Abstract
Observations of the Galactic Center supermassive black hole Sagittarius A* (Sgr A*) with very long-baseline interferometry (VLBI) are affected by interstellar scattering along our line of ...sight. At long radio observing wavelengths (≲1 cm), the scattering heavily dominates image morphology. At 3.5 mm (86 GHz), the intrinsic source structure is no longer sub-dominant to scattering, and thus the intrinsic emission from Sgr A* is resolvable with the Global Millimeter VLBI Array (GMVA). Long-baseline detections to the phased Atacama Large Millimeter/submillimeter Array (ALMA) in 2017 provided new constraints on the intrinsic and scattering properties of Sgr A*, but the stochastic nature of the scattering Requires multiple observing epochs to reliably estimate its statistical properties. We present new observations with the GMVA+ALMA, taken in 2018, which confirm non-Gaussian structure in the scattered image seen in 2017. In particular, the ALMA–GBT baseline shows more flux density than expected for an anistropic Gaussian model, providing a tight constraint on the source size and an upper limit on the dissipation scale of interstellar turbulence. We find an intrinsic source extent along the minor axis of ∼100
μ
as both via extrapolation of longer wavelength scattering constraints and direct modeling of the 3.5 mm observations. Simultaneously fitting for the scattering parameters, we find an at-most modestly asymmetrical (major-to-minor axis ratio of 1.5 ± 0.2) intrinsic source morphology for Sgr A*.
Making sense of rapidly evolving evidence on genetic associations is crucial to making genuine advances in human genomics and the eventual integration of this information in the practice of medicine ...and public health. Assessment of the strengths and weaknesses of this evidence, and hence the ability to synthesize it, has been limited by inadequate reporting of results. The STrengthening the REporting of Genetic Association studies (STREGA) initiative builds on the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement and provides additions to 12 of the 22 items on the STROBE checklist. The additions concern population stratification, genotyping errors, modeling haplotype variation, Hardy-Weinberg equilibrium, replication, selection of participants, rationale for choice of genes and variants, treatment effects in studying quantitative traits, statistical methods, relatedness, reporting of descriptive and outcome data, and the volume of data issues that are important to consider in genetic association studies. The STREGA recommendations do not prescribe or dictate how a genetic association study should be designed but seek to enhance the transparency of its reporting, regardless of choices made during design, conduct, or analysis.
Few studies have investigated the association between the full range of birth weight and the risk of childhood obesity in high-, middle- and low-income countries. The aim of the present study is to ...assess the association between different levels of birth weight and the risk of obesity among children aged 9-11 years in 12 countries.
A multinational, cross-sectional study of 5141 children aged 9-11 years was conducted in 12 countries. Height and weight were obtained using standardized methods. Time spent in moderate-to-vigorous physical activity (MVPA), sedentary and sleeping were objectively measured using 24-h, waist-worn accelerometer (Actigraph GT3X+) monitored for 7 days. Birth weight and other factors (regions, parental education, maternal history of gestational diabetes, children age, gender, breast feeding, gestational age, unhealthy diet scores and healthy diet scores) were collected by parental and children's questionnaires. Multilevel modeling was used to account for the nested nature of the data.
The overall prevalence of obesity (BMI z-score>+2 s.d.) was 15.4% for boys and 10.0% for girls. There was a positive association between birth weight and BMI z-scores. The multivariable-adjusted odds ratios (ORs) of childhood obesity were significantly higher among children whose birth weights were 3500-3999 g (OR 1.45; 95% confidence interval (CI): 1.10-1.92), and >4000 g (OR 2.08; 95% CI: 1.47-2.93), compared with the reference group (2500-2999 g). The positive association between birth weight and the odds of childhood obesity was seen in girls, whereas a U-shaped association appeared in boys.
High levels of birth weight, defined as birth weight ⩾3500 g, were associated with increased odds of obesity among 9-11-year-old children in 12 countries. However, sex differences in the association between birth weight and the risk of obesity need to be considered when planning interventions to reduce childhood obesity.
We explore the oft-repeated claim that river water quality in Great Britain is “better now than at any time since the Industrial Revolution”. We review available data and ancillary evidence for seven ...different categories of water pollutants: (i) biochemical oxygen demand (BOD) and ammonia; (ii) heavy metals; (iii) sewage-associated organic pollutants (including hormone-like substances, personal care product and pharmaceutical compounds); (iv) macronutrients (nitrogen and phosphorus); (v) pesticides; (vi) acid deposition and (vii) other variables, including natural organic matter and pathogenic micro-organisms. With a few exceptions, observed data are scarce before 1970. However, we can speculate about some of the major water quality pressures which have existed before that. Point-source pollutants are likely to have increased with population growth, increased connection rates to sewerage and industrialisation, although the increased provision of wastewater treatment during the 20th century will have mitigated this to some extent. From 1940 to the 1990s, pressures from nutrients and pesticides associated with agricultural intensification have increased in many areas. In parallel, there was an increase in synthetic organic compounds with a “down-the-drain” disposal pathway. The 1990s saw general reductions in mean concentrations of metals, BOD and ammonia (driven by the EU Urban Waste Water Treatment Directive), a levelling out of nitrate concentrations (driven by the EU Nitrate Directive), a decrease in phosphate loads from both point-and diffuse-sources and some recovery from catchment acidification. The current picture is mixed: water quality in many rivers downstream of urban centres has improved in sanitary terms but not with respect to emerging contaminants, while river quality in catchments with intensive agriculture is likely to remain worse now than before the 1960s. Water quality is still unacceptably poor in some water bodies. This is often a consequence of multiple stressors which need to be better-identified and prioritised to enable continued recovery.
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•Water quality in British rivers has changed substantially since the industrial revolution.•Between 1760 and 1940 point-source pressures are likely to have increased.•From 1940 pressures from nutrients and pesticides have increased in many areas.•The current picture is mixed: urban quality has improved, rural quality has declined.•Diffuse-source pollution and novel pollutants remain as significant water quality threats.
Micronized Cu (μ-Cu) is used as a wood preservative, replacing toxic chromated copper arsenate (CCA). Micronized Cu is malachite Cu2CO3(OH)2 that has been milled to micron/submicron particles, with ...many particle diameters less than 100 nm, mixed with biocides and then used to treat wood. In addition to concerns about the fate of the Cu from μ-Cu, there is interest in the fate of the nano-Cu (n-Cu) constituents. We examined movement of Cu from μ-Cu-treated wood after placing treated-wood stakes into model wetland ecosystems. Release of Cu into surface and subsurface water was monitored. Surface water Cu reached maximum levels 3 days after stake installation and remained elevated if the systems remained inundated. Subsurface water Cu levels were 10% of surface water levels at day 3 and increased gradually thereafter. Sequential filtering indicated that a large portion of the Cu in solution was associating with soluble organics, but there was no evidence for n-Cu in solution. After 4 months, Cu in thin-sections of treated wood and adjacent soil were characterized with micro X-ray absorption fine structure spectroscopy (μ-XAFS). Localization and speciation of Cu in the wood and adjacent soil using μ-XAFS clearly indicated that Cu concentrations decreased over time in the treated wood and increased in the adjacent soil. However, n-Cu from the treated wood was not found in the adjacent soil or plant roots. The results of this study indicate that Cu in the μ-Cu-treated wood dissolves and migrates into adjacent soil and waters primarily in ionic form (i.e., Cu2+) and not as nano-sized Cu particles. A reduced form of Cu (Cu2S) was identified in deep soil proximal to the treated wood, indicating strong reducing conditions. The formation of the insoluble Cu2S effectively removes some portion of dissolved Cu from solution, reducing movement of Cu2+ to the water column and diminishing exposure.
Schematic depiction of wood stake placement in wetland mesocosm followed by undisturbed core sampling and preparation of wood:soil thin sections for investigation at the Advanced Photon Source (Argonne National Laboratory). Bottom section shows X–Y Cu chemistry map across wood and soil interface. Color legend refers to the relative Cu concentration observed by XAS. Display omitted
•Micronized Malachite replaces chromated copper arsenate as a wood preservative.•The concern is that nano-sized Malachite may escape from treated-wood.•Malachite treated wood in wetland mesocosms released Cu2+ to soil and water.•Wetland soil Cu speciation showed Cu(II and I) organics, Cu on Fe oxides, and Cu2S.•No evidence of nano-sized Malachite Cu2CO3(OH)2 escapement was found.
Acoustic exposure and behavior of 8 sperm whales were recorded with acoustic and movement-recording tags before, during and after 5 separate 1–2
h controlled sound exposures of industry-provided ...airgun arrays. None of the 8 whales changed behavioral state (7 foraging, 1 resting) following the start of ramp-up at distances of 7–13
km, or full array exposures at 1–13
km. The most closely approached whale rested throughout exposure but started a foraging dive shortly after the airguns ceased, possibly indicating a delay in foraging during exposure. Using visual tracking and dead-reckoning of tagged animals, we found that their direction-of-movement was random with respect to the airguns, but correlated with their direction-of-movement just prior to the start of exposure, indicating that the tested whales did not show horizontal avoidance of the airguns. Oscillations in pitch generated by swimming movements during foraging dives were on average 6% lower during exposure than during the immediately following post-exposure period, with all 7 foraging whales exhibiting less pitching (
p=0.014). Buzz rates, a proxy for attempts to capture prey, were 19% lower during exposure but given natural variation in buzz rates and the small numbers of whales, this effect was not statistically significant (
P=0.141). Though additional studies are strongly recommended, these initial results indicate that sperm whales in the highly exposed Gulf of Mexico habitat do not exhibit avoidance reactions to airguns, but suggest they are affected at ranges well beyond those currently regulated due to more subtle effects on their foraging behavior.
We present constraints on the annihilation cross section of weakly interacting massive particles dark matter based on the joint statistical analysis of four dwarf galaxies with VERITAS. These results ...are derived from an optimized photon weighting statistical technique that improves on standard imaging atmospheric Cherenkov telescope (IACT) analyses by utilizing the spectral and spatial properties of individual photon events. We report on the results of ∼230 hours of observations of five dwarf galaxies and the joint statistical analysis of four of the dwarf galaxies. We find no evidence of gamma-ray emission from any individual dwarf nor in the joint analysis. The derived upper limit on the dark matter annihilation cross section from the joint analysis is 1.35×10−23 cm3 s−1 at 1 TeV for the bottom quark (bb¯) final state, 2.85×10−24 cm3 s−1 at 1 TeV for the tau lepton (τ+τ−) final state and 1.32×10−25 cm3 s−1 at 1 TeV for the gauge boson (γγ) final state.
Given their sheer cumulative biomass and ubiquitous presence, parasites are increasingly recognized as essential components of most food webs. Beyond their influence as consumers of host tissue, many ...parasites also have free-living infectious stages that may be ingested by non-host organisms, with implications for energy and nutrient transfer, as well as for pathogen transmission and infectious disease dynamics. This has been particularly well-documented for the cercaria free-living stage of digenean trematode parasites within the Phylum Platyhelminthes. Here, we aim to synthesize the current state of knowledge regarding cercariae consumption by examining: (a) approaches for studying cercariae consumption; (b) the range of consumers and trematode prey documented thus far; (c) factors influencing the likelihood of cercariae consumption; (d) consequences of cercariae consumption for individual predators (e.g. their viability as a food source); and (e) implications of cercariae consumption for entire communities and ecosystems (e.g. transmission, nutrient cycling and influences on other prey). We detected 121 unique consumer-by-cercaria combinations that spanned 60 species of consumer and 35 trematode species. Meaningful reductions in transmission were seen for 31 of 36 combinations that considered this; however, separate studies with the same cercaria and consumer sometimes showed different results. Along with addressing knowledge gaps and suggesting future research directions, we highlight how the conceptual and empirical approaches discussed here for consumption of cercariae are relevant for the infectious stages of other parasites and pathogens, illustrating the use of cercariae as a model system to help advance our knowledge regarding the general importance of parasite consumption.
Bacterial meningitis remains a major cause of morbidity and mortality in young infants. Understanding the epidemiology and burden of disease is important.
Prospective, enhanced, national ...population-based active surveillance was undertaken to determine the incidence, etiology, and outcome of bacterial meningitis in infants aged <90 days in the United Kingdom and Ireland.
During July 2010-July 2011, 364 cases were identified (annual incidence, 0.38/1000 live births; 95% confidence interval CI, .35-.42). In England and Wales, the incidence of confirmed neonatal bacterial meningitis was 0.21 (n = 167; 95% CI, .18-.25). A total of 302 bacteria were isolated in 298 (82%) of the cases. The pathogens responsible varied by route of admission, gestation at birth, and age at infection. Group B Streptococcus (GBS) (150/302 50%; incidence, 0.16/1000 live births; 95% CI, .13-.18) and Escherichia coli (41/302 14%; incidence, 0.04/1000; 95% CI, .03-.06) were responsible for approximately two-thirds of identified bacteria. Pneumococcal (28/302 9%) and meningococcal (23/302 8%) meningitis were rare in the first month, whereas Listeria meningitis was seen only in the first month of life (11/302 4%). In hospitalized preterm infants, the etiology of both early- and late-onset meningitis was more varied. Overall case fatality was 8% (25/329) and was higher for pneumococcal meningitis (5/26 19%) than GBS meningitis (7/135 5%; P = .04) and for preterm (15/90 17%) compared with term (10/235 4%; P = .0002) infants.
The incidence of bacterial meningitis in young infants remains unchanged since the 1980s and is associated with significant case fatality. Prevention strategies and guidelines to improve the early management of cases should be prioritized.
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