Background: Rolandic epileptiform discharges (RED) may be associated with behavioral difficulties and low school performance. The aim of this study was to assess whether sulthiame is effective in ...improving electroencephalogram (EEG) pathology, and whether these changes are paralleled by improved school performance and behavior.
Methods: In this single‐center study at a university hospital, 38 children with RED (27 boys, 11 girls; mean age, 6 years; range, 3–11 years), but no overt seizures, were included. Sixteen of them were treated with sulthiame (3–10 mg/kg). The observational period was 12 months. In both groups serial EEG was performed, and school performance and behavioral skills were assessed by parents and teachers.
Results: Children treated with sulthiame showed marked improvement on EEG pathology when compared to the non‐treated group (75% vs 44%; P= 0.149). Improvement of EEG pathology was significantly associated with better school performance and normalization of behavioral difficulties (P= 0.016). A significant positive correlation was established between sulthiame treatment and improved intellectual/school performance and behavior (P < 0.05). Side‐effects (transient episodes of tachypnea) were rare (four children; 25%).
Conclusion: EEG pathology can be improved with sulthiame in children with RED. The EEG changes were associated with improved clinical outcome parameters. The present findings need to be confirmed in a larger randomized controlled trial.
Corporate Performance Management (CPM) is a basic approach which examines the relationship between corporate performance and process optimization. How to successfully introduce CPM in practice is ...demonstrated through project reports from E.ON, British Telecom, Credit Suisse and Vodafone among others. The methods and tools presented here guarantee a continuous and automated monitoring of the corporate performance and enable Business Process Excellence to be permanently established in the company by company-internal and company-external benchmarking. The articles in this book focus on the use of the ARIS Controlling Platform developed by IDS Scheer.
We report three unrelated boys with X-linked adrenoleukodystrophy with onset of typical neurological symptoms of cerebral adrenoleukodystrophy between the age of 7 and 11 years. In contrast to the ...expected rapid progression, these patients showed an apparent arrest of initial neurological deterioration for subsequent periods of 5–12 years. Repeated neuroimaging revealed no progression of demyelination. Despite regional variability of demyelination, proton magnetic resonance spectroscopy revealed a specific metabolic pattern in all patients, with only moderate reduction of
N-acetylaspartate, normal or reduced choline-containing compounds, normal or enhanced
myo-inositol and no detectable lactate, which differs from findings in progressive cerebral adrenoleukodystrophy which usually exhibits a severe reduction of
N-acetylaspartate and marked increases of choline-containing compounds,
myo-inositol, and lactate. The ability to identify this newly described subgroup of patients with cerebral adrenoleukodystrophy is important for medical advice and planning of therapy.
Since its emergence in the early nineties as an innovative tool for corporate reorganization, Business Reengineering has evolved considerably, and even now its tenets are experiencing something of a ...renaissance. In the last few years, additional, dynamic methods such as activity-based cost calculation, the process-based Balanced Scorecard, or Process Mining have been introduced for use together with static process analysis. In this context, the term Corporate Performance Management is used to denote all the long-term, process-oriented modes of action and approach that have been adopted in companies. Specifically with regard to the ARIS methodology, a number of proven method-based and software solutions have been developed over the years, which enable performance-based company controlling.
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