How to cite this article: McKenzie Y.A., Alder A., Anderson W., Wills A., Goddard L., Gulia P., Jankovich E., Mutch P., Reeves L.B., Singer A. & Lomer M.C.E. on behalf of Gastroenterology Specialist ...Group of the British Dietetic Association. (2012) British Dietetic Association evidence‐based practice guidelines for the dietary management of irritable bowel syndrome in adults. J Hum Nutr Diet . 25, 260–274
Background: Irritable bowel syndrome (IBS) is a chronic debilitating functional gastrointestinal disorder. Diet and lifestyle changes are important management strategies. The aim of these guidelines is to systematically review key aspects of the dietary management of IBS, with the aim of providing evidence‐based guidelines for use by registered dietitians.
Methods: Questions relating to diet and IBS symptom management were developed by a guideline development group. These included the role of milk and lactose, nonstarch polysaccharides (NSP), fermentable carbohydrates in abdominal bloating, probiotics and empirical or elimination diets. A comprehensive literature search was conducted and relevant studies from January 1985 to November 2009 were identified using the electronic database search engines: Cinahl, Cochrane Library, Embase, Medline, Scopus and Web of Science. Evidence statements, recommendations, good practice points and research recommendations were developed.
Results: Thirty studies were critically appraised. A dietetic care pathway was produced following a logical sequence of treatment and formed the basis of these guidelines. Three lines of dietary management were identified. First line: Clinical and dietary assessment, healthy eating and lifestyle management with some general advice on lactose and NSP. Second line: Advanced dietary interventions to improve symptoms based on NSP, fermentable carbohydrates and probiotics. Third line: Elimination and empirical diets. Research recommendations were also identified relating to the need for adequately powered and well designed randomised controlled trials.
Conclusions: These guidelines provide evidence‐based details of how to achieve the successful dietary management of IBS.
Identification of the CD1a+ moDC as an inflammatory subset with specialized activation of RLR and associated cytokine and functional activities.
Cytosolic RIG‐I‐like helicases (RLR) are PRRs involved ...in type I IFN production and antiviral immunity. This study focuses to the comparison of the expression, function, and signaling cascades associated to RLR in the previously identified CD14−DC‐SIGN+PPARγlowCD1a+ and CD14lowDC‐SIGN+PPARγhighCD1a− human moDC subsets. Our results revealed that the expression of RLR genes and proteins as well as the activity of the coupled signaling pathways are significantly higher in the CD1a+ subset than in its phenotypically and functionally distinct counterpart. Specific activation of RLR in moDCs by poly(I:C) or influenza virus was shown to induce the secretion of IFN‐β via IRF3, whereas induction of proinflammatory cytokine responses were predominantly controlled by TLR3. The requirement of RLR‐mediated signaling in CD1a+ moDCs for priming naïve CD8+ T lymphocytes and inducing influenza virus‐specific cellular immune responses was confirmed by RIG‐I/MDA5 silencing, which abrogated these functions. Our results demonstrate the subset‐specific activation of RLR and the underlying mechanisms behind its cytokine secretion profile and identify CD1a+ moDCs as an inflammatory subset with specialized functional activities. We also provide evidence that this migratory DC subset can be detected in human tonsil and reactive LNs.
Our paper deals with some new aspects of ambulatory (Holter) ECG monitoring extending its indications and using for risk management purpose. Remote sensing consists of the transmittal of patient ...information, such as ECG, X-rays, or patient records, from a remote site to a collaborator in a distant site. Our earlier developed internet based ECG system was unique for on/off-line analysis of long-term ECG registrations. After the 5-year experience in a smaller region of Budapest, Hungary involving a municipal hospital and the surrounding outpatient cardiology departments and general practitioners, we decided to integrate into our new ECG equipment, the CardioClient the results. In the first clinical study of the four was a wavelet, non-linear heart rate analysis in sudden cardiac death patients using the Internet and the GPRS mobile communication. After the wavelet transformation by the Haar wavelet and the Daubechies 10-tap wavelet, the phase-space of the wavelet-coefficient standard deviation and the scale parameters showed an excellent separation in the scale-range of 3-6 between the two groups: in that region, the average scaling exponents was 0.14plusmn0.04 for Group-A, and 1.22plusmn0.27 for Group-B (p<0.001). In the next study, we used the Internet database of long-term ambulatory, mobile, GPRS electrocardiograms for the for risk stratification of patients through the cardiovascular continuum. From our ambulatory mobile GPRS ECG database the following a priori groups were defined after a 24 months follow-up: G1: N=227 patients (without manifest cardiovascular disease, clusterized "boxes" based on the age, sex, cholesterol level, diabetes, hypertension ); G2: N=89 patients (postinfarction group); G3: N=66 (patients with chronic heart failure) with (+) or without (-): all-cause death (acD), myocardial infarction (MI), malignant ventricular arrhythmia (MVA), sudden cardiac death (SCD). The actual vs. predicted values were analyzed with chi-square test. The best significance levels (p<0.001) were found with method in G1/MI+, G2/SCD+, G3/acD+, G3/SCD+ groups. In the third study a wavelet analysis of late potentials based on long-term, high-resolution, mobile, GPRS ECG data was performed. These pathological changes were also detected by the Haar and Daubechies_4 wavelets, but in a narrower space (110-128 ms and 180-240) and with lesser significance (p<0.01). Late potentials were found in Group-A (N=21) in 18 cases with Morlet, 16 with Haar, 19 with Daub-4 analysis, and in 15 cases using all the 3 waves; for Group-B the data were 5, 9, 8, 5, respectively. In the fourth clinical study the prognostic value of the nonlinear dynamicity measurement of atrial fibrillation waves detected by GPRS Internet long-term ECG monitoring were analyzed. The multivariate discriminant model selects the best parameters stepwise, the entry or removal based on the minimalization of the Wilks' lambda. Three variables remained finally: x1 = CI mean-value at log r=-1.0 (m9-14), x2 = CI mean-value at log r=-0.5 (m12-17), and x3 = CD_cg. The Wilks' lambda was 0.011, chi-square 299.68, significancy: p<0.001.
Iconoteca dei botanici
Bib. dell'Orto botanico IB.JJ.28
Tit. e data pubbl. attr. dal catalogatore. Montata su cartone 190 x 140 mm. Condizionamento 2007 Stato di conservazione: buono Nota ms sul r: A ...mio Maestro P. A. Saccardo L'allievo riconoscente P. Nersès Diratzouyan - Nato ad Artvin, nell'Armenia Russa, li 22 Giugno 1875.
Locating the human diploid channel Marcus, Joseph N.; Anderson, Elizabeth A.; O'Kane‐Murphy, Barbara ...
Cytometry,
19/May , Letnik:
9, Številka:
3
Journal Article
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