Discovery of genetic mutations that have a significant association with economically important traits would benefit beef cattle breeders. Objectives were to identify with an in silico approach new ...SNP in 8 genes involved in digestive function and metabolic processes and to examine the associations between the identified SNP and feed efficiency and performance traits. The association between SNP and daily DMI, ADG, midpoint metabolic weight (MMWT), residual feed intake (RFI), and feed conversion ratio (FCR; the ratio of average daily DMI to ADG) was tested in discovery and validation populations using a univariate mixed-inheritance animal model fitted in ASReml. Substitution effect of the T allele of SNP rs41256901 in protease, serine, 2 (trypsin 2; PRSS2) was associated with FCR (-0.293 ± 0.08 kg DMI kg(-1) BW gain; P < 0.001) and RFI (-0.199 ± 0.08 kg; P < 0.01) and although not significant in the validation population, the phase of association remained. In the cholecystokinin B receptor (CCKBR) gene, genotypes in rs42670351 were associated with RFI (P < 0.05) whereas genotypes in rs42670352 were associated with RFI (P = 0.002) and DMI (P < 0.05). Substitution of the G allele in rs42670352 was associated with DMI (-0.236 ± 0.12 kg; P = 0.055) and RFI (-0.175 ± 0.09 kg; P = 0.05). Substitution of the G allele of SNP rs42670353 was associated with ADG (0.043 ± 0.02 kg/d; P < 0.01) and FCR (0.114 ± 0.05 kg BW gain kg(-1) DMI; P < 0.05). In the validation dataset, SNP rs42670352 in gene CCKBR was significant for RFI and DMI and had the same phase of associations; SNP rs42670353 was significantly associated with FCR with same phase of association and the C allele in SNP rs42670351 was validated as decreasing DMI, RFI, and FCR. Substituting the G allele of SNP rs42670352 in CCKBR2 was associated with decreasing DMI and RFI in the validation study. New SNP were reported in genes PRSS2 and CCKBR, being associated with feed efficiency and performance traits in beef cattle. The association between these SNP with fertility, carcass, and meat quality traits must still be tested.
This study was conducted to evaluate the anatomical and functional results of sigmoid colon vaginoplasty. From June 2000 to June 2005, 26 patients with congenital vaginal agenesis were evaluated and ...treated with sigmoid colon reconstruction at Ain Shams University Maternity Hospital as a primary procedure in 17 patients and a secondary procedure in 9 patients after previous failed Abbe-McIndoe vaginoplasty elsewhere. The anatomical results were good in 22 patients, while 3 patients suffered from introital stenosis. Two of them were treated successfully by dilatation while one required Z-plasty. Eight patients were lost to follow-up and only ten patients are currently sexually active as the rest were divorced or remained unmarried. Of the sexually active patients, 8 (80%) had satisfactory intercourse whereas 2 (20%) complained of dyspareunia. Sigmoid colon vaginoplasty has satisfactory long-term anatomical and functional results and should be considered as primary option for the treatment of vaginal agenesis.
Cross Coherence time frequency transform and independent component analysis (ICA) method were used to analyse the electroencephalogram (EEG) signals in resting and action states during open and close ...eyes conditions. From the topographical scalp distributions of delta, theta, alpha, and beta power spectrum can clearly discriminate between the signal when the eyes were open or closed, but it was difficult to distinguish between resting and action states when the eyes were closed. In open eyes condition, the frontal area (Fp1, Fp2) was activated (higher power) in delta and theta bands whilst occipital (O1, O2) and partial (P3, P4, Pz) area of brain was activated alpha band in closed eyes condition. The cross coherence method of time frequency analysis is capable of discrimination between rest and action brain signals in closed eyes condition.
Inconsistency in the definition of conflict is a fundamental issue of the traffic conflict technique and raises questions about the validity of this technique. A significant aspect of inconsistency ...is that thresholds to distinguish traffic conflicts from normal events have not been clearly determined. The study presented in this paper proposed a peak-over-threshold (POT) approach to determine postencroachment time thresholds between traffic conflicts and normal events. The determined thresholds were evaluated by testing the correlation between the defined conflicts and observed crashes. A further regression analysis was conducted to explain heterogeneity of POT-determined thresholds. The results show that traffic conflicts defined by POT-determined thresholds have a relatively strong relationship with observed crashes, and the Pearson’s correlation coefficient is .66. Moreover, the threshold heterogeneity in this study mainly stems from the variety of exposure (i.e., traffic volume). This study also implies that the POT approach, which can account for possible heterogeneity in thresholds, is promising for improving the validity of the traffic conflict technique.
Abstract Introduction Caesarean section (CS) is a significant risk factor for venous thromboembolism.. Low molecular weight heparin (LMWH) is commonly used for thromboprophylaxis post emergency ...caesarean delivery. However, no consensus exists regarding LMWH thromboprophylaxis following elective caesarean section. Measures of thrombin formation may indicate the full anticoagulant activity of LMWH in this setting. Materials and methods Anti-Xa, tissue factor pathway inhibitor (TFPI), thrombin anti-thrombin complex (TAT) and endogenous thrombin potential (ETP) were measured in twenty healthy women who received 4,500 IU tinzaparin 6 hours post CS (CS1), twenty women who received 4,500 IU tinzaparin at 10–12 hours post delivery (CS2) and twenty women post spontaneous vaginal delivery (SVD). Results Prior to initiation of LMWH, TAT levels at 6 hours post delivery were significantly higher in the CS1 and CS2 groups than the SVD group (P < 0.002); TAT levels were significantly reduced up to 24 hours post LMWH treatment despite declining anti-Xa levels (P < 0.001). In CS1, peak thrombin and ETP were significantly reduced following LMWH prophylaxis (P < 0.0001; P < 0.002) and reverted to pre-delivery levels 10 hours post LMWH. TFPI levels mirror anti-Xa levels during the 24 hours following LMWH treatment in CS1 group with peak levels coinciding with peak anti-Xa levels 4 hours post injection. Conclusion In women post caesarean section, anti-Xa levels do not reflect the full anticoagulant effects of LMWH. In-vivo thrombin production (TAT) is effectively reduced even when anti-Xa levels are negligible. LMWH thromboprophylaxis in this healthy cohort of patients appears to have a sustained effect in reducing excess thrombin production post elective caesarean section.
Nano-hydroxyapatite formation by using ultrasonic Ismail K. Al-Khateeb; Ammar M. Hamza; Ezalden J. Abduljabar
Maǧallaẗ ǧāmiʻaẗ al-anbār li-l-ʻulūm al-ṣirfaẗ/Maǧallaẗ ǧāmiʻaẗ al-Anbār li-l-ʻulūm al-ṣirfaẗ,
06/2018, Letnik:
11, Številka:
3
Journal Article
Recenzirano
Odprti dostop
Hydroxyapatite nanoparticles were synthesized, using a wet chemical technique from diammonium hydrogen phosphate and calcium nitrate tetrahydrate precursors, Ammonia used in control of the acidic ...function at 11. The use of ultrasound to study the impact on the particle sizes. The prepared powder was used for further characterization. The prepared Nano-hydroxyapatite powder was characterized for phase composition, using X-ray diffraction elemental dispersive X-ray and Fourier transform infrared spectroscopy. The elemental compositions of the Nano-hydroxyapatite were analyzed. The particle size and morphology were studied using the scanning electron microscope (SEM), The scanning electron microscope are among the particles are bacilli, where he was treated article ultrasound waves 50 watt gave sizes up to 30 nm, and when it was treated card 40 watts gave sizes up to 50 nm.
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