The adult high-grade B-cell lymphomas sharing molecular features with Burkitt lymphoma (BL) are highly aggressive lymphomas with poor clinical outcome. High-resolution structural and functional ...genomic analysis of adult Burkitt lymphoma (BL) and high-grade B-cell lymphoma with BL gene signature (adult-molecularly defined BL mBL) revealed the MYC-ARF-p53 axis as the primary deregulated pathway. Adult-mBL had either unique or more frequent genomic aberrations (del13q14, del17p, gain8q24, and gain18q21) compared with pediatric-mBL, but shared commonly mutated genes. Mutations in genes promoting the tonic B-cell receptor (BCR)→PI3K pathway (TCF3 and ID3) did not differ by age, whereas effectors of chronic BCR→NF-κB signaling were associated with adult-mBL. A subset of adult-mBL had BCL2 translocation and mutation and elevated BCL2 mRNA and protein expression, but had a mutation profile similar to mBL. These double-hit lymphomas may have arisen from a tumor precursor that acquired both BCL2 and MYC translocations and/or KMT2D (MLL2) mutation. Gain/amplification of MIR17HG and its paralogue loci was observed in 50% of adult-mBL. In vitro studies suggested miR-17∼92's role in constitutive activation of BCR signaling and sensitivity to ibrutinib. Overall integrative analysis identified an interrelated gene network affected by copy number and mutation, leading to disruption of the p53 pathway and the BCR→PI3K or NF-κB activation, which can be further exploited in vivo by small-molecule inhibitors for effective therapy in adult-mBL.
•Adult-mBLs have distinct and more frequent DNA copy number abnormalities compared with pediatric-mBL.•Comprehensive genomic analysis revealed that the BCR signaling pathway is a potential therapeutic target in adult-mBL.
We present measurements of partial branching fractions of inclusive semileptonic B → Xuℓ+ νℓ decays using the full Belle dataset of 711 fb−1 of integrated luminosity at the Υ(4S) resonance and for ℓ ...= e, μ. Inclusive semileptonic B → Xuℓ+ νℓ decays are Cabibbo-Kobayashi-Maskawa (CKM) suppressed and measurements are complicated by the large background from CKM favored B → Xcℓ+ νℓ transitions, which have a similar signature. Using machine learning techniques, we reduce this and other backgrounds effectively, while retaining access to a large fraction of the B → Xuℓ+νℓ phase space and high signal efficiency. We measure partial branching fractions in three phase-space regions covering about 31% to 86% of the accessible B → Xuℓ+νℓ phase space. The most inclusive measurement corresponds to the phase space with lepton energies of EBℓ > 1 GeV, and we obtain ΔB ( B → Xuℓ+νℓ) = (1.59 ± 0.07 ± 0.16) × 10−3 from a two-dimensional fit of the hadronic mass spectrum and the four-momentum-transfer squared distribution, with the uncertainties denoting the statistical and systematic error. We find |Vub| = (4.10 ± 0.09 ± 0.22 ± 0.15) × 10−3 from an average of four calculations for the partial decay rate with the third uncertainty denoting the average theory error. This value is higher but compatible with the determination from exclusive semileptonic decays within 1.3 standard deviations. In addition, we report charmless inclusive partial branching fractions separately for B + and B 0 mesons as well as for electron and muon final states. No isospin breaking or lepton flavor universality violating effects are observed.
Based on a data sample of 983 fb$^{-1}$ collected with the Belle detector at
the KEKB asymmetric-energy $e^+e^-$ collider, we present the study of the
heavy-flavor-conserving decay $\Xi_{c}^{0}\to ...\Lambda_{c}^{+}\pi^{-}$ with
$\Lambda_{c}^{+}$ reconstructed via its $pK^{-} \pi^{+}$ decay mode. The
branching fraction ratio $\mathcal{B}(\Xi_{c}^{0}\to
\Lambda_{c}^{+}\pi^{-})/\mathcal{B}(\Xi_{c}^{0}\to \Xi^{-}\pi^{+})$ is measured
to be $0.38 \pm 0.04 \pm 0.04$. Combing with the world average value of
$\mathcal{B}(\Xi_{c}^{0}\to \Xi^{-}\pi^{+})$, the branching fraction
$\mathcal{B}(\Xi_{c}^{0}\to \Lambda_{c}^{+}\pi^{-})$ is deduced to be $(0.54
\pm 0.05 \pm 0.05 \pm 0.12)\%$. Here, the uncertainties above are statistical,
systematic, and from $\mathcal{B}(\Xi_c^{0} \to \Xi^{-}\pi^{+})$, respectively.
The somatosensory evoked potentials (SEPs), following stimulation of both the posterior tibial nerve (PTSEP) and pudendal nerve (PNSEP), comprise of the lumbar negative, subcortical and cortical ...potential. These can be used to assess the long somatosensory pathway, including peripheral, intraspinal and intracranial conduction along the entire length. This study aimed to compare the central conduction time between the PTSEP and the PNSEP, and to investigate the relationship between the intraspinal and intracranial conduction time in the SEP pathway. The SEPs following stimulation of the posterior tibial nerve at the ankle and the pudendal nerve at the shaft of the penis were analyzed in 20 normal male subjects. The central conduction of the PNSEP was found to be slower than that of the PTSEP (p <0.05). This difference is due to a delay in conduction rather than that of intracranial conduction.
The DC conductivity (
σ
DC) of poly(3,4-ethylenedioxythiophene) (PEDOT) doped with poly(4-styrenesulfonate) (PSS) with various organic solvents was measured. The solvents used were dimethyl sulfoxide ...(DMSO),
N,
N-dimethyl formamide (DMF), tetrahydrofuran (THF), and H
2O (as pristine solvent). Room temperature DC conductivity
σ
DC(RT) of a free standing film of PEDOT/PSS with H
2O was measured to be ∼0.8
S/cm. Through a change of solvents used,
σ
DC(RT) of the samples increases from ∼0.8 to ∼80
S/cm. The temperature dependence of DC conductivity
σ
DC(
T) of PEDOT/PSS with H
2O followed a quasi one-dimensional variable range hopping model, while that of PEDOT/PSS prepared from DMSO, DMF, and THF followed a power law (
σ
DC ∝
T
β
). From X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and electron paramagnetic resonance (EPR) experiments, the doping concentration of the systems with different solvents was approximately the same. We analyzed that the screening effect of the solvent plays an important role for the variation of
σ
DC of the PEDOT/PSS systems.
Recent findings have indicated that insulin-like growth factors (IGF-I and IGF-II) may play a role in neoplasia. Alteration of serum IGFs or IGF Binding Proteins (IGFBPs) have been reported in some ...tumors. In this study, we measured serum IGF-I, IGF-II and IGFBPs profile in gastric cancer by radioimmunoassay and Western ligand blots. The serum IGF-I level in gastric cancer was significantly lower than in control subjects (65.2 +/- 26.5 vs 148.4 +/- 55.2 ng/ml, p < 0.01) and was further decreased to 45.5 +/- 20.9 ng/ml after surgery. The serum IGF-II level was slightly higher than that in control subjects (826.3 +/- 360.2 vs 735.7 +/- 154.6 ng/ml) but it was significantly decreased after surgery (525.7 +/- 220.1 ng/ml, p < 0.05). The serum IGFBP-3 level was not significantly different from those in control subjects. However, we observed a decreased level of serum IGFBP-3 after surgery, and incubation of postoperative serum with control serum resulted in a significant reduction of IGFBP-3 level. The reduction of IGFBP-3 in postoperative serum was mainly due to surgery associated IGFBP-3 protease activity. This protease activity was totally inhibited by aprotinin, EDTA and PMSF but not by pepstatin and leupeptin. This inhibition pattern is consistant with cation dependent serine protease. We speculate that proteolysis of IGFBP-3 may contribute to increase the bioavailability of IGFs.
Pulmonary Endometriosis is a rare disease entity and we report a 23-year-old single woman with a history of hemoptysis in association with menstruation. She was previously treated effectively with ...hormone therapy for 3 months, but decided to undergo surgical resection because of the high cost of hormone therapy. Radiographic finding of the chest showed haziness in the right lower lung field, and chest CT showed a ground-glass appearance in the posterobasal and laterobasal segment. The patient underwent basal segmentectomy of the right lower lobe. There was no incidence of hemoptysis during her menstruation following the operation.
A stationary one-dimensional nonlinear code, as a design tool, for a helix traveling wave tube
(TWT) is developed using Lagrangian large-signal approach. The analytic solutions of the electronic
and ...the circuit equation are derived and combined to establish a set of simple expressions for
developing a simple code without using any numerical method. The present simple code quickly
nds the TWT performance parameters, such as the output power, gain, and eciency, in an
analytic and straightforward manner. The results from the present simple code are compared
with those from numerical work and the particle-in-cell (PIC) code and are found to be in good
agreement. Also, design of a helix TWT with over 200 watts of output power in frequency range of
2-18GHz is carried out using present code. KCI Citation Count: 0
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