We here report a case with esophageal cancer located on solely esophageal varices, requiring an endoscopic mucosal resection. A 69-year-old woman was referred to our hospital for further evaluation ...of the with an esophageal lesion suspected of being a superficial cancer. On upper gastrointestinal endoscopy, a slightly depressed, superficial, reddish lesion located solely on esophageal varices was found, it was diagnosed as a superficial esophageal cancer using special endoscopic techniques. Treatment was first performed for the esophageal varices using endoscopic procedures (endoscopic injection sclerotherapy(EIS), endoscopic variceal ligation(EVL), and endoscopic clipping). After eradication of the varices, the disappearance of vessels under the cancer was confirmed by endoscopic ultrasonography(EUS). Since then, endoscopic mucosal resection(EMR)of the cancer lesion was carried out without the occurence of any severe complications. On histopathology, the intraepithelial cancer, was found to have been completely resected without lymphatic or vascular permeation. The approach used in this patient is useful for the diagnosis and the treatment of superficial esophageal cancer located solely on varices.
The patient was an 85 year-old man with hematemesis. Upper gastrointestinal endoscopy revealed a Dieulafoy's ulcer with bleeding, which was stopped by endoscopic procedures. The patient bled for the ...second time next morning and underwent an endoscopy, which showed four bleeding Dieulafoy's ulcers other than the first ulcer whose hemostasis was confirmed. These four ulcers were treated with endoscopic procedures with a result of successful hemostasis. This may be a rare case where multiple gastric Dieulafoy's ulcers developed metachronously after successful treatment of a Dieulafoy's ulcer.
In myeloproliferative neoplasms (MPN), Janus kinase 2 (JAK2) is activated by mutations including JAK2V617F (JAK2VF). It is unclear whether JAK kinases i.e. JAK1, JAK2, JAK3, or tyrosine kinase 2 ...(TYK2) other than JAK2 have cooperative actions such as enhancement or suppression of JAK2. If other kinases enhance activation, therapies that co-target them could have a therapeutic efficacy. We examined the role of TYK2 in Jak2VF-induced murine MPN.
We crossed Jak2VF transgenic mice and Tyk2-knockout (Tyk2KO) mice to generate Jak2VF/Tyk2KO mice. The disease severity and treatment effect with a JAK2 inhibitor was compared between Jak2VF and Jak2VF/Tyk2KO mice.
Both types of mice developed MPN, and there were no differences in peripheral blood counts, spleen weight, or survival period. Upon JAK2 inhibitor therapy, both types of mice had equally improved leukocytosis and splenomegaly.
TYK2 does not have cooperative effects with JAK2VF upon MPN onset nor in the presence of a JAK2 inhibitor.
TET2 mutation in diffuse large B-cell lymphoma Yoko Kubuki; Takumi Yamaji; Tomonori Hidaka ...
Journal of Clinical and Experimental Hematopathology,
03/2016, Letnik:
56, Številka:
3
Journal Article
Recenzirano
Ten-eleven translocation-2 (TET2) mutation is frequently observed in myeloid malignancies, and loss-of-function of TET2 is essential for the initiation of malignant hematopoiesis. TET2 mutation ...presents across disease entities and was reported in lymphoid malignancies. We investigated TET2 mutations in 27 diffuse large B-cell lymphoma (DLBCL) patients and found a frameshift mutation in 1 case (3.7%). TET2 mutation occurred in some populations of DLBCL patients and was likely involved in the pathogenesis of their malignancies.
We have examined the utility of the convex echo probe, which has the fine gutter of a puncture needle in laparoscopic radio frequency ablation therapy. When we use a flexible linear echo probe in RFA ...treatment, we have to puncture tumor with the hand piece in free hand. But it is difficult to treat in the case of HCC which is located in S1 and the lower area of S5 and S6 because we have a narrow space where colon, duodenum and netz are close for safe and exact puncturing of the tumor. We used a convex echo probe in RFA to the above mentioned area of the liver. We punctured with the hand piece exactly and easily without preliminary puncturing of the tumor. So we can perform RFA treatment successfully and safely by a choice of an appropriate echo probe.
69歳女性．B型+アルコール性肝硬変による食道静脈瘤上に不整発赤を認め，NBI（narrow band imaging）併用拡大内視鏡にて上皮内癌と診断した．静脈瘤の治療後（内視鏡的硬化療法，食道静脈瘤結紮術，クリッピング）に超音波内視鏡にて血管消失を確認し，癌病変の内視鏡的粘膜切除術を安全に施行できた．同様の症例では上述の非侵襲的検査を適切に組み合わせて用いることが非常に有用であると思われた．
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