This paper proposes an innovative global solution which is a pioneering work applying automated machine learning algorithms to remarkable precision sparse underwater direction-of-arrival (DOA) ...estimation that views the subaquatic sparse-sampling DOA estimation problem as a classification prediction task. The proposed solution, termed automated multi-layer perceptron discriminative neural network (AutoMPDNN), is built upon a Bayesian optimization framework. AutoMPDNN transforms sparsely sampled time-domain signals into the complex domain, preserving essential components in a one-source single-snapshot scenario. Leveraging Bayesian optimization principles, the algorithm embeds necessary hyperparameters into the loss function, effectively defining it as a maximum likelihood problem using the upper confidence bound function and incorporating sparse signal features. We also explore the model space architecture and introduce variants of AutoMPDNN, denoted as AutoMPDNNs_ln (n = 2,3,4). Through a series of plane wave simulation experiments, it is demonstrated that AutoMPDNN achieves the highest prediction performance for one-source single-snapshot scenarios compared to classical DOA estimation algorithms that incorporate sparse representation approaches, as well as contemporary deep learning DOA methods under varying conditions.
Abstract
Background
To forecast the human immunodeficiency virus (HIV) incidence and mortality of post-neonatal population in East Asia including North Korea, South Korea, Mongolia, Japan and China ...Mainland and Taiwan province.
Methods
The data on the incidence and mortality of HIV in post-neonatal population from East Asia were obtained from the Global Burden of Diseases (GBD). The morbidity and mortality of post-neonatal HIV population from GBD 2000 to GBD 2013 were applied as the training set and the morbidity and mortality from GBD 2014 to GBD 2019 were used as the testing set. The hybrid of ARIMA and LSTM model was used to construct the model for assessing the morbidity and mortality in the countries and territories of East Asia, and predicting the morbidity and mortality in the next 5 years.
Results
In North Korea, the incidence and mortality of HIV showed a rapid increase during 2000–2010 and a gradual decrease during 2010–2019. The incidence of HIV was predicted to be increased and the mortality was decreased. In South Korea, the incidence was increased during 2000–2010 and decreased during 2010–2019, while the mortality showed fluctuant trend. As predicted, the incidence of HIV in South Korea might be increased and the mortality might be decreased during 2020–2025. In Mongolia, the incidence and mortality were slowly decreased during 2000–2005, increased during 2005–2015, and rapidly decreased till 2019. The predicted incidence and mortality of HIV showed a decreased trend. As for Japan, the incidence of HIV was rapidly increased till 2010 and then decreased till 2015. The predicted incidence of HIV in Japan was gradually increased. The mortality of HIV in Japan was fluctuant during 2000–2019 and was slowly decreased as predicted. The incidence and mortality of HIV in Taiwan during 2000–2019 was increased on the whole. The predicted incidence of HIV during was stationary and the mortality was decreased. In terms of China Mainland, the incidence and mortality of HIV was fluctuant during 2000–2019. The predicted incidence of HIV in China Mainland was stationary while the mortality was rapidly decreased.
Conclusion
On the whole, the incidence of HIV combined with other diseases in post-neonatal population was increased before 2010 and then decreased during 2010–2019 while the mortality of those patients was decreased in East Asia.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The 2019 coronavirus disease pandemic has been a governance challenge for countries and cities worldwide. In China, the community-based joint prevention and control governance mechanism is one of the ...highlights of the “Chinese experience” in fighting the pandemic. As aging accelerates, communities can take on more functions in managing the health of their residents. Especially in the post-pandemic era, the actual needs of community residents in terms of health, medical care, and elderly care need to be addressed. This paper uses a questionnaire to understand the current situation of community health management in Beijing, followed by the selection of four typical communities for in-depth interviews, and uses the triple process of open coding, selective coding, and theoretical coding of the grounded theory to analyze residents' needs and willingness for proactive health management. More than 80 concepts, 41 categories, and 6 master categories were obtained from 204 initial statements. The “logical line” of the relationship between the main categories was constructed, and we developed a conceptual model of community-based proactive health management, consisting of six dimensions: (1) perception and willingness, (2) primary population, (3) health behavior paradigm, (4) management mechanism, (5) information technology applications, and (6) facilities and services. The study aims to contribute to the community-based health management in China and for the international community and provide strategies to improve community-based health management.
The dynamic change in land use can reflect the change in the ecological environment and social economy. Zhangjiajie is the famous mountain tourist city in China having a dual core central structure ...constituting the urban central area and Wulingyuan Scenic Area (referred to as DCC). This study is based on the land use data of Zhangjiajie in 2000, 2010, and 2020. It analyzed the dynamic change in the pattern of land use, its cause and effects using the method of human-computer interaction for remote sensing image interpretation. The study revealed: (1) the growth of construction land is the maximum, while cultivated land and grassland are mostly transformed into construction and forest land. (2) The reasons why Zhangjiajie with limited cultivated, and idle industrial land was mainly transformed into tourism construction land, especially the townships around DCC. (3) The development of townships around DCC should build industrial belts for coordinated development. This study attempts to analyze the development dilemma and outlet of Zhangjiajie's DCC on its surrounding 12 townships using the results of land use change aiming to realize the integrated development of DCC and township area, to provide practical experience for green development of township industry around mega-tourist attraction.
In the context of rapid urbanization, building an ecological security pattern that takes into account both ecological protection and economic growth is of great significance for guiding high-quality ...regional development. Taking the Hefei metropolitan area as an example, we identified the ecological source from three aspects—the importance of ecosystem services, ecological sensitivity, and landscape connectivity—by using NPP-VIIRS night light data, impervious surfaces, and the topographical index to the rest of the landscape resistance surface, and the least cumulative resistance model to identify ecological corridors and ecological buffer zones. We then constructed a comprehensive regional ecological security pattern. The results show the following: (1) The ecological source area of the Hefei metropolitan area is 15,538.74 km2, accounting for 24.5% of the total study area. It is mainly composed of the Dabie Mountains, the Yangtze River, the Huai River, and Chaohu Lake. (2) The area of an ecological buffer zone, ecological transition zone, and development and construction zone account for 21.8%, 39.7%, and 38.5%, respectively. Among them, the ecological buffer zone serves as a protective barrier for the ecological source area; therefore, development and construction activities should be restricted. The ecological transition zone should be constructed with low development intensity, and the development and construction zone can be carried out with greater development intensity. (3) The total length of the ecological corridor is 2816.89 km, with the mainland of the corridor being cultivated land. Identified by superposition of the land use, the area of conflict of urban expansion is 305.23 km2, mainly distributed along the Yangtze River and around Chao Lake. The results may provide decision support for the construction of ecological security in the study area.
Forest parks are among the most important reserves. Forest recreation reflects the time requirements for resource usage and economic coordination for sustainable development. Human activities in ...forest parks are a major force for continuing space production. However, with the rapid development of forest recreation, expanded spaces and excessive expectations make sustainable development a great challenge. Analyzing the spaces of forest recreation; making conclusions about the spatial features; and analyzing requests regarding multiple characters, multi-functions, and land usage are all done through the process of space production, which based on the "Three Dimensions." According to the problems of space alienation occurring in forest recreation, this paper proposes that the logic of space governance should return to the nature of the Three Dimensions itself. "Space justice production" and "reconstruction of we" should also offer countermeasures and advice for building a classification mechanism for the rights, responsibilities, and interests of recreation spaces; establishing recreation space control zones and strategies; and promoting space expansion simulations and facility scale measurement. The construction of spatial relationships and forms of social, ecological, and natural justice is necessary to offer a new method of space production and consumption balance for natural reserves.
Coronaviruses have evolved a variety of strategies to exploit normal cellular processes and signalling pathways for their efficient reproduction in a generally hostile cellular environment. One ...immediate-early response gene (IEG) family, the AP-1 gene family, was previously shown to be activated by coronavirus infection. In this study, we report that another IEG family, the EGR family, is also activated in cells infected with four different coronaviruses in three genera, i.e. gammacoronavirus infectious bronchitis virus (IBV), alphacoronaviruses porcine epidemic diarrhoea virus (PEDV) and human coronavirus-229E (HCoV-229E), and betacoronavirus HCoV-OC43. Knockdown of EGR1 reduced the expression of cJUN and cFOS, and knockdown of cJUN and/or cFOS reduced the expression of EGR1, demonstrating that these two IEG families may be cross-activated and mutual regulated. Furthermore, ERK1/2 was identified as an upstream kinase, and JNK and p38 as inhibitors of EGR1 activation in coronavirus-infected cells. However, upregulation of EGR family genes, in particular EGR1, appears to play a differential role in regulating viral replication, apoptosis and antiviral response. EGR1 was shown to play a limited role in regulation of coronavirus replication, and an anti-apoptotic role in cells infected with IBV or PEDV, but not in cells infected with HCoV-229E. Upregulation of EGR1 may also play a differential role in the regulation of antiviral response against different coronaviruses. This study reveals a novel regulatory network shared by different coronaviruses in the immediate-early response of host cells to infection.
In this study, we aimed to better understand the difference between the functions of the two types of granulosa cells and sought to discover more key genes involved in follicle development and ...follicle selection. Herein, we separately collected pre-hierarchical follicle granulosa cells (PHGCs) and preovulatory follicle granulosa cells (POGCs) for RNA extraction; the transcriptomes of the two groups were compared via RNA-seq. A total of 5273 differentially expressed genes (DEGs) were identified between the PHGCs and POGCs; 2797 genes were up-regulated and 2476 were down-regulated in the PHGCs compared with the POGCs. A qPCR analysis confirmed that the expression patterns of 16 randomly selected DEGs were highly consistent with the RNA-seq results. In the POGCs, many of the genes with the most significant increase in expression were related to steroid hormone synthesis. In addition, the genes with the most significant decline in expression, including
and
, were related to the inhibition of steroid hormone synthesis. These results suggest that steroid hormones play a key role in follicle development. Furthermore, a Gene Ontology (GO) analysis revealed that these DEGs were mainly involved in the primary metabolic process, the carbohydrate metabolic process, the cellular process, ribosomes, the cytoplasm, and intracellular processes. A Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that the DEGs were mainly enriched in steroid biosynthesis, the cell cycle, ribosomes, the TGF-beta signaling pathway, focal adhesion, and so on. We also observed the morphology of the follicles at different developmental stages, and the results showed that the thickness of the granular layer of the small yellow follicles (SYFs) decreased significantly with further development. In addition, we also found that the thickness of the granulosa layer of hens over 300 days old was significantly lower than that of 200-day-old hens. In short, these data indicate that the tissue morphology and function of granulosa cells change throughout follicle development.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
