Surface‐enhanced Raman spectroscopy (SERS) has shown strength in non‐invasive, rapid, trace analysis and has been used in many fields in medicine. Machine learning (ML) is an algorithm that can ...imitate human learning styles and structure existing content with the knowledge to effectively improve learning efficiency. Integrating SERS and ML can have a promising future in the medical field. In this review, we summarize the applications of SERS combined with ML in recent years, such as the recognition of biological molecules, rapid diagnosis of diseases, developing of new immunoassay techniques, and enhancing SERS capabilities in semi‐quantitative measurements. Ultimately, the possible opportunities and challenges of combining SERS with ML are addressed.
ML to the help for SERS: Applications of Surface‐Enhanced Raman Spectroscopy (SERS) combined with Machine Learning (ML) in recent years are summarized in this review, including the recognition of biological molecules, rapid diagnosis of diseases, developing of new immunoassay techniques, and enhancing SERS capabilities in semi‐quantitative measurements.
The efficient delivery of a therapeutic gene into target tissues has remained a major obstacle in realizing a viable gene-based medicine. Herein, we introduce a facile and universal strategy to ...construct a DNA nanostructure-based codelivery system containing a linear tumor therapeutic gene (p53) and a chemotherapeutic drug (doxorubicin, DOX) for combined therapy of multidrug resistant tumor (MCF-7R). This novel codelivery system, which is structurally similar to a kite, is rationally designed to contain multiple functional groups for the targeted delivery and controlled release of the therapeutic cargoes. The self-assembled DNA nanokite achieves efficient gene delivery and exhibits effective inhibition of tumor growth in vitro and in vivo without apparent systemic toxicity. These structurally and chemically well-defined codelivery nanovectors provide a new platform for the development of gene therapeutics for not only cancer but also a wide range of diseases.
Terahertz waveguide multiplexers: A review Tan, Zhen; Zhang, Qin‐Yi; Lei, Ya‐Lin ...
Microwave and optical technology letters,
July 2023, 2023-07-00, 20230701, Letnik:
65, Številka:
7
Journal Article
Recenzirano
Terahertz (THz) band, which owns abundant and underexplored frequency spectrum, has provided rich scientific and technological opportunities in numerous research fields, such as radio astronomy, ...atmospheric science and high‐speed communication. As one of the key components in THz systems, the multiplexer cannot only separate/combine different bands, but can also promote the development of THz instruments toward wider band and more multibands. Thanks to the high‐precision computer numerical control milling and micromachining technologies, a lot of THz waveguide multiplexers have been reported in recent years. According to the classification of design configurations, this article offers a brief overview on the developed THz multiplexers. In addition, the performance and system applications of different waveguide‐typed multiplexers are discussed. Therefore, this review will provide a valuable reference for the further development of THz waveguide multiplexers with high performance.
Preparation of density-graded aluminum foam He, Si-Yuan; Zhang, Yi; Dai, Ge ...
Materials science & engineering. A, Structural materials : properties, microstructure and processing,
11/2014, Letnik:
618
Journal Article
Recenzirano
Density-graded aluminum foams were successfully prepared via cooling the foam melts having not yet grown fully. The effects of TiH2 content and cooling timing on the density gradient were ...experimentally investigated. The mechanical properties of graded samples were examined through quasi-static compression tests and impact tests.
Caspase-3 and hydrogen peroxide (H2O2) are closely associated with numerous diseases, both of them are vital in different physiological and pathological conditions. They are closely related and also ...can act independently. The selective and accurate determination of caspase-3 and H2O2 simultaneously to determine their state of being in different situations is of great significance for further study of their molecular mechanisms and the elucidation of their biological functions. In our latest research, a AuNPL-crown nanoprobe was obtained by attaching (4-aminosulfonylphenyl) boronic acid (4-APBA) and peptide-FITC (NH2-Asp-Glu-Val-Asp (DEVD)-FITC) to gold nanoplates (AuNPLs). The fabricated AuNPL-crown nanoprobe was used for dual-channel and real-time tracking of the dynamic changes in caspase-3 and H2O2 based on fluorescence resonance energy transfer (FRET)/surface-enhanced Raman spectroscopy (SERS) technology. The AuNPL-crown nanoprobe not only provides synergy but can also achieve noninterference, making the results more reliable and repeatable. This study simultaneously traced the dynamic changes of caspase-3 and H2O2 on a single probe, which provides a potential new platform for the analysis of caspase-3 and H2O2 in the biological environment with high accuracy, sensitivity, convenience, and efficiency. In summary, we develop a new strategy for the simultaneous detection of different substances on a single probe.
Nanoscale robots have potential as intelligent drug delivery systems that respond to molecular triggers. Using DNA origami we constructed an autonomous DNA robot programmed to transport payloads and ...present them specifically in tumors. Our nanorobot is functionalized on the outside with a DNA aptamer that binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells, and the blood coagulation protease thrombin within its inner cavity. The nucleolin-targeting aptamer serves both as a targeting domain and as a molecular trigger for the mechanical opening of the DNA nanorobot. The thrombin inside is thus exposed and activates coagulation at the tumor site. Using tumor-bearing mouse models, we demonstrate that intravenously injected DNA nanorobots deliver thrombin specifically to tumor-associated blood vessels and induce intravascular thrombosis, resulting in tumor necrosis and inhibition of tumor growth. The nanorobot proved safe and immunologically inert in mice and Bama miniature pigs. Our data show that DNA nanorobots represent a promising strategy for precise drug delivery in cancer therapy.
Using the DNA origami technique, we constructed a DNA nanodevice functionalized with small interfering RNA (siRNA) within its inner cavity and the chemotherapeutic drug doxorubicin (DOX), ...intercalated in the DNA duplexes. The incorporation of disulfide bonds allows the triggered mechanical opening and release of siRNA in response to intracellular glutathione (GSH) in tumors to knockdown genes key to cancer progression. Combining RNA interference and chemotherapy, the nanodevice induced potent cytotoxicity and tumor growth inhibition, without observable systematic toxicity. Given its autonomous behavior, exceptional designability, potent antitumor activity and marked biocompatibility, this DNA nanodevice represents a promising strategy for precise drug design for cancer therapy.
An autonomous tubular DNA nanodevice is constructed to deliver a chemotherapeutic drug and siRNAs. This nanodevice can realize on‐demand targeting, respond to stimuli in the intracellular environment and release multiple molecular payloads for combined antitumor activity.
Electrochemiluminescence (ECL), as an advanced sensing process, can selectively control the generation of excited states by changing the potential. However, most of the existing ECL systems rely on ...poisonous coreactants to provide radicals for luminescence; although the ECL efficiency was improved, the athematic coreactants will cause unpredictable interference to the accurate analysis of trace targets. Herein, we realized the ECL of nonemitting molecules by performing intramolecular electron transfer in the olefin-linked covalent organic frameworks (COFs), with a high efficiency of 63.7%. Employing internal dissolved oxygen as the coreactant, it is well suitable for the analysis of various complex samples in the environment. Taking nuclear contamination analysis as the goal orientation, we further illustrated a design of a “turn-on” uranyl ion monitoring system integrating fast response, low detection limit, and high selectivity, showing that new ECL-COFs are promising to facilitate environment-related sensing analysis and structure-feature correlation mechanism exploration.
A conformal circularly polarized (CP) H-plane horn antenna with broadband and low-profile characteristics is proposed in this communication, which is integrated with quasi-Yagi and wrapped around a ...hollow cylinder. The H-plane horn based on bent corrugated substrate integrated waveguide (BCSIW) technology and the quasi-Yagi with fan-shaped driving elements provide the vertical and horizontal linear-polarized waves, respectively, which generates CP radiation combined with the suitable phase delay provided by the transition section. The proposed antenna is wrapped around a hollow metallic cylinder with a radius of 100 mm and a height of 90 mm. The measured voltage standing wave ratio (VSWR) of the fabricated antenna is less than 2.0 in the frequency range over 9.4 GHz (81%), while the axial ratio (AR) is below 3 dB from 9.4 to 21.7 GHz (78%). The antenna also exhibits a stable radiation pattern with a peak gain of 12.1 dBi and a cross-polarization below −17 dB over the whole frequency range. It is observed that the measured results agree well with simulated ones.
PDF
