•A NiCoCrAlY coating that has been oxidized at high temperature is removed by electrochemical stripping.•The recoated coating exhibits lower oxidation rate, but is more likely to spall off during ...cyclic oxidation.•Elements interdiffusion with the alloy substrate causes the difference in oxidation behavior.•The consumption of Al in the recoated coating was larger than that in the ordinary one after diffusion into the alloy.
NiCoCrAlY coating that has been oxidized at high temperature is successfully removed by electrochemical stripping from a nickel-based superalloy, which is followed by recoating a fresh one. Then oxidation behavior of the recoated NiCoCrAlY coating is investigated in comparison with the ordinary one. Results indicate that the recoated coating exhibits a lower oxidation rate with a rate constant of 3.1×10−14 g2 cm-4s-1 at 1000 °C. However, its oxide scale is more likely to spall off than that of the ordinary one in cyclic oxidation. Elements interdiffusion between the NiCoCrAlY coatings and the alloy substrate leads to the different oxidation behavior.
Stem cell marker CD82 plays a vital role in the oncogenesis and progression of acute myelogenous leukemia (AML), especially in sharing properties of leukemia stem cells (LSCs). The Wnt/β-catenin ...pathway is required for the development of LSCs in AML. The present study aimed to validate whether CD82 supports the survival of LSCs in pediatric AML via activation of Wnt/β-catenin signaling pathway.
CD82 expression and its correlation with molecules downstream of Wnt/β-catenin pathway in samples from pediatric AML patients were analyzed. Forced or downregulated expression of CD82 in AML cells was evaluated for the effects of CD82 on cell proliferation, cycle regulation, apoptosis, and adriamycin chemoresistance and to validate the underlying mechanism.
Aberrant expression of CD82 in pediatric AML patients was found. CD82 messenger RNA expression correlated positively with downstream molecules of Wnt/β-catenin pathway in AML children. Knockdown of CD82 induced apoptosis, suppressed growth, and decreased adriamycin chemoresistance in AML cells. CD82 accelerated β-catenin nuclear location and then stimulated the expression of downstream molecules of Wnt/β-catenin pathway.
CD82 regulates the proliferation and chemotherapy resistance of AML cells via activation of the Wnt/β-catenin pathway, which suggest that the CD82 may be a potential therapeutic target in AML children.
Using perioperative VTE prophylactic anticoagulant pathway delicacy management, we aimed to explore the role of clinical pharmacists in perioperative VTE prophylactic anticoagulant treatment and the ...effect of the clinical medicine pathway implementation.
In compliance with evidence-based medicine, combined with clinical practice, clinical pharmacists participated in the formulation of the perioperative anticoagulant clinical medicine pathway. The PDCA cycle was strictly implemented. Urologic Department, Affiliated Hospital of Qingdao University, Qingdao Shandong, China, served as a pilot department for the evaluation of the effect of drug clinical pathway implementation.
The anticoagulant clinical medicine pathway for the urologic department was formulated and implemented from October 2020 to August 2021. The entry rate gradually increased, and the accuracy of thrombosis risk assessment improved. The proportion of drugs in the department and the per capita drug cost decreased significantly.
The perioperative VTE prophylactic anticoagulant pathway showed significant achievements in the rational use of urologic anticoagulant drugs, lowering the cost of medical care. Therefore, it could be considered a novel long-term mechanism for rational analgesia drug use.
Ultra-short-term load demand forecasting is significant to the rapid response and real-time dispatching of the power demand side. Considering too many random factors that affect the load, this paper ...combines convolution, long short-term memory (LSTM), and gated recurrent unit (GRU) algorithms to propose an ultra-short-term load forecasting model based on deep learning. Firstly, more than 100,000 pieces of historical load and meteorological data from Beijing in the three years from 2016 to 2018 were collected, and the meteorological data were divided into 18 types considering the actual meteorological characteristics of Beijing. Secondly, after the standardized processing of the time-series samples, the convolution filter was used to extract the features of the high-order samples to reduce the number of training parameters. On this basis, the LSTM layer and GRU layer were used for modeling based on time series. A dropout layer was introduced after each layer to reduce the risk of overfitting. Finally, load prediction results were output as a dense layer. In the model training process, the mean square error (MSE) was used as the objective optimization function to train the deep learning model and find the optimal super parameter. In addition, based on the average training time, training error, and prediction error, this paper verifies the effectiveness and practicability of the load prediction model proposed under the deep learning structure in this paper by comparing it with four other models including GRU, LSTM, Conv-GRU, and Conv-LSTM.
Tomonaga-Luttinger liquid (TLL), a peculiar one-dimensional (1D) electronic behavior due to strong correlation, was first studied in 1D nanostructures and has attracted significant attention over the ...last several decades. With the rise of new two-dimensional (2D) quantum materials, 1D nanostructures in 2D materials have provided a new platform with a well-defined configuration at the atomic scale for studying TLL electronic behavior. In this paper, we review the recent progress of TLL electronic features in emerging 2D materials embedded with various 1D nanostructures, including island edges, domain walls, and 1D moiré patterns. Specifically, novel physical phenomena, such as 1D edge states in 2D transition metal dichalcogenides (TMDs), helical TLL in 2D topological insulators (2DTI), and chiral TLL in 2D quantum Hall systems, are described and discussed at the nanoscale. We also analyze challenges and opportunities at the frontier of this research area.
Abstract Quantum spin liquids (QSLs) are in a quantum disordered state that is highly entangled and has fractional excitations. As a highly sought-after state of matter, QSLs were predicted to host ...spinon excitations and to arise in frustrated spin systems with large quantum fluctuations. Here we report on the experimental observation and theoretical modeling of QSL signatures in monolayer 1T-NbSe 2 , which is a newly emerging two-dimensional material that exhibits both charge-density-wave (CDW) and correlated insulating behaviors. By using scanning tunneling microscopy and spectroscopy (STM/STS), we confirm the presence of spin fluctuations in monolayer 1T-NbSe 2 by observing the Kondo resonance as monolayer 1T-NbSe 2 interacts with metallic monolayer 1H-NbSe 2 . Subsequent STM/STS imaging of monolayer 1T-NbSe 2 at the Hubbard band energy further reveals a long-wavelength charge modulation, in agreement with the spinon modulation expected for QSLs. By depositing manganese-phthalocyanine (MnPc) molecules with spin S = 3/2 onto monolayer 1T-NbSe 2 , new STS resonance peaks emerge at the Hubbard band edges of monolayer 1T-NbSe 2 . This observation is consistent with the spinon Kondo effect induced by a S = 3/2 magnetic impurity embedded in a QSL. Taken together, these experimental observations indicate that monolayer 1T-NbSe 2 is a new promising QSL material.
Previous studies have shown that benzoylaconine (BAC), a representative monoester alkaloid, has a potential anti-inflammatory effect. This study investigated the underlying molecular mechanisms using ...the mode of LPS-activated RAW264.7 macrophage cells. Our findings showed that BAC significantly suppressed the release of pro-inflammatory cytokines and mediators, including IL-6, TNF-α, IL-1β, ROS, NO, and PGE
2
. BAC treatment also effectively downregulated the elevated protein levels of iNOS and COX-2 induced by LPS in a dose-dependent manner. In this study, we found that BAC inhibited LPS-induced NF-κB activation by reducing the phosphorylation and degradation of IκBα by western blotting and blocking the nuclear translocation of p65 using an immunofluorescence assay. The elevated protein levels of JNK, p38, and ERK phosphorylation after LPS stimulation were restored effectively by BAC treatment. The protein expression of Toll-like receptor 4 (TLR4) and LPS-induced phosphorylation of TAK1, which is a crucial upstream regulatory factor of TLR-induced MAPK and NF-κB signaling, were inhibited by BAC in activated RAW264.7 macrophages. Moreover, BAC decreased the levels of TAK1 phosphorylation and pro-inflammatory cytokines and mediators associated with MAPK and NF-κB activation, similar to TLR4 inhibitor TAK-242. These findings demonstrated that BAC exhibited an anti-inflammatory effect by the inhibition of TLR-induced MAPK and NF-κB pathways, indicating that it could potentially be used for treating inflammatory diseases.
To meet the pressing needs concerning the optimization of the performance of powder metallurgy (P/M) superalloys for turbine disc applications, the effects of solution temperature on a novel high γ′ ...volume fraction P/M superalloy FGH 4107 were investigated. The results indicated that the size of the γ′ precipitates decreased dramatically as the solution temperature increased from 1160 to 1200 °C. Theoretical calculations showed that the precipitation strengthening played a dominant role in enhancing the strength of the high γ′ volume fraction P/M superalloy, and a higher solution temperature was beneficial for the modification of the γ′ phase distribution during the following cooling and aging process.
Though Olefin-linked covalent organic frameworks (oCOFs) possess excellent π-electron delocalization, the barely reversible olefin linkage brings challenges for oCOFs’ synthesis and ...functionalization. Here, we synthesize new oCOFs with tertiary amine knots which have twisted configuration and electron-donating nature. Investigation into the structural variation and photoelectric performance shows that the twisted configuration of oCOF-TFPA could favor to the intramolecular charge transfer process and reduce the possibility of aggregation-caused quenching. Photoelectrical measurements and electric band structure calculation both verify the superiority of this oCOFs’ structure in photoelectric sensing.
The olefin-linked covalent organic frameworks with tertiary amine knots could facilitate the intramolecular charge transfer process with their twisted configuration and thus benefit their photoelectrical performance.
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CMV gastroenteritis is common in patients receiving allogeneic hematopoietic stem cell transplantation and it is difficult to distinguish from acute graft-versus-host disease (aGvHD), which has very ...similar symptoms but needs quite different treatment. CMV gastroenteritis is caused by local infection or reactivation of CMV in the gastrointestinal tract while aGvHD is due to immune rejection. The gold standard of diagnosis of CMV gastroenteritis and aGvHD is gastrointestinal biopsy under endoscopy, which is invasive and can potentially lead to severe side effects. Stool samples testing with quantitative polymerase chain reaction (qPCR) may be an alternative, while the application in trace level measurements and precision are not all satisfactory enough in reported research. In this study, we designed a novel method that extracted the cell free DNA (cfDNA) from the fecal supernatant to perform digital PCR (dPCR) for the detection of CMV, analyzed the performance and compared it with the total DNA extracted by the current procedure. Twenty-two paired stool samples using two DNA extraction methods proved that the cfDNA extraction method had markedly higher DNA concentrations and control gene copy number, suggesting that cfDNA may be more informative and more useful for the detection of CMV DNA segment. The dPCR approach in detecting CMV DNA segment also exhibit good linearity (R.sup.2 = 0.997) and higher sensitivity (limit of detection at 50% was 3.534 copies/muL). Eighty-two stool samples from 44 immunocompromised patients were analyzed, CMV-positive rate was 28%, indicating that more than one-quarter of the gastrointestinal symptoms within these patients may be caused by CMV infection or reactivation. The combined results suggest that detection of CMV by dPCR in cfDNA of stool supernatant is a powerful method to identify CMV gastroenteritis and helps in clinical treatment decision making.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
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