When two materials are bonded, free-edge stress singularity usually develops at the intersection of free-surfaces and interface. The order of the free-edge stress singularity p can be obtained as a ...root of the characteristic equation deduced in terms of Airy's stress function. It is theoretically predicted that logarithmic free-edge singularity develops when the order of the singularity p has double root, but no numerical examination is available in the literature. In this study, stress distribution on the interface of the bonded dissimilar orthotropic materials is calculated by using the boundary element method (B.E.M.) under the condition where the order of the singularity has the double root of the characteristic equation. It was found that the logarithmic free-edge stress singularity developed under mechanical loading. The order of the stress singularity calculated by the nonlinear least squares method from the stress distribution obtained by B.E.M. analyses agreed well with one obtained by using the characteristic equation. The logarithmic free-edge stress singularity developed under thermal stress loading also.
Understanding of damage information in disaster situation is the most important role for emergency response headquarters in order to provide relief action. Although responder in actual large-scale ...disaster situation could not deal damage situation easily that is ascribable to difficulty for understanding of spatiotemporally damage information. This paper proposes a GIS based disaster situation displaying and sharing approach system for represent disaster damage information at emergency response headquarters in large-scale disaster, to provide association between geolocation and multimedia content which is taken into disaster affected area. Our approach presents images of damage situation upon digital map on a high resolution single and large sized display, allows helping of damage by detail of damage situation in specific area not only showing it. We designed system architecture, use case of system and human computer interaction under operation for damage situation collection on large scale tiled display system. This system can be connected multiple counter disaster sites each other with disaster controlling network in an effort to share digital pictures and/or videos of disaster situation. We also discuss task oriented intuitive input method for our disaster information GIS. We will use some tablet devices in each site to make considerations interaction of system with multiple users.
Geostatistical analyses were used to clarify the effects of the spatial structure of terrain on the spatial variability of satellite-derived surface temperatures on clear winter nights in central ...Japan. The clarification describes the mechanism for the formation of thermal belts found on mountain slopes.
The speed up of supercomputers has increased the complexity of simulations. To analyze such kind of data, new types of visualization software are needed. As one of approach for meeting this ...requirement, we are developing the “Fusion Visualization” in a project sponsored by the Japan Science and Technology Agency (JST). It can execute fused visualization of simulation data combining both volume and surface rendering. The overall concept was reported last year at the AROB 18th International Symposium in Korea. In this work, we are reporting the ongoing research with an application example related to blood flow simulation.
Overexpression of the human γ‐glutamylcysteine synthetase (γ‐GCS) gene resulted in cisplatin resistance with an increased glutathione (GSH) content, increased ATP‐dependent glutatbione S‐conjugate ...export pump (GS‐X pump) activity and decreased platinum accumulation in human lung cancer cells transfected with a γ‐GCS cDNA expression vector, as we previously reported. In this study, we examined the effects of buthionine sulfoximine (BSO), a specific inhibitor of γ‐GCS, to determine whether GSH depletion alters cisplatin resistance in a γ‐GCS‐transfected cell line, SBC‐3/ GCS. In the presence of 10 μM BSO for 4 days, SBC‐3/GCS still showed resistance to cisplatin, although it was partially reversed. Under these conditions, GS‐X pump activity remained up‐regulated in spite of low GSH content, and the platinum content was decreased. These data suggest that the GS‐X pump itself influences cisplatin resistance, as well as cellular GSH content.
Topoisomerase I-targeting anticancer agents such as 7-ethyl-10-4-(1-piperidyl)-1-piperidylcarbonyloxy-camptothecin (CPT-11) and 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(beta-D- ...glucopyranosyl)-5H-indolo2,3-apyrrolo3,4-ccarbazole-5,7(6H)-di one (NB-506) have been developed and show strong antitumor activity against various cancers. We examined the interaction of these drugs and cisplatin (CDDP), and biochemical mechanisms of synergism between them. Interaction of drugs in human small cell lung cancer cells, SBC-3, was analyzed using the isobologram method. Combinations of CDDP with NB-506, CPT-11, and an active metabolite of CPT-11, 7-ethyl-10-hydroxy-CPT (SN-38), showed synergistic effects. Formation of DNA interstrand cross-links (ICLs) on the cells was analyzed using an alkaline elution assay and increased ICLs were observed by simultaneous exposure to CDDP (1.5 microM) and NB-506 (10 nM) compared with that in response to CDDP alone. DNA repair after ICL formation induced by 3-h exposure to CDDP (1.5 microM) was reduced by NB-506 (10 nM) exposure. On the other hand, a higher concentration of CDDP (150 microM) enhanced the topoisomerase I inhibitory activity of NB-506 and SN-38 determined by relaxation of supercoiled Escherichia coli DNA. These biological interactions might result in synergistic interactions between CDDP and NB-506 or SN-38. Topoisomerase I inhibitors and CDDP may be a key regimen for cancer chemotherapy and merit further examination.
Presents the introductory welcome message from the conference proceedings. May include the conference officers' congratulations to all involved with the conference event and publication of the ...proceedings record.
Dielectric measurements were carried out on suspensions of montmorillonite clay exchanged with three different counterions: sodium, ammonium, and tetramethylammonium (TMA). Only two dielectric ...absorption peaks could be identified for the clay sample with the TMA counterion, whereas three peaks were found for the two inorganic counterions. The dielectric process observed at around 10 GHz is due to the orientation of bulk water molecules, judging from the relaxation time and relaxation strength. The relaxation strength of the process occurring at around 10 MHz was compared with the coefficient of adiabatic compressibility obtained from ultrasound velocity measurements. The increase in the relaxation strength with decreasing compressibility indicates that the process at around 10 MHz is caused by the orientation of bound water molecules on the clay samples. The relaxation strength of the process occurring at around 10 MHz for the TMA sample was remarkably small. Furthermore, the network structure of the bound water molecules can be characterized by a property peculiar to the TMA sample, taking into account the value of its Cole-Cole parameter. Results for the relaxation strength of the process occurring at around 100 kHz were compared with those for electrophoretic mobility. This comparison revealed that discrimination between bound ions and ions in the diffuse double layer is important, and both the relaxation and electrophoretic results could be satisfactorily explained by surface polarization of the clay.
The relations between surface temperature and air temperature on clear winter nights were investigated with regard to spatial scale and the vegetation effect at a local meteorological scale. The ...study was based on nighttime images obtained from the Landsat Thematic Mapper and high-density meteorological data obtained from the Automated Meteorological Data Acquisition System (AMeDAS). The correlation coefficients between the air temperatures and the surface temperatures at the AMeDAS stations were relatively high despite the simple comparison. Surface temperature alone explained 80% of the observed variation in air temperature. The spatial scales of the effect of surface temperature on air temperature and the effect of vegetation density on air temperature were related to the mean lapse rate of the atmospheric boundary layer. Air temperature was more sensitive to vegetation density when the mean lapse rate of the atmospheric boundary layer was smaller. Accuracy in the estimation of air temperature from satellite-derived surface temperature data was improved by multiple regression using the spatially averaged surface temperature and normalized difference vegetation index.
Celotno besedilo
Dostopno za:
BFBNIB, DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
With the recent IoT (Internet of Things) technology developments, new functions
are expected tothe future DIS (Disaster Information System) with IoT devices. However,
it is considered that ...theincreased IoT data would cause congestions for Internet
services, and it is necessary to consider theQoS (Quality of Service) controls for the
system. Therefore, this paper proposes the QoS controlmethods using the SDN (Software
Defined Network) by the classifications of IoT data transmissions.In detail, first of
all, the routing functions with the Extend Dijkstra’s algorithm is introduced. In
therouting, IoT data is classified into four categories, and the proper route is
selected by the Dijkstra’salgorithm with the QoS priority values of the classifications.
Also, the switching functions are introducedto avoid network congestion in the selected
route. In the switching, if the IoT traffic loadreaches more than 80 percent of the
maximum throughput of the selected route, the IoT data is distributedby the additional
route. The paper then reports the implementations of the prototype systemby using the
SDN, and the experiments show the effectiveness of the proposed methods.
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