimeter range measurements and a shape model are provided together with crude initial trajectory, spacecraft attitude information, and asteroid spin information. We compared topographic features contained in the altimeter data with those expressed by the reference shape model, and estimated long-period trajectory correction so that discrepancy between the two topographic profiles was minimized. The improved spacecraft positions are consistent with those determined by image-based stereophotoclinometry method within a few tens of meters. With such improved trajectory, the altimeter ranges can be converted to Ryugu's topographic profiles that are appropriate for geophysical interpretation. We present a geophysical application that invokes possibility of impact-induced formation of the Ryugu's western bulge.
•Hayabusa2 LIDAR data contribute to quick improvement of the spacecraft trajectory•With this trajectory, topography of Ryugu is delineated by scan observations.•Formation of Ryugu's western bulge may have been triggered by an oblique impact.
Introduction Low-grade epilepsy-associated tumors are the second most common histopathological diagnoses in cases of drug-resistant focal epilepsy. However, the connection between neuroimaging ...features and genetic alterations in these tumors is unclear, prompting an investigation into genotype-relevant neuroimaging characteristics. Methods This study retrospectively analyzed neuroimaging and surgical specimens from 46 epilepsy patients with low-grade epilepsy-associated neuroepithelial tumors that had genetic mutations identified through panel sequencing to investigate their relationship to genotypes. Results Three distinct neuroimaging groups were established: Group 1 had indistinct borders and iso T1-weighted and slightly high or high T2-weighted signal intensities without a diffuse mass effect, associated with 93.8% sensitivity and 100% specificity to BRAF V600E mutations; Group 2 exhibited sharp borders and very or slightly low T1-weighted and very high T2-weighted signal intensities with a diffuse mass effect and 100% sensitivity and specificity for FGFR1 mutations; and Group 3 displayed various characteristics. Histopathological diagnoses including diffuse low-grade glioma and ganglioglioma showed no clear association with genotypes. Notably, postoperative seizure-free rates were higher in Group 1 tumors ( BRAF V600E) than in Group 2 tumors ( FGFR1 ). Discussion These findings suggest that tumor genotype may be predicted by neuroimaging before surgery, providing insights for personalized treatment approaches.
We measured the thermal conductivity of glass beads as a simple model material in order to investigate the compressional stress dependence of the thermal conductivity of powder materials. The ...measurements were conducted in a vertically elongated cylindrical sample container under vacuum conditions. Our results suggest that the compressional stress is one of the essential factors to understand the thermal conductivity structure in the regolith layer.
To achieve the scientific objectives related to the lunar magnetic field measurements in a polar orbit at an altitude of 100 km, strict electromagnetic compatibility (EMC) requirements were applied ...to all components and subsystems of the SELENE (Kaguya) spacecraft. The magnetic cleanliness program was defined as one of the EMC control procedures, and magnetic tests were carried out for most of the engineering and flight models. The EMC performance of all components was systematically controlled and examined through a series of EMC tests. As a result, the Kaguya spacecraft was made to be very clean, magnetically. Hence reliable scientific data related to the magnetic field around the Moon were obtained by the LMAG (Lunar MAGnetometer) and the PACE (Plasma energy Angle and Composition Experiment) onboard the Kaguya spacecraft. These data have been available for lunar science use since November 2009.
Progressive external ophthalmoplegia (PEO) is one of a number of major types of mitochondrial disorders. Most sporadic PEO patients have a heteroplasmic large deletion of mitochondrial DNA (mtDNA) in ...the mitochondria in skeletal muscles. We herein analyzed mtDNA deletions using sub-cloning and Sanger sequencing of PCR products in a 31-year-old Japanese man with multiple symptoms, including PEO, muscle weakness, hearing loss, leukoencephalopathy and hypogonadism. A large number of multiple deletions was detected, as well as four kinds of deletion breakpoints identified in different locations, including m.3347_12322, m.5818_13964, m.5829_13964 and m.5837_13503.
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