A central question in neuronal network analysis is how the interaction between individual neurons produces behavior and behavioral modifications. This task depends critically on how exactly are ...signals integrated by individual nerve cells functioning as complex operational units. Regional electrical properties of branching neuronal processes that determine the input–output function of any neuron are extraordinarily complex, dynamic, and, in the general case, impossible to predict in the absence of detailed measurements. To obtain such a measurement one would, ideally, like to be able to monitor, at multiple sites, subthreshold events as they travel from the sites of origin (synaptic contacts on distal dendrites) and summate at particular locations to influence action potential initiation. It became possible recently to carry out this type of measurement using high-resolution multisite recording of membrane potential changes with intracellular voltage-sensitive dyes. This chapter reviews the development and foundation of the msethod of voltage-sensitive dye recording from individual neurons. Presently, this approach allows monitoring membrane potential transients from all parts of the dendritic tree as well as from axon collaterals and individual dendritic spines.
We present preliminary photometric results of a monitoring study of the open
cluster NGC 2660 as part of the EXPLORE/OC project to find planetary transits
in Galactic open clusters. Analyzing a total ...of 21000 stars (3000 stars with
photometry to 1% or better) yielded three light curves with low-amplitude
signals like those typically expected for transiting hot Jupiters. Although
their eclipses are most likely caused by non-planetary companions, our methods
and photometric precision illustrate the potential to detect planetary transits
around stars in nearby open clusters.
The EXPLORE Project expanded in 2003 to include a campaign to monitor rich
southern open clusters for transits of extrasolar planets (EXPLORE/OC). In May
and June 2003, we acquired precise, ...high-cadence photometry of the second open
cluster in our campaign, NGC 6208. Here, we present preliminary results from
our I-band survey of over 60000 stars in the field of NGC 6208, around 5000 of
which were monitored with photometric precision better than 1%.
We present preliminary photometric results of a monitoring study of the open cluster NGC 2660 as part of the EXPLORE/OC project to find planetary transits in Galactic open clusters. Analyzing a total ...of 21000 stars (3000 stars with photometry to 1% or better) yielded three light curves with low-amplitude signals like those typically expected for transiting hot Jupiters. Although their eclipses are most likely caused by non-planetary companions, our methods and photometric precision illustrate the potential to detect planetary transits around stars in nearby open clusters.
The EXPLORE Project expanded in 2003 to include a campaign to monitor rich southern open clusters for transits of extrasolar planets (EXPLORE/OC). In May and June 2003, we acquired precise, ...high-cadence photometry of the second open cluster in our campaign, NGC 6208. Here, we present preliminary results from our I-band survey of over 60000 stars in the field of NGC 6208, around 5000 of which were monitored with photometric precision better than 1%.
