Optical absorption spectra were studied for films of tryptophan, thiochrome and their layer-by-layer composites. It was shown that the absorption spectra were rearranged in the composites. ...Quantum-chemical modeling of the electronic structure and optical transitions of the specified molecules, and their complexes, indicate that the reason for the rearrangement of the optical spectra is the heteroassociation between the molecules of thiochrome and tryptophan, which is accompanied by significant changes in the electronic states of the formed complexes.
The Russian Federation belongs to the countries with very high cardiovascular risk. Data on risk factors for death in people of old age and long-livers are not well understood.
Objective.
To ...summarize the experience of organizing treatment and inpatient rehabilitation of elderly patients and long-livers with cardiovascular diseases, to assess their cardiovascular risk factors.
Methods.
The study involved 50 patients, aged from 77 to 97 years (average age – 86.6 ± 4.9 years), who underwent treatment and rehabilitation for cardiovascular diseases. 32 (64 %) people corresponded to old age, and 18 (36 %) people over the age of 90 years were long-livers. There were 36 (72 %) women and 14 (28 %) men.
Results.
All 50 patients had arterial hypertension. Angina pectoris was diagnosed in 49 (98 %) patients. One myocardial infarction was suffered by 4 (8 %) people, two – 3 (6 %). 7 (14 %) people had a stroke, and another (2 %) suffered from the disease twice. Atrial fibrillation was diagnosed in 8 (16 %) patients, diabetes mellitus – in 11 (22 %). Сarotid arteries stenoses were found in 23 (95.8 %) patients, in 5 of them up to 50–55 %, including one occlusion. All patients were discharged with improvement after complex therapy in accordance with guidelines.
Conclusions.
A system for the rehabilitation of elderly patients and long-livers with cardiovascular diseases has been developed. Patients of older age groups have very high cardiovascular risk and prevalence of cardiovascular risk factors. Relatively small increases in blood pressure, the degree of arterial stenosis of a less hemodynamically significant level, and the use of combined therapy for cardiovascular diseases are factors that make it possible to survive until the age of long-livers.
Many questions remain in the diagnosis, treatment, and prevention of dyslipidemia, despite the available clinical recommendations. Among these issues is the cause of cardiovascular diseases, when ...achieving and maintaining the target values of lipid metabolism. We need to change the existing paradigm. Apolipoproteins as protein components of lipoproteins can significantly more accurately characterize the dyslipidemic status of a patient, since their structure and composition are unique. A personalized strategy for the prevention and treatment of dyslipidemia is possible based on the apolipoprotein profile. At present, new data on the functions of apolipoproteins, their genetic polymorphisms, and molecular preparations for correcting their content and lipid metabolism have been proposed.
The electronic nature of 4-hydroxy-1H-pyrrolo3,4-cpyridine-1,3,6(2H,5H)-trione (HPPT) was comprehensively investigated in liquid media at room temperature using steady-state and time-resolved ...femtosecond transient absorption spectroscopic techniques. The analysis of the linear photophysical and photochemical parameters of HPPT, including steady-state absorption, fluorescence and excitation anisotropy spectra, along with the lifetimes of fluorescence emission and photodecomposition quantum yields, revealed the nature of its large Stokes shift, specific changes in the permanent dipole moments under electronic excitation, weak dipole transitions with partially anisotropic character, and high photostability. Transient absorption spectra of HPPT were obtained with femtosecond resolution and no characteristic solvate relaxation processes in protic (methanol) solvent were revealed. Efficient light amplification (gain) was observed in the fluorescence spectral range of HPPT, but no super-luminescence and lasing phenomena were detected. The electronic structure of HPPT was also analyzed with quantum-chemical calculations using a DFT/B3LYP method and good agreement with experimental data was shown. The development and investigation of new pyrrolo3,4-cpyridine derivatives are important due to their promising fluorescent properties and potential for use in physiological applications.
A comprehensive investigation of the electronic structure and fast relaxation processes in the excited states of new styryl base-type derivatives was performed using steady-state, pico-, and ...femtosecond time-resolved spectroscopic techniques. Linear photophysical parameters of new compounds, including steady-state absorption, fluorescence, and excitation anisotropy spectra, were obtained in a number of organic solvents at room temperature. A detailed analysis of the fluorescence lifetimes and ultrafast relaxation processes in the electronically excited state of the styryl bases revealed an important role of solvate dynamics and donor–acceptor strength of the molecular structures in the formation of their excited state absorption spectra. Experimental data were in good agreement with quantum chemical calculations at the time dependent density functional theory level, combined with a polarizable continuum model.
The features of the electronic structures of a series of new styryl dye bases were investigated and characterized by their steady-state and time-resolved spectral properties, including femtosecond ...transient absorption spepctroscopy and DFT quantum chemical calculations. The steady-state absorption and fluorescence spectra, fluorescence quantum yield, and lifetimes in solvents of different polarity at room temperature revealed specific redistribution of the electronic density and rearrangements in molecular geometry after electronic excitation influenced by the dimethylamino end substituents. Fast relaxation processes in the electronic structures of new styryl dye bases and the nature of their time-resolved excited state absorption spectra were investigated with femtosecond temporal resolution, and the role of twisted intramolecular charge transfer (TICT) effects was shown. Quantum chemical calculations of the electronic structure of the new styryl dye bases were performed using non-empirical Time Dependent Density Functional Theory level, and were in good agreement with experimental data.
•Dimethylamino end substituents strongly determine electronic redistribution.•Experimental and calculated lifetimes are corresponded to Strickler-Berg approach.•Photostability can be changed more than in 10 times depends on solvent polarity.•Two components in the time-resolved ESA spectra were observed without TICT.•TICT effects in the new styryl dyes bases weakly depend on solvent properties.•Possibility of TICT effects was confirmed using non-empirical TD-DFT theory level.
The Russian Federation belongs to the countries with very high cardiovascular risk. Data on risk factors for death in people of old age and long-livers are not well understood.
Objective
. To ...summarize the experience of organizing treatment and inpatient rehabilitation of elderly patients and long-livers with cardiovascular diseases, to assess their cardiovascular risk factors.
Methods
. The study involved 50 patients, aged from 77 to 97 years (average age – 86.6 ± 4.9 years), who underwent treatment and rehabilitation for cardiovascular diseases. 32 (64 %) people corresponded to old age, and 18 (36 %) people over the age of 90 years were long-livers. There were 36 (72 %) women and 14 (28 %) men.
Results
. All 50 patients had arterial hypertension. Angina pectoris was diagnosed in 49 (98 %) patients. One myocardial infarction was suffered by 4 (8 %) people, two – 3 (6 %). 7 (14 %) people had a stroke, and another (2 %) suffered from the disease twice. Atrial fibrillation was diagnosed in 8 (16 %) patients, diabetes mellitus – in 11 (22 %). Сarotid arteries stenoses were found in 23 (95.8 %) patients, in 5 of them up to 50–55 %, including one occlusion. All patients were discharged with improvement after complex therapy in accordance with guidelines.
Conclusions
. A system for the rehabilitation of elderly patients and long-livers with cardiovascular diseases has been developed. Patients of older age groups have very high cardiovascular risk and prevalence of cardiovascular risk factors. Relatively small increases in blood pressure, the degree of arterial stenosis of a less hemodynamically significant level, and the use of combined therapy for cardiovascular diseases are factors that make it possible to survive until the age of long-livers.
Analysis of the data of national and international researches on evaluation of systemic inflammation in the acute coronary syndrome over the last 10 years was carried out. The problems of application ...the most studied inflammation markers in patients with acute myocardial infarction in clinical practice are focused.
A quantum-chemical study of the atomic charges and bond orders in the cations of the linear conjugated systems was performed. It is shown that total charge in the collective system of the
π
...-electrons generates the soliton-like wave of the alternated partial charges along the conjugated chain not only in ground state but also in the excited state. The excitation is accompanied by the change of the soliton phase and the wave dimension. Additionally, it is established that the electron density redistribution at the atoms and bonds also forms the soliton-like wave. In paper, the dependence of the solitonic wave shape on the dimension and section of the polymethine is studied; established regularities in the charge distribution in excited state could be used for the molecular design of organic semiconducting materials.
Graphic abstract
PDF
