Recent advances in unmanned aerial vehicles (UAVs) for civilian use make it possible to regularly monitor geothermal environments at spatial and temporal scales that would be difficult to achieve ...using conventional methods. Previous aerial monitoring of geothermal environments has been expensive and time consuming. This paper demonstrates the use of a small (<2 kg), cost effective quadcopter UAV to safely and accurately map physical and biological characteristics of these unique habitats. Thermal infrared imaging and photogrammetry are used to capture detailed information of geothermal surface features and surrounding vegetation within the Wairakei – Tauhara geothermal field near Taupo, New Zealand. The study highlights advanced techniques in sampling, processing and analysing UAV images and identifies some research challenges and limitations in the use of UAV platforms and sensors. The application of UAVs to describe and monitor geothermal features and other environments is a rapidly developing field in science and natural resource management. This project demonstrates the utility of UAV applications in geothermal science and the potential for their use in many other areas of research.
•We attempted to capture thermal infrared images of a geothermal system with a off the shelve UAV.•We demonstrate how to covert the thermal infrared videos to still images.•We introduce the use of PIX4D software application for thermal infrared images processing.•The orthomosaic of the thermal infrared imagery is displayed and described.•Challenges faced with UAV application and possible solutions are provided.
The synthesis of complex organic molecules requires several stages, from ideation to execution, that require time and effort investment from expert chemists. Here, we report a step toward a paradigm ...of chemical synthesis that relieves chemists from routine tasks, combining artificial intelligence-driven synthesis planning and a robotically controlled experimental platform. Synthetic routes are proposed through generalization of millions of published chemical reactions and validated in silico to maximize their likelihood of success. Additional implementation details are determined by expert chemists and recorded in reusable recipe files, which are executed by a modular continuous-flow platform that is automatically reconfigured by a robotic arm to set up the required unit operations and carry out the reaction. This strategy for computer-augmented chemical synthesis is demonstrated for 15 drug or drug-like substances.
The Ise shrine complex is among Japan's most enduring national symbols, and A Social History of the Ise Shrines: Divine Capital is the first book to trace the history of the shrines from their ...beginnings in the seventh century until the present day. Ise enshrines the Sun Goddess Amaterasu, the imperial ancestress and the most prominent among kami deities, and has played a vital role in Japan's social, political and religious history. The most popular pilgrims' attraction in the land from the sixteenth century onwards, in 2013 the Ise complex once again captured the nation's attention as it underwent its periodic rebuilding, performed once every twenty years. Mark Teeuwen and John Breen demonstrate that the Ise Shrines underwent drastic re-inventions as a result of on-going contestation between different groups of people in different historical periods. They focus on the agents responsible for these re-inventions, the nature of the economic, political and ideological measures they took, and the specific techniques they deployed to ensure that Ise survived one crisis after another in the course of its long history. This book questions major assumptions about Ise, notably the idea that Ise has always been defined by its imperial connections, and that it has always been a site of Shinto. Written by leading authorities in the field of Shinto studies, this is the essential history of Japan's most significant sacred site.
A new history of Shinto Breen, John; Teeuwen, Mark
2011., 2010/01/01, 2010, 2010-03-01
eBook
This accessible guide to the development of Japan’s indigenous religion from ancient times to the present day offers an illuminating introduction to the myths, sites and rituals of kami worship, and ...their role in Shinto’s enduring religious identity. Offers a unique new approach to Shinto history that combines critical analysis with original research Examines key evolutionary moments in the long history of Shinto, including the Meiji Revolution of 1868, and provides the first critical history in English or Japanese of the Hie shrine, one of the most important in all Japan Traces the development of various shrines, myths, and rituals through history as uniquely diverse phenomena, exploring how and when they merged into the modern notion of Shinto that exists in Japan today Challenges the historic stereotype of Shinto as the unchanging, all-defining core of Japanese culture
IMPORTANCE Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood. OBJECTIVE To define the sleep and circadian phenotype of ...patients with early-stage Parkinson disease. DESIGN, SETTING, AND PARTICIPANTS Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15). MAIN OUTCOMES AND MEASURES Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene expression (Bmal1, Per2, and Rev-Erbα). RESULTS Subjective sleep complaints were present in almost half of newly diagnosed patients and correlated significantly with poorer quality of life. Patients with Parkinson disease exhibited increased sleep latency (P = .04), reduced sleep efficiency (P = .008), and reduced rapid eye movement sleep (P = .02). In addition, there was a sustained elevation of serum cortisol levels, reduced circulating melatonin levels, and altered Bmal1 expression in patients with Parkinson disease compared with controls. CONCLUSIONS AND RELEVANCE Sleep dysfunction seen in early Parkinson disease may reflect a more fundamental pathology in the molecular clock underlying circadian rhythms.
We consider the problem of bias arising from conditioning on a post-outcome collider. We illustrate this with reference to Elwert and Winship (2014) but we go beyond their study to investigate the ...extent to which inverse probability weighting might offer solutions. We use linear models to derive expressions for the bias arising in different kinds of post-outcome confounding, and we show the specific situations in which inverse probability weighting will allow us to obtain estimates that are consistent or, if not consistent, less biased than those obtained via ordinary least squares regression.
Auxin is an important phytohormone for fleshy fruit development, having been shown to be involved in the initial signal for fertilisation, fruit size through the control of cell division and cell ...expansion, and ripening related events. There is considerable knowledge of auxin-related genes, mostly from work in model species. With the apple genome now available, it is possible to carry out genomics studies on auxin-related genes to identify genes that may play roles in specific stages of apple fruit development.
High amounts of auxin in the seed compared with the fruit cortex were observed in 'Royal Gala' apples, with amounts increasing through fruit development. Injection of exogenous auxin into developing apples at the start of cell expansion caused an increase in cell size. An expression analysis screen of auxin-related genes involved in auxin reception, homeostasis, and transcriptional regulation showed complex patterns of expression in each class of gene. Two mapping populations were phenotyped for fruit size over multiple seasons, and multiple quantitative trait loci (QTLs) were observed. One QTL mapped to a region containing an Auxin Response Factor (ARF106). This gene is expressed during cell division and cell expansion stages, consistent with a potential role in the control of fruit size.
The application of exogenous auxin to apples increased cell expansion, suggesting that endogenous auxin concentrations are at least one of the limiting factors controlling fruit size. The expression analysis of ARF106 linked to a strong QTL for fruit weight suggests that the auxin signal regulating fruit size could partially be modulated through the function of this gene. One class of gene (GH3) removes free auxin by conjugation to amino acids. The lower expression of these GH3 genes during rapid fruit expansion is consistent with the apple maximising auxin concentrations at this point.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The structural dynamics of planar thin films of an ionic liquid (IL) 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (BmimNTf2) as a function of surface charge density and thickness ...were investigated using two-dimensional infrared (2D IR) spectroscopy. The films were made by spin coating a methanol solution of the IL on silica substrates that were functionalized with alkyl chains containing head groups that mimic the IL cation. The thicknesses of the ionic liquid films ranged from ∼50 to ∼250 nm. The dynamics of the films are slower than those in the bulk IL, becoming increasingly slow as the films become thinner. Control of the dynamics of the IL films can be achieved by adjusting the charge density on substrates through multilayer network surface functionalization. The charge density of the surface (number of positively charged groups in the network bound to the surface per unit area) is controlled by the duration of the functionalization reaction. As the charge density is increased, the IL dynamics become slower. For comparison, the surface was functionalized with three different neutral groups. Dynamics of the IL films on the functionalized neutral surfaces are faster than on any of the ionic surfaces but still slower than the bulk IL, even for the thickest films. These results can have implications in applications that employ ILs that have electrodes, such as batteries, as the electrode surface charge density will influence properties like diffusion close to the surface.
Anxiety disorders are common, complex psychiatric disorders with twin heritabilities of 30-60%. We conducted a genome-wide association study of Lifetime Anxiety Disorder (n
= 25 453, n
= 58 113) ...and an additional analysis of Current Anxiety Symptoms (n
= 19 012, n
= 58 113). The liability scale common variant heritability estimate for Lifetime Anxiety Disorder was 26%, and for Current Anxiety Symptoms was 31%. Five novel genome-wide significant loci were identified including an intergenic region on chromosome 9 that has previously been associated with neuroticism, and a locus overlapping the BDNF receptor gene, NTRK2. Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety.
Accurate tissue diagnosis during ovarian cancer surgery is critical to maximize cancer excision and define treatment options. Yet, current methods for intraoperative tissue evaluation can be time ...intensive and subjective. We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Here we evaluated the performance of this technology for ovarian cancer diagnosis across different sample sets, tissue types, and mass spectrometry systems.
MasSpec Pen analyses were performed on 192 ovarian, fallopian tube, and peritoneum tissue samples. Samples were evaluated by expert pathologists to confirm diagnosis. Performance using an Orbitrap and a linear ion trap mass spectrometer was tested. Statistical models were generated using machine learning and evaluated using validation and test sets.
High performance for high-grade serous carcinoma (n = 131; clinical sensitivity, 96.7%; specificity, 95.7%) and overall cancer (n = 138; clinical sensitivity, 94.0%; specificity, 94.4%) diagnoses was achieved using Orbitrap data. Variations in the mass spectra from normal tissue, low-grade, and high-grade serous ovarian cancers were observed. Discrimination between cancer and fallopian tube or peritoneum tissues was also achieved with accuracies of 92.6% and 87.9%, respectively, and 100% clinical specificity for both. Using ion trap data, excellent results for high-grade serous cancer vs normal ovarian differentiation (n = 40; clinical sensitivity, 100%; specificity, 100%) were obtained.
The MasSpec Pen, together with machine learning, provides robust molecular models for ovarian serous cancer prediction and thus has potential for clinical use for rapid and accurate ovarian cancer diagnosis.
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