Chinese medicinal retention enemas have gradually attracted the attention of clinicians as an alternative approach for tubal obstructive infertility. The purpose of this study was to investigate the ...efficacy and safety of conventional surgery combined with traditional Chinese medicinal retention enemas for the treatment of tubal obstructive infertility.
Eight electronic databases were searched from their inception to November 30, 2022. To assess the efficacy and safety of different treatments, following outcomes were measured: clinical pregnancy rate, clinical total effective rate, incidence of ectopic pregnancy, the improvement of Traditional Chinese Medicinal (TCM) symptoms, the improvement of the signs of obstructive tubal infertility and side effects.
A total of 23 Randomized Controlled Trials (RCTs) with 1909 patients met the inclusion criteria. The pooled results showed a higher pregnancy rate in the experimental group than in the control group (RR 1.75, 95% CI 1.58, 1.94, Z = 10.55, P<0.00001). The clinical total effective rate in the experimental group was higher than that in the control group (RR 1.28, 95% CI 1.23, 1.34, Z = 11.07, P<0.00001). The incidence of ectopic pregnancy in the experimental group was lower than that in the control group (RR 0.40, 95% CI 0.20, 0.77, Z = -2.73, P = 0.01).
Based on current evidence, we concluded that conventional surgery combined with traditional Chinese medicinal retention enema for tubal obstructive infertility was superior to conventional surgery alone in improving the clinical pregnancy rate, improving clinical total effective rate, improving TCM symptoms, improving the signs of obstructive tubal infertility and lowering the incidence of ectopic pregnancy. However, further clinical trials with high-quality methodologies need to be conducted.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
In this paper, a tunable electromagnetically induced transparency (EIT) structure using coupling hybrid graphene-nanostrip is proposed. The structure comprises of a vertical graphene strip (VGS) and ...a pair of horizontal graphene strips (HGSs), the horizontal graphene strips placed alternately on both sides of vertical graphene strip. The EIT-like effect could be turned by changing the Fermi level of graphene instead of refabricating the geometrical parameter of structure, and the significant merits of proposed structure is distinct EIT-like effect could be observed in two perpendicular polarization directions, the influence of electron mobility on transparency windows is also analyzed. This work demonstrate a novel EIT-like phenomenon based on metamaterial and opens a new perspective in EIT effect applications.
•A tunable EIT structure base on graphene is proposed.•EIT windows are observed in two perpendicular polarization directions.•Influence of electron mobility on transparency windows is analyzed.
•Machine learning driven study is developed to optimize the interfacial thermal transport between solid/solid heterostructure via interfacial nanostructuring.•Diverse guidance for the optimization of ...interfacial thermal transport via interfacial structural parameters and contact area are proposed.•The optimization of interfacial thermal transport is uncovered from the phonon mode mismatch and wavelength of phonons.
Heat dissipation through interfaces becomes challenging in nanodevices which impedes the dissipation of waste heat. Accordingly, effective approaches are needed to optimize interfacial thermal transport. In this work, by combining the molecular dynamics simulations and machine learning technique, we systematically study the optimization of interfacial thermal transport in Si/Ge heterostructures through interfacial nanostructuring. Three structural parameters are proposed to describe the nanostructures at interfaces and applied to the machine learning driven predictions. The results demonstrate that the interfacial thermal transport significantly depends on the interfacial nanostructures and diverse guidances are discovered for the optimization. When fixing the density of nanostructures, the interfacial thermal resistance has a minimum at specific heights of nanostructures with small angles, while the minimum is gradually disappeared for the nanostructures with larger angles. When fixing the height of nanostructures, there is also a minimum versus density but gradually disappeared with increasing angles. The nonmonotonic dependences on density and height open spaces for the optimization of interfacial thermal transport. Our spectral decomposition analysis provides physical insights into machine learning predictions and optimizations. Finally, we also summarize the machine learning predictions from the perspective of contact area, in which the distinct dependencies on nanostructuring angle and height manifest the feasibility for the further optimization of interfacial thermal transport. Our machine learning driven study provides comprehensive knowledge and guidances for the optimization of interfacial heat dissipation in nanodevices through nanostructuring.
Aim. Salivary gland adenoid cystic carcinoma (SACC) is the second highest incidence of malignant salivary gland tumor. The purpose of this study was to establish nomograms combined with SACC patients ...based on the Surveillance, Epidemiology, and End Results (SEER) database. Methods. Patients with SACC were included in the SEER∗Stat Database from 2004 to 2016. The least absolute shrinkage and selection operator (LASSO) Cox regression analysis was applied to filter potential prognostic clinical variables. Multivariate analysis from the Cox proportional hazards model was performed to determine the independent prognostic factors on overall survival (OS) and disease-specific survival (DSS), applied to develop nomograms. The Schönfeld residual test verified the proportional hazard assumption. The discrimination and consistency of nomograms was assessed and validated according to concordance index (C-index), receiver operating characteristic (ROC) curves, and calibration curves using an internal 1,000 times bootstrap resampling. The nomogram’s net clinical benefit was assessed through decision curve analysis (DCA). Results. A total of 658 patients with SACC were included. Age, T stage, N stage, M stage, histologic grade, and surgery were independent prognostic factors for OS and DSS. Based on these independent prognostic factors, nomograms were developed to predict 3-, 5-, and 10-year OS and DSS. In the validation of 1,000 times bootstrap resampling, the C-index and ROC curves had good discriminatory ability. The calibration curves indicated excellent consistency between the predicted and actual survival results in the nomograms. The DCA curves demonstrated that the nomograms had good clinical benefit and were superior to the TNM stage and other variables. Conclusions. Two nomograms developed in this study precisely predicted the 3-, 5-, and 10-year OS and DSS rates of patients with SACC in accordance with independent prognostic factors, and their clinical value is better than TNM staging, providing a prognostic reference for other SACC patients.
Aqueous zinc batteries are attracting interest because of their potential for cost-effective and safe electricity storage. However, metallic zinc exhibits only moderate reversibility in aqueous ...electrolytes. To circumvent this issue, we study aqueous Zn batteries able to form nanometric interphases at the Zn metal/liquid electrolyte interface, composed of an ion-oligomer complex. In Zn||Zn symmetric cell studies, we report highly reversible cycling at high current densities and capacities (e.g., 160 mA cm
; 2.6 mAh cm
). By means of quartz-crystal microbalance, nuclear magnetic resonance, and voltammetry measurements we show that the interphase film exists in a dynamic equilibrium with oligomers dissolved in the electrolyte. The interphase strategy is applied to aqueous Zn||I
and Zn||MnO
cells that are charged/discharged for 12,000 cycles and 1000 cycles, respectively, at a current density of 160 mA cm
and capacity of approximately 0.85 mAh cm
. Finally, we demonstrate that Zn||I
-carbon pouch cells (9 cm
area) cycle stably and deliver a specific energy of 151 Wh/kg (based on the total mass of active materials in the electrode) at a charge current density of 56 mA cm
.
Active and selective manipulation of dual–spectral electromagnetically induced transparency (EIT) metamaterial constructed by three graphene strips and vanadium dioxide (VO2) layer is proposed and ...demonstrated numerically. Simulation results illustrate that the dual-spectral EIT-like effect are induced by adjacent graphene strips acted as bright and bright mode and excited opposite-phase electric field distributions. One or two of EIT-like windows can be modulated by selectively varying graphene strip’s Fermi energy. Meanwhile, the Fermi energies of three graphene strips are varying simultaneously, the position of dual transparency windows as a whole obviously exhibit blue shift. Moreover, the amplitude of dual–spectral EIT windows can be simultaneously manipulated while frequency remain rough constant during the phase transition process of VO2. The physical mechanism underneath the phenomenon of actively and selectively tunable EIT, which is revealed by theoretically calculated results based on the classical three-oscillator model, can be attributed to the variation of resonance frequency, coupling coefficient and losses of the resonators caused by varying Fermi energy of graphene strips and conductivity of VO2.
A regioselective metal-free sulfenylation of imidazoheterocycles with heterocyclic thiols or thiones has been achieved using a cross-dehydrogenative coupling method in water. In addition, the ...procedure has several advantages including green solvents, free of foul-smelling sulfur sources, and mild conditions, thus providing considerable application potential in the pharmaceutical industry.
A palladium-catalyzed olefination of meta-C–H bonds in arenes containing oxyamides using a nitrile template as the directing group has been established. The methodology exhibited high ...meta-selectivity and tolerated different functional groups such as benzyloxyamides and olefin substrates. The desired products were obtained in good yields. This approach enabled the modification of natural products and drugs and was also applicable on the gram-scale. Furthermore, the directing template was readily removed by selective cleavage of the amide bond or the O–N bond to obtain meta-functionalized hydroxylamines and benzyl alcohols. The proposed method holds great potential for the design of novel drugs.
Aeromonas veronii has a serious impact on the aquaculture industry and human public health. The type VI secretory system (T6SS) is the virulence regulation system of gram-negative bacteria, of which ...hcp is the core component. In this study, we constructed the mutant (Δ hcp1) and complemented (C-hcp1) strains of A. veronii TH0426 were using homologous recombination to study the effect of hcp1 gene on the virulence of TH0426. We found that deletion of the hcp1 gene caused fracture of the flagella of TH0426 and significantly affected basic biological characteristics, including motility, biofilm formation, bacterial competition, and flagellate-related gene expression., In terms of pathogenicity, compared with wild-type strain, LD50 of Δ hcp1 decreased 17.5-fold (P < 0.001), adhesion and invasion of EPC ability of the Δ hcp1 significantly decreased 1.5-fold (P < 0.001), and both the bacterial load at 12 h and 24 h and the cytotoxicity of Δ hcp1 decreased significantly. In conclusion, the hcp1 gene can affect the basic biological characteristics and animal pathogenicity of TH0426 cells by regulating flagella assembly. This study is helpful to explaining the gene function of hcp1 in the T6SS and its mechanism of action in animal pathogenesis.
•hcp1 gene affects the motility, biofilm formation ability and bacterial competition of A. veronii TH0426.•hcp1 gene is involved in regulating the formation of flagella in A. veronii TH0426.•hcp1 gene negatively regulates flagellar component-related genes in A. veronii TH0426.•hcp1 gene can regulate the virulence of A. veronii TH0426.
PDF
