e21558 Background: Targeted therapy (TT) and anti-PD1 immunotherapy (IT) are standard of adjuvant stage III melanoma treatment. However, no comparative prospective randomized trials (head-to-head) ...were conducted. Data limited to a few retrospective studies. Both treatment regimens were registered in Russia in 2019. We aimed to compare adjuvant options in Russian melanoma pts. Methods: We conducted a single-center retrospective observational study approved by the IRB. We included all pts age 18 and older (one patient, female, was 14) with BRAF-mutated stage III melanoma who were treated at the N.N.Blokhin NMRC of Oncology MoH and received adjuvant therapy between Jan 2019 and Dec 2022. The primary endpoint was RFS, the secondary endpoint - OS. Cox regression analysis was used to identify prognostic factors for RFS (including substage, thickness and ulceration of primary tumor). Results: A total of 209 pts were included, mostly BRAF V600E/K, 92 (44%) male and 117 (56%) female. Median age was 50,6 years (range: 14-81). 93 (44,4%) pts received TT, 103 (49,3%) pts received IT and 13 (6,3%) didn’t receive adjuvant therapy (observation only). The observation group wasn’t analyzed due to a small number of pts. At a median follow-up of 27 mo, median RFS was 30 mo (95% CI 23-56) in TT group and wasn’t reached in IT group; median OS wasn’t reached in both groups. There weren’t statistical differences between TT and IT groups in RFS (HR 0,84, 95% CI 0,53-1,34, p = 0,47) and OS (HR 0,59, 95% CI 0,26-1,34, p = 0,21), even though at 12 mo, the rate of RFS was higher in the TT group (91.4%) compared IT group (67%), at 18 mo – 79,5% and 63,1%, 24 mo – 68,8% and 61,1% respectively. TT group had numeric but not significant RFS benefit in most subgroups. HR values for substage, thickness and ulceration are presented in the table below. Tx+T0 pts (TT, n = 7; IT, n = 13) and unknown status of ulceration (TT, n = 7; IT, n = 16) was not presented for some pts. Conclusions: Differences between TT and IT wasn't reached at a median follow-up of 27 mo. But IT-treated pts had more and earlier recurrences than TT pts. In BRAF mutated pts, adjuvant TT might prevent early recurrences more effectively than IT. These results need to be interpreted with caution given its retrospective and non-randomized nature and potential selection biases. Additional time to follow-up and biomarker analysis was planned. Table: see text
The invariant cross sections for forward charged-hadron production at zero angle in carbon–carbon collisions at a beam kinetic energy of 19.6 GeV per nucleon were measured at the U-70 accelerator in ...an experiment performed with the aid of a combined spectrometer including beam line 22 and detectors of the modified FODS setup. The beam line rigidity was varied between 7 and 70 GeV/
. The results are compared with the predictions of the FTFP model and a self-similar solution for nucleus–nucleus collisions.
The inclusive differential cross sections for forward production of nuclear fragments at an angle of 0∘ in CC collisions at beam energy 20.5 GeV/nucleon (SNN=6.3GeV) are presented. Measurements have ...been performed at the U-70 Accelerator Complex (Protvino) using a combined spectrometer on base of the beamline. Fragments selection was carried out by measuring of ionization in scintillation counters taking into account the data from threshold Cherenkov counters and hadron calorimeter. Fragment mass was determined through Cherenkov light emission angle measured in the spectrometer of ring imaging Cherenkov radiation. Data are given for fragments with charge 1≤Z≤6, atomic number 1≤A≤10 and A/Z<3.4 with momenta from 20 to 210 GeV/c. The measurements are compared with Fritiof model, statistical models and theoretical parameterizations. The discovered differences between theory and experiment are discussed.
The inclusive differential cross sections for the production of
and
mesons, protons, and antiprotons with momenta between 6 and 50 GeV/
c
and nuclear fragments of mass number
in the momentum range ...between 20 and 220 GeV/
c
were measured in carbon–lead collisions at a beam kinetic energy of 19.6 GeV per nucleon (
GeV). A comparison with the respective cross sections for carbon–carbon interactions is performed, and the dependence on the target mass number (
) is estimated. The present analysis shows that the observed particles originate predominantly from peripheral interactions.
A one-dimensional stationary problem of the dynamics of a console circular panel with applied normal pressure has been discussed. The boundary value problem has been considered for various shells, ...such as the Kirchhoff–Love shell and the Donnel–Mushtari shell with extensible and non-extensible middle plane. The possibility of finding an analytical solution for the above-said shells has been considered as well. The solution of the problem has been sought in the form of using integral expressions with Green's functions as their core. Green's functions would be the boundary value problem's solution with pressure in a form of Dirac delta function. An analytical algorithm has been developed to calculate Green's functions value for any fluctuation frequency. This algorithm is based on the numerical (in case of the Kirchhoff–Love shell and the Donnel–Mushtari shell with extensible middle plane) and precise (in any other cases) solution of the characteristic equation and also on developing a common solution in a matrix form for the boundary value problem. Examples of the calculations of dynamics of a console circular panel with applied concentrated force (Green's function) and normal pressure have been given. Comparison of various shells with the applied concentrated and distributed loads has been performed.
The results of the simulation of the spectrometer acceptance for forward production of hadrons and nuclear fragments in nucleus−nucleus collisions at the U-70 accelerator complex are presented. The ...spectrometer is composed of beamline 22 of the U-70 accelerator and the detectors of the upgraded FODS facility with location of nuclear targets at the beamline head. The calculations have been performed in the virtual Monte Carlo environment of the ROOT package from the GEANT4 toolkit (version 4.10.02.p02). The passage of secondary hadrons (charged π and
K
mesons, protons, and antiprotons), secondary light nuclei (D, T), and heavier isotopes (He, Li, Be, B, and C) have been studied. In addition to the acceptance for each type of particles and nuclei, the coefficients of their escape from an ensemble due to decays and interactions during their passage through the spectrometer have been calculated.
A procedure for finding the trajectories of charged particles on the FODS (focusing double-arm spectrometer) is described, which includes channel calibration (
r
(
t
)-dependence) of drift detectors ...for calculating the coordinates of particles and reconstruction of tracks. The organization of time measurements and construction of a least-squares functional on their basis is considered. The criteria for selecting candidates for the tracks are discussed. A procedure has been developed for obtaining geodesic corrections for drift chambers and tubes at the analysis of physical events. Accuracies of measuring the coordinates in drift chambers of 600 μm and chambers on drift tubes of 500 μm were obtained. The distribution of particle trajectories in the target is given.
—
The issues of determining the momentum of charged particles at the focusing double-arm spectrometer (FODS) are discussed. The coordinate detectors are located at the exit from the analyzing magnet, ...while a profilometer of the center of gravity of the beam at the target during an accelerator cycle is at its entrance. ANSIS finite-element analysis software is used to obtain a regular grid of magnetic field vector values measured by the Hall sensor in a part of the magnet. The charged-particle momentum is determined based on the algorithm of decision tables with a polynomial approximation. Tables are produced by the Monte Carlo method by reconstructing the motion of a particle with a prescribed momentum in the magnetic field. The accuracies in determining the particle momentum and the particle production angles while accounting for the contributions from multiple scattering, measurement errors, and approximation uncertainties are presented. The distribution of the reconstructed trajectories in the target and the momentum spectrum of particles are shown.
Relative yields of high-x.sub.F charged hadrons (pi.sup.+ or -, K.sup.+ or -, p, bar.p, and d) in proton--nucleus interactions at incident-proton momenta of 25 and 50 GeV/c were measured at an angle ...of 0degrees in the momentum range between 15 and 40 GeV/c. An upper limit on the forward production of two protons in proton--nucleus interactions at 50 GeV/c was estimated. The properties of a carbon beam with an energy of 25 GeV per nucleon and fragment yields in its interaction with nuclear targets were measured within a short exposure. DOI: 10.1134/S1063778817020090
Relative yields of high-
x
F
charged hadrons (
π
±
, К
±
,
р
,
p
¯
, and
d
) in proton–nucleus interactions at incident-proton momenta of 25 and 50 GeV/c were measured at an angle of 0° in the ...momentum range between 15 and 40 GeV/
c
. An upper limit on the forward production of two protons in proton–nucleus interactions at 50 GeV/
c
was estimated. The properties of a carbon beam with an energy of 25 GeV per nucleon and fragment yields in its interaction with nuclear targets were measured within a short exposure.
