...we hypothesized that the development of ABS associated with acquired transient QTc prolongation 24hours after the hospital admission most likely triggered TdP. ...although the prognosis for ...patients with ABS seems to be relatively good 7,9, our patient during an MG crisis developed an ABS with acquired transient QTc prolongation and associated TdP. ...we recommend carefully considering cardiac arrhythmias during MG crisis and taking measures before prescribing any QT prolonging agent in patients with ABS.
Evidence of epigenetic tags in cardiac fibrosis Grimaldi, Vincenzo, BiolD; De Pascale, Maria Rosaria, MD; Zullo, Alberto, BiolD, PhD ...
Journal of cardiology,
02/2017, Letnik:
69, Številka:
2
Journal Article
Recenzirano
Odprti dostop
Abstract In cardiac fibrosis, following an injury or a stress, non-functional fibrotic tissue substitutes normal myocardium, thus leading to progressive heart failure. Activated fibroblasts are ...principal determinants of cardiac fibrosis by producing excessive fibrotic extracellular matrix and causing hypertrophy of cardiomyocytes. Epigenetic changes, such as DNA methylation, histone modifications, and miRNAs have been involved in these mechanisms. Therefore, there is a strong interest in reverting such epigenetic transformations in order to arrest myocardial fibrotic degeneration. Demethylating agents, such as 5-aza-2′-deoxycytidine, 5-azacytidine, some selective histone deacetylase inhibitors, including mocetinostat, trichostatin A, and MPT0E014, have a direct action on important inducers of cardiac fibrosis. Also dietary compounds, such as resveratrol, can suppress the differentiation of fibroblasts to myofibroblasts. Although in vivo and in vitro studies suggest specific epigenetic therapies to treat cardiac fibrosis, the related clinical trials are still lacking. A better understanding of the epigenetic effects of dietary compounds ( e.g. curcumin and green tea catechins) on the onset and progression of cardiac fibrosis, will allow the identification of protective dietary patterns and/or the generation of novel potential epidrugs.
Purpose To show whether an intra-articular (IA) infiltration of 1 mL sodium hyaluronate (SH) into the temporomandibular joint (TMJ) would significantly reduce pain and improve joint function in ...Wilkes stage II disease, compared with the oral administration of a combination of methocarbamol and paracetamol. Patients and Methods Forty-one patients with Wilkes stage II disease were selected and randomly assigned to 2 groups. The experimental group received 1 IA infiltration of SH with assessments at days 14, 28, 56, and 84. The control group was given 2 tablets of a combination of methocarbamol 380 mg and paracetamol 300 mg every 6 hours for 4 weeks, with assessments at days 14 and 28. Results Forty-one patients were randomized into the study (SH: 20 patients, control drug: 21 patients). A statistically significant difference ( P < . 05) was detected in favor of the SH group from day 56 onward for TMJ pain at rest, from day 14 onward for pain on jaw opening, and at days 28 and 56 for pain on mastication. The TMJ function was statistically significantly ( P < .05) better in the test group at all follow-up visits. The global evaluation of efficacy by both, the patients and investigators, was better for the test group. No adverse reactions were detected with SH. Conclusions An IA infiltration of SH showed better efficacy in reducing pain and improving joint function in Wilkes stage II disease, compared with the oral administration of methocarbamol-paracetamol tablets.
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