Understanding the plant immune system is crucial for using genetics to protect crops from diseases. Plants resist pathogens via a two-tiered innate immune detection-and-response system. The first ...plant Resistance (R) gene was cloned in 1992 . Since then, many cell-surface pattern recognition receptors (PRRs) have been identified, and R genes that encode intracellular nucleotide-binding leucine-rich repeat receptors (NLRs) have been cloned. Here, we provide a list of characterized PRRs and NLRs. In addition to immune receptors, many components of immune signaling networks were discovered over the last 30 years. We review the signaling pathways, physiological responses, and molecular regulation of both PRR- and NLR-mediated immunity. Recent studies have reinforced the importance of interactions between the two immune systems. We provide an overview of interactions between PRR- and NLR-mediated immunity, highlighting challenges and perspectives for future research.
The transverse mass spectra of K0s, Lambda, Xi and Omega particles produced in Pb-Pb collisions at 40 A GeV/c have been studied for a sample of events corresponding to the most central 53% of the ...inelastic Pb-Pb cross-section. We analyze the distributions in the framework of a parameterized model inspired by hydrodynamics. The dependence of the freeze-out parameters on particle species and event centrality is discussed and comparisons with results at higher energy are shown.
The excitation of modes in the toroidal Alfvén eigenmodes (TAE) gap by an external antenna can be modelled by a driven damped harmonic oscillator. By performing a frequency scan it is possible to ...determine the damping rate of the mode through the quality factor. This method has been employed in recent Joint European Torus (JET) experiments dedicated to scenario development for the observation of alpha-driven instabilities in JET DT plasmas (i.e. plasmas composed by Deuterium and Tritium). However, the toroidal mode number n of the mode for which the measurements were performed could not be determined experimentally. The value of the damping obtained through experimental measurements for a selected time slice is then compared with those obtained from calculations performed by numerical codes for different modes with frequencies close to the experimental frequency of the antenna. This paper describes the modelling method and presents the numerical simulations carried out using a suite of codes to calculate the damping of TAE, which are compared with the value measured experimentally. The radial structures of these modes are first calculated with the ideal magnetohydrodynamic (MHD) code MISHKA. For each of these modes, the damping on thermal ions and thermal electrons and the contribution to the mode growth rate resulting from the resonant interaction with the ion cyclotron resonance heating (ICRH) accelerated ion population are calculated using the drift-kinetic code CASTOR-K. The radiative damping is calculated by using a complex resistivity in the resistive MHD code CASTOR code and the continuum damping is estimated using also the CASTOR code through the standard method of making the real part of the resistivity tend to zero. It was found the radiative damping is largely dominant over all other effects, except for the n = 3 TAE. The overall damping calculated numerically is consistent with the damping measured experimentally.
To evaluate renal effects of carprofen in healthy dogs following general anesthesia.
Randomized clinical trial.
10 English hound dogs (6 females and 4 males).
Dogs were randomly assigned to control ...(n = 5) or carprofen (5) groups. Anesthesia was induced with propofol (6 to 8 mg/kg 2.7 to 3.6 mg/lb of body weight, i.v.) and maintained with isoflurane (end-tidal concentration, 2.0%). Each dog underwent two 60-minute anesthetic episodes with 1 week between episodes, and mean arterial blood pressure was maintained between 60 and 90 mm Hg during each episode. Dogs in the carprofen group received carprofen (2.2 mg/kg 1 mg/lb, p.o.) at 9:00 AM and 6:00 PM the day before and at 7:00 AM the day of the second anesthetic episode. Glomerular filtration rates (GFR) were determined during each anesthetic episode by use of renal scintigraphy. Serum creatinine and BUN concentrations and the urine gamma-glutamyltransferase-to-creatinine concentration (urine GGT:creatinine) ratio were determined daily for 2 days before and 5 days after general anesthesia.
Significant differences were not detected in BUN and serum creatinine concentrations, urine GGT:creatinine ratio, and GFR either between or within treatment groups over time.
Carprofen did not significantly alter renal function in healthy dogs anesthetized with propofol and isoflurane. These results suggest that carprofen may be safe to use for preemptive perioperative analgesia, provided that normal cardiorespiratory function is maintained.
From December, 1997, through November, 2000, 306 deaths were documented among adult and subadult American alligators (Alligator mississippiensis) of Lake Griffin, Florida (USA). Some live alligators ...were lethargic and unresponsive to approach. To determine the cause, we examined ten alligators captured from Lake Griffin between December 1997 and June 1999. Initially, four alligators, three of which were clinically unresponsive, were sacrificed for routine diagnostic necropsy. The other six Lake Griffin alligators, and five control alligators captured from Lake Woodruff National Wildlife Refuge, Florida, where mortality was negligible, were studied extensively by clinical neurologic examination, electromyography, hematology, serum chemical analyses, and blood culture, then sacrificed and necropsied. Samples of brain, spinal cord, peripheral nerves, skeletal muscle, and major internal organs were examined by light microscopy for abnormalities. Samples of nervous tissue also were examined by electron microscopy, and samples of various tissues were collected for toxicologic analyses. Clinical signs included swimming in circles, inability to submerge, lethargy, weakness, unresponsiveness, slow reflexes, dragging the dorsal surfaces of the hind feet, head tilt, and anisocoria. Lake Griffin alligators had significantly lower distal sciatic nerve conduction velocities than Lake Woodruff alligators, and the most severely affected alligators had the lowest velocities; but morphologic abnormalities in peripheral nerves were not evident in most cases. Three severely affected alligators had acute focal necrosis of the torus semicircularis in the midbrain, two had skeletal myofiber atrophy, another had diffuse nonsuppurative encephalomyelitis, and one mildly affected alligator had skeletal myodegeneration. The cause or causes have not yet been identified.
Objective: To determine the relative contribution of work-related mechanical (injury) factors and psychosocial factors to the onset of a new episode of knee pain, in a cohort of newly employed ...workers. Methods: A prospective cohort study of newly employed workers from 12 diverse occupational settings in England (The New Workers Study). 859 newly employed workers, free of knee pain, were identified. Information about occupational mechanical factors (manual handling and postural activities), the occupational physical environment, and psychological and psychosocial factors was collected by self-completion questionnaires. Participants were followed up after 12 and 24 months to identify cases of knee pain onset. Generalised estimating equations were used to estimate the risk of new-onset knee pain, with respect to the exposures previously measured. Results: In total, over the 2-year follow-up period, 108 cases of new-onset knee pain were observed. Mechanical load, postural factors, psychological distress and work-place psychosocial factors all influenced the risk of new-onset knee pain over the 2-year follow-up period. On multivariate analysis, two factors remained independently predictive of knee pain onset: lifting or carrying heavy weights in one hand, and the level of general psychological distress. Conclusion: In addition to mechanical (injury) factors, psychological factors are important risk factors for knee pain onset as shown in a population of young newly employed workers.
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