ABSTRACT
Satellite galaxies in the cluster environment are more likely to be quenched than galaxies in the general field. Recently, it has been reported that satellite galaxy quenching depends on the ...orientation relative to their central galaxies: satellites along the major axis of centrals are more likely to be quenched than those along the minor axis. In this paper, we report a detection of such anisotropic quenching up to z ∼ 1 based on a large optically selected cluster catalogue constructed from the Hyper Suprime-Cam Subaru Strategic Program. We calculate the quiescent satellite galaxy fraction as a function of orientation angle measured from the major axis of central galaxies and find that the quiescent fractions at 0.25 < z < 1 are reasonably fitted by sinusoidal functions with amplitudes of a few per cent. Anisotropy is clearer in inner regions (<r200m) of clusters and not significant in cluster outskirts (>r200m). We also confirm that the observed anisotropy cannot be explained by differences in local galaxy density or stellar mass distribution along the two axes. Quiescent fraction excesses between the two axes suggest that the quenching efficiency contributing to the anisotropy is almost independent of stellar mass, at least down to our stellar mass limit of $M_{*}=1\times 10^{10}\, {\rm M}_{\odot }$. Finally, we argue that the physical origins of the observed anisotropy should have shorter quenching time-scales than $\sim 1\, \mathrm{Gyr}$, like ram-pressure stripping, because, for anisotropic quenching to be observed, satellites must be quenched before their initial orientation angles are significantly changed.
During development neurons are generated by sequential divisions of neural stem cells, or neuroblasts. In the insect brain progeny of certain stem cells form lineage-specific sets of projections that ...arborize in distinct brain regions, called clonal units. Though this raises the possibility that the entire neural network in the brain might be organized in a clone-dependent fashion, only a small portion of clones has been identified.
Using Drosophila melanogaster, we randomly labeled one of about 100 stem cells at the beginning of the larval stage, analyzed the projection patterns of their progeny in the adult, and identified 96 clonal units in the central part of the fly brain, the cerebrum. Neurons of all the clones arborize in distinct regions of the brain, though many clones feature heterogeneous groups of neurons in terms of their projection patterns and neurotransmitters. Arborizations of clones overlap preferentially to form several groups of closely associated clones. Fascicles and commissures were all made by unique sets of clones. Whereas well-investigated brain regions such as the mushroom body and central complex consist of relatively small numbers of clones and are specifically connected with a limited number of neuropils, seemingly disorganized neuropils surrounding them are composed by a much larger number of clones and have extensive specific connections with many other neuropils.
Our study showed that the insect brain is formed by a composition of cell-lineage-dependent modules. Clonal analysis reveals organized architecture even in those neuropils without obvious structural landmarks.
► Clonal units in the fly cerebrum are comprehensively identified ► Well-investigated brain regions have simpler architecture with fewer clones ► Neural fiber bundles are also organized in a clone-dependent manner ► Neuropils connected by these clones form community structure
Centriole duplication occurs once per cell cycle to ensure robust formation of bipolar spindles and chromosome segregation. Each newly-formed daughter centriole remains connected to its mother ...centriole until late mitosis. The disengagement of the centriole pair is required for centriole duplication. However, the mechanisms underlying centriole engagement remain poorly understood. Here, we show that Cep57 is required for pericentriolar material (PCM) organization that regulates centriole engagement. Depletion of Cep57 causes PCM disorganization and precocious centriole disengagement during mitosis. The disengaged daughter centrioles acquire ectopic microtubule-organizing-center activity, which results in chromosome mis-segregation. Similar defects are observed in mosaic variegated aneuploidy syndrome patient cells with cep57 mutations. We also find that Cep57 binds to the well-conserved PACT domain of pericentrin. Microcephaly osteodysplastic primordial dwarfism disease pericentrin mutations impair the Cep57-pericentrin interaction and lead to PCM disorganization. Together, our work demonstrates that Cep57 provides a critical interface between the centriole core and PCM.
Abstract
Background
Whole-liver radiotherapy for diffuse liver metastases can improve symptoms and abnormal liver-related blood data. However, whole-liver radiotherapy is uncommonly used in clinical ...practice in Japan. Therefore, we aimed to clarify palliative radiotherapy outcomes in Japanese patients with liver metastases.
Methods
We retrospectively reviewed databases in our institution to identify patients treated with radiotherapy (8 Gy in a single fraction) for multiple liver metastases between December 2014 and April 2021. The endpoints included pain response, liver-related blood data and adverse effects. We investigated aspartate transaminase, alanine transaminase, lactate dehydrogenase, alkaline phosphatase, γ-glutamyl transpeptidase and albumin. The mean values at whole-liver radiotherapy and after 2–4 weeks were compared using the Wilcoxon rank-sum test.
Results
A total of 73 cases in 71 patients were included. The median clinical target volume was 2118 ml (range, 133–7867 ml). Fifty-seven patients (78%) had finished aggressive treatment at the time of radiotherapy. The median follow-up period was 6 weeks. The pain response rate was 64% (18/28). The mean values of five parameters significantly improved 2–4 weeks after radiotherapy compared to those at baseline: aspartate transaminase (118 vs. 83 U/l P < 0.01); alanine transaminase (84 vs. 61 U/l P < 0.01); lactate dehydrogenase (1351 vs. 1007 U/l P = 0.027); alkaline phosphatase (1624 vs. 1216 U/l P < 0.01) and γ-glutamyl transpeptidase (663 vs. 450 U/l P = 0.037). No patients experienced radiation-induced liver disease.
Conclusions
Palliative radiotherapy is efficient and safe in Japanese patients with liver metastases. These findings will help encourage whole-liver radiotherapy use in Japan.
Palliative radiotherapy achieved good pain palliation and significant improvement of hepatic blood data for Japanese patients with LM. Moreover, no patients experienced radiation-induced liver disease.
Monitoring neural activity and associating neural dynamics with the anatomical connectome are required to understand how the brain works. Neural dynamics are measured by electrophysiology and optical ...imaging. Since the discovery of the two-photon excitation phenomenon, significant progress has been made in deep imaging for capturing neural activity from numerous neurons in vivo. The development of two-photon microscopy is aimed to image neural activity from a large and deep region with high spatial (x, y, and z) and temporal (t) resolutions at a high signal-to-noise ratio. Imaging deep regions along the optical axis (z-axis) is particularly challenging because heterogeneous biological tissues scatter and absorb light. Recent advances in the light focus modulation technology at high speeds in three dimensions (x, y, and z) have allowed multiplane two-photon imaging. z-Focus control by varifocal optical systems, such as ferroelectric liquid lenses, gradient refractive index lenses, and adaptive optical element systems, and multiplexing by time- and wavelength-division strategies have allowed to rapidly observe specimens at different focal depths. Herein, we overview the recent advances in multiplane functional imaging systems that enable four-dimensional (x, y, z, and t) analysis of neural dynamics, with a special emphasis on z-scanning mechanisms and multiplexing strategies.
•Multiplane two-photon imaging allows 4D (x, y, z, and t) analysis of neural dynamics.•Multiplane imaging is achieved using fast z-focus scanning and/or multiplexing techniques.•Fast varifocal optical system without moving objective is used in z-focus scanning.•Multiplexing via time- or wavelength-division allows signal separation and acquisition.
We present deep near-infrared spectroscopy of six quasars at 6.1 ≤ z ≤ 6.7 with Very Large Telescope/X-Shooter and Gemini-N/GNIRS. Our objects, originally discovered through a wide-field optical ...survey with the Hyper Suprime-Cam (HSC) Subaru Strategic Program (HSC-SSP), have the lowest luminosities (−25.5 mag ≤ M1450 ≤ −23.1 mag) of the z > 5.8 quasars with measured black hole (BH) masses. From single-epoch mass measurements based on Mg ii λ2798, we find a wide range in BH masses, from MBH = 107.6 to 109.3 M . The Eddington ratios Lbol/LEdd range from 0.16 to 1.1, but the majority of the HSC quasars are powered by MBH ∼ 109 M supermassive black holes (SMBHs) accreting at sub-Eddington rates. The Eddington ratio distribution of the HSC quasars is inclined to lower accretion rates than those of Willott et al., who measured the BH masses for similarly faint z ∼ 6 quasars. This suggests that the global Eddington ratio distribution is wider than has previously been thought. The presence of MBH ∼ 109 M SMBHs at z ∼ 6 cannot be explained with constant sub-Eddington accretion from stellar remnant seed BHs. Therefore, we may be witnessing the first buildup of the most massive BHs in the first billion years of the universe, the accretion activity of which is transforming from active growth to a quiescent phase. Measurements of a larger complete sample of z 6 low-luminosity quasars, as well as deeper observations with future facilities, will enable us to better understand the early SMBH growth in the reionization epoch.
Despite the importance of the insect nervous system for functional and developmental neuroscience, descriptions of insect brains have suffered from a lack of uniform nomenclature. Ambiguous ...definitions of brain regions and fiber bundles have contributed to the variation of names used to describe the same structure. The lack of clearly determined neuropil boundaries has made it difficult to document precise locations of neuronal projections for connectomics study. To address such issues, a consortium of neurobiologists studying arthropod brains, the Insect Brain Name Working Group, has established the present hierarchical nomenclature system, using the brain of Drosophila melanogaster as the reference framework, while taking the brains of other taxa into careful consideration for maximum consistency and expandability. The following summarizes the consortium's nomenclature system and highlights examples of existing ambiguities and remedies for them. This nomenclature is intended to serve as a standard of reference for the study of the brain of Drosophila and other insects.
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