Okosnicu rada čini koncept krajobraznog identiteta promatran iz nove perspektive – perspektive pet osnovnih ljudskih osjetila: vida, sluha, njuha, opipa i okusa. Naime, krajobrazni (i općenito ...prostorni) identitet uglavnom se shvaća kao fenomen utemeljen na prepoznatljivim vizualnim karakteristikama. Međutim, sva je okolina multiosjetilni medij, bogat informacijama iz svih područja percepcije, a i čovjek je multiosjetilno biće i doživljava okolinu s više osjetila. U skladu s tim, ishodišna je pretpostavka rada ideja da se identifikacija čovjeka, odnosno društva, s prostorom ne odvija samo kroz interakciju s njezinim vizualnim nego i auditornim, olfaktornim, taktilnim, pa i gustatornim značajkama. Za područje istraživanja odabrana je dalmatinska regija. Primjenom metode analize sadržaja, na uzorcima lirskih pjesama te promotivnih (pretežno turističkih) materijala, cilj je bio ispitati na kojim se obilježjima, vizualnim i nevizualnim, temelji društvena predodžba dalmatinskoga krajobraza. Rezultati upućuju na to da je krajobrazni identitet Dalmacije u osjetilnom smislu raznolik. Spoznaja o krajobraznom identitetu kao osjetilno višedimenzionalnoj pojavi otvara mnoga nova pitanja i mogućnosti na području krajobrazne teorije i prakse.
The article addresses the concept of landscape identity considered from a new perspective – a perspective of five fundamental human senses: sight, hearing, smell, touch and taste. Landscape identity ...is mostly understood as a phenomenon based on its distinguishable visual characteristics. However, human environment is a multisensory medium, rich in information from all fields of perception. Equally, a man is a multisensory being and experiences his environment with multiple senses. The underlying assumption is that human identification with places does not only arise from the interaction with their visual, but also with their auditory, olfactory, tactile, and even gustatory properties. As a research area, the Dalmatia region in Croatia has been chosen. By the content analysis method, applied on samples of lyric poems and promotional (mostly tourist) materials, the aim was to examine what features, visual and non-visual, the social conception of Dalmatian landscape is based on. The results show that landscape identity of Dalmatia, in terms of sensory perception, is rather diverse. Understanding landscape identity as a sensory multidimensional phenomenon opens many new questions and possibilities in the field of landscape theory and practice.
The purpose of this study was to create a fibrin-based human skin substitute in vitro with epidermal and dermal component and to assess its healing potential in deep partial and full thickness burns. ...Fibrin scaffolds were prepared from commercial fibrin glue kits. Human fibroblasts were cultured in fibrin gel. Human keratinocytes were seeded on the top of the gel. Viability of cells was determined fluorimetrically. Scanning electron microscope and immunocytochemistry analysis of cultured cells were performed. After hydrosurgical preparation of deep burn necrotic tissue, wound bed was prepared for skin substitutes. Progress of healing was documented using visual estimation and photos. Scanning electron microscope images showed good cell attachment and colony spreading of
keratinocytes and fibroblasts on fibrin scaff old. Immunofluorescent staining of cell cultures on fibrin scaffold showed expression of vimentin, a marker of fibroblast cells, cytokeratin 19, a marker of epithelial stem cells, as well as involucrin, a marker of differentiated keratinocytes. Clinical results clearly showed that appearance of the skin did not differ significantly from the areas of transplanted skin using split-thickness skin graft techniques. In conclusion, using these fibrin-cultured autografts on massive full-thickness burn resulted in good healing.
Kirurško liječenje deformiteta šaka bolesnika s buloznom epidermolizom, unatoč stalnomu napretku znanstvenih spoznaja, još je i danas obilježeno brojnim prijeporima. Cilj istraživanja je na temelju ...medicinske dokumentacije utvrditi karakteristike, specifičnosti i ishode svih bolesnika s buloznom epidermolizom koji su kirurški liječeni zbog deformiteta šake u Zagrebu u razdoblju od 1994. do 2009. godine. Zagrebački kirurški protokol rekonstrukcije (ZSRP) deformiteta šake u bolesnika s buloznom epidermolizom (EB) jedinstven je alat standardiziranih postupaka i jasno definiranog algoritma. Analizirani su značajke i ishodi u bolesnika s buloznom epidermolizom skupine bolesnika liječenih u razdoblju od 1994. do 2001. sa skupinom bolesnika koji su kirurški liječeni od 2002. do 2009. godine (s follow upom od 2 godine poslije termina operacije) s obzirom na to da su od 2002. godine u kiruršku praksu uvedene nove smjernice s brojnim modifikacijama postupka (ZSRP). Primjena Zagrebačkog kirurškog protokola rekonstrukcije deformiteta šake u bolesnika s buloznom epidermolizom sa svojim inovativnim sastavnicama ima praktične prednosti u usporedbi s prethodno primjenjivanim kirurškim postupcima zbog svoje veće učinkovitosti uz redukciju ukupnih troškova liječenja. Uzimanjem presatka kože po metodi PRST postiže se brže cijeljenje donorskog područja, uz smanjenje rizika očekivanih komplikacija u usporedbi s klasičnim tehnikama uzimanja STSG presatka kože dermatomom ili elektrodermatomom. Prema našem dosadašnjem 20-godišnjem iskustvu primjerena kirurška korekcija deformiteta šaka u bolesnika s EB-om omogućava uspješno višekratno ponavljanje kirurškog postupka koji je indiciran kao posljedica očekivane progresije lokalnog statusa zbog prirode same bolesti.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, UILJ, UKNU, UL, UM, UPUK
Cilj ovoga istraživanja bio je kreirati in vitro nadomjestak ljudske kože s epidermalnim i dermalnim dijelom. Pritom smo koristili fibrinski gel kao nosač stanica. Procijenili smo učinak nadomjestka ...kože na cijeljenje opeklina drugog i trećeg stupnja. Fibrinski gel načinjen je od komercijalnog kirurškog fibrinskog ljepila. Ljudski fibroblasti kultivirani su u samom fibrinskom nosaču. Ljudski keratinociti zasijani su na gornju površinu nosača. Vijabilnost uzgojenih stanica određena je fluorimetrijski. Nadomjestak kože analiziran je elektronskim skenirajućim mikroskopom. Napravljena je imunocitokemijska analiza kultiviranih stanica. Skenirajući mikroskop pokazao je dobro prianjanje i proliferaciju stanica kože na nosaču. Imunocitokemijska analiza pokazala je prisutnost vimentina, biljega fibroblastnih stanica; citokeratina 19, biljega epitelnih matičnih stanica; te involukrina, biljega diferenciranih keratinocita. Klinička primjena ovih nadomjestaka kože pokazala je slične rezulatate cijeljenja kao i dijelovi rana koji su prekriveni autolognim presatcima kože djelomične debljine. Zaključujemo da nadomjestci kože bazirani na fibrinskom nosaču imaju potencijala u liječenju teških opeklina.
Abstract We report a rare case of a child with epidermolysis bullosa simplex (EBS) with plectin deficiency but without muscular dystrophy, with severe lesions of the oral cavity, oropharyngeal, ...hypopharyngeal, laryngeal, tracheal and bronchial mucosa. Case report and a review of the world literature are used. The literature review revealed only five similar patients with EBS without muscular dystrophy complicated by respiratory involvement. This paper highlights the potentially serious complications of the EB in the form of breathing, swallowing and speech difficulties and describes the specific problems encountered in the treatment of this patient. Epidermolysis bullosa (EB) is a group of severe hereditary diseases, primarily of the skin, but which can also involve the respiratory and gastrointestinal tract mucosa. Respiratory tract involvement is usually only found in certain types of EB. The oral cavity and oropharynx are involved more frequently than the hypopharynx, larynx and trachea. Involvement of laryngeal and tracheal mucosa is generally associated with an increased morbidity and mortality, numerous complications and therapeutic difficulties, and is more common in junctional EB and dystrophic EB than in EBS. We present a rare case of a child with EBS and plectin deficiency with pronounced lesions of respiratory tract mucosa from the oral cavity to the bronchi and even extending into the trachea. Deciding on tracheotomy requires thorough consideration and should not be taken lightly.
To assess the efficacy of the procedural consolidation concept (PCC) at reducing the number of sessions of general anesthesia necessary for treating children with epidermolysis bullosa (EB).
We ...examined the records of children treated at Children's Hospital of Zagreb between April 1999 and December 2007. Children treated before the introduction of PCC in January 2005 (n=39) and after (n=48) were analyzed in order to determine the effect of PCC on the occurrence of complications, days of hospitalization, and number of hospitalizations.
During the study period, 53 patients underwent 220 sessions of general anesthesia for a total of 743 surgical interventions per session. Before the introduction of PCC (n=39 patients, 83 sessions), the median number of interventions per session was 2 (range 1-5), and after the introduction of PCC (n=48 patients, 137 sessions) it was 4 (range 3-7, P<0.001). After the introduction of PCC, the median number of complications per anesthesia session increased from 2 (range 0-10) to 3 (range 0-10) (P=0.027), but the median number of complications per surgical procedure decreased from 1 (range 0-10) to 0.6 (range 0-2.5) (P<0.001). PCC lengthened each anesthesia session from a median of 65 minutes (range 35-655) to 95 minutes (range 50-405), (P<0.001). Total length of hospitalization was similar before (median 1, range 1-4) and after (median 1, range 1-3) introduction of PCC (P=0.169). The number of hospitalization days per procedure was 3 times lower after the introduction of PCC (median 0.3, range 0.2-3) than before (median 1, range 0.75-1.7) (P<0.001).
PCC should be considered an option in the surgical treatment of children with EB.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
Epidermolysis bullosa is a group of inherited disorders characterized by blister formation on the skin and mucous membrane as the result of molecular defects in genes coding for different structural ...proteins. They present with a wide clinical spectrum of manifestations because of a variety of molecular defects. Therapy depends on the form of the disease, severity and extent of skin involvement and extracutaneous manifestations, and consists of supportive skin care and supportive care for other organ systems. Skin care includes protection against trauma, proper skin care, treatment of blisters and erosions, and regular dermatological controls for early detection of skin cancer.
RANE KOD DJECE I BULOZNA EPIDERMOLIZA PUSTIŠEK, NIVES; BABIĆ, IRENA; KLJENAK, ANTUN ...
Acta medica Croatica,
02/2013, Letnik:
66, Številka:
Suplement 1
Web Resource
Odprti dostop
Bulozne epidermolize skupina su nasljednih bolesti karakteriziranih pojavom mjehura na koži i sluznicama kao posljedicom genetskih defekata u strukturnim proteinima kože. Klinička slika pojedinih ...oblika i podoblika bolesti može bitno varirati. terapijski pristup ovisi o obliku bolesti, jačini kožnog i sistemnog zahvaćanja i sastoji se od suportivne terapije kutanih i ekstrakutanih manifestacija, te zahvaća multidisciplinarni pristup stručnjaka različitih specijalnosti. njega kože uključuje zaštitu od potencijalnih trauma, pravilnu njegu i liječenje mjehura rana te redovite dermatološke kontrole zbog ranog otkrivanja kožnih tumora.
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