Purpose - In case of automobile parts, there has been a lot of progress in the study on supplier development plans and SCM in industrial progress study as well as on the relationship between ERP and ...SCM. But supplier development program providers have researched on SCM performance in accordance with the interests of the supplier development program most, thus, buyers were knowledgeable about the earlier program performance. Therefore, the purpose of this study is to prove correlation factor, supplier factor, purchaser factor affecting SCM performance and ERP activating diffusion through the process of supplier development. Supplier development maturity formation model is considered important variables as mediators related to the procedure. Finally, the performance formation model of the supplier development maturity through supplier development factor would be presented as the outcome of this study. Research design, data, and methodology - Data gathering was as follows: questionnaires were delivered to 87 companies that have business connection with H Company. The empirical research to test our hypothesis was grounded on statistical analysis (adapting SPSS 19.0 & AMOS 19.0). The hypothesis is that the supplier development factor variables consist of correlation factor, supplier factor, purchaser factor, and have non-negative effects on the next variables: mediators such as supplier development maturity; and the supplier development maturity variables have a positive effect on the next variables: ERP activating diffusion, ERP activating diffusion has a non-negative effect on supply chain performance. We experimented the hypothesized model using path analysis with latent variables. Results - First, it was known that cooperation , reliability , comprehension on the purpose of SDP , adaptation of change , knowledge transfer program , have significant positive effects on supplier development maturity. Second, supplier development maturity has positive effects significantly on ERP activating diffusion . Finally, the causal relationships from ERP activating diffusion to SCM performance were significantly accepted. Its significance, as through the hypotheses, presented a structural model for the elaboration, suppliers develop maturity, and ultimately SCM performance that affect ERP leveraging spread beyond the concept of maturity of information system. Therefore, it was a mainstay of research on the existing ERP has they believed. Conclusion - First, with the fast changes in business circumstances, company should get the right information to implement SCM appropriately. For successful SCM, firms should understand the supplier development maturity formation and ERP activating diffusion. Second, supplier development factor has significant effects on supplier development maturity. Third, mediator such as supplier development maturity significantly affects ERP activating diffusion. Finally, ERP activating diffusion has significant impacts on SCM performance. This study makes a meaningful contribution to further appreciation on how supplier development maturity formation affects SCM performance. This study shows implications. First, there would not have been dealt with introducing the concept of supplier development maturity. Second, through empirical analysis and provider factors, the providers will develop the maturity that affect interactive factors between purchaser and supplier.
Several systems-level datasets designed to dissect host-pathogen interactions during influenza A infection have been reported. However, apparent discordance among these data has hampered their full ...utility toward advancing mechanistic and therapeutic knowledge. To collectively reconcile these datasets, we performed a meta-analysis of data from eight published RNAi screens and integrated these data with three protein interaction datasets, including one generated within the context of this study. Further integration of these data with global virus-host interaction analyses revealed a functionally validated biochemical landscape of the influenza-host interface, which can be queried through a simplified and customizable web portal (http://www.metascape.org/IAV). Follow-up studies revealed that the putative ubiquitin ligase UBR4 associates with the viral M2 protein and promotes apical transport of viral proteins. Taken together, the integrative analysis of influenza OMICs datasets illuminates a viral-host network of high-confidence human proteins that are essential for influenza A virus replication.
Display omitted
•Meta-analysis of influenza OMICs datasets reveals high-confidence virus-host interactions•Integration of orthogonal data exposes unique host and restriction factor activities•Experimental validation of virus-host circuits supports robustness of approach•The host E3 ligase UBR4 is identified as essential for virus budding and pathogenesis
Tripathi et al. have reconciled and integrated divergent influenza “OMICs” studies to reveal a functionally validated virus-host interaction network of high-confidence human proteins essential for influenza A virus replication. The authors leverage this approach to identify UBR4 as a host protein essential for virus budding and pathogenesis.
택배산업의 서비스품질 성과형성 모델 송장근; 김태룡; Song, Jang-Gwen ...
Journal of distribution science,
04/2012, Letnik:
10, Številka:
4
Journal Article
Recenzirano
Odprti dostop
The popularity of courier services in Korea has made it an essential part of the country's domestic logistics industry, bolstering the growth not only of the national economy, but also the quality of ...people's daily lives. An effective strategy for courier companies in Korea would be to provide high-quality services to their existing target markets with the goal of maximizing customer loyalty. This study investigates structural relationships between customer loyalty and service quality as a set of factors and between customer trust and customer satisfaction. These antecedent relationships will be used to understand the "performance formation model" through service quality. In this study, service quality, as a set of factors, is considered to be the independent variable, while customer satisfaction and customer trust are both treated as intervening variables. Finally, customer loyalty is the dependent variable. Following a review of the literature, this paper's proffered hypothesis will be investigated in terms of whether the independent and intervening variables significantly affect customer loyalty. A statistical analysis of the empirical research was carried out using both SPSS 18.0 and AMOS 18.0 The results of this study's empirical analysis show three conclusions. First, among the intervening variables (customer satisfaction and customer trust), customer satisfaction is significantly correlated with customer loyalty. Customer trust, however, was shown to have little or no relationship to customer loyalty. Second, the quality of service variable seems to influence customer satisfaction, customer trust, and customer loyalty. Third, with respect to the relationship of intervening variables, customer trust affects customer satisfaction. Thus, the companies that have a competitive advantage in Korea have successfully maximized customer loyalty for their existing customers. Courier companies will need to research and study customer needs. Therefore, this research suggests that effective courier service management can be better understood through the application of the service quality performance formation model, which can enhance the quality of service provided by domestic courier services. This research is limited to investigating qualitative variables, such as the service quality factors, customer satisfaction, and customer trust. It would be helpful for future research on courier services to consider quantitative variables, such as price and weight. 한국의 택배산업은 국가경제뿐만 아니라 국민의 일상생활을 지원하는 국내 물류산업의 핵심부분으로 발전해왔다. 택배기업의 효율적 전략은 고객충성도를 최대화 할 수 있는 고품질 서비스를 목표고객에게 제시하는 것이다. 본 연구는 한국택배산업에 서비스품질을 적용하여 택배서비스 품질, 고객만족과 고객신뢰 및 고객충성도간의 구조적인 관계를 밝히고, '서비스품질 성과형성모델'을 얻고자 하는 것이다. 이를 위해 택배서비스 품질요인을 독립변수로, 고객만족과 고객신뢰를 매개변수로, 택배서비스의 성과(고객충성도)를 종속변수로 하였다. 문헌연구를 통해 가설을 설정한 후 독립변수와 매개변수가 종속변수인 고객충성도에 유의한 영향을 주는 것을 검증하였다. 본 연구는 실증적 연구 방법으로 설문을 통한 통계분석기법을 행하였으며 SPSS 18.0 과 AMOS 18.0을 이용하여 분석을 실행하였다. 택배산업을 대상으로 한 본 연구의 실증적 분석을 통해 세 가지 결과를 보여주었다. 첫째, 매개변수인 고객만족은 충성도에 유의한 영향을 준다. 그러나 또 하나의 매개변수인 신뢰는 고객 충성도에 유의한 영향을 주지 않는다. 둘째, 독립변수인 택배 서비스의 품질은 고객 만족, 신뢰 및 고객 충성도에 유의한 영향을 준다. 셋째, 매개변수간의 관계에서 고객신뢰는 고객만족에 유의한 영향을 주는 선행관계임을 알 수 있었다. 한국에서 택배기업은 경쟁 우위를 갖기 위해 고객 충성도를 극대화하려 하고 있다. 본 연구는 서비스품질 성과형성 모델을 통한 택배서비스의 효율적 관리에 관한 연구를 수행하였고, 이를 통해 국내 택배기업들에게 택배서비스 관리를 위한 설명력 있는 결과를 제시한 것이 실무적 기여가 있다고 할 수 있다. 본 연구의 한계점으로는, 변수의 구성에 있어서, 고객만족, 고객신뢰, 고객충성도와 같은 정성적 변수의 관계를 살펴보았는데 가격, 중량과 같은 정량적 변수를 고려하지 않은 점이다.
Purpose - This study aims to clarify through which process asset specificity and supplier development project (SDP) affect performance. Cooperation, partnership, the level of information exchange, ...and the importance of information sharing are considered significant variables as mediators related to the process. Finally, the performance formation model of the supply chain through asset specificity and supplier development project would be suggested as being a result of this study. Research design, data, and methodology - Data collection was as follows: questionnaires were distributed to 250 companies that have business ties with H Company. The empirical study to test our hypothesis was based on statistical analysis (using SPSS 19.0 and AMOS 19.0). The hypothesis of this paper is that the asset specificity and supplier development project variables have positive effects on the following variables: mediators such as cooperation and partnership (reliability and dependence); and the cooperation and partnership variables have a positive effect on the following variables: level of information sharing, the importance of information sharing, and level of information sharing; the importance of information sharing has a positive effect on supply chain performance. We tested our hypothesized model utilizing path analysis with latent variables. Results - First, it was found that asset specificity has significant positive effects on cooperation (H1), reliability (H2), and dependability (H3). Second, it was proved that the level of comprehension on the purpose of SDP has positive effects significantly on cooperation (H4), reliability (H5), and dependability (H6). Third, the hypotheses related to cooperation were all significantly accepted. The relationships of cooperation with the level (H7) and importance (H8) of information sharing were significant. Fourth, the hypotheses related to reliability were all significantly accepted. The relationships of reliability with the level (H9) and importance (H10) of information sharing were significant. In terms of dependability, however, the hypotheses were partially accepted. The effect of dependability was significant on the importance of information sharing (H12), but insignificant on the level of information sharing (H11). Finally, the causal relationships from the level of information sharing to SCM performance (H13) and from the importance of information sharing to SCM performance (H14) were both significantly accepted. Conclusion - First, with rapid changes in the business environment, enterprises should acquire the right information to properly implement SCM. For successful SCM, firms should understand the supplier development project. Second, asset specificity and the level of comprehension on SDP have significant effects both on cooperation and partnership (reliability and dependability). Third, mediators such as cooperation, reliability, and dependability significantly affect the level and importance of information sharing. Fourth, the level and importance of information sharing have significant impacts on SCM performance. This paper makes a meaningful contribution to further the understanding of how SDP affects SCM performance. Finally, successful SCM performance is achieved by information sharing through a collaborative environment and partnership (confidence & dependence) rather than by investing only in setting up an information system.
Purpose - The objective of this paper is to investigate the effect of asset specificity, the level of information sharing, the importance of information sharing, and an integrated collaborative ...environment on supply chain performance. Research design, data, and methodology - Data collection was implemented as follows: questionnaires were distributed to 250 companies that have business ties with Halla Climate Control Corporation. The empirical study to test our hypothesis was based on statistical analysis (using SPSS 18.0 and AMOS 18.0). The hypothesis of this paper is that the asset specificity variable has positive effects on the following variables: Level of information sharing, the importance of information sharing, and integrated collaborative environment. Moreover the variables, the level of information sharing, and the importance of information sharing are strongly influenced by the variable integrated collaborative environment, and these when combined, have an effect on the dependent variable, supply chain performance. We tested our hypothesized model utilizing path analysis with latent variables. Results - According to the results of our analysis, hypothesis H1, which tests whether there is a relationship between asset specificity and the integrated collaborative environment, is supported at the 0.01 level. Hypotheses H2 and H3 were also confirmed, and asset specificity had positive effects (+) on the level of information sharing variable. The importance of the information sharing variable was statistically significant at the 0.01 level. Hypotheses H4 and H5 posited that the integrated collaborative environment variable would have a positive effect on the level of information sharing; the importance of information sharing variable was strongly supported statistically, with a significant p-value below. Moreover, the level of information sharing (H6), and the importance of information sharing (H7) variables also had a statistically relevant influence on supply chain performance. As a result, existence of a collaborative system between companies would influence supply chain performance by strengthening real-time information access and information sharing. Thus, it is important to construct a collaborative environment where information sharing among companies and cooperation is possible. Conclusions - First, with rapid changes in the business environment, it becomes necessary for enterprises to acquire the right information in order to properly implement SCM. For successful SCM, firms should understand the importance of collaboration with supply chain partners and an internally built collaboration system, which in turn will better promote a partnership commitment with suppliers as well as collaborative integration with buyers. A collaborative system, as we suggest in this paper, facilitates the maintenance of a long-term relationship of trust, and can help reinforce information sharing. Second, it is necessary to increase information sharing over time via a collaborative system so that employees of the suppliers become aware of the system. The more proactive and positive attitudes are towards such a collaborative system by the managerial group, the higher the level of information sharing will be among the users. Successful SCM performance is achieved by information sharing through a collaborative environment rather than by investing only in setting up an information system.
It has lately been recognized that the distributing and exchanging of the R&D information in science & technology is the critical factor to improve the research productivity But it has very ...difficulty in integrating the R&D information due to the dispersion and heterogeneity in data sources, and semantic and structural difference in describing data, so the process of managing the R&D information of national R&D projects has been ineffective so far. In this study, we research the method to collect R&D information created R&D institute spreading R&D information among the researcher and institute, people. First, we analyze and survey R&D information and data structure related R&D in such fields as science and technology. Then, we extract and group the relevant factors from information created through research activities for building the integrated R&D information framework. Therefore, we can produce the intelligent information service through R&D information distribution and improve the interoperability between the research institutions.
The metabolism of glucose and glutamine, primary carbon sources utilized by mitochondria to generate energy and macromolecules for cell growth, is directly regulated by mTORC1. We show that glucose ...and glutamine, by supplying carbons to the TCA cycle to produce ATP, positively feed back to mTORC1 through an AMPK-, TSC1/2-, and Rag-independent mechanism by regulating mTORC1 assembly and its lysosomal localization. We discovered that the ATP-dependent TTT-RUVBL1/2 complex was disassembled and repressed by energy depletion, resulting in its decreased interaction with mTOR. The TTT-RUVBL complex was necessary for the interaction between mTORC1 and Rag and formation of mTORC1 obligate dimers. In cancer tissues, TTT-RUVBL complex mRNAs were elevated and positively correlated with transcripts encoding proteins of anabolic metabolism and mitochondrial function—all mTORC1-regulated processes. Thus, the TTT-RUVBL1/2 complex responds to the cell’s metabolic state, directly regulating the functional assembly of mTORC1 and indirectly controlling the nutrient signal from Rags to mTORC1.
Display omitted
► Glucose and glutamine feed back to promote mTORC1 signaling through ATP production ► Energetic stress prevents mTOR lysosomal localization independently of AMPK and Rag ► ATP-dependent TTT-RUVBL complex is disassembled and repressed by energetic stress ► TTT-RUVBL is required for mTORC1 functional assembly and lysosomal localization
The association between body mass index (BMI) and noncardia gastric cancer (NCGC) risk remains controversial. The purpose of our study was to examine the association of BMI with NCGC risk with ...consideration of Helicobacter pylori (HP) biomarkers. This international nested case–control study, composed of 1,591 incident NCGC cases and 1,953 matched controls, was established from eight cohorts in China, Japan and Korea, where the majority of NCGCs are diagnosed worldwide. HP antibody biomarkers were measured in blood collected at cohort enrollment by multiplex serology. The NCGC risk according to baseline BMI was estimated using logistic regression to produce odds ratios (ORs) and 95% confidence intervals (CIs). We found a U‐shaped association between BMI category and NCGC risk. Compared to those with reference BMI (22.6–25.0 kg/m2), those with lower and higher BMI had an increased NCGC risk (BMI <18.5 kg/m2, OR = 1.56, 95% CI = 1.04–2.34; BMI >27.5 kg/m2, OR = 1.48, 95% CI = 1.15–1.91; adjusted for age, sex and smoking). The U‐shaped association was persistent among subjects with HP infection and high‐risk biomarkers (HP+ CagA+: BMI <18.5 kg/m2, OR = 1.60, 95% CI = 1.00–2.55; BMI >27.5 kg/m2, OR = 1.59, 95% CI = 1.21–2.11; and Omp+ HP0305+: BMI <18.5 kg/m2, OR = 1.88, 95% CI = 1.04–3.42; BMI >27.5 kg/m2, OR = 1.70, 95% CI = 1.20–2.42, respectively). Our study provides evidence of significantly increased NCGC risk among individuals with low or high BMI, including in subjects with high‐risk HP biomarkers (HP+ CagA+, Omp+ HP0305+) in the high‐risk area of East Asia.
What's new?
Gastric‐cancer (GC) mortality in East Asian countries accounts for 58% of GC deaths worldwide. Does body mass index (BMI) affect GC risk in these populations? In this prospective study, the authors found a U‐shaped association between BMI and non‐cardia GC risk. This association also held true for subjects with high‐risk biomarkers for Helicobacter pylori infection. These results indicate that maintaining normal body weight is important for reducing gastric‐cancer risk in East Asia, which may help guide public health strategies.
Although many microbial rhodopsins have been discovered many of organisms in a variety of habitats, little is known about the property and diversity of rhodopsin in flavobacteria. Recent studies ...discovered that many proteorhodopsin (PR)-like proteins exist in genomes of flavobacteria. Following the isolation of a flavobacterial rhodopsins (FR) from the flavobacteria IMCC1997 from the East Sea of Korea, we characterized its photochemical features. We confirmed that the FR expression is induced by light in the IMCC1997 cell. Upon receiving light energy in vitro, the proton acceptor (D83) and donor (E94) of the FR translocate protons from intracellular to extracellular regions. Compared with proteorhodopsin (PR), the FR from IMCC 1997 cells is very unstable, which may be explained by their primary sequence differences. The ratio of all trans/13-cis retinal conformation does not influence this stability. To measure the stability of FR, we tested heat endurance at 70 °C and found that the heat endurance time of some FR mutants increased. Based upon these results, we found the helix E of this protein to be critical for the unstability of FR.
•A light absorbing protein is isolated from Flaovobacteria IMCC1997•The FR has mainly absorbed 557 nm light at pH 7 and it has proton outward pumping activity as PR•The FR has very weak stability under high temperature (70 °C) not like GPR•Large enhancement of heat stability is observed when the helix E of FR is replaced to that of GPR
PDF
