Objective
The aim of the study was to assess the performance and diagnostic value of a dual energy CT approach to reduce metal artefacts in subjects with metallic implants.
Methods
31 patients were ...examined in the area of their metallic implants using a dual energy CT protocol (filtered 140 kVp and 100 kVp spectrum, tube current relation: 3:1). Specific post-processing was applied to generate energies of standard 120 and 140 kVp spectra as well as a filtered 140 kVp spectrum with mean photon energies of 64, 69 and 88 keV, respectively, and an optimized hard spectrum of 95–150 keV. Image quality and diagnostic value were subjectively and objectively determined.
Results
Image quality was rated superior to the standard image in 29/31 high energy reconstructions; the diagnostic value was rated superior in 27 patients. Image quality and diagnostic value scores improved significantly from 3.5 to 2.1 and from 3.6 to 1.9, respectively. In several exams decisive diagnostic features were only discernible in the high energy reconstructions. The density of the artefacts decreased from −882 to −341 HU.
Conclusions
Dual Energy CT with specific postprocessing can reduce metal artefacts and may significantly enhance diagnostic value in the evaluation of metallic implants.
Over the past few decades, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, no reference standards currently exist to quantify individual ...differences in neuroimaging metrics over time, in contrast to growth charts for anthropometric traits such as height and weight
. Here we assemble an interactive open resource to benchmark brain morphology derived from any current or future sample of MRI data ( http://www.brainchart.io/ ). With the goal of basing these reference charts on the largest and most inclusive dataset available, acknowledging limitations due to known biases of MRI studies relative to the diversity of the global population, we aggregated 123,984 MRI scans, across more than 100 primary studies, from 101,457 human participants between 115 days post-conception to 100 years of age. MRI metrics were quantified by centile scores, relative to non-linear trajectories
of brain structural changes, and rates of change, over the lifespan. Brain charts identified previously unreported neurodevelopmental milestones
, showed high stability of individuals across longitudinal assessments, and demonstrated robustness to technical and methodological differences between primary studies. Centile scores showed increased heritability compared with non-centiled MRI phenotypes, and provided a standardized measure of atypical brain structure that revealed patterns of neuroanatomical variation across neurological and psychiatric disorders. In summary, brain charts are an essential step towards robust quantification of individual variation benchmarked to normative trajectories in multiple, commonly used neuroimaging phenotypes.
A pronounced, widespread and persistent regime shift among marine ecosystems is observable on temperate rocky reefs as a result of sea urchin overgrazing. Here, we empirically define regime-shift ...dynamics for this grazing system which transitions between productive macroalgal beds and impoverished urchin barrens. Catastrophic in nature, urchin overgrazing in a well-studied Australian system demonstrates a discontinuous regime shift, which is of particular management concern as recovery of desirable macroalgal beds requires reducing grazers to well below the initial threshold of overgrazing. Generality of this regime-shift dynamic is explored across 13 rocky reef systems (spanning 11 different regions from both hemispheres) by compiling available survey data (totalling 10 901 quadrats surveyed in situ) plus experimental regime-shift responses (observed during a total of 57 in situ manipulations). The emergent and globally coherent pattern shows urchin grazing to cause a discontinuous 'catastrophic' regime shift, with hysteresis effect of approximately one order of magnitude in urchin biomass between critical thresholds of overgrazing and recovery. Different life-history traits appear to create asymmetry in the pace of overgrazing versus recovery. Once shifted, strong feedback mechanisms provide resilience for each alternative state thus defining the catastrophic nature of this regime shift. Importantly, human-derived stressors can act to erode resilience of desirable macroalgal beds while strengthening resilience of urchin barrens, thus exacerbating the risk, spatial extent and irreversibility of an unwanted regime shift for marine ecosystems.
The aim of this study was to assess the feasibility of a differentiation of iodine from other materials and of different body tissues using dual energy CT. Ten patients were scanned on a SOMATOM ...Definition Dual Source CT (DSCT; Siemens, Forchheim, Germany) system in dual energy mode at tube voltages of 140 and 80 kVp and a ratio of 1:3 between tube currents. Weighted CT Dose Index ranged between 7 and 8 mGy, remaining markedly below reference dose values for the respective body regions. Image post-processing with three-material decomposition was applied to differentiate iodine or collagen from other tissue. The results showed that a differentiation and depiction of contrast material distribution is possible in the brain, the lung, the liver and the kidneys with or without the underlying tissue of the organ. In angiographies, bone structures can be removed from the dataset to ease the evaluation of the vessels. The differentiation of collagen makes it possible to depict tendons and ligaments. Dual energy CT offers a more specific tissue characterization in CT and can improve the assessment of vascular disease. Further studies are required to draw conclusions on the diagnostic value of the individual applications.
We present spectroscopic evidence for the creation of entangled macroscopic quantum states in two current-biased Josephson-junction qubits coupled by a capacitor. The individual junction bias ...currents are used to control the interaction between the qubits by tuning the energy level spacings of the junctions in and out of resonance with each other. Microwave spectroscopy in the 4 to 6 gigahertz range at 20 millikelvin reveals energy levels that agree well with theoretical results for entangled states. The single qubits are spatially separate, and the entangled states extend over the 0.7-millimeter distance between the two qubits.
We present constraints on extensions of the minimal cosmological models dominated by dark matter and dark energy, ΛCDM and wCDM, by using a combined analysis of galaxy clustering and weak ...gravitational lensing from the first-year data of the Dark Energy Survey (DES Y1) in combination with external data. We consider four extensions of the minimal dark energy-dominated scenarios: (1) nonzero curvature Ωk, (2) number of relativistic species Neff different from the standard value of 3.046, (3) time-varying equation-of-state of dark energy described by the parameters w0 and wa (alternatively quoted by the values at the pivot redshift, wp, and wa), and (4) modified gravity described by the parameters μ0 and Σ0 that modify the metric potentials. We also consider external information from Planck cosmic microwave background measurements; baryon acoustic oscillation measurements from SDSS, 6dF, and BOSS; redshift-space distortion measurements from BOSS; and type Ia supernova information from the Pantheon compilation of datasets. Constraints on curvature and the number of relativistic species are dominated by the external data; when these are combined with DES Y1, we find Ωk=0.0020−0.0032+0.0037 at the 68% confidence level, and the upper limit Neff<3.28(3.55) at 68% (95%) confidence, assuming a hard prior Neff>3.0. For the time-varying equation-of-state, we find the pivot value (wp,wa)=(−0.91−0.23+0.19,−0.57−1.11+0.93) at pivot redshift zp=0.27 from DES alone, and (wp,wa)=(−1.01−0.04+0.04,−0.28−0.48+0.37) at zp=0.20 from DES Y1 combined with external data; in either case we find no evidence for the temporal variation of the equation of state. For modified gravity, we find the present-day value of the relevant parameters to be Σ0=0.43−0.29+0.28 from DES Y1 alone, and (Σ0,μ0)=(0.06−0.07+0.08,−0.11−0.46+0.42) from DES Y1 combined with external data. These modified-gravity constraints are consistent with predictions from general relativity.
The survey description and the near-, mid-, and far-infrared flux properties are presented for the 258 galaxies in the Local Volume Legacy (LVL). LVL is a Spitzer Space Telescope legacy program that ...surveys the local universe out to 11 Mpc, built upon a foundation of ultraviolet, H Delta *a, and Hubble Space Telescope imaging from 11HUGS (11 Mpc H Delta *a and Ultraviolet Galaxy Survey) and ANGST (ACS Nearby Galaxy Survey Treasury). LVL covers an unbiased, representative, and statistically robust sample of nearby star-forming galaxies, exploiting the highest extragalactic spatial resolution achievable with Spitzer. As a result of its approximately volume-limited nature, LVL augments previous Spitzer observations of present-day galaxies with improved sampling of the low-luminosity galaxy population. The collection of LVL galaxies shows a large spread in mid-infrared colors, likely due to the conspicuous deficiency of 8 Delta *mm polycyclic aromatic hydrocarbon emission from low-metallicity, low-luminosity galaxies. Conversely, the far-infrared emission tightly tracks the total infrared emission, with a dispersion in their flux ratio of only 0.1 dex. In terms of the relation between the infrared-to-ultraviolet ratio and the ultraviolet spectral slope, the LVL sample shows redder colors and/or lower infrared-to-ultraviolet ratios than starburst galaxies, suggesting that reprocessing by dust is less important in the lower mass systems that dominate the LVL sample. Comparisons with theoretical models suggest that the amplitude of deviations from the relation found for starburst galaxies correlates with the age of the stellar populations that dominate the ultraviolet/optical luminosities.
Dual-energy CT: general principles Johnson, Thorsten R C
American journal of roentgenology (1976),
11/2012, Letnik:
199, Številka:
5 Suppl
Journal Article
Recenzirano
In dual-energy CT (DECT), two CT datasets are acquired with different x-ray spectra. These spectra are generated using different tube potentials, partially also with additional filtration at 140 kVp. ...Spectral information can also be resolved by layer detectors or quantum-counting detectors. Several technical approaches-that is, sequential acquisition, rapid voltage switching, dual-source CT (DSCT), layer detector, quantum-counting detector-offer different spectral contrast and dose efficiency. Various postprocessing algorithms readily provide clinically relevant spectral information.
DECT offers the possibility to exploit spectral information for diagnostic purposes. There are different technical approaches, all of which have inherent advantages and disadvantages, especially regarding spectral contrast and dose efficiency. There are numerous clinical applications of DECT that are easily accessible with specific postprocessing algorithms.
When combined with infrared observations with the Spitzer telescope (3 to 160 μm), the Herschel
Space Observatory now fully samples the thermal dust emission up to 500 μm and enables us to better ...estimate the total infrared-submm energy budget (L
TIR) of nearby galaxies. We present new empirical calibrations to estimate resolved and integrated total infrared luminosities from Spitzer and Herschel bands used as monochromatic or combined tracers. We base our calibrations on resolved elements of nearby galaxies (3 to 30 Mpc) observed with Herschel. We perform a resolved spectral energy distribution (SED) modelling of these objects using the Draine & Li dust models and investigate the influence of the addition of Spectral and Photometric Imaging Receiver (SPIRE) measurements in the estimation of L
TIR. We find that using data up to 250 μm leads to local L
TIR values consistent with those obtained with a complete coverage (up to 500 μm) within ±10 per cent for most of our resolved elements. We then study the distribution of energy in the resolved SEDs of our galaxies. The bulk of energy (30-50 per cent) is contained in the 70-160 μm band. The 24-70 μm fraction decreases with increasing metallicity. The 160-1100 μmsubmillimetre band can account for up to 25 per cent of the L
TIR in metal-rich galaxies. We investigate the correlation between the total infrared (TIR) surface brightnesses/luminosities and monochromatic Spitzer and Herschel surface brightnesses/luminosities. The three Photodetector Array Camera and Spectrometer (PACS) bands can be used as reliable monochromatic estimators of the L
TIR, the 100 μm band being the most reliable monochromatic tracer. There is also a strong correlation between the SPIRE 250 μm and L
TIR, although with more scatter than for the PACS relations. We also study the ability of our monochromatic relations to reproduce integrated L
TIR of nearby galaxies as well as L
TIR of z ∼ 1-3 sources. Finally, we provide calibration coefficients that can be used to derive TIR surface brightnesses/luminosities from a combination of Spitzer and Herschel surface brightnesses/fluxes and analyse the associated uncertainties.
To qualitatively and quantitatively compare virtual nonenhanced (VNE) data sets derived from dual-energy (DE) computed tomography (CT) with true nonenhanced (TNE) data sets in the same patients and ...to calculate potential radiation dose reductions for a dual-phase renal multidetector CT compared with a standard triple-phase protocol.
This prospective study was approved by the institutional review board; all patients provided written informed consent. Seventy one men (age range, 30-88 years) and 39 women (age range, 22-87 years) underwent preoperative DE CT that included unenhanced, DE nephrographic, and delayed phases. DE CT parameters were 80 and 140 kV, 96 mAs (effective). Collimation was 14 x 1.2 mm. CT numbers were measured in renal parenchyma and tumor, liver, aorta, and psoas muscle. Image noise was measured on TNE and VNE images. Exclusion of relevant anatomy with the 26-cm field of view detector was quantified with a five-point scale (0 = none, 4 = >75%). Image quality and noise (1 = none, 5 = severe) and acceptability for VNE and TNE images were rated. Effective radiation doses for DE CT and TNE images were calculated. Differences were tested with a Student t test for paired samples.
Mean CT numbers (+/- standard deviation) on TNE and VNE images, respectively, for renal parenchyma were 30.8 HU +/- 4.0 and 31.6 HU +/- 7.1, P = .29; liver, 55.8 HU +/- 8.6 and 57.8 HU +/- 10.1, P = .11; aorta, 42.1 HU +/- 4.1 and 43.0 HU +/- 8.8, P = .16; psoas, 47.3 HU +/- 5.6 and 48.1 HU +/- 9.3 HU, P = .38. No exclusion of the contralateral kidney was seen in 50 patients, less than 25% was seen in 43, 25%-50% was seen in 13, and 50%-75% was seen in four. Mean image noise was 1.71 +/- 0.71 for VNE and 1.22 +/- 0.45 for TNE (P < .001); image quality was 1.70 HU +/- 0.72 for VNE and 1.15 HU +/- 0.36 for TNE (P < .0001). In all but three patients radiologists accepted VNE images as replacement for TNE images. Mean effective dose for DE CT scans of the abdomen was 5.21 mSv +/- 1.86 and that for nonenhanced scans was 4.97 mSv +/- 1.43. Mean dose reduction by omitting the TNE scan was 35.05%.
In patients with renal masses, DE CT can provide high-quality VNE data sets, which are a reasonable approximation of TNE data sets. Integration of DE scanning into a renal mass protocol will lower radiation exposure by 35%.
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