We present a search for signatures of neutrino mixing of electron anti-neutrinos with additional hypothetical sterile neutrino flavors using the Double Chooz experiment. The search is based on data ...from 5 years of operation of Double Chooz, including 2 years in the two-detector configuration. The analysis is based on a profile likelihood, i.e. comparing the data to the model prediction of disappearance in a data-to-data comparison of the two respective detectors. The analysis is optimized for a model of three active and one sterile neutrino. It is sensitive in the typical mass range
5
×
10
-
3
eV
2
≲
Δ
m
41
2
≲
3
×
10
-
1
eV
2
for mixing angles down to
sin
2
2
θ
14
≳
0.02
. No significant disappearance additionally to the conventional disappearance related to
θ
13
is observed and correspondingly exclusion bounds on the sterile mixing parameter
θ
14
as a function of
Δ
m
41
2
are obtained.
Celotno besedilo
Dostopno za:
DOBA, IZUM, KILJ, NUK, PILJ, PNG, SAZU, SIK, UILJ, UKNU, UL, UM, UPUK
A
bstract
A
θ
13
oscillation analysis based on the observed antineutrino rates at the Double Chooz far and near detectors for different reactor power conditions is presented. This approach provides a ...so far unique simultaneous determination of
θ
13
and the total background rates without relying on any assumptions on the specific background contributions. The analysis comprises 865 days of data collected in both detectors with at least one reactor in operation. The oscillation results are enhanced by the use of 24.06 days (12.74 days) of reactor-off data in the far (near) detector. The analysis considers the
ν
¯
e
interactions up to a visible energy of 8.5 MeV, using the events at higher energies to build a cosmogenic background model considering fast-neutrons interactions and
9
Li decays. The background-model-independent determination of the mixing angle yields sin
2
(2
θ
13
) = 0
.
094 ± 0
.
017, being the best-fit total background rates fully consistent with the cosmogenic background model. A second oscillation analysis is also performed constraining the total background rates to the cosmogenic background estimates. While the central value is not significantly modified due to the consistency between the reactor-off data and the background estimates, the addition of the background model reduces the uncertainty on
θ
13
to 0.015. Along with the oscillation results, the normalization of the anti-neutrino rate is measured with a precision of 0.86%, reducing the 1.43% uncertainty associated to the expectation.
A
bstract
The yields and production rates of the radioisotopes
9
Li and
8
He created by cosmic muon spallation on
12
C, have been measured by the two detectors of the Double Chooz experiment. The ...identical detectors are located at separate sites and depths, which means that they are subject to different muon spectra. The near (far) detector has an overburden of ∼120 m.w.e. (∼300 m.w.e.) corresponding to a mean muon energy of 32.1 ± 2.0 GeV (63.7 ± 5.5 GeV). Comparing the data to a detailed simulation of the
9
Li and
8
He decays, the contribution of the
8
He radioisotope at both detectors is found to be compatible with zero. The observed
9
Li yields in the near and far detectors are 5.51 ± 0.51 and 7.90 ± 0.51, respectively, in units of 10
−8
μ
−1
g
−1
cm
2
. The shallow overburdens of the near and far detectors give a unique insight when combined with measurements by KamLAND and Borexino to give the first multi-experiment, data driven relationship between the
9
Li yield and the mean muon energy according to the power law
Y
=
Y
0
E
μ
/
1
GeV
α
¯
, giving
α
¯
=
0.72
±
0.06
and
Y
0
= (0.43 ± 0.11) × 10
−8
μ
−1
g
−1
cm
2
. This relationship gives future liquid scintillator based experiments the ability to predict their cosmogenic
9
Li background rates.
We present a search for signatures of neutrino mixing of electron anti-neutrinos with additional hypothetical sterile neutrino flavors using the Double Chooz experiment. The search is based on data ...from 5 years of operation of Double Chooz, including 2 years in the two-detector configuration. The analysis is based on a profile likelihood, i.e.\ comparing the data to the model prediction of disappearance in a data-to-data comparison of the two respective detectors. The analysis is optimized for a model of three active and one sterile neutrino. It is sensitive in the typical mass range \(5 \cdot 10^{-3} \) eV\(^2 \lesssim \Delta m^2_{41} \lesssim 3\cdot 10^{-1} \) eV\(^2\) for mixing angles down to \(\sin^2 2\theta_{14} \gtrsim 0.02\). No significant disappearance additionally to the conventional disappearance related to \(\theta_{13} \) is observed and correspondingly exclusion bounds on the sterile mixing parameter \(\theta_{14} \) as function of \( \Delta m^2_{41} \) are obtained.
The yields and production rates of the radioisotopes $^9$Li and $^8$He
created by cosmic muon spallation on $^{12}$C, have been measured by the two
detectors of the Double Chooz experiment. The ...identical detectors are located
at separate sites and depths, which means they are subject to different muon
spectra. The near (far) detector has an overburden of $\sim$120 m.w.e.
($\sim$300 m.w.e.) corresponding to a mean muon energy of
$32.1\pm2.0\,\mathrm{GeV}$ ($63.7\pm5.5\,\mathrm{GeV}$). Comparing the data to
a detailed simulation of the $^9$Li and $^8$He decays, the contribution of the
$^8$He radioisotope at both detectors is found to be compatible with zero. The
observed $^9$Li yields in the near and far detectors are $5.51\pm0.51$ and
$7.90\pm0.51$, respectively, in units of $10^{-8}\mu ^{-1} \mathrm{g^{-1}
cm^{2} }$. The shallow overburdens of the near and far detectors give a unique
insight when combined with measurements by KamLAND and Borexino to give the
first multi--experiment, data driven relationship between the $^9$Li yield and
the mean muon energy according to the power law $Y = Y_0( <E_{\mu} >/
1\,\mathrm{GeV})^{\overline{\alpha}}$, giving $\overline{\alpha}=0.72\pm0.06$
and $Y_0=(0.43\pm0.11)\times 10^{-8}\mu ^{-1} \mathrm{g^{-1} cm^{2}}$. This
relationship gives future liquid scintillator based experiments the ability to
predict their cosmogenic $^9$Li background rates.
The yields and production rates of the radioisotopes \(^9\)Li and \(^8\)He created by cosmic muon spallation on \(^{12}\)C, have been measured by the two detectors of the Double Chooz experiment. The ...identical detectors are located at separate sites and depths, which means they are subject to different muon spectra. The near (far) detector has an overburden of \(\sim\)120 m.w.e. (\(\sim\)300 m.w.e.) corresponding to a mean muon energy of \(32.1\pm2.0\,\mathrm{GeV}\) (\(63.7\pm5.5\,\mathrm{GeV}\)). Comparing the data to a detailed simulation of the \(^9\)Li and \(^8\)He decays, the contribution of the \(^8\)He radioisotope at both detectors is found to be compatible with zero. The observed \(^9\)Li yields in the near and far detectors are \(5.51\pm0.51\) and \(7.90\pm0.51\), respectively, in units of \(10^{-8}\mu ^{-1} \mathrm{g^{-1} cm^{2} }\). The shallow overburdens of the near and far detectors give a unique insight when combined with measurements by KamLAND and Borexino to give the first multi--experiment, data driven relationship between the \(^9\)Li yield and the mean muon energy according to the power law \(Y = Y_0( <E_{\mu} >/ 1\,\mathrm{GeV})^{\overline{\alpha}}\), giving \(\overline{\alpha}=0.72\pm0.06\) and \(Y_0=(0.43\pm0.11)\times 10^{-8}\mu ^{-1} \mathrm{g^{-1} cm^{2}}\). This relationship gives future liquid scintillator based experiments the ability to predict their cosmogenic \(^9\)Li background rates.
RNA 3' end processing provides a source of transcriptome diversification which affects various (patho)-physiological processes. A prime example is the transcript isoform switch that leads to the ...read-through expression of the long non-coding RNA
, at the expense of the shorter polyadenylated transcript
.
is required for assembly of paraspeckles (PS), nuclear bodies that protect cancer cells from oncogene-induced replication stress and chemotherapy. Searching for proteins that modulate this event, we identified factors involved in the 3' end processing of polyadenylated RNA and components of the Integrator complex. Perturbation experiments established that, by promoting the cleavage of
, Integrator forces
to
isoform switching and, thereby, restrains PS assembly. Consistently, low levels of Integrator subunits correlated with poorer prognosis of cancer patients exposed to chemotherapeutics. Our study establishes that Integrator regulates PS biogenesis and a link between Integrator, cancer biology, and chemosensitivity, which may be exploited therapeutically.
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