Despite general acceptance that the retinotopic organisation of human V4 (hV4) takes the form of a single, uninterrupted ventral hemifield, measured retinotopic maps of this visual area are often ...incomplete. Here, we test hypotheses that artefact from draining veins close to hV4 cause inverted BOLD responses that may serve to obscure a portion of the lower visual quarterfield-including the lower vertical meridian-in some hemispheres. We further test whether correcting such responses can restore the 'missing' retinotopic coverage in hV4. Subjects (N = 10) viewed bowtie, ring, drifting bar and full field flash stimuli. Functional EPIs were acquired over approximately 1.5h and analysed to reveal retinotopic maps of early visual cortex, including hV4. Normalised mean maps (which show the average EPI signal amplitude) were constructed by voxel-wise averaging of the EPI time course and used to locate venous eclipses, which can be identified by a decrease in the EPI signal caused by deoxygenated blood. Inverted responses are shown to cluster in these regions and correcting these responses improves maps of hV4 in some hemispheres, including restoring a complete hemifield map in one. A leftwards bias was found whereby 6/10 left hemisphere hV4 maps were incomplete, while this was the case in only 1/10 right hemisphere maps. Incomplete hV4 maps did not correspond with venous artefact in every instance, with incomplete maps being present in the absence of a venous eclipse and complete maps coexisting with a proximate venous eclipse. We also show that mean maps of upper surfaces (near the boundary between cortical grey matter and CSF) provide highly detailed maps of veins on the cortical surface. Results suggest that venous eclipses and inverted voxels can explain some incomplete hV4 maps, but cannot explain the remainder nor the leftwards bias in hV4 coverage reported here.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
•7 Tesla submillimeter whole-brain dataset.•105 intrinsically aligned quantitative contrasts from a single scan acquisition.•Probabilistic atlases of the basal ganglia based on >1000 manual ...delineations.•Data freely available for further analyses.
Normative databases allow testing of novel hypotheses without the costly collection of magnetic resonance imaging (MRI) data. Here we present the Amsterdam Ultra-high field adult lifespan database (AHEAD). The AHEAD consists of 105 7 Tesla (T) whole-brain structural MRI scans tailored specifically to imaging of the human subcortex, including both male and female participants and covering the entire adult life span (18–80 yrs). We used these data to create probability maps for the subthalamic nucleus, substantia nigra, internal and external segment of the globus pallidus, and the red nucleus. Data was acquired at a submillimeter resolution using a multi-echo (ME) extension of the second gradient-echo image of the MP2RAGE sequence (MP2RAGEME) sequence, resulting in complete anatomical alignment of quantitative, R1-maps, R2*-maps, T1-maps, T1-weighted images, T2*-maps, and quantitative susceptibility mapping (QSM). Quantitative MRI maps, and derived probability maps of basal ganglia structures are freely available for further analyses.
This study examined perceptual differentiation of specular from diffuse shading for the recovery of surface color and gloss. In Experiment 1, we parametrically varied the mesoscale relief height of ...globally planar surfaces, specular sharpness and the orientation of the surface relative to the light source. We obtained psychophysical matches for perceived color saturation and value (HSV), but also considered whether the main effects could be influenced by color space used when transforming data to perceptually-uniform CIE LCH space. Results revealed strong interactions between perceived color attributes and the lighting conditions, the structure of specular reflections, and surface relief. Declines in saturation were observed with increasing specular roughness (using an HSV color representation), but no similar decline was observed in chroma (using a CIE LCH color representation). Experiment 2 found strong negative correlations between perceived gloss and specular roughness. Perceived gloss also depended on mesoscopic relief height and orientation of the surface relative to the light source. Declines in perceived gloss moderately accounted for the variability in color saturation and value matches obtained in Experiment 1. We found information about perceived specular coverage could further improve the model's accountability of perceived color saturation and lightness (Experiment 3). These findings together suggest that perceived color saturation and color value depends on the visual system's ability to distinguish the underlying diffuse shading from specular highlights in images.
Functional neuroimaging experiments that employ naturalistic stimuli (natural scenes, films, spoken narratives) provide insights into cognitive function “in the wild”. Natural stimuli typically ...possess crowded, spectrally dense, dynamic, and multimodal properties within a rich multiscale structure. However, when using natural stimuli, various challenges exist for creating parametric manipulations with tight experimental control. Here, we revisit the typical spectral composition and statistical dependences of natural scenes, which distinguish them from abstract stimuli. We then demonstrate how to selectively degrade subtle statistical dependences within specific spatial scales using the wavelet transform. Such manipulations leave basic features of the stimuli, such as luminance and contrast, intact. Using functional neuroimaging of human participants viewing degraded natural images, we demonstrate that cortical responses at different levels of the visual hierarchy are differentially sensitive to subtle statistical dependences in natural images. This demonstration supports the notion that perceptual systems in the brain are optimally tuned to the complex statistical properties of the natural world. The code to undertake these stimulus manipulations, and their natural extension to dynamic natural scenes (films), is freely available.
HPB surgery in the time of COVID Alsaoudi, T; Chung, WY; Isherwood, J ...
British journal of surgery,
November 2020, 2020-11-00, 20201101, Letnik:
107, Številka:
12
Journal Article
Old Rules Never Die Humayun-Zakaria, N; Isherwood, J
European journal of vascular and endovascular surgery,
02/2016, Letnik:
51, Številka:
2
Journal Article
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