According to Modern-Era Retrospective Research Analysis for Research and
Applications (MERRA-2) temperature and wind datasets in 2019, this
study presents the global variations in the ...eastward-propagating wavenumber
1 (E1), 2 (E2), 3 (E3) and 4 (E4) planetary waves (PWs) and their diagnostic
results in the polar middle atmosphere. We clearly demonstrate the eastward
wave modes exist during winter periods with westward background wind in both
hemispheres. The maximum wave amplitudes in the Southern Hemisphere (SH) are
slightly larger and lie lower than those in the Northern Hemisphere (NH).
Moreover, the wave perturbations peak at lower latitudes with smaller
amplitudes as the wavenumber increases. The period of the E1 mode varies between 3–5 d in both hemispheres, while the period of the E2 mode is slightly longer in
the NH (∼ 48 h) than in the SH (∼ 40 h). The
periods of the E3 are ∼ 30 h in both the SH and the NH, and the period
of E4 is ∼ 24 h. Despite the shortening of wave periods with
the increase in wavenumber, their mean phase speeds are relatively stable, ∼ 53, ∼ 58, ∼ 55 and ∼ 52 m/s at 70∘ latitudes for E1, E2, E3 and
E4, respectively. The eastward PWs occur earlier with increasing zonal
wavenumber, which agrees well with the seasonal variations in the critical
layers generated by the background wind. Our diagnostic analysis also
indicates that the mean flow instability in the upper stratosphere and upper
mesosphere might contribute to the amplification of the eastward PWs.
The westward quasi‐6‐day wave (Q6DW) with zonal wavenumber 1 is a prominent and recurrent phenomenon in the mesosphere and lower thermosphere (MLT) and has a significant impact on day‐to‐day ...ionospheric variability. Geopotential height measurements from Aura Microwave Limb Sounder and Specified Dynamics Whole Atmosphere Community Climate Model eXtended Version simulations during 2005–2019 are utilized to study the climatological variations of Q6DW. The spectral analysis clearly indicates that four typical Q6DW events occur in the MLT region before and after the two equinoxes in 1 year. The wave amplitudes in the summer hemisphere are considerably larger than the amplitudes in the winter hemisphere. The Eliassen‐Palm flux diagnostics show that the wave source of the post‐September equinox event is located in both hemispheres, while the sources of the other three Q6DW events are in the winter hemisphere. The diagnostic analysis results show that the climatological features of Q6DW are primarily due to the seasonal variations of the mean flow, which can determine the Q6DW critical layers, baroclinic/barotropic instability, and waveguides. Specifically, the Q6DW can be amplified in the summer hemisphere mesosphere at high latitudes during pre‐ and postequinox periods when the critical layers penetrate the unstable region. At the two equinoxes, the Q6DW can also propagate into the MLT region with similar amplitudes in both hemispheres due to the weak zonal mean flow but without additional amplification. At the two solstices, the Q6DW is suppressed because the critical layers envelop the whole unstable region, which prevents its amplification through wave‐mean flow interaction.
Key Points
The quasi‐6‐day wave (Q6DW) event occurs climatologically four times in the MLT region before and after the two equinoxes every year
The source, propagation, and amplification of Q6DW are well exhibited based on the 15‐year SD‐Whole Atmosphere Community Climate Model‐X simulation
The variations of the Q6DW critical layer, waveguide, and wave source are all responsible for its climatological features
Diffuse large B-cell lymphoma (DLBCL) is characterized by its clinical and biological heterogeneity. The clinical prognostic implications of tumor-associated macrophages (TAMs) in DLBCL remain ...controversial and the correlation between TAMs and peripheral absolute monocyte count (AMC) has not yet been elucidated.
In 221 untreated, newly diagnosed patients with DLBCL, we evaluated the prognostic value of TAMs using immunohistochemical analysis, as well as the association of TAMs and AMC.
We found that high CD68 or high CD163 expression was correlated with clinicopathological characteristics, high CD163 expression was an adverse predictor for both overall survival (OS) hazard ratio (HR) = 2.265, P = 0.005 and progression- free survival (PFS) (HR = 1.925, P = 0.017) in patients with DLBCL. Patients with high CD68 or high CD163 expression had significantly poorer OS and PFS than those with low CD68 or low CD163 expression, respectively (CD68: OS: P<0.001, PFS: P<0.001; CD163: OS: P<0.001, PFS: P<0.001), even in the rituximab era. Moreover, high-risk patients could be further identified by the expression of CD68 or CD163, especially in those classified as low/intermediate risk by International Prognostic Index (IPI). Furthermore, the significant positive correlation was also detected between CD68 expression or CD163 expression and AMC (r = 0.256, P<0.001; r = 0.303, P<0.001).
Patients with high expression of TAMs tend to have poorer OS and PFS, even in the rituximab era, and have positive correlation with AMC. Therefore, the peripheral AMC is a useful prognostic marker reflecting the status of the tumor microenvironment (TME) in DLBCL.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
The Sounding of the Atmosphere using Broadband Emission Radiometry satellite instrument has been measuring the mesospheric global temperature since February 2002, providing the longest continuous ...data set to statistically study the climatology and anomaly of the quasi‐two‐day waves (QTDWs), including the westward zonal wave number 2 (W2), 3 (W3), and 4 (W4) modes. It is found that the W2 QTDW generally peaks earliest, followed by the W3 mode with the W4 QTDW being amplified lastly. This temporal pattern is always disordered during the sudden stratospheric warming (SSW) periods. The temperature oscillations of the QTDW usually peak at nearly the same period at different altitudes and different latitudes for a certain case but would be different from year to year. The statistical results show that the periods of the W2 QTDWs are more frequently observed to be at 45–48 hr and the periods of the W3 mode are mostly confined between 45 and 52 hr. Nevertheless, the oscillations of the W4 QTDW peak more dispersedly between 41 and 56 hr. The W3 QTDW is usually the strongest among the three modes, whereas it is sometimes equal to or even weaker than W2 and W4 QTDWs, especially during SSW periods. Besides, we found that the vertical distribution of the W3 QTDW splits into a bimodal structure during the SSW periods of 2006 and 2011. And the solar cycle trend of the QTDWs is frequently disturbed by a 2‐ to 5‐year variability, which seems to be a common feature for all the QTDW modes.
Key Points
SABER temperature data sets during 2003–2018 austral summers are analyzed to statistically study the climatology and anomaly of the QTDWs
Anomalous QTDW behaviors, regarding their temporal variations, periods, and amplitudes, are frequently identified during SSW periods
The long‐term trend of the QTDWs is usually disturbed by a 2‐ to 5‐year variability, which seems to be a common feature for all the QTDW modes
FeCo2O4 nanoparticles with abundant oxygen vacancies were produced by laser fragmentation. The oxygen vacancies can lower the thermodynamic energy barriers as well as accelerate the electron ...transfer, eventually promoting oxygen evolution and reduction reactions simultaneously.
Abstract Due to state-of-art analytical techniques, non-invasive exhaled volatile organic compounds (VOCs) analysis has become a potential method for early diagnosis of lung cancer. We collected ...breath samples from 43 patients with non-small cell lung cancer (NSCLC) and 41 normal controls using Tedlar® gas bags. The VOCs were extracted with solid phase micro-extraction (SPME) and analyzed by gas chromatography (GC)/mass spectrometry (MS). The number of VOCs detected in each breath sample ranged from 68 to 114. Among the VOCs 1-butanol and 3-hydroxy-2-butanone were found at significantly higher concentrations in breath of the lung cancer patients compared to the controls. VOCs levels were not significantly different between early stage lung cancer patients and late stage lung cancer patients. Lung adenocarcinoma was significantly related to higher VOCs concentrations in the breath. Our data showed that 1-butanol and 3-hydroxy-2-butanone in breath could possibly be taken as useful breath biomarkers for discerning potential lung cancer patients and VOCs analysis could be used as a complementary test for the diagnosis of lung cancer.
Colletotrichum species are important plant pathogens, causing anthracnose in virtually every crop grown throughout the world. However, little is known about the species that infect watermelon. A ...total of 526 strains were isolated from diseased watermelon samples of eight major watermelon growing provinces in China. Phylogenetic analyses using seven loci (ITS, gadph, chs-1, his3, act, tub2, and gs) coupled with morphology of 146 representative isolates showed that they belonged to 12 known species of Colletotrichum, including C. aenigma, C. chlorophyti, C. fructicola, C. jiangxiense, C. karstii, C. magnum, C. nymphaeae, C. nigrum, C. orbiculare, C. plurivorum, C. sojae, and C. truncatum and three new species, here described as C. citrulli, C. kaifengense, and C. qilinense. Colletotrichum orbiculare was the dominant species. Pathogenicity tests revealed that all isolates of the species described above were pathogenic, with C. magnum and C. kaifengense being the most aggressive to leaves and fruits, respectively. This is the first report of C. aenigma, C. chlorophyti, C. fructicola, C. jiangxiense, C. nymphaeae, C. nigrum, C. plurivorum, and C. sojae on watermelon. These findings shed light on the Colletotrichum spp. involved in watermelon anthracnose and provide useful information for implementing effective control of watermelon anthracnose in China.
Aberrant monocyte chemoattractant protein-1 (MCP-1) and CC chemokine receptor 2 (CCR2) expression in malignant tissues have been reported; however, their role in hematological malignancies prognosis ...remains little known. The aim of this study was to investigate the prognostic value of MCP-1 and CCR2 expression in patients with diffuse large B cell lymphoma (DLBCL). The study included 221 patients with DLBCL. MCP-1 and CCR2 expression was analyzed by immunohistochemical staining and its correlations with clinicopathologic features and prognosis were evaluated. High expression of MCP-1 or CCR2 was correlated with clinicopathological characteristics, and an adverse prognostic factor for overall survival (OS) and progression-free survival (PFS) of DLBCL patients. Also, significant positive correlation between MCP-1 and CCR2 expression was revealed (
r
= 0.545,
P
< 0.001). Patients with high MCP-1 or high CCR2 expression had significantly poorer OS and PFS than those with low MCP-1 or low CCR2 expression (OS:
P
< 0.001,
P
< 0.001; PFS:
P
< 0.001,
P
< 0.001), respectively, even in the rituximab era, and MCP-1 or CCR2 expression could further identify high-risk patients otherwise classified as low/intermediate risk by the International Prognostic Index (IPI) alone. Furthermore, incorporation of MCP-1 or CCR2 expression into the IPI score could improve prognostic value for OS. This is the first report describing the clinicopathological features and survival outcome according to expression of MCP-1 and CCR2 in DLBCL.
AIM To explore novel therapeutic target of cisplatin resistance in human gastric cancer.METHODS The sensitivity of SGC7901 cells and cisplatin-resistant SGC7901 cells(SGC7901/DDP) for cisplatin were ...detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. High-quality total RNA which isolated from SGC7901/DDP cells and SGC7901 cells were used for mR NA microarray analysis. Results were analyzed bioinformatically to predict their roles in the development of cisplatin resistance and the expression of 13 dysregulated mR NAs we selected were validated by quantitative real-time polymerase chain reaction(qR T-PCR). RESULTS SGC7901/DDP cells highly resistant to cisplatin demonstrated by MTT assay. A total of 1308 m RNAs(578 upregulated and 730 downregulated) were differentially expressed(fold change ≥ 2 and P-value < 0.05) in the SGC7901/DDP cells compared with SGC7901 cells. The expression of mR NAs detected by q RT-PCR were consistent with the microarray results. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes pathway and protein-protein interaction analysis demonstrated that the differentially expressed mR NAs were enriched in PI3K-Akt, Notch, MAPK, ErbB, Jak-STAT, NF-kappa B signaling pathways which may be involved in cisplatin resistance. Several genes such as PDE3 B, VEGFC, IGFBP3, TLR4, HIPK2 and EGF may associated with drug resistance of gastric cancer cells to cisplatin.CONCLUSION Exploration of those altered mR NAs may provide more promising strategy in diagnosis and therapy for gastric cancer with cisplatin resistance.
Gastric cancer (GC) is one of the most common malignant tumors worldwide. Previous studies have reported that aldehyde dehydrogenase-1A1 (ALDH1A1) and cluster of differentiation (CD)-133 are ...considered to be cancer stem cell markers in GCs. The present study immunohistochemically examined the distribution and expression of two tumor stem cell markers, CD133 and ALDH1A1, in both primary tumors and para-tumor tissues. In 91 cases with stage III, 57 (62%) were positive for ALDH1A1 and 60 (66%) were positive for CD133. ALDH1A1 was detected in para-tumors and cancerous tissues of the stomach, and the immunoreactivity of the tumors was stronger than that in para-tumor tissues. CD133 was only detected in tumors. The expression of ALDH1A1 was significantly associated with advanced T/N stage (T stage, P=0.012; N stage, P=0.023) and poor differentiation (P=0.020), while CD133 was associated with advanced T stage (P=0.007). Univariate and multivariate Cox proportional hazards analysis revealed that tumor stage, CD133 expression, vascular invasion and sex were independent predictors of disease-free survival (DFS) time, and tumor size, vascular invasion and sex were independent predictors of overall survival (OS) time in patients with GC. Patients with CD133.sup.+ GC had poorer DFS (P=0.042), while ALDH1A1.sup.+ was not associated with poorer DFS. In regard to chemotherapy, improvements in survival were not observed after the addition of taxane compared with two-drug therapy. However, the subgroup analysis indicated that in the ALDH1AT subgroup, and CD133.sup.+ and ALDH1A1 subgroups, an increased OS was observed in two-drug therapy (P=0.043). The results of the present study indicate that ALDH1A1 and CD133 may play an important role in tumor invasion, metastasis and prognosis, and ALDH1AT expression does not benefit the taxane-based triple chemotherapeutic regimen in patients with GC. Key words: aldehyde dehydrogenase-1A1, cluster of differentiation-133, stomach neoplasm, prognosis, adjuvant chemotherapy
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