Objectives : There are various things that the society demands from psychosomatic medical care. The school psychosomatic medical care is naturally included in part of them. The measures toward the ...problems of mind and body including psychosomatic disorders in schools these days seem to be an urgent issue. By taking this opportunity, we would like to address how we can meet the social needs through the attempts that Nishi-Kobe medical center is making in the field of school psychosomatic medical care. Methods : We will introduce the practice and results which psychosomatic medical care can contribute to school teachers through case conferences, study meetings, seminars, and often team medical care programs which Nishi-Kobe medical center offers. Results : We have practiced school psychosomatic medical care through the case conferences (which we started for the purpose of taking away the boundaries of school health instructors between junior high school and senior high school), the infant case study meetings (where a place is offered to discuss how to grasp the minds and bodies of infants), Nishi-Kobe children's psychosomatic disease study meeting (people with various occupations gather and discuss recent topics of psychosomatic medicines through a case study), the study meeting in cooperation with the Board of Education (a teacher presents a case), seminars to school counselors and teachers, participation of school health instructors to the team medical care that we developed in our hospital. In these meetings, the wide topics of psychosomatic care such as asthma, a irritable colon syndrome, eating disorder, and brief therapy were discussed. By these practices, we were able to contribute not only to specific treatment and collaboration but also to the personnel training. Conclusions : In the school psychosomatic medical care, what we should do is to practice in wide collaboration with school teachers. By doing so, we believe we could train talented people and eventually that will lead us to meet the needs of society, and schools in particular.
We have previously demonstrated that microsomal prostaglandin E synthase-1 (mPGES-1), an inducible terminal enzyme for PGE2 synthesis, aggravates brain inflammation and neurotoxicity in ...collagenase-induced intracerebral hemorrhage (ICH) mice. In this study, we investigated the role of microglial mPGES-1 in the hemoglobin (Hb)-induced inflammatory responses and neurotoxicity in vitro. At first, we investigated the effect of Hb on mPGES-1 induction and PGE2 production using neuronal cell line, SH-SY5Y cells and microglial cell line, BV-2 cells. mPGES-1 was significantly induced by Hb in BV-2 cells, but not in SH-SY5Y cells. PGE2 production after Hb exposure was increased in BV-2 cells but decreased in SH-SY5Ycells. Therefore, we next investigated the role of microglial mPGES-1 in Hb responses using primary microglial culture obtained from Wild-type (WT) and mPGES-1 knock out (KO) mice. Hb significantly increased PGE2 production in WT microglia, but not in mPGES-1 KO microglia. The Hb-induced mRNA expressions of TNF-α and IL-1β in mPGES-1 KO microglia were significantly less than those in WT microglia. Furthermore, Hb-induced neurotoxicity of cortical neurons cocultured with mPGES-1 KO microglia was less severe than that cocultured with WT microglia. These results suggest that microglial mPGES-1 contributes to neuronal death after ICH through PGE2 production and regulation of inflammatory cytokines. Thus, mPGES-1 may be a promising therapeutic target for the treatment of ICH.
Objective: We have previously reported on how the participation of school health instructors can directly influence the effect and significance of integrated treatment for childhood onset anorexia ...nervosa. Recently, the prevention of eating disorders in schools has attracted attention. Beginning in 2000, after two-years of preparation, health instructors of junior high schools in the District A of Kobe City participated in a program of educational activities focused on the prevention of eating disorders. This study investigates the effect of these activities on the percentage of emaciated children. Methods: We investigated changes in the percentage of emaciated students (the proportion of students with weight equal to or less than 80% of standard weight) from District A, Kobe City, after school health instructors began conducting the above educational activities. This was compared with the percentage of emaciated students from District B which closely resembled the residential environment and emaciation percentage in District A, but where these activities had not been carried out. Results: 1. Before beginning the program of educational activities, an increased tendency in the percentage of emaciation had been seen, but the percentage significantly decreased after starting the activities. 2. In District B where activities were not performed, no significant changes in the percentage of emaciation were seen. Conclusions: The decrease in emaciation was directly due to the activities of school health instructors focused on the prevention of eating disorders in children. This indicates that prevention of childhood onset eating disorder is possible.
The clinical efficacy and safety of MK-0787/MK-0791 were compared with piperacillin (PIPC) in respiratory tract infections by a well controlled study. Drugs were administered by intravenous drip ...infusion twice a day for 14 days, at a daily of 1 g/1 g of MK-0787/MK-0791 or 4 g of PIPC. The following results were obtained. 1. Out of 367 patients (183 administered MK-0787/MK-0791, 184 PIPC) included in this trial, the clinical efficacy of 301 patients (155 received MK-0787/MK-0791, 146 PIPC) was evaluated by the committee members. 2. The clinical efficacy rates in all cases evaluated by the committee members were 80.0% in MK-0787/MK-0791 and 71.7% in PIPC, respectively, and no significant difference was observed between the two drugs. Wheras, the clinical efficacy rates evaluated by the attending physicians were 82.0% in MK-07871/MK-0791 and 72.0% in PIPC, and significant difference was observed between the two drugs. 3. No significant difference was observed between the clinical efficacy of the two drugs evaluated by the committee members in patients with pneumonia or pulmonary suppuration. But in patients with chronic respiratory tract infections, the clinical efficacy rates were 83.5% in MK-0787/MK-0791 and 63.0% in PIPC, respectively, therefore MK-0787/MK-0791 was significantly superior to PIPC. The clinical efficacy evaluated by both the attending physicians and the committee members in those patients were observed to be similar. 4. The clinical and bacteriological efficacy against causative organisms in all cases were observed to have no significant difference between the two drugs, but MK-0787/MK-0791 was significantly superior to PIPC in single infections by P. aeruginosa. 5. No significant difference was observed between the two drugs in regard to side effects or abnormality in laboratory findings. 6. The usefulness of MK-0787/MK-0791 was superior to PIPC in all cases and in patients with chronic respiratory tract infections judged by committee members, and in patients with chronic respiratory tract infections judged by attending physicians. From these results it was concluded that MK-0787/MK-0791 is an extremely useful drug in the treatment of respiratory tract infections.
インドネシアにおける健康な牛, 豚の糞便からのサルモネラの分離 中村, 政幸; Istiyaningsih; 中島, 直彦 ...
Japanese journal of veterinary science,
1989, Letnik:
51, Številka:
5
Journal Article
Odprti dostop
インドネシアの健康な牛, 豚の糞便から分離したサルモネラの血清型は, 牛ではS. newport, S. dublin, 豚ではS paratyphi-Bが多く, 他にS. lexington(牛, 豚), S. typhimunun(豚), S. enteritidis(豚)等も分離された. これらの分離株はすべて薬剤感受性であり, プラスミドはS. typhimurium, S. ...dublin, S. enteritidis等において検出された.
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