Moyamoya disease is a rare disorder associated with progressive intracranial arterial stenosis with fragile, small collateralization that gives an angiographic appearance of a puff of smoker or, in ...Japanese, “moya-moya”. We report a case of coronary artery ostial occlusive disease as an extracranial manifestation of Moyamoya. In the case, we demonstrate that thigh risk features of cardiac positron emission tomography (PET) that ultimately lead to the diagnosis of coronary artery occlusion.
The rising prevalence of heart failure with limited transplant availability has resulted in increased use of continuous left ventricular assist device (LVAD) support. LVAD driveline remains exposed ...to environment which predisposes it to high rates of infection. We describe a case of a persistent driveline infection in a patient for which 18F-FDG PET/CT was utilized to diagnose deep-seated infection.
MicroRNAs (miRNAs) are key regulators of gene expression in eukaryotes where they can function to downregulate expression levels or functioning of messenger RNAs (mRNAs) that are targeted by mature ...miRNAs displaying sequence homology. The ‘active’ mature miRNA forms are short RNAs which are processed from longer precursor miRNA molecules that have a stem-loop structure. While artificial miRNAs have been developed for gene knockdown experiments in a range of eukaryotes, it is not known whether artificial or endogenous miRNAs can functionally knockdown mRNA levels in the model marine diatom Phaeodactylum tricornutum. Here, we investigate the potential use of artificial microRNAs (amiRNAs) for targeted gene knockdowns in P. tricornutum, by generation of transformants harbouring a transgene cassette for the generation of amiRNAs designed to target the endogenous phytoene synthase (PSY) gene. In P. tricornutum, the amiRNA stem-loop precursor was processed to produce a mature amiRNA that successfully targeted the PSY mRNA and reduced PSY mRNA levels. As the PSY gene is a key component of the carotenoid biosynthetic pathway, the levels of carotenoids in the P. tricornutum amiRNA knockdown lines were reduced relative to untransformed control lines. This study demonstrates that artificial miRNAs can be successfully deployed for gene knockdown experiments in the model diatom P. tricornutum, providing a powerful tool for future metabolic engineering and synthetic biology experimentation in this model marine diatom.
Open field burning of rice crop residues in Punjab, India is a annual feature which is a serious environmental concern as thick smog engulfs the entire region, air quality index reaches to alarming ...levels and people struggle to breathe in the highly polluted air. The present study is an attempt to evaluate, in monetary terms, the willingness of people that a biomass based power plant be set up so that the practice of open field burning is halted. The willingness to pay (WTP) of people has been studied in Sangrur district, Punjab using Discrete Choice Experiments. Respondents representing the actual demographic of the district were randomly selected for the experiment. The study revealed that the highest WTP ( ₹ 187) was observed for the economic benefits of the power plant, that is, increase in revenue of the farmers and, employment and training opportunities for the locals. This was followed by the WTP for benefits that biomass based power plant would offer by reducing the health risks (₹ 165) associated with the burning of rice crop residues. The results of the study thus provide economic valuations of externalities associated with open field burning as well as underline the directions for bioenergy development in the state of Punjab, India.
•RPL and CL models applied to quantify the WTP for externalities associated with setting up of a biomass based power plant.•WTP for reduction in open field burning of rice crop residues was lowest (approximately Rs. 4).•Highest WTP (₹ 187) was observed with respect to the economic benefits of setting up a biomass based power plant.•Statistically significant WTP for health benefits indicated high concern amongst masses relating to open field burning.
•an abusive language detection model that perform multiclass classification of offensive language.•experimented with five deep learning models: Bi-LSTM, LSTM, Bi-GRU, GRU, and multi-dense ...LSTM.•dataset is classified in to three levels: offensive language categorization (Level A), offensive language detection (Level B), and offensive language target identification (Level c).•Gated Recurrent Unit (GRU) achieved the highest accuracy for Level A (78.65 %) and Level B (88.59 %). However, for Level C, all models except for the Long Short-Term Memory (LSTM) model achieved near-perfect accuracy values of 99.9 %.
With the rapid growth of social media culture, the use of offensive or hateful language has surged, which necessitates the development of effective abusive language detection models for online platforms. This paper focuses on developing a multi-class classification model to identify different types of offensive language. The input data is taken in the form of labeled tweets and is classified into offensive language detection, offensive language categorization, and offensive language target identification. The data undergoes pre-processing, which removes NaN value and punctuation, as well as performs tokenization followed by the generation of a word cloud to assess data quality. Further, the tf-idf technique is used for the selection of features. In the case of classifiers, multiple deep learning techniques, namely, bidirectional gated recurrent unit, multi-dense long short-term memory, bidirectional long short-term memory, gated recurrent unit, and long short-term memory, are applied where it has been found that all the models, except long short-term memory, achieved a high accuracy of 99.9 % for offensive language target identification. Bidirectional LSTM and multi-dense LSTM obtained the lowest loss and RMSE values of 0.01 and 0.1, respectively. This research provides valuable insights and contributes to the development of effective abusive language detection methods to promote a safe and respectful online environment. The insights gained can aid platform administrators in efficiently moderating content and taking appropriate actions against offensive language.
The study investigates the effect of Valsartan, an Angiotensin II type 1 receptor blocker (ARB), on the blunted neuroprotective response of ischemic post-conditioning (iPoCo) in rats subjected to ...High Fat Diet (HFD).
The neuroprotective response of iPoCo is blunted in conditions of vascular endothelial dysfunction (ED) associated with hypercholesterolemia, diabetes, hypertension,
Objectives: The study was undertaken to investigate the effect of Valsartan, an ARB, on the blunted neuroprotective response of iPoCo in rats subjected to HFD.
Wistar rats were subjected to HFD for 56 days. The cerebral ischemic injury was induced by bilateral common carotid artery occlusion (BCCAO) for 12 min followed by reperfusion of 24 hrs. iPoCo was induced by three preceding cycles of ischemia and reperfusion lasting 1 min each given immediately after BCCAO at the onset of prolonged reperfusion. The extent of the injury was assessed in terms of memory impairment using the Morris Water Maze test (MWM), sensorimotor disturbance using the neurological severity score (NSS), and cerebral infarct size using triphenyl tetrazolium chloride staining. Series of biochemical estimations including brain thiobarbituric acid reactive species (TBARS); reduced glutathione (GSH); myeloperoxidase (MPO); tumor necrosis factor-α (TNF-α); Nrf-2 and serum cholesterol, serum nitrite levels were performed.
BCCAO produced significant cerebral injury indicated by increased cerebral infarct size, memory impairment, increased NSS, and various biochemical alterations (increased cholesterol, TBARS, MPO, TNF-α, Nrf-2, and decreased nitrite and GSH levels). Significant neutrophil infiltration was also observed. iPoCo attenuated BCCAO-induced injury with respect to the above parameters in normal rats. The protective response of iPoCo was lost in HFD-treated rats. Treatment of Valsartan attenuated cerebral injury, potentiated the neuroprotective response of iPoCo in normal rats, and also restored the blunted neuroprotective effect of iPoCo in HFD-treated rats along with enhanced Nrf-2 levels.
Valsartan exerted a neuroprotective effect by virtue of its multiple actions with a crucial role of Nrf2 activation.
Introduction: No existing local literature and guidance is currently available regarding shade selection by the patients for artificial teeth set of complete denture. Results of studies done in other ...countries cannot be generalised in our local population; hence there is a need to know the desires of our population. Keeping this research question in mind, this study reflects the behavioural aspects and wishes of patients towards artificial teeth shades. Aim: To observe and compare the shade preferences of artificial teeth during complete denture fabrication in diverse sample of both male and female patients in two different dental colleges. Materials and Methods: A cross-sectional study was conducted in the Department of Prosthodontics and Crown and Bridge, KM Shah Dental College and Hospital, Vadodara and Sri Guru Ram Das Institute of Dental Sciences and Research, Amritsar during the time period of May 2016 to September 2019. A total of 824 participants with complete denture treatment needs, participated from two different dental colleges. Upper anterior molds of Acry Rock (Ruthinium Dental Products Pvt., Ltd.,) acrylic teeth in 18 different shades of A1, A2, A3 A3.5, A4, B1, B2, B3, B4, C1, C2, C3, C4, D2, D3, D4, E1and F1 were used and participants were asked to choose aesthetically pleasing shades for themselves in both the colleges. The frequency distribution was recorded and compared using the Chi-square test for statistical analysis for preference of shades between male and female participants of two colleges. Results: The most preferred shades were A1, B1, D2 and E1 by both male and female participants in both the colleges and the shade selection was statistically significant (p-value=0.0018), while no statistically significant difference was seen in preference of shades between male and female participants at both the colleges. Conclusion: Patients primarily preferred the lighter shades with high values. This should be kept in mind during treatment planning to increase the psychological acceptance of aged patients towards artificial dentures.
Suicide rates are higher in those who identify as transgender or gender nonconforming (TGNC) compared to the overall population. Suicide risk factors include discrimination, family rejection, ...internalized transphobia, and being denied appropriate bathroom or housing access. It is important to assess the risk of suicide among transgender and gender-nonconforming patients and discuss past experiences of prejudice or maltreatment to prevent further victimization. This narrative review includes the most pertinent literature from the past 17 years on issues related to suicide among individuals who identify as TGNC. .
Phalsa is a tropical and subtropical fruit that is high in nutritional value and is primarily cultivated for its fruit. As, Phalsa fruit contain high number of vitamins (A and C), minerals (calcium, ...phosphorus, and iron), and fibre while being low in calories and fat. The fruit and seed of Phalsa contain 18 amino acids, the majority of which are aspartic acid, glutamic acid, and leucine. Based on in vivo and in vitro studies phalsa plant possess high antioxidant, anti-inflammatory, anticancer, antimicrobial, antidiabetic properties. However, antioxidant properties are found in the form of vitamin C, total phenolic, anthocyanin, flavonoid, and tannin. The phalsa plant's fruits and leaves have substantial anticancer action against cancer cell lines. Because of the presence of a broad range of physiologically active chemicals, investigations on phalsa plants revealed that some plant parts have radioprotective qualities. The anti-glycosidase and anti-amylase activity of aqueous fresh fruit extract was shown to be substantial. The phalsa plant contains an abundance of biologically active chemicals, allowing it to control microorganisms through a variety of processes. Phalsa methanolic leaf extract was revealed to have antimalarial and antiemetic effects. The hot and cold polysaccharide fractions extracted from the phalsa plant have potent hepatoprotective and therapeutic properties. Therefore, this review is based on the nutritional, bioactive, phytochemicals, and potential pharmacological uses of phalsa. The potential health benefits and economic potential of the phalsa berry's phytochemicals are promising areas for further study.
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