We report far-infrared and submillimeter observations of supernova 1987A, the star whose explosion was observed on 23 February 1987 in the Large Magellanic Cloud, a galaxy located 160,000 light years ...away. The observations reveal the presence of a population of cold dust grains radiating with a temperature of about 17 to 23 kelvin at a rate of about 220 times the luminosity of the Sun. The intensity and spectral energy distribution of the emission suggest a dust mass of about 0.4 to 0.7 times the mass of the Sun. The radiation must originate from the supernova ejecta and requires the efficient precipitation of all refractory material into dust. Our observations imply that supernovae can produce the large dust masses detected in young galaxies at very high redshifts.
A class of cis-regulatory elements, called enhancers, play a central role in orchestrating spatiotemporally precise gene-expression programs during development. Consequently, divergence in enhancer ...sequence and activity is thought to be an important mediator of inter- and intra-species phenotypic variation. Here, we give an overview of emerging principles of enhancer function, current models of enhancer architecture, genomic substrates from which enhancers emerge during evolution, and the influence of three-dimensional genome organization on long-range gene regulation. We discuss intricate relationships between distinct elements within complex regulatory landscapes and consider their potential impact on specificity and robustness of transcriptional regulation.
Enhancers play important regulatory roles in gene expression during development, disease pathogenesis, and evolution. This Review integrates the current understanding of the sequence, architecture, and evolutionary features of enhancers, highlighting the emerging principles of enhancer function in transcriptional regulation.
The Pan-STARRS1 Database and Data Products Flewelling, H. A.; Magnier, E. A.; Chambers, K. C. ...
The Astrophysical journal. Supplement series,
11/2020, Letnik:
251, Številka:
1
Journal Article
Recenzirano
Odprti dostop
Abstract
This paper describes the organization of the database and the catalog data products from the Pan-STARRS1 3
π
Steradian Survey. The catalog data products are available in the form of an ...SQL-based relational database from MAST, the Mikulski Archive for Space Telescopes at STScI. The database is described in detail, including the construction of the database, the provenance of the data, the schema, and how the database tables are related. Examples of queries for a range of science goals are included.
Abstract
Soft-elasticity in monodomain liquid crystal elastomers (LCEs) is promising for impact-absorbing applications where strain energy is ideally absorbed at constant stress. Conventionally, ...compressive and impact studies on LCEs have not been performed given the notorious difficulty synthesizing sufficiently large monodomain devices. Here, we use direct-ink writing 3D printing to fabricate bulk (>cm
3
) monodomain LCE devices and study their compressive soft-elasticity over 8 decades of strain rate. At quasi-static rates, the monodomain soft-elastic LCE dissipated 45% of strain energy while comparator materials dissipated less than 20%. At strain rates up to 3000 s
−1
, our soft-elastic monodomain LCE consistently performed closest to an ideal-impact absorber. Drop testing reveals soft-elasticity as a likely mechanism for effectively reducing the severity of impacts – with soft elastic LCEs offering a Gadd Severity Index 40% lower than a comparable isotropic elastomer. Lastly, we demonstrate tailoring deformation and buckling behavior in monodomain LCEs via the printed director orientation.
This study examines the patterns and predictors of post-traumatic stress disorder (PTSD) symptom trajectories among adolescent survivors following the Wenchuan earthquake in China.
A total of 1573 ...adolescent survivors were followed up at 6, 12, 18 and 24 months post-earthquake. Participants completed the Posttraumatic Stress Disorder Self-Rating Scale (PTSD-SS), Adolescent Self-Rating Life Events Checklist, Social Support Rate Scale, and the Simplified Coping Style Questionnaire. Distinct patterns of PTSD symptom trajectories were established through grouping participants based on time-varying changes of developing PTSD (i.e. reaching the clinical cut-off on the PTSD-SS). Multivariate logistic regressions were used to examine predictors for trajectory membership.
PTSD prevalence rates at 6, 12, 18 and 24 months were 21.0, 23.3, 13.5 and 14.7%, respectively. Five PTSD symptom trajectories were observed: resistance (65.3% of the sample), recovery (20.0%), relapsing/remitting (3.3%), delayed dysfunction (4.2%) and chronic dysfunction (7.2%). Female gender and senior grade were related to higher risk of developing PTSD symptoms in at least one time point, whereas being an only child increased the possibility of recovery relative to chronic dysfunction. Family members' injury/loss and witness of traumatic scenes could also cause PTSD chronicity. More negative life events, less social support, more negative coping and less positive coping were also common predictors for not developing resistance or recovery.
Adolescents' PTSD symptoms showed an anniversary reaction. Although many adolescents remain euthymic or recover over time, some adolescents, especially those with the risk factors noted above, exhibit chronic, delayed or relapsing symptoms. Thus, the need for individualized intervention with these adolescents is indicated.
The technology of the next few decades could possibly allow us to explore with robotic probes the closest stars outside our Solar System, and maybe even observe some of the recently discovered ...planets circling these stars. This book looks at the reasons for exploring our stellar neighbors and at the technologies we are developing to build space probes that can traverse the enormous distances between the stars. In order to reach the nearest stars, we must first develop a propulsion technology that would take our robotic probes there in a reasonable time. Such propulsion technology has radically different requirements from conventional chemical rockets, because of the enormous distances that must be crossed. Surprisingly, many propulsion schemes for interstellar travel have been suggested and await only practical engineering solutions and the political will to make them a reality. This is a result of the tremendous advances in astrophysics that have been made in recent decades and the perseverance and imagination of tenacious theoretical physicists. This book explores these different propulsion schemes - all based on current physics - and the challenges they present to physicists, engineers, and space exploration entrepreneurs. This book will be helpful to anyone who really wants to understand the principles behind and likely future course of interstellar travel and who wants to recognizes the distinctions between pure fantasy (such as Star Trek's 'warp drive') and methods that are grounded in real physics and offer practical technological solutions for exploring the stars in the decades to come. Kelvin Long was born in Cambridge, England. He holds a Bachelors degree in Aerospace Engineering and a Masters degree in Astrophysics, both from Queen Mary College University of London. He has been a college and university teacher and served for several years in the Parachute Regiment Volunteer Reserve of the British Army. He currently works as a physicist in industry. He has published numerous papers and articles on the subject of astrophysics and space exploration and is currently the Assistant Editor of the Journal of the British Interplanetary Society. He has also contributed to many other publications on interstellar travel. He has appeared on the Austrian Broadcasting Radio Station FM4 as well as in the documentary How to Colonize the Stars produced by Christian Darkin. He is a Fellow of the Royal Astronomical Society, a chartered member of the Institute of Physics, a member of The Planetary Society, a member of the American Institute of Aeronautics Astronautics, Fellow of the British Interplanetary Society, and an associate member of the International Association for Astronomical Artists. He is a Practitioner of the Tau Zero Foundation, which actively promotes and coordinates international research into interstellar flight and within this capacity was the co-founder of an interstellar research initiative called Project Icarus. He is happily married to Gemma and likes to spend his spare time reading and writing science fiction, spacecraft model building, and using his Schmidt-Cassegrain telescope.
High levels of air pollutants in Vietnam, especially particulate matters including PM2.5, can be important risk factors for respiratory diseases among children of the country. However, few studies on ...the effects of ambient air pollution on human health have been conducted in Vietnam so far. The aim of this study is to examine the association between PM2.5 and hospital admission due to acute lower respiratory infection (ALRI) among children aged < 5 years old in Ho Chi Minh city, the largest city of Vietnam. Data relating PM2.5 and hospital admission were collected from February 2016–December 2017 and a time series regression analysis was performed to examine the relationship between PM2.5 and hospital admission including the delayed effect up to three days prior to the admission. We found that each 10 μg/m3 increase in PM2.5 was associated with an increase of 3.51 (95%CI: 0.96–6.12) risk of ALRI admission among children. According to the analysis, male children are more sensitive to exposure to PM2.5 than females, while children exposed to PM2.5 are more likely to be infected with acute bronchiolitis than with pneumonia. The study demonstrated that young children in HCMC are at increased risk of ALRI admissions due to the high level of PM2.5 concentration in the city's ambient air.
Display omitted
•First study on the impact of PM2.5 on acute lower respiratory infection (ALRI) in Vietnam.•Each 10 μg/m3 increase in PM2.5 was associated with an increase of 3.51% risk of ALRI admission.•Boys were more sensitive to PM2.5 exposure than girls.•Children aged 1–2 years old were more sensitive than children in other age groups.•Significant association between PM2.5 and acute bronchiolitis but none for pneumonia.
This study demonstrates that high level of PM2.5 increased the risk of admission for acute lower respiratory infection among Vietnamese children, especially for acute bronchiolitis and among males.
Many growth factors are intimately bound to the extracellular matrix, with regulated processing and release leading to cellular stimulation. Myostatin and GDF11 are closely related members of the ...TGFβ family whose activation requires two proteolytic cleavages to release the growth factor from the prodomain. Specific modulation of myostatin and GDF11 activity by targeting growth factor-receptor interactions has traditionally been challenging. Here we demonstrate that a novel strategy for blocking myostatin and GDF11, inhibition of growth factor release, specifically and potently inhibits signaling both in vitro and in vivo. We developed human monoclonal antibodies that selectively bind the myostatin and GDF11 precursor forms, including a subset that inhibit myostatin proteolytic activation and prevent muscle atrophy in vivo. The most potent myostatin activation-blocking antibodies promoted robust muscle growth and resulted in significant gains in muscle performance in healthy mice. Altogether, we show that blocking the extracellular activation of growth factors is a potent method for preventing signaling, serving as proof of concept for a novel therapeutic strategy that can be applied to other members of the TGFβ family of growth factors.
ABSTRACT
The optical emission line spectra of X-ray binaries (XRBs) are thought to be produced in an irradiated atmosphere, possibly the base of a wind, located above the outer accretion disc. ...However, the physical nature of – and physical conditions in – the line-forming region remain poorly understood. Here, we test the idea that the optical spectrum is formed in the transition region between the cool geometrically thin part of the disc near the mid-plane and a hot vertically extended atmosphere or outflow produced by X-ray irradiation. We first present a VLT X-Shooter spectrum of XRB MAXI J1820+070 in the soft state associated with its 2018 outburst, which displays a rich set of double-peaked hydrogen and helium recombination lines. Aided by ancillary X-ray spectra and reddening estimates, we then model this spectrum with the Monte Carlo radiative transfer code python, using a simple biconical disc wind model inspired by radiation-hydrodynamic simulations of irradiation-driven outflows from XRB discs. Such a model can qualitatively reproduce the observed features; nearly all of the optical emission arising from the transonic ‘transition region’ near the base of the wind. In this region, characteristic electron densities are on the order of 1012–13 cm−3, in line with the observed flat Balmer decrement (H $\alpha$/H $\beta$ ≈ 1.3). We conclude that strong irradiation can naturally give rise to both the optical line-forming layer in XRB discs and an overlying outflow/atmosphere that produces X-ray absorption lines.
PDF
