Street Justice Jacobs, Bruce A.; Wright, Richard
05/2006
eBook
Street criminals live in a dangerous world, but they cannot realistically rely on the criminal justice system to protect them from predation by fellow lawbreakers; they are on their own when it comes ...to dealing with crimes perpetrated against them and often use retaliation as a mechanism for deterring and responding to victimization. Although retaliation lies at the heart of much of the violence that plagues many inner-city neighborhoods across the United States, it has received scant attention from criminologists. As a result, the structure, process, and forms of retaliation in the real world setting of urban America remain poorly understood. Street Justice: Retaliation in the Criminal World, first published in 2006, explores the face of modern day retaliation from the perspective of currently active criminals who have experienced it first hand, as offenders, victims, or both.
New Findings
What is the topic of this review?
We review recent work relating to exercise‐induced alterations in mitochondrial structure and function.
What advances does it highlight?
Training ...mitochondrial volume density increases due to 1) an increase cross sectional area and 2) longitudinal growth. Specific respiratory alterations appear dependent on exercise training intensity. Low‐moderate endurance training primarily improves the capacity for fat oxidation whereas high‐intensity interval training (HIT) improves global respiratory capacity. The latter includes maximal state 3 mass‐specific respiration, which is the strongest individual measure predictive of endurance performance. This highlights the importance of training specificity in endurance athletes.
Mitochondrial volume density (MitoVD) is composed of two distinct mitochondrial subpopulations— intermyofibrillar mitochondria (MitoIMF) and subsarcolemmal mitochondria (MitoSS). With exercise training, MitoVD may increase by up to 40% and is, for the most part, related to an increase in MitoIMF. Exercise‐induced adaptations in mitochondrial function depend on the intensity of training and appear to be explained predominately by an increased expression of mitochondrial enzymes that facilitate aerobic metabolism. Although mitochondrial content often increases with training, it seems that mitochondrial adaptations are not needed to facilitate maximal oxygen uptake, whereas such adaptations are of greater importance for endurance capacity.
New Findings
What is the topic of this review?
We review recent work relating to exercise‐induced alterations in mitochondrial structure and function.
What advances does it highlight?
Training mitochondrial volume density increases due to 1) an increase cross sectional area and 2) longitudinal growth. Specific respiratory alterations appear dependent on exercise training intensity. Low‐moderate endurance training primarily improves the capacity for fat oxidation whereas high‐intensity interval training (HIT) improves global respiratory capacity. The latter includes maximal state 3 mass‐specific respiration, which is the strongest individual measure predictive of endurance performance. This highlights the importance of training specificity in endurance athletes.
Summary Attention to survivors of adult cancers formally began more than 30 years ago with the founding of the National Coalition for Cancer Survivorship by representatives from 20 organisations who ...envisioned an organisation that would address survivorship issues and include friends, family, and caregivers. Since then, progress has been made in cancer care delivery, which has created challenges for and barriers to provision of optimal follow-up care to patients and survivors living with cancer as a chronic illness. Focus on post-treatment cancer care, including monitoring for long-term and late effects, and concerns regarding the effect of a cancer diagnosis and treatment on quality of life have gained momentum in the past 10 years. This impetus is largely a result of the 2005 Institute of Medicine Report From Cancer Patient to Cancer Survivor: Lost in Transition . Although the issues raised in the report were hardly novel, they gave a new and powerful voice to the cancer survivorship movement that demanded a call to action. In this Series paper, we provide an overview of the issues surrounding provision of cancer survivorship and follow-up care in the USA and discuss potential solutions to these challenges.
•The effect of data-driven supply chain capabilities on financial performance.•A significant effect of data-driven supply chains on supply chain capabilities.•Interfirm coordination is significantly ...related to financial performance.•Supply chain responsiveness is significantly related to financial performance.
Despite the importance and relevance of data-driven supply chains, there has been very limited empirical research that investigates how big data-driven supply chains affect supply chain capabilities. Drawing on the resource-based view, this study explores the effect of data-driven supply chain capabilities on financial performance. The data for this study were gathered from China’s manufacturing industry and analysed using structural equation modelling. The results indicate that a data-driven supply chain has a significant positive effect on the four dimensions of supply chain capabilities. Coordination and supply chain responsiveness are positively and significantly related to financial performance.
Featuring contributions from leading experts in science and engineering, this book explores the complex biogeochemistry of acid mine drainage, rock drainage, and acid sulfate soils. It describes how ...to predict, prevent, and remediate the environmental impact of acid drainage and the oxidation of sulfides, offering the latest sampling and analytical methods. Moreover, readers will discover new approaches for recovering valuable resources from acid mine drainage, including bioleaching. This book reviews the most current findings in the field, offering new insights into the underlying causes as well as new tools to minimize the harm of acid drainage.
Rhodococcus equi causes fatal pyogranulomatous pneumonia in foals and immunocompromised animals and humans. Despite its importance, there is currently no effective vaccine against the disease. The ...actinobacteria R. equi and the human pathogen Mycobacterium tuberculosis are related, and both cause pulmonary diseases. Recently, we have shown that essential steps in the cholesterol catabolic pathway are involved in the pathogenicity of M. tuberculosis. Bioinformatic analysis revealed the presence of a similar cholesterol catabolic gene cluster in R. equi. Orthologs of predicted M. tuberculosis virulence genes located within this cluster, i.e. ipdA (rv3551), ipdB (rv3552), fadA6 and fadE30, were identified in R. equi RE1 and inactivated. The ipdA and ipdB genes of R. equi RE1 appear to constitute the α-subunit and β-subunit, respectively, of a heterodimeric coenzyme A transferase. Mutant strains RE1ΔipdAB and RE1ΔfadE30, but not RE1ΔfadA6, were impaired in growth on the steroid catabolic pathway intermediates 4-androstene-3,17-dione (AD) and 3aα-H-4α(3'-propionic acid)-5α-hydroxy-7aβ-methylhexahydro-1-indanone (5α-hydroxy-methylhexahydro-1-indanone propionate; 5OH-HIP). Interestingly, RE1ΔipdAB and RE1ΔfadE30, but not RE1ΔfadA6, also displayed an attenuated phenotype in a macrophage infection assay. Gene products important for growth on 5OH-HIP, as part of the steroid catabolic pathway, thus appear to act as factors involved in the pathogenicity of R. equi. Challenge experiments showed that RE1ΔipdAB could be safely administered intratracheally to 2 to 5 week-old foals and oral immunization of foals even elicited a substantial protective immunity against a virulent R. equi strain. Our data show that genes involved in steroid catabolism are promising targets for the development of a live-attenuated vaccine against R. equi infections.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The increasing use of biomarkers in cancer have led to the concept of personalized medicine for patients. Personalized medicine provides better diagnosis and treatment options available to ...clinicians. Radiological imaging techniques provide an opportunity to deliver unique data on different types of tissue. However, obtaining useful information from all radiological data is challenging in the era of 'big data'. Recent advances in computational power and the use of genomics have generated a new area of research termed Radiomics. Radiomics is defined as the high throughput extraction of quantitative imaging features or texture (radiomics) from imaging to decode tissue pathology and creating a high dimensional data set for feature extraction. Radiomic features provide information about the gray-scale patterns, inter-pixel relationships. In addition, shape and spectral properties can be extracted within the same regions of interest on radiological images. Moreover, these features can be further used to develop computational models using advanced machine learning algorithms that may serve as a tool for personalized diagnosis and treatment guidance.
We examine how the shift to remote work altered responsibilities for domestic labor among partnered couples and single parents. The study draws on data from a nationally representative survey of ...2,200 US adults, including 478 partnered parents and 151 single parents, in April 2020. The closing of schools and child care centers significantly increased demands on working parents in the United States, and in many circumstances reinforced an unequal domestic division of labor.
Biodegradable and renewable polymers, such as polylactic acid, are benign alternatives for petrochemical-based plastics. Current production of polylactic acid via its key building block lactide, the ...cyclic dimer of lactic acid, is inefficient in terms of energy, time, and feedstock use. We present a direct zeolite-based catalytic process, which converts lactic acid into lactide. The shape-selective properties of zeolites are essential to attain record lactide yields, outperforming those of the current multistep process by avoiding both racemization and side-product formation. The highly productive process is strengthened by facile recovery and practical reactivation of the catalyst, which remains structurally fit during at least six consecutive reactions, and by the ease of solvent and side-product recycling.
Increasing demand for renewable feedstock-based chemicals is driving the interest of both academic and industrial research to substitute petrochemicals with renewable chemicals from biomass-derived ...resources. The search towards novel platform chemicals is challenging and rewarding, but the main research activities are concentrated on finding efficient pathways to produce familiar drop-in chemicals and polymer building blocks. A diversity of industrially important monomers like alkenes, conjugated dienes, unsaturated carboxylic acids and aromatic compounds are thus targeted from renewable feedstock. In this context, on-purpose production of 1,3-butadiene from biomass-derived feedstock is an interesting example as its production is under pressure by uncertainty of the conventional fossil feedstock. Ethanol, obtained
via
fermentation or (biomass-generated) syngas, can be converted to butadiene, although there is no large commercial activity today. Though practised on a large scale in the beginning of the 20th century, there is a growing worldwide renewed interest in the butadiene-from-ethanol route. An alternative route to produce butadiene from biomass is through direct carbohydrate and gas fermentation or indirectly
via
the dehydration of butanediols. This review starts with a brief discussion on the different feedstock possibilities to produce butadiene, followed by a comprehensive summary of the current state of knowledge regarding advances and achievements in the field of the chemocatalytic conversion of ethanol and butanediols to butadiene, including thermodynamics and kinetic aspects of the reactions with discussions on the reaction pathways and the type of catalysts developed.
This review covers old and recent catalytic achievements in the field of on-purpose synthesis of butadiene from a biomass-related feedstock, covering discussions on the various feedstock possibilities, thermodynamics, reaction conditions, reaction paths and catalyst development.
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