Genetic analysis of endometriotic lesions from 39 patients revealed mutations in cancer driver genes in 26%. In some patients, the same mutation was present in lesions from different sites. The role ...of mutations in cancer-associated genes in endometriosis needs further study.
Endometriosis is a relatively common disease, affecting up to 10% of women of reproductive age.
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Its incidence is as high as 50% among adolescents with pelvic pain.
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Clinical symptoms include dysmenorrhea, pelvic pain, and infertility.
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Endometriotic lesions are considered to be benign (nonmalignant or nonneoplastic), inflammatory, estrogen-dependent lesions that are characterized by the ectopic presence of normal-appearing, functional endometrial tissue composed of glands and stroma outside of the uterus.
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The disease is often associated with multiple lesions that can be distributed throughout the abdominal–pelvic peritoneum and visceral organs.
There are three anatomical subtypes of endometriosis: superficial . . .
People variably respond to global change in their beliefs, behaviors, and grief (associated with losses incurred). People that are less likely to believe in climate change, adopt pro-environmental ...behaviors, or report ecological grief are assumed to have different psycho-cultural orientations, and do not perceive changes in environmental condition or any impact upon themselves. We test these assumptions within the context of the Great Barrier Reef (GBR), a region currently experiencing significant climate change impacts in the form of coral reef bleaching and increasingly severe cyclones. We develop knowledge of environmental cultural services with the Environmental Schwartz Value Survey (ESVS) into four human value orientations that can explain individuals' environmental beliefs and behaviors: biospheric (i.e., concern for environment), altruistic (i.e., concern for others, and intrinsic values), egoistic (i.e., concern for personal resources) and hedonic values (i.e., concern for pleasure, comfort, esthetic, and spirituality). Using face-to-face quantitative survey techniques, where 1,934 residents were asked to agree or disagree with a range of statements on a scale of 1-10, we investigate people's (i) environmental values and value orientations, (ii) perceptions of environmental condition, and (iii) perceptions of impact on self. We show how they relate to the following climate change responses; (i) beliefs at a global and local scale, (ii) participation in pro-environmental behaviors, and (iii) levels of grief associated with ecological change, as measured by respective single survey questions. Results suggest that biospheric and altruistic values influenced all climate change responses. Egoistic values were only influential on grief responses. Perception of environmental change was important in influencing beliefs and grief, and perceptions of impact on self were only important in influencing beliefs. These results suggest that environmental managers could use people's environmental value orientations to more effectively influence climate change responses toward environmental stewardship and sustainability. Communications that target or encourage altruism (through understanding and empathy), biospherism (through information on climate change impacts on the environment), and egoism (through emphasizing the benefits, health and wellbeing derived from a natural resource in good condition), could work.
About 25% of young adults with ALL have Ph-like genotypes, which are associated with poor outcomes with conventional treatment. In this gene-expression study, a substantial fraction of Ph-like ALL ...cases were found to involve activation of kinases targeted by available agents.
Abstract
We report the discovery of K2-232 b using photometric data of the Kepler K2 satellite coupled with ground-based spectroscopic observations. K2-232 b has a mass of MP = 0.397 ± 0.037 MJ, a ...radius of RP = 1.00 ± 0.020 RJ, and a moderately low equilibrium temperature of Teq = 1030 ± 15 K due to its relatively large star–planet separation of a = 0.1036 au. K2-232 b orbits its bright (V = 9.9) late F-type host star in an eccentric orbit (e = 0.258 ± 0.025) every 11.2 d, and is one of only four well-characterized warm Jupiters having host stars brighter than V = 10. We estimate a heavy element content of 20 ± 7 M⊕ for K2-232 b, which is consistent with standard models of giant planet formation. The bright host star of K2-232 b makes this system a well-suited target for detailed follow-up observations that will aid in the study of the atmospheres and orbital evolution of giant planets at moderate separations from their host stars.
Marine microorganisms make a meal of oil Head, Ian M; Jones, D. Martin; Röling, Wilfred F. M
Nature reviews. Microbiology,
03/2006, Letnik:
4, Številka:
3
Journal Article
Recenzirano
Hundreds of millions of litres of petroleum enter the environment from both natural and anthropogenic sources every year. The input from natural marine oil seeps alone would be enough to cover all of ...the world's oceans in a layer of oil 20 molecules thick. That the globe is not swamped with oil is testament to the efficiency and versatility of the networks of microorganisms that degrade hydrocarbons, some of which have recently begun to reveal the secrets of when and how they exploit hydrocarbons as a source of carbon and energy.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Predation is a key ecological process regulating the structure and diversity of biological communities, yet predators do not exist homogeneously in nature. Coral reefs possess diverse assemblages of ...predatory fishes, the distribution and abundance of which is well documented for coastal and emergent reefs. However, for remote, isolated and submerged reefs, such as those found on pinnacles and seamounts, our understanding of predatory fish communities is limited. These features are ubiquitous in the world’s oceans and frequently targeted by fishers for their presumed fish aggregation properties. Here we describe communities of predatory fishes on a series of pinnacle reefs and contrast these to regional coastal and offshore emergent reefs. Pinnacles supported 2-4× higher abundance, biomass and diversity of predatory fishes compared to emergent reefs. They also supported unique communities, with 32 out of the 63 predator species in our study found only on pinnacle reefs. For species found on all 3 reef types, all were most abundant on pinnacles and the 6 taxa driving differences in community structure were most abundant on pinnacles. Together, our results show that predatory fishes are strongly attracted to pinnacles, although the mechanisms are still unclear. Prioritising the selection of these small ecological magnets in conservation planning would be an effective approach to target the protection of regional reef fish biodiversity.
Field monitoring of groundwater contamination plumes is an important component of managing risks for downgradient receptors and remedial strategies that rely on monitored natural attenuation. ...Collection of groundwater quality data can however take a considerable effort and be associated with high cost. Here, we investigated the relative merits of analyzing groundwater quality data using spatial compared to spatiotemporal statistical modelling and assessed the accuracy of both methods and implications for data collection requirements. The aim of this was to determine whether the quantity of data collected can be reduced, while retaining the same level of estimation accuracy, by analyzing groundwater contamination data using a spatiotemporal model which “borrows strength” across time, rather than a spatial model for individual sampling events. To capture the variability encountered under field conditions, we used three hypothetical groundwater contamination plumes with increasing complexity, and site data for a large groundwater gasoline additive plume. The results show that spatiotemporal methods can increase efficiency markedly so that, in comparison with repeated spatial analysis, spatiotemporal methods can achieve the same level of performance but with smaller sample sizes.
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•Target current industrial practice of using repeated spatial analyses•Spatiotemporal modelling methods result in clearer more accurate plume estimations.•Kriging and spline models are compared on real and hypothetical plumes.•Significantly smaller sample sizes can be used while retaining estimation accuracy.
Context. More than 50 exoplanets have been found around giant stars, revealing different properties when compared to planets orbiting solar-type stars. In particular, they are super-Jupiters and are ...not found orbiting interior to ~0.5 AU. Aims. We are conducting a radial velocity study of a sample of 166 giant stars aimed at studying the population of close-in planets orbiting giant stars and how their orbital and physical properties are influenced by the post-MS evolution of the host star. Methods. We have collected multiepoch spectra for all of the targets in our sample. We have computed precision radial velocities from FECH/CHIRON and FEROS spectra, using the I2 cell technique and the simultaneous calibration method, respectively. Results. We present the discovery of a massive planet around the giant star HIP 105854. The best Keplerian fit to the data leads to an orbital distance of 0.81 ± 0.03 AU, an eccentricity of 0.02 ± 0.03 and a projected mass of 8.2 ± 0.2 MJ. With the addition of this new planet discovery, we performed a detailed analysis of the orbital properties and mass distribution of the planets orbiting giant stars. We show that there is an overabundance of planets around giant stars with a ~ 0.5 − 0.9 AU, which might be attributed to tidal decay. Additionally, these planets are significantly more massive than those around MS and subgiant stars, suggesting that they grow via accretion either from the stellar wind or by mass transfer from the host star. Finally, we show that planets around evolved stars have lower orbital eccentricities than those orbiting solar-type stars, which suggests that they are either formed in different conditions or that their orbits are efficiently circularized by interactions with the host star.
ABSTRACT We report the detection of two new planets orbiting the K giants HD 86950 and HD 222076, based on precise radial velocities obtained with three instruments: AAT/UCLES, FEROS, and CHIRON. HD ...86950b has a period of 1270 57 days at au, and m sin . HD 222076b has days at au, and m sin . These two giant planets are typical of the population of planets known to orbit evolved stars. In addition, we find a high-amplitude periodic velocity signal ( m s−1) in HD 29399 and show that it is due to stellar variability rather than Keplerian reflex motion. We also investigate the relation between planet occurrence and host-star metallicity for the 164-star Pan-Pacific Planet Search (PPPS) sample of evolved stars. In spite of the small sample of PPPS detections, we confirm the trend of increasing planet occurrence as a function of metallicity found by other studies of planets orbiting evolved stars.
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