In 2016, the World Health Organization revised the brain tumor classification, making
mutation and 1p/19q codeletion the defining features of oligodendroglioma. To determine whether imaging ...characteristics previously associated with oligodendroglial tumors are still applicable, we evaluated the MR imaging features of genetically defined oligodendrogliomas.
One hundred forty-eight adult patients with untreated World Health Organization grade II and III infiltrating gliomas with histologic oligodendroglial morphology, known 1p/19q status, and at least 1 preoperative MR imaging were retrospectively identified. The association of 1p/19q codeletion with tumor imaging characteristics and ADC values was evaluated.
Ninety of 148 (61%) patients had 1p/19q codeleted tumors, corresponding to genetically defined oligodendroglioma, and 58/148 (39%) did not show 1p/19q codeletion, corresponding to astrocytic tumors. Eighty-three of 90 (92%) genetically defined oligodendrogliomas had noncircumscribed borders, compared with 26/58 (45%) non-1p/19q codeleted tumors with at least partial histologic oligodendroglial morphology (
< .0001). Eighty-nine of 90 (99%) oligodendrogliomas were heterogeneous on T1- and/or T2-weighted imaging. In patients with available ADC values, a lower mean ADC value predicted 1p/19q codeletion (
= .0005).
Imaging characteristics of World Health Organization 2016 genetically defined oligodendrogliomas differ from the previously considered characteristics of morphologically defined oligodendrogliomas. We found that genetically defined oligodendrogliomas were commonly poorly circumscribed and were almost always heterogeneous in signal intensity.
Publishing from your PhD Johnson, Nicola F
2010., 2011, 20170515, 2010, 2011-01-01, 2017-05-15
eBook
There is consistent pressure on all academics to publish, publish, publish. But not unless they have been awarded their PhD - considered by most to be the starting step of an academic career. So ...while the pressure is on to obtain the title, and then obtain a permanent position, and then publish journal articles, there is little support available to researchers in the nascent stage of their careers. Publishing from Your PhD precisely focuses on providing early career researchers with emotional and collegial support that is often not available in academe. It seeks to dispel nepotistic notions of superiority that places Professors and such on a pedestal. It specifically clarifies the difficulty in having written the PhD thesis and then rewriting it to suit the genre of journal articles. It does not deal with the 'how' of academic writing in general. This book endeavours to shed light on the path one must take to navigate the jungles of academia. This is an untrodden path which is unique to every researcher - especially those who employ abstract or critical theories in their research - and each journey through the jungle is different. However, because there is little literature about this embryonic journey, this book illuminates the processes and difficulties of publishing in journals and culling one's finely honed thesis into small chunks - a difficult task to which few admit.
Contents: Introduction - navigating a jungle: no worn paths; Supplies are needed, packing the backpack: what others have written; Hacking a path through unknown territory; Navigating new terrain: the demise of the book?; Flies, gnats and wasps: negotiating the gatekeepers; The night is black: no black or white in academia; Stamina is needed for survival: choosing the right journal; Fighting the heat, hunger and thirst: dealing with rejection; Thorny bushes and muddy swamps: things that slow you down; The final destination has moved, hack another path: the process of culling and prioritising. Prologue: introducing the interviews with the academics: Professor Jan Herrington; Professor Paul Chandler; Professor Lori Lockyer; Professor Jan Wright; Professor Wilma Vialle; Professor Sara Dolnicar; Conclusion: negotiating the crowded jungle - acknowledge successful navigation; References; Index.
Dr Nicola F. Johnson recently published The Multiplicities of Internet Addiction: The Misrecognition of Leisure and Learning with Ashgate (2009). She is a senior lecturer in teacher education in the Faculty of Education at Monash University, Victoria, Australia. Nicola is an early career researcher who has recently been awarded her PhD (2008) and commenced a full-time career as an academic in early 2007.
Ethics and the Use of Force Johnson, James Turner
2011, 20160513, 2013, 2016-05-13, 2016-05-18, 2011-05-01, 20110101
eBook
Highlighting the just war tradition in historical perspective, this valuable study looks at contemporary implications drawn out in the context of several important contemporary debates: within the ...field of religion, including both Christian and Islamic thought; within the field of debate related to the international law of armed conflicts; within the field of policy relating to the use of armed force where the issue is just war thinking vs. realism; and debates over pressing contemporary issues in the ethics of war which cross disciplinary lines. James Turner Johnson has been writing on just war tradition since 1975, developing the historical understanding of just war and seeking to draw out its implications for contemporary armed conflict. He is frequently asked to lecture on topics drawn from his work. This current book brings together a number of essays which reflect his recent thinking on understanding how and why just war tradition coalesced in the first place, how and why it has developed as it has, and relating contemporary just war reasoning to the historical tradition of just war.
In India, the majority of people believe that any form of mass media can reflect society. Advertising is one of the most important and influential media products. Advertisements (Ads) are known for ...being convincing, particularly television ads, which are thought to be the most successful kind of mass-market advertising. Advertising serves as a critical agent of socialization in modern developed societies and is used to maintain specific social structures. The current research article uses discourse analysis to examine how the idea of women's employment is presented in selected Indian television commercials. This study primarily focuses on the use of language in advertisements that are used to control people's thoughts. After analysis, it was found that when the majority of household advertisements, label women in a subordinate position, some brands challenge these stereotypes. The storylines focused on women's empowerment are receiving a warm reception from society. Advertisements that portray women positively have more chances of success, making the brand unique and standing out among the mass.
Sclerosing Epithelioid Fibrosarcoma (SEF) is a rare malignant fibroblastic neoplasm with typical presentation in the soft tissue, and with uncommon presentation in bone. Characterized by having ...comparable histopathology to other sarcomas, SEF has classically been difficult to diagnose. Classical hallmarks of SEF include MUC4 immunoreactivity and the presence of ESWR1-CREM3L1 fusion, as well as a dense sclerotic hyalinized stroma filled with epithelioid cells in various arrangements (cords, nests or trabeculae).
Typical presentation occurs in middle aged adults with a predilection for the lower extremities. SEF has a poor prognosis with high risk of metastasis and recurrence, as well as an aggressive clinical course. This case study presents primary SEF of the right mandible in a 13-year-old male. Due to the limited amount of case studies on primary SEF of the bone, we discuss diagnosis, histopathology, and treatment of the lesion to aid in formation of treatment protocol. The patient experienced pulmonary metastasis 9 months after wide excisional surgery and fibular free flap reconstruction of the right mandibular surgical site. More recently, he also experienced an episode of recurrence, which has complicated the restorative aspect of the treatment plan.
Due to the rarity of SEF, limited published research exists to help guide clinicians towards efficient and timely diagnoses and the need for adjunctive therapies in addition to wide excision. We hope this study helps add to current research and protocols.
Mana mātātuhi Witehira, Dr. Johnson
Visible language,
10/2021, Letnik:
53, Številka:
1
Journal Article
Recenzirano
This article follows the growth of written communication by Aotearoa New Zealand's indigenous Maori. The research focuses on nineteenth century developments, linking four significant areas of Maori ...writing--tuhi rerehua (calligraphy), tuhi motumotu (printing), tuhi waitohu (lettering), and tatai kupu toi (typography)--into a continuous whakapapa (genealogy) of what might be described as hoahoa whakairoiro Maori. Through a number of fascinating case studies, the research sheds light on the distinctive history of Maori lettering and typography. While some of these subjects have been explored separately within the literature of Maori cultural history, none have connected these practices into a definitive Maori tradition of creating and using letterforms for the purpose of visual communication. Importantly, this work also introduces a number of new kupu Maori relating to Maori visual communication design. For the indigenous Māori of Aotearoa New Zealand, written language remains a relatively new method for communicating and storing information.
The group A streptococcal C5a peptidase (SCPA) is a major surface virulence protein that facilitates the establishment of local infection by group A streptococci (GAS). We measured the human immune ...response to SCPA, using a standardized indirect enzyme-linked immunosorbent assay. Paired acute and convalescent serum samples from children with GAS-associated pharyngitis were assayed, and a strong immune response to SCPA was demonstrated that was independent of the infecting M type and the age of the patient. Western blot analysis of bacterial extracts revealed that all tested M types expressed SCPA. The immune response to SCPA correlated with the anti–streptolysin O and anti–DNase B responses. These data confirm the immunogenicity of SCPA in humans. Previous knowledge of SPCA’s role in virulence, its highly conserved nature, and the results of mouse protection studies make SCPA an ideal vaccine candidate for the prevention of GAS disease
Central xanthoma of the mandible in a 12-year-old boy Woo, Dr. Victoria; Ahmadian, Dr. Moni; Anagnost, Dr. Miran Rhee ...
Oral surgery, oral medicine, oral pathology and oral radiology,
20/May , Letnik:
133, Številka:
5
Journal Article
Recenzirano
Xanthomas are benign proliferations of lipid-laden macrophages that most often affect the skin and extensor ten- dons. The majority of lesions occur in the setting of systemic conditions associated ...with altered lipid metabolism, such as hyperlipidemia and diabetes mellitus. Intraosseous xanthomas are uncommon and can affect both the axial and appendicular skeleton. We describe a 12-year-old boy who presented with a large unilocular radiolucency of the right posterior mandible pericoronal to an impacted third molar. Intraoral examination revealed no mucosal abnormalities or evidence of cortical expansion. The lesion was completely enucleated and microscopic exami- nation showed a proliferation of large cells with abundant foamy to eosinophilic, granular cytoplasm, varying in distribution from loose sheets to compact clusters with minimal intervening fibrous connective tissue. The lesional cells demonstrated strong and diffuse reactivity with CD68, favoring a non-Langerhans cell histiocytic process and supporting a diagnosis of central xanthoma. Subsequent medical evaluation was negative for lipid abnormalities, endocrinopathies, and lipidoses. Gnathic xanthomas are exceedingly rare with less than 40 cases reported to date. Lesions have a strong predilection for the mandible and most frequently present as unilocular radiolucencies with no significant symptoms. Diagnosis can be challenging due to their nonspecific clinicoradiographic presentation and microscopic overlap with other histiocytic processes. Treatment consists of thorough curettage and recurrences are uncommon, especially in the absence of systemic manifestations. Although rare, recognition of this entity is of clinical interest as lesions that precede the diagnosis of a dyslipidemia or lipidosis may serve as a harbinger of un- derlying disease.
Contact-sports are known to have higher risk of orofacial injuries due to the bodily contact with other players or equipment. Kabaddi is a traditional contact-sport of India that has gained an ...international recognition. There is a paucity of data regarding prevalence of traumatic dental and orofacial injuries among the Kabaddi players. Hence this study aimed to assess the prevalence, distribution and pattern of orofacial injuries among the Kabaddi players of Delhi and NCR region.
This observational cross-sectional study was designed as per the best practices of epidemiology and reported as per the STROBE guidelines. The sample size was calculated as 440 and comprised of 10–18 years old players of either gender. Cluster random sampling was performed and the information was collected by one-calibrated evaluator by using a self-designed proforma. The injuries were classified as per standard criteria and the description of each episode was recorded. Statistical analysis was performed using the Statistical software-STATA-version-14(StataCorpLLC,Texas,USA).
Total of 393 players were included in the study (Males-295, Females-98) with majority of them between 15 and 18 years of age. The prevalence of traumatic episode was 49.11% and the prevalence orofacial-trauma was 44.02%.The frequency of extraoral-injuries was higher when compared to the intraoral injuries, with orbit(26.67%) being the commonest-site. Most of the players had not received adequate emergency treatment in the first incident which had improved in the second.
The prevalence of traumatic orofacial injuries in 10–18 years old Kabaddi players of Delhi-NCR region was found to be 44.02% while the prevalence of traumatic episodes was 49.11%. The prevalence of dental injuries was 5.1%. Majority of the players perceived that Kabaddi can lead to orofacial-injuries.
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